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P61107

- RAB14_RAT

UniProt

P61107 - RAB14_RAT

Protein

Ras-related protein Rab-14

Gene

Rab14

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion By similarity. Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269GTPCurated
    Nucleotide bindingi66 – 705GTPCurated
    Nucleotide bindingi124 – 1274GTPCurated
    Nucleotide bindingi154 – 1563GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. glycoprotein binding Source: RGD
    3. GTPase activity Source: UniProtKB
    4. GTP binding Source: UniProtKB
    5. protein binding Source: IntAct

    GO - Biological processi

    1. apical protein localization Source: RGD
    2. body fluid secretion Source: RGD
    3. embryo development Source: UniProtKB
    4. endocytic recycling Source: UniProtKB
    5. fibroblast growth factor receptor signaling pathway Source: UniProtKB
    6. Golgi to endosome transport Source: UniProtKB
    7. GTP catabolic process Source: GOC
    8. intracellular transport Source: UniProtKB
    9. protein transport Source: UniProtKB-KW
    10. regulation of protein localization Source: RGD
    11. small GTPase mediated signal transduction Source: InterPro
    12. vesicle-mediated transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_199176. Translocation of GLUT4 to the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-14
    Gene namesi
    Name:Rab14
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620881. Rab14.

    Subcellular locationi

    Recycling endosome By similarity. Early endosome membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Golgi apparatus membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or Mycobacterium.By similarity

    GO - Cellular componenti

    1. alveolar lamellar body Source: RGD
    2. apical plasma membrane Source: RGD
    3. cytoplasmic vesicle membrane Source: Reactome
    4. cytosol Source: UniProtKB
    5. early endosome Source: UniProtKB
    6. early endosome membrane Source: UniProtKB-SubCell
    7. Golgi membrane Source: UniProtKB-SubCell
    8. Golgi stack Source: UniProtKB
    9. late endosome Source: UniProtKB
    10. lysosome Source: UniProtKB
    11. nuclear outer membrane-endoplasmic reticulum membrane network Source: UniProtKB
    12. perinuclear region of cytoplasm Source: UniProtKB
    13. phagocytic vesicle Source: UniProtKB
    14. phagocytic vesicle membrane Source: UniProtKB-SubCell
    15. plasma membrane Source: UniProtKB
    16. recycling endosome Source: UniProtKB
    17. rough endoplasmic reticulum Source: UniProtKB
    18. trans-Golgi network transport vesicle Source: UniProtKB
    19. transport vesicle Source: RGD

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi25 – 251S → N: Mimicks the GTP-bound state and is enriched in the Golgi region. 1 Publication
    Mutagenesisi70 – 701Q → L: Mimicks the GDP-bound state. 1 Publication
    Mutagenesisi124 – 1241N → I: Enriched in the Golgi region. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 215214Ras-related protein Rab-14PRO_0000121187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity
    Modified residuei215 – 2151Cysteine methyl esterBy similarity
    Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP61107.
    PRIDEiP61107.

    PTM databases

    PhosphoSiteiP61107.

    Expressioni

    Tissue specificityi

    Widely expressed (at protein level). Highest levels found in whole brain, spinal cord, heart, kidney and lung.

    Gene expression databases

    GenevestigatoriP61107.

    Interactioni

    Subunit structurei

    Interacts with KIF16B. Interacts with ZFYVE20 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NISCHQ9Y2I19EBI-917845,EBI-2688731From a different organism.

    Protein-protein interaction databases

    BioGridi250177. 2 interactions.
    IntActiP61107. 6 interactions.
    MINTiMINT-4542699.
    STRINGi10116.ENSRNOP00000025649.

    Structurei

    3D structure databases

    ProteinModelPortaliP61107.
    SMRiP61107. Positions 7-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 489Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP61107.
    KOiK07881.
    PhylomeDBiP61107.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61107-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT    50
    RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN 100
    HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF 150
    LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG 200
    RLTSEPQPQR EGCGC 215
    Length:215
    Mass (Da):23,927
    Last modified:January 23, 2007 - v3
    Checksum:iB435AAC6F562B007
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83680 mRNA. Translation: AAA41994.1.
    PIRiE42148.
    RefSeqiNP_446041.1. NM_053589.1.
    UniGeneiRn.163656.
    Rn.6008.

    Genome annotation databases

    GeneIDi94197.
    KEGGirno:94197.
    UCSCiRGD:620881. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83680 mRNA. Translation: AAA41994.1 .
    PIRi E42148.
    RefSeqi NP_446041.1. NM_053589.1.
    UniGenei Rn.163656.
    Rn.6008.

    3D structure databases

    ProteinModelPortali P61107.
    SMRi P61107. Positions 7-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250177. 2 interactions.
    IntActi P61107. 6 interactions.
    MINTi MINT-4542699.
    STRINGi 10116.ENSRNOP00000025649.

    PTM databases

    PhosphoSitei P61107.

    Proteomic databases

    PaxDbi P61107.
    PRIDEi P61107.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 94197.
    KEGGi rno:94197.
    UCSCi RGD:620881. rat.

    Organism-specific databases

    CTDi 51552.
    RGDi 620881. Rab14.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P61107.
    KOi K07881.
    PhylomeDBi P61107.

    Enzyme and pathway databases

    Reactomei REACT_199176. Translocation of GLUT4 to the plasma membrane.

    Miscellaneous databases

    NextBioi 55334.
    PROi P61107.

    Gene expression databases

    Genevestigatori P61107.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
      Elferink L.A., Anzai K., Scheller R.H.
      J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Rab14 is involved in membrane trafficking between the Golgi complex and endosomes."
      Junutula J.R., De Maziere A.M., Peden A.A., Ervin K.E., Advani R.J., van Dijk S.M., Klumperman J., Scheller R.H.
      Mol. Biol. Cell 15:2218-2229(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-25; GLN-70 AND ASN-124.

    Entry informationi

    Entry nameiRAB14_RAT
    AccessioniPrimary (citable) accession number: P61107
    Secondary accession number(s): P35287, Q969L0, Q9UI11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3