Reviewed, UniProtKB/Swiss-Prot P61084 (DEOC2_STAAM)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase 2
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase 2
      Short name=Deoxyriboaldolase 2
      Short name=DERA 2

Gene names

Name:	deoC2
Ordered Locus Names:	SAV2137

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Deoxyribose-phosphate aldolase 2 HAMAP MF_00114		PRO_0000057258
Sites
	Active site	151	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	180	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61084-1 [UniParc]. Last modified April 26, 2004. Version 1. Checksum: 4C658CF15A637077	FASTA	220	23,341
	10 20 30 40 50 60 MNSAKLIDHT LLKPESTRTQ IDQIIDEAKA YHFKSVCVNP THVKYAAERL ADSEVLVCTV 70 80 90 100 110 120 IGFPLGASTT ATKAFETEDA IQNGADEIDM VINIGALKDG RFDDVQQDIE AVVKAAKGHT 130 140 150 160 170 180 VKVIIETVLL DHDEIVKASE LTKVAGADFV KTSTGFAGGG ATAEDVKLMK DTVGADVEVK 190 200 210 220 ASGGVRNLED FNKMVEAGAT RIGASAGVQI MQGLEADSDY

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000017 Genomic DNA. Translation: BAB58299.1.
RefSeq	NP_372661.1.
3D structure databases
HSSP	HSSP built from PDB template 1O0Y based on UniProtKB Q9X1P5.
ModBase	Search...
Protein-protein interaction databases
STRING	P61084.
2-D gel databases
World-2DPAGE	0002:P61084.
Genome annotation databases
GeneID	1122153.
GenomeReviews	Gene locus SAV2137 in contig BA000017_GR.
KEGG	sav:SAV2137.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P61084.
OMA	FPSGKHH.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV2137-MON.
Family and domain databases
HAMAP	MF_00114. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC2_STAAM

Accession

Primary (citable) accession number: P61084
Secondary accession number(s): Q99SC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)