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P61076 (TRXR2_PLAF7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thioredoxin reductase 2
Short name=TrxR2
EC=1.8.1.9
Gene names
Name:trxr2
ORF Names:PFI1170c
OrganismPlasmodium falciparum (isolate 3D7)
Taxonomic identifier36329 [NCBI]
Taxonomic lineageEukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is a redox-active disulfide bond By similarity.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRedox-active center
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

thioredoxin-disulfide reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 617617Thioredoxin reductase 2
PRO_0000067987

Regions

Nucleotide binding119 – 14830FAD By similarity
Compositional bias2 – 9695Asn-rich

Sites

Active site5851Proton acceptor By similarity

Amino acid modifications

Disulfide bond164 ↔ 169Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P61076 [UniParc].

Last modified January 19, 2010. Version 2.
Checksum: 50E1692E12D73C1D

FASTA61768,698
        10         20         30         40         50         60 
MNNVISFIGN SSNKYFQINQ LHFIRIINKN IHSKNNLINS NSSYNVFYNK YFIKNTFQNK 

        70         80         90        100        110        120 
NKLSSIYSKL NFSIKNMCKD KNEKKNYEHV NANEKNGYLA SEKNELTKNK VEEHTYDYDY 

       130        140        150        160        170        180 
VVIGGGPGGM ASAKEAAAHG ARVLLFDYVK PSSQGTKWGI GGTCVNVGCV PKKLMHYAGH 

       190        200        210        220        230        240 
MGSIFKLDSK AYGWKFDNLK HDWKKLVTTV QSHIRSLNFS YMTGLRSSKV KYINGLAKLK 

       250        260        270        280        290        300 
DKNTVSYYLK GDLSKEETVT GKYILIATGC RPHIPDDVEG AKELSITSDD IFSLKKDPGK 

       310        320        330        340        350        360 
TLVVGASYVA LECSGFLNSL GYDVTVAVRS IVLRGFDQQC AVKVKLYMEE QGVMFKNGIL 

       370        380        390        400        410        420 
PKKLTKMDDK ILVEFSDKTS ELYDTVLYAI GRKGDIDGLN LESLNMNVNK SNNKIIADHL 

       430        440        450        460        470        480 
SCTNIPSIFA VGDVAENVPE LAPVAIKAGE ILARRLFKDS DEIMDYSYIP TSIYTPIEYG 

       490        500        510        520        530        540 
ACGYSEEKAY ELYGKSNVEV FLQEFNNLEI SAVHRQKHIR AQKDEYDLDV SSTCLAKLVC 

       550        560        570        580        590        600 
LKNEDNRVIG FHYVGPNAGE VTQGMALALR LKVKKKDFDN CIGIHPTDAE SFMNLFVTIS 

       610 
SGLSYAAKGG CGGGKCG

« Hide

References

« Hide 'large scale' references
[1]"Thioredoxin networks in the malarial parasite Plasmodium falciparum."
Nickel C., Rahlfs S., Deponte M., Koncarevic S., Becker K.
Antioxid. Redox Signal. 8:1227-1239(2006) [PubMed: 16910770] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome sequence of the human malaria parasite Plasmodium falciparum."
Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. expand/collapse author list , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.
Nature 419:498-511(2002) [PubMed: 12368864] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate 3D7.
[3]"Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z. expand/collapse author list , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
Nature 419:527-531(2002) [PubMed: 12368867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate 3D7.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF508128 mRNA. Translation: AAQ07981.1.
AL844508 Genomic DNA. Translation: CAX64232.1.
RefSeqXP_002808951.1. XM_002808905.1.

3D structure databases

ProteinModelPortalP61076.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsPFI1170c:mRNA; PFI1170c:pep; PFI1170c.
GeneID813514.
GenomeReviewsGene locus trxr2 in contig AL844508_GR.
KEGGpfa:PFI1170c.

Phylogenomic databases

GeneTreeEPrGT00050000003671.
ProtClustDBPTZ00052.

Family and domain databases

InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR006338. Thioredoxin/glutathione_Rdtase.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KOK00384.
PANTHERPTHR22912:SF23. Reduct_Se. 1 hit.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
TIGRFAMsTIGR01438. TGR. 1 hit.
PROSITEPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRXR2_PLAF7
AccessionPrimary (citable) accession number: P61076
Secondary accession number(s): Q71G50
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 19, 2010
Last modified: January 25, 2012
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents