Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P61073 (CXCR4_HUMAN)

Last modified February 9, 2010. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    C-X-C chemokine receptor type 4
      Short name=CXC-R4
      Short name=CXCR-4
Alternative name(s):
    Stromal cell-derived factor 1 receptor
      Short name=SDF-1 receptor
    Fusin
    Leukocyte-derived seven transmembrane domain receptor
      Short name=LESTR
    LCR1
    FB22
    NPYRL
    HM89
    CD_antigen=CD184
Gene names
Name: CXCR4
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Ref.1 Ref.2 Ref.6 Ref.16 Ref.17

Subunit structure

Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2. Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.28 Ref.31

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Domain

The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity. Ref.22

Post-translational modification

Sulfation on Tyr-21 is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.

O- and N-glycosylated. Asn-11 is the principal site of N-glycosylation. There appears to be very little or no glycosylation on Asn-176. N-glycosylation masks coreceptor function in both X4 and R5 laboratory-adapted and primary HIV-1 strains through inhibiting interaction with their Env glycoproteins. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity. Ref.24 Ref.26

Involvement in disease

Defects in CXCR4 are a cause of WHIM syndrome [MIM:193670]; also known as warts, hypogammaglobulinemia, infections and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis. Ref.27

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Was originally (Ref.1 and Ref.2) thought to be a receptor for neuropeptide Y type 3 (NPY3R) (NPY3-R).

Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
Proteoglycan
Sulfation
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processG-protein coupled receptor protein signaling pathway Ref.23

Inferred from direct assay. Source: UniProtKB

activation of MAPK activity

Traceable author statement. Source: ProtInc

apoptosis

Traceable author statement. Source: ProtInc

chemotaxis

Traceable author statement. Source: ProtInc

elevation of cytosolic calcium ion concentration

Traceable author statement. Source: ProtInc

immune response

Traceable author statement. Source: ProtInc

inflammatory response Ref.4

Traceable author statement. Source: ProtInc

initiation of viral infection

Inferred from Experiment. Source: Reactome

interspecies interaction between organisms

Inferred from electronic annotation. Source: UniProtKB-KW

response to hypoxia

Inferred from expression pattern. Source: UniProtKB

response to virus

Traceable author statement. Source: ProtInc

   Cellular componentcell leading edge

Inferred from direct assay. Source: UniProtKB

cytoplasm

Traceable author statement. Source: ProtInc

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Traceable author statement. Source: ProtInc

   Molecular functionC-C chemokine receptor activity

Inferred from electronic annotation. Source: InterPro

C-X-C chemokine receptor activity Ref.7

Non-traceable author statement. Source: UniProtKB

actin binding

Inferred from direct assay. Source: UniProtKB

coreceptor activity

Traceable author statement. Source: ProtInc

myosin light chain binding

Inferred from direct assay. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MYH9P355794EBI-489411,EBI-350338

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P61073-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P61073-2)

Also known as: CXCR4-LO;

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MEGIS → MSIPLPLLQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352C-X-C chemokine receptor type 4
PRO_0000069352

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 63241 Potential
Topological domain64 – 7916Cytoplasmic Potential
Transmembrane80 – 99202 Potential
Topological domain100 – 11011Extracellular Potential
Transmembrane111 – 132223 Potential
Topological domain133 – 15422Cytoplasmic Potential
Transmembrane155 – 175214 Potential
Topological domain176 – 20025Extracellular Potential
Transmembrane201 – 220205 Potential
Topological domain221 – 24020Cytoplasmic Potential
Transmembrane241 – 261216 Potential
Topological domain262 – 28524Extracellular Potential
Transmembrane286 – 305207 Potential
Topological domain306 – 35247Cytoplasmic Potential
Motif133 – 1353Important for signaling

Amino acid modifications

Modified residue211Sulfotyrosine Ref.26 Ref.31
Modified residue3191Phosphoserine Ref.29 Ref.30
Modified residue3481Phosphoserine Ref.30
Modified residue3511Phosphoserine Ref.30
Glycosylation111N-linked (GlcNAc...) Ref.24
Glycosylation181O-linked (Xyl...) (chondroitin sulfate) Ref.26
Glycosylation1761N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 186 By similarity

Natural variations

Alternative sequence1 – 55MEGIS → MSIPLPLLQ in isoform 2.
VSP_001890

Experimental info

Mutagenesis71Y → F: Sulfate incorporation greatly reduced; when associated with F-12 and F-21. Moderate reduction in sulfate incorporation; when associated with F-12 and A-18. No sulfate incorporation and binding PDF1alpha greatly reduced; when associated with F-12; A-18 and F-21. Ref.26
Mutagenesis81T → A: No effect on sulfate incorporation; when associated with A-9 and A-13. Ref.26
Mutagenesis91S → A: No effect on sulfate incorporation; when associated with A-8 and A-13. Ref.26
Mutagenesis111N → A: Reduced molecular weight. Enhanced coreceptor activity on R5 HIV-1 isolate Envs. Slight further enhancement of coreceptor activity; when associated with A-13. Ref.24
Mutagenesis121Y → F: Sulfate incorporation greatly reduced; when associated with F-7 and F-21. Moderate reduction in sulfate incorporation; when associated with F-7 and A-18. No sulfate incorporation and binding PDF1alpha greatly reduced; when associated with F-7; A-18 and F-21. Ref.26
Mutagenesis131T → A: Enhanced coreceptor activity on R5 HIV-1 isolate Envs. No effect on sulfate incorporation; when associated with A-8 and A-9. Ref.24
Mutagenesis181S → A: Sulfate incorporation greatly reduced; when associated with F-21. Moderate reduction in sulfate incorporation; when associated with F-7 and F-12. No sulfate incorporation and binding PDF1alpha greatly reduced; when associated with F-7; F-12; and F-21. Ref.26
Mutagenesis211Y → F: Sulfate incorporation greatly reduced; when associated with F-7 and F-12. Sulfate incorporation greatly reduced; when associated with A-18. No sulfate incorporation and binding PDF1alpha greatly reduced; when associated with F-7; F-12 and A-18. Ref.26
Mutagenesis1761N → A: Enhanced coreceptor activity on R5 HIV-1 isolate Envs; when associated with A-11. Ref.24

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 26, 2004. Version 1.
Checksum: 8C8476A186786B83

FASTA35239,746
        10         20         30         40         50         60 
MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL TGIVGNGLVI 

        70         80         90        100        110        120 
LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL 

       130        140        150        160        170        180 
YSSVLILAFI SLDRYLAIVH ATNSQRPRKL LAEKVVYVGV WIPALLLTIP DFIFANVSEA 

       190        200        210        220        230        240 
DDRYICDRFY PNDLWVVVFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT 

       250        260        270        280        290        300 
TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI 

       310        320        330        340        350 
LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS 

« Hide

Isoform 2 (CXCR4-LO) [UniParc] [UniParc].

Checksum: 83F9E099F41FAB9B
Show »

FASTA35640,221

References

« Hide 'large scale' references
[1]"Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation."
Herzog H., Hort Y.J., Shine J., Selbie L.A.
DNA Cell Biol. 12:465-471(1993) [PubMed: 8329116] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PRELIMINARY FUNCTION.
Tissue: Lung.
[2]"A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells."
Jazin E.E., Yoo H., Blomqvist A.G., Yee F., Weng G., Walker M.W., Salon J., Larhammar D., Wahlestedt C.R.
Regul. Pept. 47:247-258(1993) [PubMed: 8234909] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PRELIMINARY FUNCTION.
Tissue: Fetal brain.
[3]"Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen."
Federsppiel B., Melhado I.G., Duncan A.M.V., Delaney A.D., Schappert K., Clark-Lewis I., Jirik F.R.
Genomics 16:707-712(1993) [PubMed: 8325644] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal spleen.
[4]"Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes."
Loetscher M., Geiser T., O'Reilly T., Zwahlen R., Baggiolini M., Moser B.
J. Biol. Chem. 269:232-237(1994) [PubMed: 8276799] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Monocyte.
[5]"Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors."
Nomura H., Nielsen B.W., Matsushima K.
Int. Immunol. 5:1239-1249(1993) [PubMed: 7505609] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[6]"HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor."
Feng Y., Broder C.C., Kennedy P.E., Berger E.A.
Science 272:872-877(1996) [PubMed: 8629022] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION OF ITS HIV-1 CORECEPTOR FUNCTION.
[7]"Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1."
Wegner S.A., Ehrenberg P.K., Chang G., Dayhoff D.E., Sleeker A.L., Michael N.L.
J. Biol. Chem. 273:4754-4760(1998) [PubMed: 9468539] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Peripheral blood leukocyte.
[8]"Genomic organization and promoter characterization of human CXCR4 gene."
Caruz A., Samsom M., Alonso J.M., Alcami J., Baleux F., Virelizier J.-L., Parmentier M., Arenzana-Seisdedos F.
FEBS Lett. 426:271-278(1998) [PubMed: 9599023] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]"Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion."
Xiao L., Weiss S.H., Qari S.H., Rudolph D., Zhao C., Denny T.N., Hodge T., Lal R.B.
AIDS Res. Hum. Retroviruses 15:1201-1208(1999) [PubMed: 10480633] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[10]"Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues."
Frodl R., Gierschik P., Moepps B.
J. Recept. Signal Transduct. 18:321-344(1998) [PubMed: 9879064] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Peripheral blood lymphocyte.
[11]"CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant."
Gupta S.K., Pillarisetti K.
J. Immunol. 163:2368-2372(1999) [PubMed: 10452968] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Neutrophil.
[12]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Warren C.N., Aronstam R.S., Sharma S.V.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[13]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[14]SeattleSNPs variation discovery resource
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[15]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon.
[16]"The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry."
Bleul C.C., Farzan M., Choe H., Parolin C., Clark-Lewis I., Sodroski J., Springer T.A.
Nature 382:829-833(1996) [PubMed: 8752280] [Abstract]
Cited for: FUNCTION.
[17]"The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1."
Oberlin E., Amara A., Bachelerie F., Bessia C., Virelizier J.-L., Arenzana-Seisdedos F., Schwartz O., Heard J.-M., Clark-Lewis I., Legler D.F., Loetscher M., Baggiolini M., Moser B.
Nature 382:833-835(1996) [PubMed: 8752281] [Abstract]
Cited for: FUNCTION.
[18]Erratum
Oberlin E., Amara A., Bachelerie F., Bessia C., Virelizier J.-L., Arenzana-Seisdedos F., Schwartz O., Heard J.-M., Clark-Lewis I., Legler D.F., Loetscher M., Baggiolini M., Moser B.
Nature 384:288-288(1996)
[19]"Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines."
Lapham C.K., Ouyang J., Chandrasekhar B., Nguyen N.Y., Dimitrov D.S., Golding H.
Science 274:602-605(1996) [PubMed: 8849450] [Abstract]
Cited for: CHARACTERIZATION AS HIV-1 CORECEPTOR.
[20]"CD4-independent infection by HIV-2 is mediated by fusin/CXCR4."
Endres M.J., Clapham P.R., Marsh M., Ahuja M., Turner J.D., McKnight A., Thomas J.F., Stoebenau-Haggarty B., Choe S., Vance P.J., Wells T.N.C., Power C.A., Sutterwala S.S., Doms R.W., Landau N.R., Hoxie J.A.
Cell 87:745-756(1996) [PubMed: 8929542] [Abstract]
Cited for: CHARACTERIZATION AS HIV-2 PRIMARY RECEPTOR IN SOME ISOLATES.
[21]"Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry."
Farzan M., Mirzabekov T., Kolchinsky P., Wyatt R., Cayabyab M., Gerard N.P., Gerard C., Sodroski J., Choe H.
Cell 96:667-676(1999) [PubMed: 10089882] [Abstract]
Cited for: SULFATION.
[22]"Identification of CXCR4 domains that support coreceptor and chemokine receptor functions."
Doranz B.J., Orsini M.J., Turner J.D., Hoffman T.L., Berson J.F., Hoxie J.A., Peiper S.C., Brass L.F., Doms R.W.
J. Virol. 73:2752-2761(1999) [PubMed: 10074122] [Abstract]
Cited for: DOMAINS, INTERACTION WITH HIV-1 SURFACE PROTEIN GP120.
[23]"beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4."
Cheng Z.J., Zhao J., Sun Y., Hu W., Wu Y.L., Cen B., Wu G.-X., Pei G.
J. Biol. Chem. 275:2479-2485(2000) [PubMed: 10644702] [Abstract]
Cited for: INTERACTION WITH ARRB2.
[24]"N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates."
Chabot D.J., Chen H., Dimitrov D.S., Broder C.C.
J. Virol. 74:4404-4413(2000) [PubMed: 10756055] [Abstract]
Cited for: GLYCOSYLATION AT ASN-11, INTERACTION WITH HIV-1 ENV, SUBUNIT, MUTAGENESIS OF ASN-11; THR-13 AND ASN-176.
[25]"Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1."
Xiao H., Neuveut C., Tiffany H.L., Benkirane M., Rich E.A., Murphy P.M., Jeang K.-T.
Proc. Natl. Acad. Sci. U.S.A. 97:11466-11471(2000) [PubMed: 11027346] [Abstract]
Cited for: INTERACTION WITH HIV-1 TAT.
[26]"The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry."
Farzan M., Babcock G.J., Vasilieva N., Wright P.L., Kiprilov E., Mirzabekov T., Choe H.
J. Biol. Chem. 277:29484-29489(2002) [PubMed: 12034737] [Abstract]
Cited for: GLYCOSYLATION AT SER-18, IDENTIFICATION OF PROTEOGLYCAN, INTERACTION WITH CXCL12, SULFATION AT TYR-21, MUTAGENESIS OF TYR-7; THR-8; SER-9; TYR-12; SER-18 AND TYR-21.
[27]"Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease."
Hernandez P.A., Gorlin R.J., Lukens J.N., Taniuchi S., Bohinjec J., Francois F., Klotman M.E., Diaz G.A.
Nat. Genet. 34:70-74(2003) [PubMed: 12692554] [Abstract]
Cited for: DISEASE.
[28]"Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells."
Forde S., Tye B.J., Newey S.E., Roubelakis M., Smythe J., McGuckin C.P., Pettengell R., Watt S.M.
Blood 109:1825-1833(2007) [PubMed: 17077324] [Abstract]
Cited for: INTERACTION WITH CD164.
[29]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, MASS SPECTROMETRY.
[30]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319; SER-348 AND SER-351, MASS SPECTROMETRY.
[31]"Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12)."
Veldkamp C.T., Seibert C., Peterson F.C., Sakmar T.P., Volkman B.F.
J. Mol. Biol. 359:1400-1409(2006) [PubMed: 16725153] [Abstract]
Cited for: STRUCTURE BY NMR OF 1-38, SULFATION AT TYR-21, MASS SPECTROMETRY, INTERACTION WITH CXCL12.
+Additional computationally mapped references.

Web resources

CXCR4base

CXCR4 mutation db

Wikipedia

CXC chemokine receptors entry

Wikipedia

CXCR4 entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L01639 mRNA. Translation: AAA16594.1.
M99293 mRNA. Translation: AAA16617.1.
X71635 mRNA. Translation: CAA50641.1.
L06797 mRNA. Translation: AAA03209.1.
D10924 mRNA. Translation: BAA01722.1.
AF005058 Genomic DNA. Translation: AAB93982.1.
AF052572 Genomic DNA. Translation: AAC34581.1.
AF025375 mRNA. Translation: AAB81970.1.
Y14739 Genomic DNA. Translation: CAA75034.1.
AJ224869 Genomic DNA. Translation: CAA12166.1. Sequence problems.
AF147204 mRNA. Translation: AAF00130.1.
AY242129 mRNA. Translation: AAO92296.1.
BT006660 mRNA. Translation: AAP35306.1.
AY728138 Genomic DNA. Translation: AAU05775.1.
BC020968 mRNA. Translation: AAH20968.1.
IPIIPI00028159.
IPI00216445.
PIRA45747.
RefSeqNP_001008540.1.
NP_003458.1.
UniGeneHs.593413

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2K03NMR-B/D1-38[»]
2K04NMR-B/D1-38[»]
2K05NMR-B/D1-38[»]
SMRP61073. Positions 37-318.
ModBaseSearch...

Protein-protein interaction databases

IntActP61073. 2 interactions.
STRINGP61073.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP61073.

Proteomic databases

PRIDEP61073.

Genome annotation databases

EnsemblENST00000241393; ENSP00000241393; ENSG00000121966; Homo sapiens. [Genome view]
GeneID7852.
KEGGhsa:7852.
UCSCuc002tuy.1. human.
uc002tuz.1. human.

Organism-specific databases

CTD7852.
GeneCardsGC02M136588.
H-InvDBHIX0002482.
HGNCHGNC:2561. CXCR4.
HPACAB011447.
MIM162643. gene.
193670. phenotype.
Orphanet51636. WHIM syndrome.
PharmGKBPA27058.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18826.
HOVERGENP61073.
OMAFNRIFLP.

Enzyme and pathway databases

Pathway_Interaction_DBephrinbrevpathway. Ephrin B reverse signaling.
hif1_tfpathway. HIF-1-alpha transcription factor network.
s1p_s1p3_pathway. S1P3 pathway.
syndecan_4_pathway. Syndecan-4-mediated signaling events.
ReactomeREACT_14797. Signaling by GPCR.
REACT_6185. HIV Infection.

Gene expression databases

ArrayExpressP61073.
BgeeP61073.
CleanExHS_CXCR4.
GenevestigatorP61073.
GermOnlineENSG00000121966. Homo sapiens.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR000355. Chmkine_rcpt.
IPR001277. CXC_4_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR00645. CXCCHMKINER4.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00452. Framycetin.
NextBio30286.
PMAP-CutDBP61073.
SOURCESearch...

Entry information

Entry nameCXCR4_HUMAN
AccessionPrimary (citable) accession number: P61073
Secondary accession number(s): O60835 expand/collapse secondary AC list , P30991, P56438, Q9UKN2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: February 9, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents