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Protein

Thermosome subunit alpha

Gene

thsA

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTKOD69014:GH72-689-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosome subunit alpha
Alternative name(s):
Chaperonin subunit alpha
Thermosome subunit 1
Gene namesi
Name:thsA
Synonyms:cpkA
Ordered Locus Names:TK0678
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Thermosome subunit alphaPRO_0000128397Add
BLAST

Interactioni

Subunit structurei

Forms a Heterooligomeric complex of two stacked eight-membered rings.By similarity

Protein-protein interaction databases

STRINGi69014.TK0678.

Structurei

3D structure databases

SMRiP61111. Positions 9-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiCOG0459.
HOGENOMiHOG000226732.
InParanoidiP61111.
OMAiSHHMVTD.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLSGQPVV ILPEGTQRYV GRDAQRLNIL AARIIAETVR TTLGPKGMDK
60 70 80 90 100
MLVDSLGDIV VTNDGATILD KIDLQHPAAK MMVEVAKTQD KEAGDGTTTA
110 120 130 140 150
VVIAGELLRK AEELLDQNIH PSIIIKGYAL AAEKAQEILD EIAIRVDPDD
160 170 180 190 200
EETLLKIAAT SITGKNAESH KELLAKLAVE AVKQVAEKKD GKYVVDLDNI
210 220 230 240 250
KFEKKAGEGV EESELVRGVV IDKEVVHPRM PKRVENAKIA LINEALEVKK
260 270 280 290 300
TETDAKINIT SPDQLMSFLE QEEKMLKDMV DHIAQTGANV VFVQKGIDDL
310 320 330 340 350
AQHYLAKYGI MAVRRVKKSD MEKLAKATGA KIVTNVKDLT PEDLGYAEVV
360 370 380 390 400
EERKLAGENM IFVEGCKNPK AVTILIRGGT EHVIDEVERA LEDAVKVVKD
410 420 430 440 450
VMEDGAVLPA GGAPEIELAI RLDEYAKQVG GKEALAIENF ADALKIIPKT
460 470 480 490 500
LAENAGLDTV EMLVKVISEH KNRGLGIGID VFEGKPADML EKGIIEPLRV
510 520 530 540
KKQAIKSASE AAIMILRIDD VIAAKATKPE GGQGGGMPGG MGGMDMGM
Length:548
Mass (Da):59,170
Last modified:May 10, 2004 - v1
Checksum:iD7B4F3889E02A88A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018432 Genomic DNA. Translation: BAA76952.1.
AP006878 Genomic DNA. Translation: BAD84867.1.
PIRiT43915.
RefSeqiYP_183091.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84867; BAD84867; TK0678.
GeneIDi3234606.
KEGGitko:TK0678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018432 Genomic DNA. Translation: BAA76952.1.
AP006878 Genomic DNA. Translation: BAD84867.1.
PIRiT43915.
RefSeqiYP_183091.1. NC_006624.1.

3D structure databases

SMRiP61111. Positions 9-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi69014.TK0678.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD84867; BAD84867; TK0678.
GeneIDi3234606.
KEGGitko:TK0678.

Phylogenomic databases

eggNOGiCOG0459.
HOGENOMiHOG000226732.
InParanoidiP61111.
OMAiSHHMVTD.

Enzyme and pathway databases

BioCyciTKOD69014:GH72-689-MONOMER.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a second subunit of molecular chaperonin from Pyrococcus kodakaraensis KOD1: analysis of an ATPase-deficient mutant enzyme."
    Izumi M., Fujiwara S., Takagi M., Kanaya S., Imanaka T.
    Appl. Environ. Microbiol. 65:1801-1805(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.
  2. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiTHSA_THEKO
AccessioniPrimary (citable) accession number: P61111
Secondary accession number(s): O24729, Q9Y8I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 1, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.