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P61111

- THSA_THEKO

UniProt

P61111 - THSA_THEKO

Protein

Thermosome subunit alpha

Gene

thsA

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (10 May 2004)
      Previous versions | rss
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    Functioni

    Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTKOD69014:GH72-689-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thermosome subunit alpha
    Alternative name(s):
    Chaperonin subunit alpha
    Thermosome subunit 1
    Gene namesi
    Name:thsA
    Synonyms:cpkA
    Ordered Locus Names:TK0678
    OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
    Taxonomic identifieri69014 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000536: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548Thermosome subunit alphaPRO_0000128397Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a Heterooligomeric complex of two stacked eight-membered rings.By similarity

    Protein-protein interaction databases

    STRINGi69014.TK0678.

    Structurei

    3D structure databases

    ProteinModelPortaliP61111.
    SMRiP61111. Positions 9-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCP-1 chaperonin family.Curated

    Phylogenomic databases

    eggNOGiCOG0459.
    HOGENOMiHOG000226732.

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProiIPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    IPR012714. Thermosome_arc.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00304. TCOMPLEXTCP1.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
    PROSITEiPS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLSGQPVV ILPEGTQRYV GRDAQRLNIL AARIIAETVR TTLGPKGMDK    50
    MLVDSLGDIV VTNDGATILD KIDLQHPAAK MMVEVAKTQD KEAGDGTTTA 100
    VVIAGELLRK AEELLDQNIH PSIIIKGYAL AAEKAQEILD EIAIRVDPDD 150
    EETLLKIAAT SITGKNAESH KELLAKLAVE AVKQVAEKKD GKYVVDLDNI 200
    KFEKKAGEGV EESELVRGVV IDKEVVHPRM PKRVENAKIA LINEALEVKK 250
    TETDAKINIT SPDQLMSFLE QEEKMLKDMV DHIAQTGANV VFVQKGIDDL 300
    AQHYLAKYGI MAVRRVKKSD MEKLAKATGA KIVTNVKDLT PEDLGYAEVV 350
    EERKLAGENM IFVEGCKNPK AVTILIRGGT EHVIDEVERA LEDAVKVVKD 400
    VMEDGAVLPA GGAPEIELAI RLDEYAKQVG GKEALAIENF ADALKIIPKT 450
    LAENAGLDTV EMLVKVISEH KNRGLGIGID VFEGKPADML EKGIIEPLRV 500
    KKQAIKSASE AAIMILRIDD VIAAKATKPE GGQGGGMPGG MGGMDMGM 548
    Length:548
    Mass (Da):59,170
    Last modified:May 10, 2004 - v1
    Checksum:iD7B4F3889E02A88A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018432 Genomic DNA. Translation: BAA76952.1.
    AP006878 Genomic DNA. Translation: BAD84867.1.
    PIRiT43915.
    RefSeqiYP_183091.1. NC_006624.1.

    Genome annotation databases

    EnsemblBacteriaiBAD84867; BAD84867; TK0678.
    GeneIDi3234606.
    KEGGitko:TK0678.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018432 Genomic DNA. Translation: BAA76952.1 .
    AP006878 Genomic DNA. Translation: BAD84867.1 .
    PIRi T43915.
    RefSeqi YP_183091.1. NC_006624.1.

    3D structure databases

    ProteinModelPortali P61111.
    SMRi P61111. Positions 9-526.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 69014.TK0678.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD84867 ; BAD84867 ; TK0678 .
    GeneIDi 3234606.
    KEGGi tko:TK0678.

    Phylogenomic databases

    eggNOGi COG0459.
    HOGENOMi HOG000226732.

    Enzyme and pathway databases

    BioCyci TKOD69014:GH72-689-MONOMER.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProi IPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    IPR012714. Thermosome_arc.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00304. TCOMPLEXTCP1.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsi TIGR02339. thermosome_arch. 1 hit.
    PROSITEi PS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a second subunit of molecular chaperonin from Pyrococcus kodakaraensis KOD1: analysis of an ATPase-deficient mutant enzyme."
      Izumi M., Fujiwara S., Takagi M., Kanaya S., Imanaka T.
      Appl. Environ. Microbiol. 65:1801-1805(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.
    2. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
      Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
      Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.

    Entry informationi

    Entry nameiTHSA_THEKO
    AccessioniPrimary (citable) accession number: P61111
    Secondary accession number(s): O24729, Q9Y8I3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3