P61105 (RAB2A_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-2A

Gene names

Name:	RAB2A
Synonyms:	RAB2

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for protein transport from the endoplasmic reticulum to the Golgi complex.
Subunit structure	Interacts with PRKCI By similarity.
Subcellular location	Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome By similarity. Endoplasmic reticulum membrane; Lipid-anchor Potential. Golgi apparatus membrane; Lipid-anchor Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum-Golgi intermediate compartment membrane Inferred from electronic annotation. Source: UniProtKB-SubCell melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GDP binding Inferred from sequence or structural similarity. Source: UniProtKB GTP binding Inferred from sequence or structural similarity. Source: UniProtKB GTPase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Ras-related protein Rab-2A		PRO_0000121065
Regions
	Nucleotide binding	13 – 21	9	GTP By similarity
	Nucleotide binding	61 – 65	5	GTP By similarity
	Nucleotide binding	119 – 122	4	GTP By similarity
	Nucleotide binding	149 – 151	3	GTP By similarity
	Region	1 – 19	19	Required for interaction with PRKCI By similarity
	Motif	35 – 43	9	Effector region By similarity
Amino acid modifications
	Lipidation	211	1	S-geranylgeranyl cysteine Ref.3
	Lipidation	212	1	S-geranylgeranyl cysteine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P61105 [UniParc]. Last modified April 26, 2004. Version 1. Checksum: F8731E3F8FB399A3	FASTA	212	23,546
	10 20 30 40 50 60 MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI DGKQIKLQIW 70 80 90 100 110 120 DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW LEDARQHSNS NMVIMLIGNK 130 140 150 160 170 180 SDLESRREVK KEEGEAFARE HGLIFMETSA KTASNVEEAF INTAKEIYEK IQEGVFDINN 190 200 210 EANGIKIGPQ HAATNATHAG NQGGQQAGGG CC

References

[1]	"Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments." Chavrier P., Parton R.G., Hauri H.P., Simons K., Zerial M. Cell 62:317-329(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line." Chavrier P., Vingron M., Sander C., Simons K., Zerial M. Mol. Cell. Biol. 10:6578-6585(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Cocker spaniel. Tissue: Kidney.
[3]	"Isoprenoid modification of rab proteins terminating in CC or CXC motifs." Khosravi-Far R., Lutz R.J., Cox A.D., Conroy L., Bourne J.R., Sinensky M., Balch W.E., Buss J.E., Der C.J. Proc. Natl. Acad. Sci. U.S.A. 88:6264-6268(1991) [PubMed] [Europe PMC] [Abstract] Cited for: ISOPRENYLATION AT CYS-211 AND CYS-212.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M35521 mRNA. Translation: AAA30888.1.
PIR	A39648.
RefSeq	NP_001003318.1. NM_001003318.1.
UniGene	Cfa.44676.
3D structure databases
ProteinModelPortal	P61105.
ModBase	Search...
Proteomic databases
PaxDb	P61105.
PRIDE	P61105.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	404009.
KEGG	cfa:404009.
Organism-specific databases
CTD	5862.
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	P61105.
KO	K07877.
OrthoDB	EOG41G354.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P61105.
NextBio	20817496.

Entry information

Entry name

RAB2A_CANFA

Accession

Primary (citable) accession number: P61105
Secondary accession number(s): P08886

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program