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P61075

- CDC2H_PLAF7

UniProt

P61075 - CDC2H_PLAF7

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Protein

Cell division control protein 2 homolog

Gene

CRK2

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321ATPPROSITE-ProRule annotation
Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: GeneDB_Pfalciparum
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein phosphorylation Source: GeneDB_Pfalciparum
  2. regulation of cell cycle Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CRK2
Synonyms:PK5
ORF Names:MAL13P1.279
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1356900.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: GeneDB_Pfalciparum
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Cell division control protein 2 homologPRO_0000085741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphothreonineBy similarity
Modified residuei15 – 151PhosphotyrosineBy similarity
Modified residuei158 – 1581Phosphothreonine; by CAKBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP61075.

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.By similarity

Protein-protein interaction databases

STRINGi5833.MAL13P1.279-1.

Structurei

3D structure databases

ProteinModelPortaliP61075.
SMRiP61075. Positions 1-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 284281Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233024.
InParanoidiP61075.
KOiK04563.
OMAiMGSKKYS.
PhylomeDBiP61075.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61075-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKYHGLEKI GEGTYGVVYK AQNNYGETFA LKKIRLEKED EGIPSTTIRE
60 70 80 90 100
ISILKELKHS NIVKLYDVIH TKKRLVLVFE HLDQDLKKLL DVCEGGLESV
110 120 130 140 150
TAKSFLLQLL NGIAYCHDRR VLHRDLKPQN LLINREGELK IADFGLARAF
160 170 180 190 200
GIPVRKYTHE VVTLWYRAPD VLMGSKKYST TIDIWSVGCI FAEMVNGTPL
210 220 230 240 250
FPGVSEADQL MRIFRILGTP NSKNWPNVTE LPKYDPNFTV YEPLPWESFL
260 270 280
KGLDESGIDL LSKMLKLDPN QRITAKQALE HAYFKENN
Length:288
Mass (Da):32,996
Last modified:April 26, 2004 - v1
Checksum:iBF8C2935F872F6F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844509 Genomic DNA. Translation: CAD52689.1.
RefSeqiXP_001350280.1. XM_001350244.1.

Genome annotation databases

EnsemblProtistsiMAL13P1.279:mRNA; MAL13P1.279:pep; MAL13P1.279.
GeneIDi813841.
KEGGipfa:MAL13P1.279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844509 Genomic DNA. Translation: CAD52689.1 .
RefSeqi XP_001350280.1. XM_001350244.1.

3D structure databases

ProteinModelPortali P61075.
SMRi P61075. Positions 1-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5833.MAL13P1.279-1.

Chemistry

BindingDBi P61075.
ChEMBLi CHEMBL1908388.

Proteomic databases

PRIDEi P61075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi MAL13P1.279:mRNA ; MAL13P1.279:pep ; MAL13P1.279 .
GeneIDi 813841.
KEGGi pfa:MAL13P1.279.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_1356900.

Phylogenomic databases

HOGENOMi HOG000233024.
InParanoidi P61075.
KOi K04563.
OMAi MGSKKYS.
PhylomeDBi P61075.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
    Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
    , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
    Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.

Entry informationi

Entry nameiCDC2H_PLAF7
AccessioniPrimary (citable) accession number: P61075
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3