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Protein

Zinc finger CCCH domain-containing protein 6

Gene

ZC3H6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri273 – 29927C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32828C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35224C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 6
Gene namesi
Name:ZC3H6
Synonyms:KIAA2035, ZC3HDC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24762. ZC3H6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670510.

Polymorphism and mutation databases

BioMutaiZC3H6.
DMDMi332278115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11891189Zinc finger CCCH domain-containing protein 6PRO_0000213901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1158 – 11581PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP61129.
MaxQBiP61129.
PaxDbiP61129.
PeptideAtlasiP61129.
PRIDEiP61129.

PTM databases

iPTMnetiP61129.
PhosphoSiteiP61129.
SwissPalmiP61129.

Expressioni

Gene expression databases

BgeeiP61129.
CleanExiHS_ZC3H6.
GenevisibleiP61129. HS.

Organism-specific databases

HPAiHPA036019.
HPA036020.

Interactioni

Protein-protein interaction databases

BioGridi132014. 1 interaction.
STRINGi9606.ENSP00000386764.

Structurei

3D structure databases

ProteinModelPortaliP61129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili27 – 7347Sequence analysisAdd
BLAST
Coiled coili353 – 38533Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi388 – 545158Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri273 – 29927C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32828C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35224C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1040. Eukaryota.
COG5084. LUCA.
GeneTreeiENSGT00530000063288.
HOGENOMiHOG000231733.
HOVERGENiHBG063914.
InParanoidiP61129.
OMAiDEYSTYS.
OrthoDBiEOG79GT5K.
PhylomeDBiP61129.
TreeFamiTF321641.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 3 hits.
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSEHAGHD REDGELEDGE IDDAGFEEIQ EKEAKENEKQ KSEKAYRKSR
60 70 80 90 100
KKHKKEREKK KSKRRKREKH KHNSPSSDDS SDYSLDSDVE HTESSHKKRT
110 120 130 140 150
GFYRDYDIPF TQRGHISGSY ITSKKGQHNK KFKSKEYDEY STYSDDNFGN
160 170 180 190 200
YSDDNFGNYG QETEEDFANQ LKQYRQAKET SNIALGSSFS KESGKKQRMK
210 220 230 240 250
GVQQGIEQRV KSFNVGRGRG LPKKIKRKER GGRTNKGPNV FSVSDDFQEY
260 270 280 290 300
NKPGKKWKVM TQEFINQHTV EHKGKQICKY FLEGRCIKGD QCKFDHDAEL
310 320 330 340 350
EKRKEICKFY LQGYCTKGEN CIYMHNEFPC KFYHSGAKCY QGDNCKFSHD
360 370 380 390 400
DLTKETKKLL DKVLNTDEEL INEDERELEE LRKRGITPLP KPPPGVGLLP
410 420 430 440 450
TPPEHFPFSD PEDDFQTDFS DDFRKIPSLF EIVVKPTVDL AHKIGRKPPA
460 470 480 490 500
FYTSASPPGP QFQGSSPHPQ HIYSSGSSPG PGPNMSQGHS SPVMHPGSPG
510 520 530 540 550
HHPCAGPPGL PVPQSPPLPP GPPEIVGPQN QAGVLVQPDT SLTPPSMGGA
560 570 580 590 600
YHSPGFPGHV MKVPRENHCS PGSSYQQSPG EMQLNTNYES LQNPAEFYDN
610 620 630 640 650
YYAQHSIHNF QPPNNSGDGM WHGEFAQQQP PVVQDSPNHG SGSDGSSTRT
660 670 680 690 700
GHGPLPVPGL LPAVQRALFV RLTQRYQEDE EQTSTQPHRA PSKEEDDTVN
710 720 730 740 750
WYSSSEEEEG SSVKSILKTL QKQTETLRNQ QQPSTELSTP TDPRLAKEKS
760 770 780 790 800
KGNQVVDPRL RTIPRQDIRK PSESAPLDLR LAWDPRKLRG NGSGHIGSSV
810 820 830 840 850
GGAKFDLHHA NAGTNVKHKR GDDDDEDTER ELREKAFLIP LDASPGIMLQ
860 870 880 890 900
DPRSQLRQFS HIKMDITLTK PNFAKHIVWA PEDLLPVPLP KPDPVSSINL
910 920 930 940 950
PLPPLIADQR LNRLWNTKSD LHQNTVSIDP KLAAKAKINT TNREGYLEQF
960 970 980 990 1000
GDSHGSGAKL GDPRLQKNFD PRLHRLPNTE SHQVVMKDSH ASKGAPHLPR
1010 1020 1030 1040 1050
SNPGSSQPSG AGTSNSGSGA LPPYAPKLSS SAGLPLGTST SVLSGISLYD
1060 1070 1080 1090 1100
PRDHGSSSTS ELATASSGEN SKNQKKSGGL KSSDKTEPSP GEAILPQKPS
1110 1120 1130 1140 1150
PNVGVTLEGP ADPQADVPRS SGKVQVPAVH SLPVQALTGL IRPQYSDPRQ
1160 1170 1180
ARQPGQGSPT PDNDPGRETD DKSLKEVFKT FDPTASPFC
Length:1,189
Mass (Da):131,670
Last modified:May 3, 2011 - v2
Checksum:i474CCCD8D9E4C466
GO

Sequence cautioni

The sequence BAC85608.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87128.1 differs from that shown. Reason: Frameshift at position 1120. Curated
The sequence BAC87128.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti741 – 7411T → A in BAC85608 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115115 Genomic DNA. No translation available.
AB111887 mRNA. Translation: BAC98375.1.
BC155540 mRNA. Translation: AAI55541.1.
BC167154 mRNA. Translation: AAI67154.1.
AK123404 mRNA. Translation: BAC85608.1. Different initiation.
AK127776 mRNA. Translation: BAC87128.1. Sequence problems.
CCDSiCCDS46393.1.
RefSeqiNP_940983.2. NM_198581.2.
UniGeneiHs.190477.

Genome annotation databases

EnsembliENST00000343936; ENSP00000340298; ENSG00000188177.
ENST00000409871; ENSP00000386764; ENSG00000188177.
GeneIDi376940.
KEGGihsa:376940.
UCSCiuc002thq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115115 Genomic DNA. No translation available.
AB111887 mRNA. Translation: BAC98375.1.
BC155540 mRNA. Translation: AAI55541.1.
BC167154 mRNA. Translation: AAI67154.1.
AK123404 mRNA. Translation: BAC85608.1. Different initiation.
AK127776 mRNA. Translation: BAC87128.1. Sequence problems.
CCDSiCCDS46393.1.
RefSeqiNP_940983.2. NM_198581.2.
UniGeneiHs.190477.

3D structure databases

ProteinModelPortaliP61129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132014. 1 interaction.
STRINGi9606.ENSP00000386764.

PTM databases

iPTMnetiP61129.
PhosphoSiteiP61129.
SwissPalmiP61129.

Polymorphism and mutation databases

BioMutaiZC3H6.
DMDMi332278115.

Proteomic databases

EPDiP61129.
MaxQBiP61129.
PaxDbiP61129.
PeptideAtlasiP61129.
PRIDEiP61129.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343936; ENSP00000340298; ENSG00000188177.
ENST00000409871; ENSP00000386764; ENSG00000188177.
GeneIDi376940.
KEGGihsa:376940.
UCSCiuc002thq.2. human.

Organism-specific databases

CTDi376940.
GeneCardsiZC3H6.
HGNCiHGNC:24762. ZC3H6.
HPAiHPA036019.
HPA036020.
neXtProtiNX_P61129.
PharmGKBiPA142670510.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1040. Eukaryota.
COG5084. LUCA.
GeneTreeiENSGT00530000063288.
HOGENOMiHOG000231733.
HOVERGENiHBG063914.
InParanoidiP61129.
OMAiDEYSTYS.
OrthoDBiEOG79GT5K.
PhylomeDBiP61129.
TreeFamiTF321641.

Miscellaneous databases

ChiTaRSiZC3H6. human.
GenomeRNAii376940.
PROiP61129.

Gene expression databases

BgeeiP61129.
CleanExiHS_ZC3H6.
GenevisibleiP61129. HS.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 3 hits.
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Yamakawa H., Ohara O.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-1189.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-1189.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-1189.
    Tissue: Fetal brain and Hippocampus.
  5. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1158, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiZC3H6_HUMAN
AccessioniPrimary (citable) accession number: P61129
Secondary accession number(s): A9JR71, Q6ZW96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 3, 2011
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.