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Protein

Thermosome subunit alpha

Gene

thsA

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-674-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosome subunit alpha
Alternative name(s):
Chaperonin subunit alpha
Thermosome subunit 1
Gene namesi
Name:thsA
Synonyms:cpkA
Ordered Locus Names:TK0678
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283971 – 548Thermosome subunit alphaAdd BLAST548

Interactioni

Subunit structurei

Forms a Heterooligomeric complex of two stacked eight-membered rings.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi69014.TK0678

Structurei

Secondary structure

1548
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 20Combined sources4
Helixi21 – 40Combined sources20
Beta strandi50 – 53Combined sources4
Beta strandi59 – 62Combined sources4
Helixi65 – 71Combined sources7
Helixi77 – 92Combined sources16
Helixi97 – 116Combined sources20
Helixi121 – 142Combined sources22
Helixi151 – 162Combined sources12
Helixi166 – 170Combined sources5
Helixi171 – 185Combined sources15
Beta strandi187 – 191Combined sources5
Helixi197 – 199Combined sources3
Beta strandi200 – 208Combined sources9
Helixi210 – 212Combined sources3
Beta strandi214 – 222Combined sources9
Beta strandi232 – 242Combined sources11
Beta strandi255 – 257Combined sources3
Helixi262 – 285Combined sources24
Beta strandi289 – 295Combined sources7
Helixi299 – 307Combined sources9
Beta strandi311 – 313Combined sources3
Helixi318 – 328Combined sources11
Beta strandi332 – 335Combined sources4
Helixi336 – 338Combined sources3
Helixi341 – 343Combined sources3
Beta strandi345 – 355Combined sources11
Beta strandi358 – 364Combined sources7
Beta strandi370 – 380Combined sources11
Helixi381 – 403Combined sources23
Beta strandi406 – 409Combined sources4
Helixi413 – 429Combined sources17
Helixi431 – 443Combined sources13
Helixi446 – 455Combined sources10
Helixi459 – 473Combined sources15
Beta strandi477 – 480Combined sources4
Turni481 – 484Combined sources4
Beta strandi485 – 488Combined sources4
Turni489 – 493Combined sources5
Beta strandi495 – 497Combined sources3
Helixi498 – 516Combined sources19
Beta strandi518 – 523Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3RX-ray2.90A/B/C/D1-548[»]
ProteinModelPortaliP61111
SMRiP61111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiarCOG01257 Archaea
COG0459 LUCA
HOGENOMiHOG000226732
InParanoidiP61111
KOiK22447
OMAiYATDEYG
OrthoDBiPOG093Z02BT

Family and domain databases

CDDicd03343 cpn60, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
IPR012714 Thermosome_arc
PANTHERiPTHR11353 PTHR11353, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02339 thermosome_arch, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P61111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLSGQPVV ILPEGTQRYV GRDAQRLNIL AARIIAETVR TTLGPKGMDK
60 70 80 90 100
MLVDSLGDIV VTNDGATILD KIDLQHPAAK MMVEVAKTQD KEAGDGTTTA
110 120 130 140 150
VVIAGELLRK AEELLDQNIH PSIIIKGYAL AAEKAQEILD EIAIRVDPDD
160 170 180 190 200
EETLLKIAAT SITGKNAESH KELLAKLAVE AVKQVAEKKD GKYVVDLDNI
210 220 230 240 250
KFEKKAGEGV EESELVRGVV IDKEVVHPRM PKRVENAKIA LINEALEVKK
260 270 280 290 300
TETDAKINIT SPDQLMSFLE QEEKMLKDMV DHIAQTGANV VFVQKGIDDL
310 320 330 340 350
AQHYLAKYGI MAVRRVKKSD MEKLAKATGA KIVTNVKDLT PEDLGYAEVV
360 370 380 390 400
EERKLAGENM IFVEGCKNPK AVTILIRGGT EHVIDEVERA LEDAVKVVKD
410 420 430 440 450
VMEDGAVLPA GGAPEIELAI RLDEYAKQVG GKEALAIENF ADALKIIPKT
460 470 480 490 500
LAENAGLDTV EMLVKVISEH KNRGLGIGID VFEGKPADML EKGIIEPLRV
510 520 530 540
KKQAIKSASE AAIMILRIDD VIAAKATKPE GGQGGGMPGG MGGMDMGM
Length:548
Mass (Da):59,170
Last modified:May 10, 2004 - v1
Checksum:iD7B4F3889E02A88A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018432 Genomic DNA Translation: BAA76952.1
AP006878 Genomic DNA Translation: BAD84867.1
PIRiT43915
RefSeqiWP_011249629.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD84867; BAD84867; TK0678
GeneIDi3234606
KEGGitko:TK0678
PATRICifig|69014.16.peg.659

Similar proteinsi

Entry informationi

Entry nameiTHSA_THEKO
AccessioniPrimary (citable) accession number: P61111
Secondary accession number(s): O24729, Q9Y8I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health