Reviewed, UniProtKB/Swiss-Prot P61141 (SYUA_LAGLA)

Names and origin

Protein names

Recommended name:
    Alpha-synuclein

Gene names

Name:

SNCA

Organism

Lagothrix lagotricha (Common woolly monkey)

Taxonomic identifier

9519 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Atelidae › Atelinae › Lagothrix

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May be involved in the regulation of dopamine release and transport By similarity.
Subunit structure	Interacts with UCHL1 By similarity.
Subcellular location	CytoplasmBy similarity.
Post-translational modification	Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress By similarity. Ubiquitinated. The predominant conjugate is the diubiquitinated form By similarity.
Sequence similarities	Belongs to the synuclein family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat
PTM	Phosphoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	regulation of dopamine secretion Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Alpha-synuclein		PRO_0000184023
Amino acid modifications
	Modified residue	125	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61141-1 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: 89BDCDD1E2FB649E	FASTA	140	14,446
	10 20 30 40 50 60 MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK 70 80 90 100 110 120 EQVTSVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDHS GKSEEGAPQE GILEDMPVDP 130 140 DNEAYEMPSE EGYQDYEPEA

References

[1]	"Alpha-synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates." Hamilton B.A. Genomics 83:739-742(2004) [PubMed: 15028296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY362334 , AY362330, AY362331, AY362332, AY362333 Genomic DNA. Translation: AAQ85073.1.
3D structure databases
SMR	P61141. Positions 1-140.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P61141.
Family and domain databases
InterPro	IPR001058. Synuclein. IPR002460. Synuclein_alpha. [Graphical view]
Gene3D	G3DSA:1.10.287.700. Synuclein. 1 hit.
PANTHER	PTHR13820. Synuclein. 1 hit.
Pfam	PF01387. Synuclein. 1 hit. [Graphical view]
PRINTS	PR01212. ASYNUCLEIN. PR01211. SYNUCLEIN.
ProDom	PD010631. Synuclein. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

SYUA_LAGLA

Accession

Primary (citable) accession number: P61141

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	November 25, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)