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P61080

- UB2D1_MOUSE

UniProt

P61080 - UB2D1_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 D1

Gene

Ube2d1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: MGI
    4. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of protein ubiquitination Source: UniProtKB
    2. protein K48-linked ubiquitination Source: Ensembl
    3. protein polyubiquitination Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
    REACT_205250. Phosphorylation of the APC/C.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
    REACT_207679. Separation of Sister Chromatids.
    REACT_210462. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_215601. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
    REACT_220505. Signaling by BMP.
    REACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    REACT_222875. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_226192. IKK complex recruitment mediated by RIP1.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D1 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein D1
    Ubiquitin-conjugating enzyme E2(17)KB 1
    Ubiquitin-conjugating enzyme E2-17 kDa 1
    Ubiquitin-protein ligase D1
    Gene namesi
    Name:Ube2d1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2384911. Ube2d1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. protein complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Ubiquitin-conjugating enzyme E2 D1PRO_0000082461Add
    BLAST

    Proteomic databases

    PaxDbiP61080.
    PRIDEiP61080.

    PTM databases

    PhosphoSiteiP61080.

    Expressioni

    Gene expression databases

    ArrayExpressiP61080.
    BgeeiP61080.
    GenevestigatoriP61080.

    Interactioni

    Subunit structurei

    Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with RNF11.By similarity

    Protein-protein interaction databases

    BioGridi229694. 3 interactions.
    STRINGi10090.ENSMUSP00000020085.

    Structurei

    3D structure databases

    ProteinModelPortaliP61080.
    SMRiP61080. Positions 1-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    HOGENOMiHOG000233455.
    HOVERGENiHBG063308.
    InParanoidiP61080.
    KOiK06689.
    OMAiWQATISG.
    OrthoDBiEOG7PCJGX.
    PhylomeDBiP61080.
    TreeFamiTF101108.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61080-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF    50
    FLTVHFPTDY PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS 100
    KVLLSICSLL CDPNPDDPLV PDIAQIYKSD KEKYNRHARE WTQKYAM 147
    Length:147
    Mass (Da):16,602
    Last modified:April 26, 2004 - v1
    Checksum:i2E96FD0179EE119D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC019464 mRNA. Translation: AAH19464.1.
    CCDSiCCDS35933.1.
    RefSeqiNP_663395.1. NM_145420.2.
    UniGeneiMm.270530.

    Genome annotation databases

    EnsembliENSMUST00000020085; ENSMUSP00000020085; ENSMUSG00000019927.
    GeneIDi216080.
    KEGGimmu:216080.
    UCSCiuc007foo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC019464 mRNA. Translation: AAH19464.1 .
    CCDSi CCDS35933.1.
    RefSeqi NP_663395.1. NM_145420.2.
    UniGenei Mm.270530.

    3D structure databases

    ProteinModelPortali P61080.
    SMRi P61080. Positions 1-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229694. 3 interactions.
    STRINGi 10090.ENSMUSP00000020085.

    PTM databases

    PhosphoSitei P61080.

    Proteomic databases

    PaxDbi P61080.
    PRIDEi P61080.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020085 ; ENSMUSP00000020085 ; ENSMUSG00000019927 .
    GeneIDi 216080.
    KEGGi mmu:216080.
    UCSCi uc007foo.2. mouse.

    Organism-specific databases

    CTDi 7321.
    MGIi MGI:2384911. Ube2d1.

    Phylogenomic databases

    eggNOGi COG5078.
    HOGENOMi HOG000233455.
    HOVERGENi HBG063308.
    InParanoidi P61080.
    KOi K06689.
    OMAi WQATISG.
    OrthoDBi EOG7PCJGX.
    PhylomeDBi P61080.
    TreeFami TF101108.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
    REACT_205250. Phosphorylation of the APC/C.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
    REACT_207679. Separation of Sister Chromatids.
    REACT_210462. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_215601. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
    REACT_220505. Signaling by BMP.
    REACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    REACT_222875. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_226192. IKK complex recruitment mediated by RIP1.

    Miscellaneous databases

    NextBioi 374972.
    PROi P61080.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61080.
    Bgeei P61080.
    Genevestigatori P61080.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiUB2D1_MOUSE
    AccessioniPrimary (citable) accession number: P61080
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3