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P61141 (SYUA_LAGLA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha-synuclein
Gene names
Name:SNCA
OrganismLagothrix lagotricha (Common woolly monkey)
Taxonomic identifier9519 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniAtelidaeAtelinaeLagothrix

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in the regulation of dopamine release and transport By similarity.

Subunit structure

Interacts with UCHL1 By similarity.

Subcellular location

Cytoplasm By similarity.

Post-translational modification

Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress By similarity.

Ubiquitinated. The predominant conjugate is the diubiquitinated form By similarity.

Sequence similarities

Belongs to the synuclein family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   PTMPhosphoprotein
Ubl conjugation
Gene Ontology (GO)
   Biological processregulation of dopamine secretion

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Alpha-synuclein
PRO_0000184023

Amino acid modifications

Modified residue1251Phosphotyrosine; by FYN By similarity
Modified residue1291Phosphoserine; by PLK2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P61141 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: 89BDCDD1E2FB649E

FASTA14014,446
        10         20         30         40         50         60 
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK 

        70         80         90        100        110        120 
EQVTSVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDHS GKSEEGAPQE GILEDMPVDP 

       130        140 
DNEAYEMPSE EGYQDYEPEA 

« Hide

References

[1]"Alpha-synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates."
Hamilton B.A.
Genomics 83:739-742(2004) [PubMed: 15028296] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY362334 expand/collapse EMBL AC list , AY362330, AY362331, AY362332, AY362333 Genomic DNA. Translation: AAQ85073.1.

3D structure databases

ProteinModelPortalP61141.
SMRP61141. Positions 1-140.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000481.

Family and domain databases

InterProIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
Gene3DG3DSA:1.10.287.700. Synuclein. 1 hit.
PANTHERPTHR13820. Synuclein. 1 hit.
PfamPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetSearch...

Entry information

Entry nameSYUA_LAGLA
AccessionPrimary (citable) accession number: P61141
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families