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Protein

Ras-related protein Rab-14

Gene

RAB14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTP9
Nucleotide bindingi66 – 70GTP5
Nucleotide bindingi124 – 127GTP4
Nucleotide bindingi154 – 156GTP3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • myosin V binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119396-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.
SignaLinkiP61106.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-14
Gene namesi
Name:RAB14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:16524. RAB14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51552.
OpenTargetsiENSG00000119396.
PharmGKBiPA34104.

Polymorphism and mutation databases

BioMutaiRAB14.
DMDMi85700392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001211852 – 215Ras-related protein Rab-14Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP61106.
MaxQBiP61106.
PaxDbiP61106.
PeptideAtlasiP61106.
PRIDEiP61106.

PTM databases

iPTMnetiP61106.
PhosphoSitePlusiP61106.
SwissPalmiP61106.

Expressioni

Gene expression databases

BgeeiENSG00000119396.
CleanExiHS_RAB14.
ExpressionAtlasiP61106. baseline and differential.
GenevisibleiP61106. HS.

Organism-specific databases

HPAiCAB037066.
HPA026419.

Interactioni

Subunit structurei

Interacts with KIF16B (By similarity). Interacts with ZFYVE20.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EXOC5Q8IW243EBI-1056404,EBI-10171392
OCRLQ019683EBI-1056404,EBI-6148898

GO - Molecular functioni

  • myosin V binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119605. 48 interactors.
DIPiDIP-42491N.
IntActiP61106. 23 interactors.
MINTiMINT-2882831.
STRINGi9606.ENSP00000362946.

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 17Combined sources9
Helixi24 – 33Combined sources10
Beta strandi48 – 55Combined sources8
Beta strandi58 – 66Combined sources9
Helixi70 – 72Combined sources3
Helixi75 – 82Combined sources8
Beta strandi85 – 92Combined sources8
Helixi96 – 100Combined sources5
Helixi102 – 112Combined sources11
Beta strandi118 – 124Combined sources7
Helixi129 – 131Combined sources3
Helixi136 – 145Combined sources10
Beta strandi149 – 152Combined sources4
Turni155 – 157Combined sources3
Helixi161 – 172Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z0FX-ray2.15A2-175[»]
4D0GX-ray2.50A8-180[»]
4DRZX-ray2.30A1-177[»]
ProteinModelPortaliP61106.
SMRiP61106.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61106.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0097. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOVERGENiHBG009351.
InParanoidiP61106.
KOiK07881.
OMAiQRDVTFE.
OrthoDBiEOG091G0QOB.
PhylomeDBiP61106.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR030702. Rab14.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PANTHERiPTHR24073:SF185. PTHR24073:SF185. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Length:215
Mass (Da):23,897
Last modified:January 23, 2007 - v4
Checksum:iBC8A8B98FB9944AC
GO

Sequence cautioni

The sequence CAI12361 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0129864A → T.3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152463 mRNA. Translation: AAF00150.1.
AF203689 mRNA. Translation: AAF19400.1.
AY553875 mRNA. Translation: AAS64573.1.
AF112206 mRNA. Translation: AAF17194.1.
AL162081 mRNA. Translation: CAB82414.1.
AK023524 mRNA. Translation: BAB14598.1.
AK090889 mRNA. Translation: BAG52243.1.
AF498949 mRNA. Translation: AAM21097.1.
AL137068 Genomic DNA. Translation: CAD20124.1.
AL137068 Genomic DNA. Translation: CAI12361.1. Sequence problems.
CR457394 mRNA. Translation: CAG33675.1.
CH471090 Genomic DNA. Translation: EAW87487.1.
BC006081 mRNA. Translation: AAH06081.1.
CCDSiCCDS6827.1.
RefSeqiNP_057406.2. NM_016322.3.
UniGeneiHs.371563.

Genome annotation databases

EnsembliENST00000373840; ENSP00000362946; ENSG00000119396.
GeneIDi51552.
KEGGihsa:51552.
UCSCiuc004blc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152463 mRNA. Translation: AAF00150.1.
AF203689 mRNA. Translation: AAF19400.1.
AY553875 mRNA. Translation: AAS64573.1.
AF112206 mRNA. Translation: AAF17194.1.
AL162081 mRNA. Translation: CAB82414.1.
AK023524 mRNA. Translation: BAB14598.1.
AK090889 mRNA. Translation: BAG52243.1.
AF498949 mRNA. Translation: AAM21097.1.
AL137068 Genomic DNA. Translation: CAD20124.1.
AL137068 Genomic DNA. Translation: CAI12361.1. Sequence problems.
CR457394 mRNA. Translation: CAG33675.1.
CH471090 Genomic DNA. Translation: EAW87487.1.
BC006081 mRNA. Translation: AAH06081.1.
CCDSiCCDS6827.1.
RefSeqiNP_057406.2. NM_016322.3.
UniGeneiHs.371563.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z0FX-ray2.15A2-175[»]
4D0GX-ray2.50A8-180[»]
4DRZX-ray2.30A1-177[»]
ProteinModelPortaliP61106.
SMRiP61106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119605. 48 interactors.
DIPiDIP-42491N.
IntActiP61106. 23 interactors.
MINTiMINT-2882831.
STRINGi9606.ENSP00000362946.

PTM databases

iPTMnetiP61106.
PhosphoSitePlusiP61106.
SwissPalmiP61106.

Polymorphism and mutation databases

BioMutaiRAB14.
DMDMi85700392.

Proteomic databases

EPDiP61106.
MaxQBiP61106.
PaxDbiP61106.
PeptideAtlasiP61106.
PRIDEiP61106.

Protocols and materials databases

DNASUi51552.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373840; ENSP00000362946; ENSG00000119396.
GeneIDi51552.
KEGGihsa:51552.
UCSCiuc004blc.4. human.

Organism-specific databases

CTDi51552.
DisGeNETi51552.
GeneCardsiRAB14.
HGNCiHGNC:16524. RAB14.
HPAiCAB037066.
HPA026419.
MIMi612673. gene.
neXtProtiNX_P61106.
OpenTargetsiENSG00000119396.
PharmGKBiPA34104.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0097. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOVERGENiHBG009351.
InParanoidiP61106.
KOiK07881.
OMAiQRDVTFE.
OrthoDBiEOG091G0QOB.
PhylomeDBiP61106.
TreeFamiTF300032.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119396-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.
SignaLinkiP61106.

Miscellaneous databases

ChiTaRSiRAB14. human.
EvolutionaryTraceiP61106.
GeneWikiiRAB14.
GenomeRNAii51552.
PROiP61106.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119396.
CleanExiHS_RAB14.
ExpressionAtlasiP61106. baseline and differential.
GenevisibleiP61106. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR030702. Rab14.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PANTHERiPTHR24073:SF185. PTHR24073:SF185. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB14_HUMAN
AccessioniPrimary (citable) accession number: P61106
Secondary accession number(s): B3KR31
, P35287, Q5JVD4, Q6Q7K5, Q969L0, Q9UI11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 149 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.