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Protein

Deoxyribose-phosphate aldolase 1

Gene

deoC1

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.By similarity

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei151 – 1511Schiff-base intermediate with acetaldehydeBy similarity
Active sitei180 – 1801By similarity

GO - Molecular functioni

  1. deoxyribose-phosphate aldolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate catabolic process Source: UniProtKB-HAMAP
  2. deoxyribonucleotide catabolic process Source: InterPro
  3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-138-MONOMER.
UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolase 1 (EC:4.1.2.4)
Short name:
DERA 1
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase 1
Phosphodeoxyriboaldolase 1
Short name:
Deoxyriboaldolase 1
Gene namesi
Name:deoC1
Synonyms:dra
Ordered Locus Names:SAV0138
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Deoxyribose-phosphate aldolase 1PRO_0000057257Add
BLAST

2D gel databases

World-2DPAGE0002:P61108.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0138.

Structurei

3D structure databases

ProteinModelPortaliP61108.
SMRiP61108. Positions 5-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0274.
HOGENOMiHOG000241645.
KOiK01619.
OMAiEICMDAG.
OrthoDBiEOG6QZMW5.
PhylomeDBiP61108.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

P61108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFEKYIDHT LLKPESTRTQ IDQIIDEAKA YNFKSVCVNP THVKYAAERL
60 70 80 90 100
ADSEVLVCTV IGFPLGASTT ATKAFETEDA IQNGADEIDM VINIGALKDG
110 120 130 140 150
RFDDVQQDIE AVVKAAKGHT VKVIIETVLL DHDEIVKASE LTKAAGADFV
160 170 180 190 200
KTSTGFAGGG ATAEDVKLMK DTVGADVEVK ASGGVRNLED FNKMVEAGAT
210 220
RIGASAGVQI MQGLEADSDY
Length:220
Mass (Da):23,472
Last modified:April 26, 2004 - v1
Checksum:iA77DAC561C6B70A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56300.1.
RefSeqiNP_370662.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56300; BAB56300; SAV0138.
GeneIDi1120097.
KEGGisav:SAV0138.
PATRICi19560877. VBIStaAur52173_0136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56300.1.
RefSeqiNP_370662.1. NC_002758.2.

3D structure databases

ProteinModelPortaliP61108.
SMRiP61108. Positions 5-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0138.

2D gel databases

World-2DPAGE0002:P61108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56300; BAB56300; SAV0138.
GeneIDi1120097.
KEGGisav:SAV0138.
PATRICi19560877. VBIStaAur52173_0136.

Phylogenomic databases

eggNOGiCOG0274.
HOGENOMiHOG000241645.
KOiK01619.
OMAiEICMDAG.
OrthoDBiEOG6QZMW5.
PhylomeDBiP61108.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.
BioCyciSAUR158878:GJJ5-138-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiDEOC1_STAAM
AccessioniPrimary (citable) accession number: P61108
Secondary accession number(s): Q99X77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: January 7, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.