Reviewed, UniProtKB/Swiss-Prot P61108 (DEOC1_STAAM)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase 1
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase 1
      Short name=Deoxyriboaldolase 1
      Short name=DERA 1

Gene names

Name:	deoC1
Synonyms:	dra
Ordered Locus Names:	SAV0138

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose 1-phosphate: step 2/2.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 220	220	Deoxyribose-phosphate aldolase 1
Sites
	Active site	151	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	180	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61108-1 [UniParc]. Last modified April 26, 2004. Version 1. Checksum: A77DAC561C6B70A3	FASTA	220	23,472
	10 20 30 40 50 60 MKFEKYIDHT LLKPESTRTQ IDQIIDEAKA YNFKSVCVNP THVKYAAERL ADSEVLVCTV 70 80 90 100 110 120 IGFPLGASTT ATKAFETEDA IQNGADEIDM VINIGALKDG RFDDVQQDIE AVVKAAKGHT 130 140 150 160 170 180 VKVIIETVLL DHDEIVKASE LTKAAGADFV KTSTGFAGGG ATAEDVKLMK DTVGADVEVK 190 200 210 220 ASGGVRNLED FNKMVEAGAT RIGASAGVQI MQGLEADSDY

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000017 Genomic DNA. Translation: BAB56300.1.
RefSeq	NP_370662.1.
3D structure databases
HSSP	HSSP built from PDB template 1O0Y based on UniProtKB Q9X1P5.
ModBase	Search...
2-D gel databases
World-2DPAGE	0002:P61108.
Genome annotation databases
GeneID	1120097.
GenomeReviews	Gene locus SAV0138 in contig BA000017_GR.
KEGG	sav:SAV0138.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P61108.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV0138-MON.
Family and domain databases
HAMAP	MF_00114. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProDom	P61108. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	P61108.
ProtoNet	Search...

Entry information

Entry name

DEOC1_STAAM

Accession

Primary (citable) accession number: P61108
Secondary accession number(s): Q99X77

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	July 22, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)