P61111 (THSA_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thermosome subunit alpha

Alternative name(s):
Chaperonin subunit alpha
Thermosome subunit 1

Gene names

Name:	thsA
Synonyms:	cpkA
Ordered Locus Names:	TK0678

Organism

Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus › Thermococcus kodakarensis

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity By similarity.
Subunit structure	Forms a Heterooligomeric complex of two stacked eight-membered rings By similarity.
Sequence similarities	Belongs to the TCP-1 chaperonin family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	Thermosome subunit alpha		PRO_0000128397

Sequences

	Sequence		Length	Mass (Da)
	P61111 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: D7B4F3889E02A88A	FASTA	548	59,170
	10 20 30 40 50 60 MAQLSGQPVV ILPEGTQRYV GRDAQRLNIL AARIIAETVR TTLGPKGMDK MLVDSLGDIV 70 80 90 100 110 120 VTNDGATILD KIDLQHPAAK MMVEVAKTQD KEAGDGTTTA VVIAGELLRK AEELLDQNIH 130 140 150 160 170 180 PSIIIKGYAL AAEKAQEILD EIAIRVDPDD EETLLKIAAT SITGKNAESH KELLAKLAVE 190 200 210 220 230 240 AVKQVAEKKD GKYVVDLDNI KFEKKAGEGV EESELVRGVV IDKEVVHPRM PKRVENAKIA 250 260 270 280 290 300 LINEALEVKK TETDAKINIT SPDQLMSFLE QEEKMLKDMV DHIAQTGANV VFVQKGIDDL 310 320 330 340 350 360 AQHYLAKYGI MAVRRVKKSD MEKLAKATGA KIVTNVKDLT PEDLGYAEVV EERKLAGENM 370 380 390 400 410 420 IFVEGCKNPK AVTILIRGGT EHVIDEVERA LEDAVKVVKD VMEDGAVLPA GGAPEIELAI 430 440 450 460 470 480 RLDEYAKQVG GKEALAIENF ADALKIIPKT LAENAGLDTV EMLVKVISEH KNRGLGIGID 490 500 510 520 530 540 VFEGKPADML EKGIIEPLRV KKQAIKSASE AAIMILRIDD VIAAKATKPE GGQGGGMPGG MGGMDMGM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a second subunit of molecular chaperonin from Pyrococcus kodakaraensis KOD1: analysis of an ATPase-deficient mutant enzyme." Izumi M., Fujiwara S., Takagi M., Kanaya S., Imanaka T. Appl. Environ. Microbiol. 65:1801-1805(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.
[2]	"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018432 Genomic DNA. Translation: BAA76952.1. AP006878 Genomic DNA. Translation: BAD84867.1.
PIR	T43915.
RefSeq	YP_183091.1. NC_006624.1.
3D structure databases
ProteinModelPortal	P61111.
SMR	P61111. Positions 9-526.
ModBase	Search...
Protein-protein interaction databases
STRING	69014.TK0678.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD84867; BAD84867; TK0678.
GeneID	3234606.
KEGG	tko:TK0678.
Phylogenomic databases
eggNOG	COG0459.
HOGENOM	HOG000226732.
OMA	EDKHENM.
ProtClustDB	CLSK253695.
Family and domain databases
InterPro	IPR017998. Chaperone_TCP-1. IPR002194. Chaperonin_TCP-1_CS. IPR002423. Cpn60/TCP-1. IPR012714. Thermosome_arc. [Graphical view]
PANTHER	PTHR11353. PTHR11353. 1 hit. PTHR11353:SF27. PTHR11353:SF27. 1 hit.
Pfam	PF00118. Cpn60_TCP1. 1 hit. [Graphical view]
PRINTS	PR00304. TCOMPLEXTCP1.
SUPFAM	SSF48592. GroEL-ATPase. 1 hit.
TIGRFAMs	TIGR02339. thermosome_arch. 1 hit.
PROSITE	PS00750. TCP1_1. 1 hit. PS00751. TCP1_2. 1 hit. PS00995. TCP1_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THSA_PYRKO

Accession

Primary (citable) accession number: P61111
Secondary accession number(s): O24729, Q9Y8I3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program