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P61025

- CKS1_MOUSE

UniProt

P61025 - CKS1_MOUSE

Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

Cks1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.By similarity

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_220647. SCF(Skp2)-mediated degradation of p27/p21.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 1
    Short name:
    CKS-1
    Alternative name(s):
    Sid 1334
    Gene namesi
    Name:Cks1b
    Synonyms:Cks1, Sid1334
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1889208. Cks1b.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 1PRO_0000206236Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP61025.
    PRIDEiP61025.

    PTM databases

    PhosphoSiteiP61025.

    Expressioni

    Gene expression databases

    ArrayExpressiP61025.
    BgeeiP61025.
    CleanExiMM_CKS1B.
    GenevestigatoriP61025.

    Interactioni

    Subunit structurei

    Forms a homohexamer that can probably bind six kinase subunits.By similarity

    Protein-protein interaction databases

    BioGridi207564. 1 interaction.
    MINTiMINT-255215.

    Structurei

    3D structure databases

    ProteinModelPortaliP61025.
    SMRiP61025. Positions 5-74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CKS family.Curated

    Phylogenomic databases

    eggNOGiNOG272189.
    GeneTreeiENSGT00390000011006.
    HOVERGENiHBG003626.
    InParanoidiP61025.
    KOiK02219.
    OMAiRGWIHYM.
    OrthoDBiEOG735413.
    PhylomeDBiP61025.
    TreeFamiTF101142.

    Family and domain databases

    Gene3Di3.30.170.10. 1 hit.
    InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view]
    PfamiPF01111. CKS. 1 hit.
    [Graphical view]
    PRINTSiPR00296. CYCLINKINASE.
    SMARTiSM01084. CKS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55637. SSF55637. 1 hit.
    PROSITEiPS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61025-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ   50
    SQGWVHYMIH EPEPHILLFR RPLPKKPKK 79
    Length:79
    Mass (Da):9,660
    Last modified:April 26, 2004 - v1
    Checksum:iE64207B140FA38D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025409 mRNA. Translation: BAA84694.1.
    AK010414 mRNA. Translation: BAC25295.1.
    AK011782 mRNA. Translation: BAB27837.1.
    BC076579 mRNA. Translation: AAH76579.1.
    CCDSiCCDS38493.1.
    RefSeqiNP_058600.1. NM_016904.1.
    UniGeneiMm.3049.

    Genome annotation databases

    EnsembliENSMUST00000029679; ENSMUSP00000029679; ENSMUSG00000028044.
    GeneIDi54124.
    KEGGimmu:54124.
    UCSCiuc008pzl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025409 mRNA. Translation: BAA84694.1 .
    AK010414 mRNA. Translation: BAC25295.1 .
    AK011782 mRNA. Translation: BAB27837.1 .
    BC076579 mRNA. Translation: AAH76579.1 .
    CCDSi CCDS38493.1.
    RefSeqi NP_058600.1. NM_016904.1.
    UniGenei Mm.3049.

    3D structure databases

    ProteinModelPortali P61025.
    SMRi P61025. Positions 5-74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207564. 1 interaction.
    MINTi MINT-255215.

    PTM databases

    PhosphoSitei P61025.

    Proteomic databases

    PaxDbi P61025.
    PRIDEi P61025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029679 ; ENSMUSP00000029679 ; ENSMUSG00000028044 .
    GeneIDi 54124.
    KEGGi mmu:54124.
    UCSCi uc008pzl.1. mouse.

    Organism-specific databases

    CTDi 1163.
    MGIi MGI:1889208. Cks1b.

    Phylogenomic databases

    eggNOGi NOG272189.
    GeneTreei ENSGT00390000011006.
    HOVERGENi HBG003626.
    InParanoidi P61025.
    KOi K02219.
    OMAi RGWIHYM.
    OrthoDBi EOG735413.
    PhylomeDBi P61025.
    TreeFami TF101142.

    Enzyme and pathway databases

    Reactomei REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.

    Miscellaneous databases

    NextBioi 310913.
    PROi P61025.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61025.
    Bgeei P61025.
    CleanExi MM_CKS1B.
    Genevestigatori P61025.

    Family and domain databases

    Gene3Di 3.30.170.10. 1 hit.
    InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view ]
    Pfami PF01111. CKS. 1 hit.
    [Graphical view ]
    PRINTSi PR00296. CYCLINKINASE.
    SMARTi SM01084. CKS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55637. SSF55637. 1 hit.
    PROSITEi PS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse cks1 sid1334."
      Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Saito T.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCKS1_MOUSE
    AccessioniPrimary (citable) accession number: P61025
    Secondary accession number(s): P33551, Q6ZWX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3