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Protein

Interleukin-13

Gene

IL13

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 132112Interleukin-13PRO_0000015551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi48 ↔ 76By similarity
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi64 ↔ 90By similarity
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP61126.

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000044414.

Structurei

3D structure databases

ProteinModelPortaliP61126.
SMRiP61126. Positions 21-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP61126.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG78SQMB.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLTTVIA LTCLGGFASP GPVPPSTALR ELIEELVNIT QNQKAPLCNG
60 70 80 90 100
SMVWSINLTA GVYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS
110 120 130
SLHVRDTKIE VAQFVKDLLL HLKKLFREGR FN
Length:132
Mass (Da):14,287
Last modified:May 10, 2004 - v1
Checksum:i6522B77DB87FC3CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY480012 Genomic DNA. Translation: AAR32991.1.
RefSeqiNP_001008992.1. NM_001008992.1.
UniGeneiPtr.6156.

Genome annotation databases

EnsembliENSPTRT00000031885; ENSPTRP00000044414; ENSPTRG00000017219.
GeneIDi449564.
KEGGiptr:449564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY480012 Genomic DNA. Translation: AAR32991.1.
RefSeqiNP_001008992.1. NM_001008992.1.
UniGeneiPtr.6156.

3D structure databases

ProteinModelPortaliP61126.
SMRiP61126. Positions 21-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000044414.

Proteomic databases

PaxDbiP61126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000031885; ENSPTRP00000044414; ENSPTRG00000017219.
GeneIDi449564.
KEGGiptr:449564.

Organism-specific databases

CTDi3596.

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiP61126.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG78SQMB.
TreeFamiTF336383.

Miscellaneous databases

NextBioi20832679.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pan troglodytes genomic region including interleukin 13 (IL13) gene and interleukin 4 (IL4) gene."
    Sakagami T., Nakajima T., Saito N., Hayasaka I., Inoue I.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiIL13_PANTR
AccessioniPrimary (citable) accession number: P61126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.