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Protein

Ras-related protein Rab-14

Gene

RAB14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTP9
Nucleotide bindingi66 – 70GTP5
Nucleotide bindingi124 – 127GTP4
Nucleotide bindingi154 – 156GTP3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • myosin V binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-6798695 Neutrophil degranulation
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
SignaLinkiP61106

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-14
Gene namesi
Name:RAB14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000119396.10
HGNCiHGNC:16524 RAB14
MIMi612673 gene
neXtProtiNX_P61106

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51552
OpenTargetsiENSG00000119396
PharmGKBiPA34104

Polymorphism and mutation databases

BioMutaiRAB14
DMDMi85700392

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001211852 – 215Ras-related protein Rab-14Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP61106
MaxQBiP61106
PaxDbiP61106
PeptideAtlasiP61106
PRIDEiP61106

PTM databases

iPTMnetiP61106
PhosphoSitePlusiP61106
SwissPalmiP61106

Expressioni

Gene expression databases

BgeeiENSG00000119396
CleanExiHS_RAB14
ExpressionAtlasiP61106 baseline and differential
GenevisibleiP61106 HS

Organism-specific databases

HPAiCAB037066
HPA026419

Interactioni

Subunit structurei

Interacts with KIF16B (By similarity). Interacts with ZFYVE20.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • myosin V binding Source: UniProtKB

Protein-protein interaction databases

BioGridi11960555 interactors.
DIPiDIP-42491N
IntActiP61106 32 interactors.
MINTiP61106
STRINGi9606.ENSP00000362946

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 17Combined sources9
Helixi24 – 33Combined sources10
Beta strandi48 – 55Combined sources8
Beta strandi58 – 66Combined sources9
Helixi70 – 72Combined sources3
Helixi75 – 82Combined sources8
Beta strandi85 – 92Combined sources8
Helixi96 – 100Combined sources5
Helixi102 – 112Combined sources11
Beta strandi118 – 124Combined sources7
Helixi129 – 131Combined sources3
Helixi136 – 145Combined sources10
Beta strandi149 – 152Combined sources4
Turni155 – 157Combined sources3
Helixi161 – 172Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z0FX-ray2.15A2-175[»]
4D0GX-ray2.50A8-180[»]
4DRZX-ray2.30A1-177[»]
ProteinModelPortaliP61106
SMRiP61106
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61106

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0097 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOVERGENiHBG009351
InParanoidiP61106
KOiK07881
OMAiGVQHKPA
OrthoDBiEOG091G0QOB
PhylomeDBiP61106
TreeFamiTF300032

Family and domain databases

CDDicd04122 Rab14, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030702 Rab14
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PANTHERiPTHR24073:SF654 PTHR24073:SF654, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Length:215
Mass (Da):23,897
Last modified:January 23, 2007 - v4
Checksum:iBC8A8B98FB9944AC
GO

Sequence cautioni

The sequence CAI12361 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0129864A → T3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152463 mRNA Translation: AAF00150.1
AF203689 mRNA Translation: AAF19400.1
AY553875 mRNA Translation: AAS64573.1
AF112206 mRNA Translation: AAF17194.1
AL162081 mRNA Translation: CAB82414.1
AK023524 mRNA Translation: BAB14598.1
AK090889 mRNA Translation: BAG52243.1
AF498949 mRNA Translation: AAM21097.1
AL137068 Genomic DNA Translation: CAD20124.1
AL137068 Genomic DNA Translation: CAI12361.1 Sequence problems.
CR457394 mRNA Translation: CAG33675.1
CH471090 Genomic DNA Translation: EAW87487.1
BC006081 mRNA Translation: AAH06081.1
CCDSiCCDS6827.1
RefSeqiNP_057406.2, NM_016322.3
UniGeneiHs.371563

Genome annotation databases

EnsembliENST00000373840; ENSP00000362946; ENSG00000119396
GeneIDi51552
KEGGihsa:51552
UCSCiuc004blc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRAB14_HUMAN
AccessioniPrimary (citable) accession number: P61106
Secondary accession number(s): B3KR31
, P35287, Q5JVD4, Q6Q7K5, Q969L0, Q9UI11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome