P61129 (ZC3H6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger CCCH domain-containing protein 6

Gene names

Name:	ZC3H6
Synonyms:	KIAA2035, ZC3HDC6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1189 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 3 C3H1-type zinc fingers.
Sequence caution	The sequence BAC85608.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC87128.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC87128.1 differs from that shown. Reason: Frameshift at position 1120.

Ontologies

Keywords
Domain	Coiled coil Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1189	1189	Zinc finger CCCH domain-containing protein 6		PRO_0000213901
Regions
	Zinc finger	273 – 299	27	C3H1-type 1
	Zinc finger	301 – 328	28	C3H1-type 2
	Zinc finger	329 – 352	24	C3H1-type 3
	Coiled coil	27 – 73	47	Potential
	Coiled coil	353 – 385	33	Potential
	Compositional bias	388 – 545	158	Pro-rich
Experimental info
	Sequence conflict	741	1	T → A in BAC85608. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P61129 [UniParc]. Last modified May 3, 2011. Version 2. Checksum: 474CCCD8D9E4C466	FASTA	1,189	131,670
	10 20 30 40 50 60 MTDSEHAGHD REDGELEDGE IDDAGFEEIQ EKEAKENEKQ KSEKAYRKSR KKHKKEREKK 70 80 90 100 110 120 KSKRRKREKH KHNSPSSDDS SDYSLDSDVE HTESSHKKRT GFYRDYDIPF TQRGHISGSY 130 140 150 160 170 180 ITSKKGQHNK KFKSKEYDEY STYSDDNFGN YSDDNFGNYG QETEEDFANQ LKQYRQAKET 190 200 210 220 230 240 SNIALGSSFS KESGKKQRMK GVQQGIEQRV KSFNVGRGRG LPKKIKRKER GGRTNKGPNV 250 260 270 280 290 300 FSVSDDFQEY NKPGKKWKVM TQEFINQHTV EHKGKQICKY FLEGRCIKGD QCKFDHDAEL 310 320 330 340 350 360 EKRKEICKFY LQGYCTKGEN CIYMHNEFPC KFYHSGAKCY QGDNCKFSHD DLTKETKKLL 370 380 390 400 410 420 DKVLNTDEEL INEDERELEE LRKRGITPLP KPPPGVGLLP TPPEHFPFSD PEDDFQTDFS 430 440 450 460 470 480 DDFRKIPSLF EIVVKPTVDL AHKIGRKPPA FYTSASPPGP QFQGSSPHPQ HIYSSGSSPG 490 500 510 520 530 540 PGPNMSQGHS SPVMHPGSPG HHPCAGPPGL PVPQSPPLPP GPPEIVGPQN QAGVLVQPDT 550 560 570 580 590 600 SLTPPSMGGA YHSPGFPGHV MKVPRENHCS PGSSYQQSPG EMQLNTNYES LQNPAEFYDN 610 620 630 640 650 660 YYAQHSIHNF QPPNNSGDGM WHGEFAQQQP PVVQDSPNHG SGSDGSSTRT GHGPLPVPGL 670 680 690 700 710 720 LPAVQRALFV RLTQRYQEDE EQTSTQPHRA PSKEEDDTVN WYSSSEEEEG SSVKSILKTL 730 740 750 760 770 780 QKQTETLRNQ QQPSTELSTP TDPRLAKEKS KGNQVVDPRL RTIPRQDIRK PSESAPLDLR 790 800 810 820 830 840 LAWDPRKLRG NGSGHIGSSV GGAKFDLHHA NAGTNVKHKR GDDDDEDTER ELREKAFLIP 850 860 870 880 890 900 LDASPGIMLQ DPRSQLRQFS HIKMDITLTK PNFAKHIVWA PEDLLPVPLP KPDPVSSINL 910 920 930 940 950 960 PLPPLIADQR LNRLWNTKSD LHQNTVSIDP KLAAKAKINT TNREGYLEQF GDSHGSGAKL 970 980 990 1000 1010 1020 GDPRLQKNFD PRLHRLPNTE SHQVVMKDSH ASKGAPHLPR SNPGSSQPSG AGTSNSGSGA 1030 1040 1050 1060 1070 1080 LPPYAPKLSS SAGLPLGTST SVLSGISLYD PRDHGSSSTS ELATASSGEN SKNQKKSGGL 1090 1100 1110 1120 1130 1140 KSSDKTEPSP GEAILPQKPS PNVGVTLEGP ADPQADVPRS SGKVQVPAVH SLPVQALTGL 1150 1160 1170 1180 IRPQYSDPRQ ARQPGQGSPT PDNDPGRETD DKSLKEVFKT FDPTASPFC

References

[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The nucleotide sequence of a long cDNA clone isolated from human." Nagase T., Kikuno R., Yamakawa H., Ohara O. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-1189. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-1189.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-1189. Tissue: Fetal brain and Hippocampus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC115115 Genomic DNA. No translation available. AB111887 mRNA. Translation: BAC98375.1. BC155540 mRNA. Translation: AAI55541.1. BC167154 mRNA. Translation: AAI67154.1. AK123404 mRNA. Translation: BAC85608.1. Different initiation. AK127776 mRNA. Translation: BAC87128.1. Sequence problems.
IPI	IPI00410656.
RefSeq	NP_940983.2. NM_198581.2.
UniGene	Hs.190477.
3D structure databases
ProteinModelPortal	P61129.
SMR	P61129. Positions 296-387.
ModBase	Search...
PTM databases
PhosphoSite	P61129.
Polymorphism databases
DMDM	47117369.
Proteomic databases
PRIDE	P61129.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343936; ENSP00000340298; ENSG00000188177. ENST00000409871; ENSP00000386764; ENSG00000188177.
GeneID	376940.
KEGG	hsa:376940.
Organism-specific databases
CTD	376940.
GeneCards	GC02P113033.
HGNC	HGNC:24762. ZC3H6.
HPA	HPA036019.
neXtProt	NX_P61129.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19300.
HOGENOM	HBG446706.
HOVERGEN	HBG063914.
InParanoid	P61129.
OMA	PIQALTG.
OrthoDB	EOG4CG081.
Gene expression databases
ArrayExpress	P61129.
Bgee	P61129.
CleanEx	HS_ZC3H6.
Genevestigator	P61129.
GermOnline	ENSG00000188177. Homo sapiens.
Family and domain databases
InterPro	IPR000571. Znf_CCCH. [Graphical view]
Pfam	PF00642. zf-CCCH. 1 hit. [Graphical view]
SMART	SM00356. ZnF_C3H1. 3 hits. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ZC3H6_HUMAN

Accession

Primary (citable) accession number: P61129
Secondary accession number(s): A9JR71, Q6ZW96

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 3, 2011
Last modified:	January 25, 2012
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.