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Protein

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Gene

St3gal4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids.By similarity

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-2022854. Keratan sulfate biosynthesis.
R-RNO-4085001. Sialic acid metabolism.
R-RNO-975577. N-Glycan antennae elongation.
R-RNO-977068. Termination of O-glycan biosynthesis.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Chemistry

SwissLipidsiSLP:000001443.

Names & Taxonomyi

Protein namesi
Recommended name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (EC:2.4.99.-)
Short name:
Alpha 2,3-ST 4
Short name:
Beta-galactoside alpha-2,3-sialyltransferase 4
Alternative name(s):
Alpha 2,3-sialyltransferase IV
Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
ST3Gal IV
Short name:
ST3GalIV
Sialyltransferase 4C
Short name:
SIAT4-C
Gene namesi
Name:St3gal4
Synonyms:Siat4c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303068. St3gal4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2618Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini27 – 333307LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4PRO_0000149265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 273By similarity
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence analysis
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP61131.
PRIDEiP61131.

Expressioni

Gene expression databases

GenevisibleiP61131. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013243.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiP61131.
KOiK03494.
OMAiIHYYEQI.
OrthoDBiEOG76X609.
PhylomeDBiP61131.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

P61131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKSHWKLL ALALVLVVVM VWYSISREDR YIEFFYFPVS EKKEPCFQGE
60 70 80 90 100
AERQASKIFG NHSREQPIFL QLKDYFWVKT PSAYELPFGT KGSEDLLLRV
110 120 130 140 150
LAITSYSIPE SIQSLECRRC VVVGNGHRLK NSSLGGVINK YDVVIRLNNA
160 170 180 190 200
PVAGYEGDVG SKTTIRLFYP ESAHFDPKIE NNPDTLLVLV AFKAMDFHWI
210 220 230 240 250
ETILSDKKRV RKGFWKQPPL IWDVNPKQIR ILNPFFMEIA ADKLLSLPIQ
260 270 280 290 300
QPRKIKQKPT TGLLAITLAL HLCDLVHIAG FGYPDAYNKK QTIHYYEQIT
310 320 330
LKSMAGSGHN VSQEAVAIKR MLEMGAVKNL TYF
Length:333
Mass (Da):38,043
Last modified:May 10, 2004 - v1
Checksum:i8D086A0F73C79791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ626825 mRNA. Translation: CAF25183.1.
BC089057 mRNA. Translation: AAH89057.1.
RefSeqiNP_976082.1. NM_203337.2.
XP_006242851.1. XM_006242789.2.
XP_008764282.1. XM_008766060.1.
UniGeneiRn.24125.

Genome annotation databases

EnsembliENSRNOT00000013243; ENSRNOP00000013243; ENSRNOG00000009850.
GeneIDi363040.
KEGGirno:363040.
UCSCiRGD:1303068. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ626825 mRNA. Translation: CAF25183.1.
BC089057 mRNA. Translation: AAH89057.1.
RefSeqiNP_976082.1. NM_203337.2.
XP_006242851.1. XM_006242789.2.
XP_008764282.1. XM_008766060.1.
UniGeneiRn.24125.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013243.

Chemistry

SwissLipidsiSLP:000001443.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Proteomic databases

PaxDbiP61131.
PRIDEiP61131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013243; ENSRNOP00000013243; ENSRNOG00000009850.
GeneIDi363040.
KEGGirno:363040.
UCSCiRGD:1303068. rat.

Organism-specific databases

CTDi6484.
RGDi1303068. St3gal4.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiP61131.
KOiK03494.
OMAiIHYYEQI.
OrthoDBiEOG76X609.
PhylomeDBiP61131.
TreeFamiTF354325.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-RNO-2022854. Keratan sulfate biosynthesis.
R-RNO-4085001. Sialic acid metabolism.
R-RNO-975577. N-Glycan antennae elongation.
R-RNO-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

PROiP61131.

Gene expression databases

GenevisibleiP61131. RN.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Phylogeny of sialyltransferases."
    Harduin-Lepers A., Martinez-Duncker I., Mollicone R., Delannoy P., Oriol R.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSIA4C_RAT
AccessioniPrimary (citable) accession number: P61131
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.