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Protein

Interleukin-13

Gene

IL13

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001555121 – 132Interleukin-13Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 76By similarity
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi64 ↔ 90By similarity
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP61126

Expressioni

Gene expression databases

BgeeiENSPTRG00000017219

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000044414

Structurei

3D structure databases

ProteinModelPortaliP61126
SMRiP61126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiP61126
KOiK05435
OMAiVYCAALE
OrthoDBiEOG091G10SR
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLTTVIA LTCLGGFASP GPVPPSTALR ELIEELVNIT QNQKAPLCNG
60 70 80 90 100
SMVWSINLTA GVYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS
110 120 130
SLHVRDTKIE VAQFVKDLLL HLKKLFREGR FN
Length:132
Mass (Da):14,287
Last modified:May 10, 2004 - v1
Checksum:i6522B77DB87FC3CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY480012 Genomic DNA Translation: AAR32991.1
RefSeqiNP_001008992.1, NM_001008992.1
UniGeneiPtr.6156

Genome annotation databases

GeneIDi449564
KEGGiptr:449564

Similar proteinsi

Entry informationi

Entry nameiIL13_PANTR
AccessioniPrimary (citable) accession number: P61126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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