Reviewed, UniProtKB/Swiss-Prot P61133 (LYG_TAKRU)

Names and origin

Protein names	Recommended name:     Lysozyme g     EC=3.2.1.17 Alternative name(s):     1,4-beta-N-acetylmuramidase
Organism	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifier	31033 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 23 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Lysozyme g		PRO_0000193519
Sites
	Active site	71	1	By similarity
	Active site	84	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61133-1 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: 335B0AE93EC6E4C8	FASTA	190	20,868
	10 20 30 40 50 60 MPYGKIEDIK TSGASDVTAA QDGLKEGGWK SSHRMAEIDS NRMENYRTII NEAGRQCDVD 70 80 90 100 110 120 PAVIAGIISR ESRAGNQLIN GWGDHGKAFG LMQIDVTPPP NGGGHTPVGT WDSLEHLIQA 130 140 150 160 170 180 TEILVEFIER IKTKFPRWNA DQHLKGALAA YNKGEKNVES YASVDAKTTG KDYSNDVVAR 190 AQWYKSNMGF

References

[1]	"Molecular cloning, expression of chicken- and goose-type lysozyme gene of torafugu (Takifugu rubripes)." Miyadai T., Ootani M., Iwata K. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pronephros.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB126244 mRNA. Translation: BAD02934.2.
RefSeq	NP_001027764.1.
UniGene	Tru.1983
3D structure databases
SMR	P61133. Positions 2-190.
ModBase	Search...
Protein family/group databases
CAZy	GH23. Glycoside Hydrolase Family 23.
Genome annotation databases
Ensembl	ENSTRUT00000008741; ENSTRUP00000008690; ENSTRUG00000003703; Takifugu rubripes. [Genome view]
GeneID	445926.
Phylogenomic databases
eggNOG	fiNOG16201.
HOVERGEN	P61133.
Enzyme and pathway databases
BRENDA	3.2.1.17. 281122.
Family and domain databases
InterPro	IPR002152. Glyco_hydro_23. IPR008258. Lytic_TGlycosylase-like_cat. [Graphical view]
Pfam	PF01464. SLT. 1 hit. [Graphical view]
PIRSF	PIRSF001065. Lysozyme_g. 1 hit.
PRINTS	PR00749. LYSOZYMEG.
ProtoNet	Search...

Entry information

Entry name

LYG_TAKRU

Accession

Primary (citable) accession number: P61133

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	April 26, 2005
Last modified:	January 19, 2010
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)