Reviewed, UniProtKB/Swiss-Prot P61076 (TRXR2_PLAF7)

Names and origin

Protein names

Recommended name:
    Thioredoxin reductase 2
      Short name=TrxR2
    EC=1.8.1.9

Gene names

Name:	trxr2
ORF Names:	PFI1170c

Organism

Plasmodium falciparum (isolate 3D7) [Complete proteome]

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	617 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond By similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NADP or NADPH binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 617	617	Thioredoxin reductase 2		PRO_0000067987
Regions
	Nucleotide binding	119 – 148	30	FAD By similarity
	Compositional bias	2 – 96	95	Asn-rich
Sites
	Active site	585	1	Proton acceptor By similarity
Amino acid modifications
	Disulfide bond	164 ↔ 169		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61076-1 [UniParc]. Last modified January 19, 2010. Version 2. Checksum: 50E1692E12D73C1D	FASTA	617	68,698
	10 20 30 40 50 60 MNNVISFIGN SSNKYFQINQ LHFIRIINKN IHSKNNLINS NSSYNVFYNK YFIKNTFQNK 70 80 90 100 110 120 NKLSSIYSKL NFSIKNMCKD KNEKKNYEHV NANEKNGYLA SEKNELTKNK VEEHTYDYDY 130 140 150 160 170 180 VVIGGGPGGM ASAKEAAAHG ARVLLFDYVK PSSQGTKWGI GGTCVNVGCV PKKLMHYAGH 190 200 210 220 230 240 MGSIFKLDSK AYGWKFDNLK HDWKKLVTTV QSHIRSLNFS YMTGLRSSKV KYINGLAKLK 250 260 270 280 290 300 DKNTVSYYLK GDLSKEETVT GKYILIATGC RPHIPDDVEG AKELSITSDD IFSLKKDPGK 310 320 330 340 350 360 TLVVGASYVA LECSGFLNSL GYDVTVAVRS IVLRGFDQQC AVKVKLYMEE QGVMFKNGIL 370 380 390 400 410 420 PKKLTKMDDK ILVEFSDKTS ELYDTVLYAI GRKGDIDGLN LESLNMNVNK SNNKIIADHL 430 440 450 460 470 480 SCTNIPSIFA VGDVAENVPE LAPVAIKAGE ILARRLFKDS DEIMDYSYIP TSIYTPIEYG 490 500 510 520 530 540 ACGYSEEKAY ELYGKSNVEV FLQEFNNLEI SAVHRQKHIR AQKDEYDLDV SSTCLAKLVC 550 560 570 580 590 600 LKNEDNRVIG FHYVGPNAGE VTQGMALALR LKVKKKDFDN CIGIHPTDAE SFMNLFVTIS 610 SGLSYAAKGG CGGGKCG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Thioredoxin networks in the malarial parasite Plasmodium falciparum." Nickel C., Rahlfs S., Deponte M., Koncarevic S., Becker K. Antioxid. Redox Signal. 8:1227-1239(2006) [PubMed: 16910770] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 3D7.
[2]	"Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13." Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z. , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G. Nature 419:527-531(2002) [PubMed: 12368867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF508128 mRNA. Translation: AAQ07981.1. AL844508 Genomic DNA. Translation: CAX64232.1.
3D structure databases
SMR	P61076. Positions 40-529.
ModBase	Search...
Genome annotation databases
KEGG	pfa:PFI1170c.
Phylogenomic databases
OMA	PTKIEQI.
Family and domain databases
InterPro	IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR012999. Pyr_OxRdtase_I_AS. IPR001327. Pyr_OxRdtase_NAD_bd. IPR006338. Thioredoxin/glutathione_Rdtase. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
PANTHER	PTHR22912:SF23. Reduct_Se. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00945. HGRDTASE.
TIGRFAMs	TIGR01438. TGR. 1 hit.
PROSITE	PS00076. PYRIDINE_REDOX_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXR2_PLAF7

Accession

Primary (citable) accession number: P61076
Secondary accession number(s): Q71G50

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	January 19, 2010
Last modified:	February 9, 2010
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)