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P61111 (THSA_THEKO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thermosome subunit alpha
Alternative name(s):
Chaperonin subunit alpha
Thermosome subunit 1
Gene names
Name:thsA
Synonyms:cpkA
Ordered Locus Names:TK0678
OrganismThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]
Taxonomic identifier69014 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity By similarity.

Subunit structure

Forms a Heterooligomeric complex of two stacked eight-membered rings By similarity.

Sequence similarities

Belongs to the TCP-1 chaperonin family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 548548Thermosome subunit alpha
PRO_0000128397

Sequences

Sequence LengthMass (Da)Tools
P61111 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: D7B4F3889E02A88A

FASTA54859,170
        10         20         30         40         50         60 
MAQLSGQPVV ILPEGTQRYV GRDAQRLNIL AARIIAETVR TTLGPKGMDK MLVDSLGDIV 

        70         80         90        100        110        120 
VTNDGATILD KIDLQHPAAK MMVEVAKTQD KEAGDGTTTA VVIAGELLRK AEELLDQNIH 

       130        140        150        160        170        180 
PSIIIKGYAL AAEKAQEILD EIAIRVDPDD EETLLKIAAT SITGKNAESH KELLAKLAVE 

       190        200        210        220        230        240 
AVKQVAEKKD GKYVVDLDNI KFEKKAGEGV EESELVRGVV IDKEVVHPRM PKRVENAKIA 

       250        260        270        280        290        300 
LINEALEVKK TETDAKINIT SPDQLMSFLE QEEKMLKDMV DHIAQTGANV VFVQKGIDDL 

       310        320        330        340        350        360 
AQHYLAKYGI MAVRRVKKSD MEKLAKATGA KIVTNVKDLT PEDLGYAEVV EERKLAGENM 

       370        380        390        400        410        420 
IFVEGCKNPK AVTILIRGGT EHVIDEVERA LEDAVKVVKD VMEDGAVLPA GGAPEIELAI 

       430        440        450        460        470        480 
RLDEYAKQVG GKEALAIENF ADALKIIPKT LAENAGLDTV EMLVKVISEH KNRGLGIGID 

       490        500        510        520        530        540 
VFEGKPADML EKGIIEPLRV KKQAIKSASE AAIMILRIDD VIAAKATKPE GGQGGGMPGG 


MGGMDMGM 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a second subunit of molecular chaperonin from Pyrococcus kodakaraensis KOD1: analysis of an ATPase-deficient mutant enzyme."
Izumi M., Fujiwara S., Takagi M., Kanaya S., Imanaka T.
Appl. Environ. Microbiol. 65:1801-1805(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.
[2]"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018432 Genomic DNA. Translation: BAA76952.1.
AP006878 Genomic DNA. Translation: BAD84867.1.
PIRT43915.
RefSeqYP_183091.1. NC_006624.1.

3D structure databases

ProteinModelPortalP61111.
SMRP61111. Positions 9-526.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING69014.TK0678.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD84867; BAD84867; TK0678.
GeneID3234606.
KEGGtko:TK0678.

Phylogenomic databases

eggNOGCOG0459.
HOGENOMHOG000226732.

Enzyme and pathway databases

BioCycTKOD69014:GH72-689-MONOMER.

Family and domain databases

Gene3D1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PANTHERPTHR11353. PTHR11353. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00304. TCOMPLEXTCP1.
SUPFAMSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsTIGR02339. thermosome_arch. 1 hit.
PROSITEPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHSA_THEKO
AccessionPrimary (citable) accession number: P61111
Secondary accession number(s): O24729, Q9Y8I3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families