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Protein

Proliferating cell nuclear antigen

Gene

PCNA

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-PFA-110320. Translesion Synthesis by POLH.
R-PFA-174411. Polymerase switching on the C-strand of the telomere.
R-PFA-4615885. SUMOylation of DNA replication proteins.
R-PFA-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
R-PFA-69091. Polymerase switching.
R-PFA-69166. Removal of the Flap Intermediate.
R-PFA-69183. Processive synthesis on the lagging strand.

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Short name:
PCNA
Alternative name(s):
Cyclin
Gene namesi
Name:PCNA
ORF Names:PF13_0328
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1361900.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: GeneDB
  • PCNA complex Source: GO_Central

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491731 – 274Proliferating cell nuclear antigenAdd BLAST274

PTM databases

SwissPalmiP61074.

Interactioni

Subunit structurei

Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP61074.
SMRiP61074.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

HOGENOMiHOG000211098.
InParanoidiP61074.
KOiK04802.
OMAiSDGFDKY.
PhylomeDBiP61074.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiView protein in InterPro
IPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
PANTHERiPTHR11352:SF0. PTHR11352:SF0. 1 hit.
PfamiView protein in Pfam
PF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
PRINTSiPR00339. PCNACYCLIN.
TIGRFAMsiTIGR00590. pcna. 1 hit.
PROSITEiView protein in PROSITE
PS01251. PCNA_1. 1 hit.
PS00293. PCNA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P61074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEAKLNNAS ILKKLFECIK DLVNDANVDA DESGLKLQAL DGNHVSLVSL
60 70 80 90 100
HLLDSGFSHY RCDRERVLGV NIASLNKVFK LCGANESVVI SSKDDEDNLN
110 120 130 140 150
FVFENNKEDK VTNFSLKLMS IELDSLNIPD CEEGFDAEVE LSSKELTNIF
160 170 180 190 200
RNLSEFSDTV FIEIDSNCIK FTTKGIVGDA EVALKPRDST SEDDIGVTIK
210 220 230 240 250
SKKKIKQSFA IKYLNLFSKS NILADVVVLG LSDSRPIEFK YEIKDTSPDS
260 270
DTLKIGFVKF FLAPKMDDDM DNKD
Length:274
Mass (Da):30,587
Last modified:April 26, 2004 - v1
Checksum:iE3128F7397DD1687
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA. Translation: CAD52739.1.
RefSeqiXP_001350330.1. XM_001350294.1.

Genome annotation databases

EnsemblProtistsiCAD52739; CAD52739; PF3D7_1361900.
GeneDBiPF3D7_1361900.1:pep.
GeneIDi814288.
KEGGipfa:PF13_0328.

Similar proteinsi

Entry informationi

Entry nameiPCNA_PLAF7
AccessioniPrimary (citable) accession number: P61074
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families