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P61107

- RAB14_RAT

UniProt

P61107 - RAB14_RAT

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Protein

Ras-related protein Rab-14

Gene

Rab14

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269GTPCurated
Nucleotide bindingi66 – 705GTPCurated
Nucleotide bindingi124 – 1274GTPCurated
Nucleotide bindingi154 – 1563GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. glycoprotein binding Source: RGD
  3. GTPase activity Source: UniProtKB
  4. GTP binding Source: UniProtKB

GO - Biological processi

  1. apical protein localization Source: RGD
  2. body fluid secretion Source: RGD
  3. embryo development Source: UniProtKB
  4. endocytic recycling Source: UniProtKB
  5. fibroblast growth factor receptor signaling pathway Source: UniProtKB
  6. Golgi to endosome transport Source: UniProtKB
  7. GTP catabolic process Source: GOC
  8. intracellular transport Source: UniProtKB
  9. protein transport Source: UniProtKB-KW
  10. regulation of protein localization Source: RGD
  11. small GTPase mediated signal transduction Source: InterPro
  12. vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_199176. Translocation of GLUT4 to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-14
Gene namesi
Name:Rab14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620881. Rab14.

Subcellular locationi

Recycling endosome By similarity. Early endosome membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or Mycobacterium.By similarity

GO - Cellular componenti

  1. alveolar lamellar body Source: RGD
  2. apical plasma membrane Source: RGD
  3. cytoplasmic vesicle membrane Source: Reactome
  4. cytosol Source: UniProtKB
  5. early endosome Source: UniProtKB
  6. Golgi stack Source: UniProtKB
  7. late endosome Source: UniProtKB
  8. lysosome Source: UniProtKB
  9. nuclear outer membrane-endoplasmic reticulum membrane network Source: UniProtKB
  10. perinuclear region of cytoplasm Source: UniProtKB
  11. phagocytic vesicle Source: UniProtKB
  12. plasma membrane Source: UniProtKB
  13. recycling endosome Source: UniProtKB
  14. rough endoplasmic reticulum Source: UniProtKB
  15. trans-Golgi network transport vesicle Source: UniProtKB
  16. transport vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi25 – 251S → N: Mimicks the GTP-bound state and is enriched in the Golgi region. 1 Publication
Mutagenesisi70 – 701Q → L: Mimicks the GDP-bound state. 1 Publication
Mutagenesisi124 – 1241N → I: Enriched in the Golgi region. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 215214Ras-related protein Rab-14PRO_0000121187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity
Modified residuei215 – 2151Cysteine methyl esterBy similarity
Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP61107.
PRIDEiP61107.

PTM databases

PhosphoSiteiP61107.

Expressioni

Tissue specificityi

Widely expressed (at protein level). Highest levels found in whole brain, spinal cord, heart, kidney and lung.

Gene expression databases

GenevestigatoriP61107.

Interactioni

Subunit structurei

Interacts with KIF16B. Interacts with ZFYVE20 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NISCHQ9Y2I19EBI-917845,EBI-2688731From a different organism.

Protein-protein interaction databases

BioGridi250177. 2 interactions.
IntActiP61107. 6 interactions.
MINTiMINT-4542699.
STRINGi10116.ENSRNOP00000025649.

Structurei

3D structure databases

ProteinModelPortaliP61107.
SMRiP61107. Positions 7-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 489Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP61107.
KOiK07881.
PhylomeDBiP61107.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61107-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATTPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Length:215
Mass (Da):23,927
Last modified:January 23, 2007 - v3
Checksum:iB435AAC6F562B007
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83680 mRNA. Translation: AAA41994.1.
PIRiE42148.
RefSeqiNP_446041.1. NM_053589.1.
UniGeneiRn.163656.
Rn.6008.

Genome annotation databases

GeneIDi94197.
KEGGirno:94197.
UCSCiRGD:620881. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83680 mRNA. Translation: AAA41994.1 .
PIRi E42148.
RefSeqi NP_446041.1. NM_053589.1.
UniGenei Rn.163656.
Rn.6008.

3D structure databases

ProteinModelPortali P61107.
SMRi P61107. Positions 7-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250177. 2 interactions.
IntActi P61107. 6 interactions.
MINTi MINT-4542699.
STRINGi 10116.ENSRNOP00000025649.

PTM databases

PhosphoSitei P61107.

Proteomic databases

PaxDbi P61107.
PRIDEi P61107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 94197.
KEGGi rno:94197.
UCSCi RGD:620881. rat.

Organism-specific databases

CTDi 51552.
RGDi 620881. Rab14.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P61107.
KOi K07881.
PhylomeDBi P61107.

Enzyme and pathway databases

Reactomei REACT_199176. Translocation of GLUT4 to the plasma membrane.

Miscellaneous databases

NextBioi 55334.
PROi P61107.

Gene expression databases

Genevestigatori P61107.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
    Elferink L.A., Anzai K., Scheller R.H.
    J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Rab14 is involved in membrane trafficking between the Golgi complex and endosomes."
    Junutula J.R., De Maziere A.M., Peden A.A., Ervin K.E., Advani R.J., van Dijk S.M., Klumperman J., Scheller R.H.
    Mol. Biol. Cell 15:2218-2229(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-25; GLN-70 AND ASN-124.

Entry informationi

Entry nameiRAB14_RAT
AccessioniPrimary (citable) accession number: P61107
Secondary accession number(s): P35287, Q969L0, Q9UI11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3