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Reviewed, UniProtKB/Swiss-Prot P61141 (SYUA_LAGLA)

Last modified November 25, 2008. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alpha-synuclein
Gene names
Name: SNCA
OrganismLagothrix lagotricha (Common woolly monkey)
Taxonomic identifier9519 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniAtelidaeAtelinaeLagothrix

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

May be involved in the regulation of dopamine release and transport By similarity.

Subunit structure

Interacts with UCHL1 By similarity.

Subcellular location

CytoplasmBy similarity.

Post-translational modification

Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress By similarity.

Ubiquitinated. The predominant conjugate is the diubiquitinated form By similarity.

Sequence similarities

Belongs to the synuclein family.

Ontologies

Keywords

   Cellular componentCytoplasm
   DomainRepeat
   PTMPhosphoprotein
Ubl conjugation

Gene Ontology (GO)

   Biological processregulation of dopamine secretion

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Alpha-synuclein
PRO_0000184023

Amino acid modifications

Modified residue1251Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P61141-1 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: 89BDCDD1E2FB649E

FASTA14014,446
        10         20         30         40         50         60 
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK 

        70         80         90        100        110        120 
EQVTSVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDHS GKSEEGAPQE GILEDMPVDP 

       130        140 
DNEAYEMPSE EGYQDYEPEA 

« Hide

References

[1]"Alpha-synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates."
Hamilton B.A.
Genomics 83:739-742(2004) [PubMed: 15028296] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

AY362334 expand/collapse EMBL AC list , AY362330, AY362331, AY362332, AY362333 Genomic DNA. Translation: AAQ85073.1.

3D structure databases

SMRP61141. Positions 1-140.
ModBaseSearch...

Phylogenomic databases

HOVERGENP61141.

Family and domain databases

InterProIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
Gene3DG3DSA:1.10.287.700. Synuclein. 1 hit.
PANTHERPTHR13820. Synuclein. 1 hit.
PfamPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.
ProDomPD010631. Synuclein. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameSYUA_LAGLA
AccessionPrimary (citable) accession number: P61141
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 25, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents