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Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

Cks1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: MGI
  • mitotic cell cycle phase transition Source: MGI
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central
  • regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-MMU-69231. Cyclin D associated events in G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Short name:
CKS-1
Alternative name(s):
Sid 1334
Gene namesi
Name:Cks1b
Synonyms:Cks1, Sid1334
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1889208. Cks1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 1PRO_0000206236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61025.
MaxQBiP61025.
PaxDbiP61025.
PeptideAtlasiP61025.
PRIDEiP61025.

PTM databases

iPTMnetiP61025.
PhosphoSiteiP61025.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028044.
CleanExiMM_CKS1B.
ExpressionAtlasiP61025. baseline and differential.
GenevisibleiP61025. MM.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207564. 1 interaction.
MINTiMINT-255215.
STRINGi10090.ENSMUSP00000029679.

Structurei

3D structure databases

ProteinModelPortaliP61025.
SMRiP61025. Positions 5-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP61025.
KOiK02219.
OMAiIPKNRLM.
OrthoDBiEOG091G18GQ.
PhylomeDBiP61025.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ
60 70
SQGWVHYMIH EPEPHILLFR RPLPKKPKK
Length:79
Mass (Da):9,660
Last modified:April 26, 2004 - v1
Checksum:iE64207B140FA38D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025409 mRNA. Translation: BAA84694.1.
AK010414 mRNA. Translation: BAC25295.1.
AK011782 mRNA. Translation: BAB27837.1.
BC076579 mRNA. Translation: AAH76579.1.
CCDSiCCDS38493.1.
RefSeqiNP_058600.1. NM_016904.1.
UniGeneiMm.3049.

Genome annotation databases

EnsembliENSMUST00000029679; ENSMUSP00000029679; ENSMUSG00000028044.
GeneIDi54124.
KEGGimmu:54124.
UCSCiuc008pzl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025409 mRNA. Translation: BAA84694.1.
AK010414 mRNA. Translation: BAC25295.1.
AK011782 mRNA. Translation: BAB27837.1.
BC076579 mRNA. Translation: AAH76579.1.
CCDSiCCDS38493.1.
RefSeqiNP_058600.1. NM_016904.1.
UniGeneiMm.3049.

3D structure databases

ProteinModelPortaliP61025.
SMRiP61025. Positions 5-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207564. 1 interaction.
MINTiMINT-255215.
STRINGi10090.ENSMUSP00000029679.

PTM databases

iPTMnetiP61025.
PhosphoSiteiP61025.

Proteomic databases

EPDiP61025.
MaxQBiP61025.
PaxDbiP61025.
PeptideAtlasiP61025.
PRIDEiP61025.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029679; ENSMUSP00000029679; ENSMUSG00000028044.
GeneIDi54124.
KEGGimmu:54124.
UCSCiuc008pzl.1. mouse.

Organism-specific databases

CTDi1163.
MGIiMGI:1889208. Cks1b.

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP61025.
KOiK02219.
OMAiIPKNRLM.
OrthoDBiEOG091G18GQ.
PhylomeDBiP61025.
TreeFamiTF101142.

Enzyme and pathway databases

ReactomeiR-MMU-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-MMU-69231. Cyclin D associated events in G1.

Miscellaneous databases

PROiP61025.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028044.
CleanExiMM_CKS1B.
ExpressionAtlasiP61025. baseline and differential.
GenevisibleiP61025. MM.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKS1_MOUSE
AccessioniPrimary (citable) accession number: P61025
Secondary accession number(s): P33551, Q6ZWX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.