Reviewed, UniProtKB/Swiss-Prot P61080 (UB2D1_MOUSE)

Names and origin

Protein names

Recommended name:
    Ubiquitin-conjugating enzyme E2 D1
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase D1
    Ubiquitin carrier protein D1
    Ubiquitin-conjugating enzyme E2-17 kDa 1
    E2(17)KB 1

Gene names

Name:

Ube2d1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X By similarity. Interacts with RNF11 By similarity.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	positive regulation of protein ubiquitination Inferred from sequence or structural similarity. Source: UniProtKB protein polyubiquitination Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: MGI ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 147	147	Ubiquitin-conjugating enzyme E2 D1		PRO_0000082461
Sites
	Active site	85	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61080-1 [UniParc]. Last modified April 26, 2004. Version 1. Checksum: 2E96FD0179EE119D	FASTA	147	16,602
	10 20 30 40 50 60 MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF FLTVHFPTDY 70 80 90 100 110 120 PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 130 140 PDIAQIYKSD KEKYNRHARE WTQKYAM

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC019464 mRNA. Translation: AAH19464.1.
IPI	IPI00275607.
RefSeq	NP_663395.1.
UniGene	Mm.270530
3D structure databases
SMR	P61080. Positions 1-147.
ModBase	Search...
Protein-protein interaction databases
STRING	P61080.
Proteomic databases
PRIDE	P61080.
Genome annotation databases
Ensembl	ENSMUST00000020085; ENSMUSP00000020085; ENSMUSG00000019927; Mus musculus. [Genome view]
GeneID	216080.
KEGG	mmu:216080.
UCSC	uc007foo.1. mouse.
Organism-specific databases
CTD	216080.
MGI	MGI:2384911. Ube2d1.
Phylogenomic databases
eggNOG	roNOG15188.
HOGENOM	HBG756483.
HOVERGEN	P61080.
InParanoid	P61080.
OMA	NDLQRDP.
PhylomeDB	P61080.
Enzyme and pathway databases
BRENDA	6.3.2.19. 244.
Gene expression databases
ArrayExpress	P61080.
Bgee	P61080.
Genevestigator	P61080.
GermOnline	ENSMUSG00000019927. Mus musculus.
Family and domain databases
InterPro	IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SMART	SM00212. UBCc. 1 hit. [Graphical view]
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	374972.
SOURCE	Search...

Entry information

Entry name

UB2D1_MOUSE

Accession

Primary (citable) accession number: P61080

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	January 19, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)