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P61025

- CKS1_MOUSE

UniProt

P61025 - CKS1_MOUSE

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Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

Cks1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.By similarity

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_220647. SCF(Skp2)-mediated degradation of p27/p21.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Short name:
CKS-1
Alternative name(s):
Sid 1334
Gene namesi
Name:Cks1b
Synonyms:Cks1, Sid1334
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1889208. Cks1b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 1PRO_0000206236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP61025.
PaxDbiP61025.
PRIDEiP61025.

PTM databases

PhosphoSiteiP61025.

Expressioni

Gene expression databases

BgeeiP61025.
CleanExiMM_CKS1B.
ExpressionAtlasiP61025. baseline and differential.
GenevestigatoriP61025.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.By similarity

Protein-protein interaction databases

BioGridi207564. 1 interaction.
MINTiMINT-255215.

Structurei

3D structure databases

ProteinModelPortaliP61025.
SMRiP61025. Positions 5-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiNOG272189.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP61025.
KOiK02219.
OMAiRGWIHYM.
OrthoDBiEOG735413.
PhylomeDBiP61025.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61025-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ
60 70
SQGWVHYMIH EPEPHILLFR RPLPKKPKK
Length:79
Mass (Da):9,660
Last modified:April 26, 2004 - v1
Checksum:iE64207B140FA38D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025409 mRNA. Translation: BAA84694.1.
AK010414 mRNA. Translation: BAC25295.1.
AK011782 mRNA. Translation: BAB27837.1.
BC076579 mRNA. Translation: AAH76579.1.
CCDSiCCDS38493.1.
RefSeqiNP_058600.1. NM_016904.1.
UniGeneiMm.3049.

Genome annotation databases

EnsembliENSMUST00000029679; ENSMUSP00000029679; ENSMUSG00000028044.
GeneIDi54124.
KEGGimmu:54124.
UCSCiuc008pzl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025409 mRNA. Translation: BAA84694.1 .
AK010414 mRNA. Translation: BAC25295.1 .
AK011782 mRNA. Translation: BAB27837.1 .
BC076579 mRNA. Translation: AAH76579.1 .
CCDSi CCDS38493.1.
RefSeqi NP_058600.1. NM_016904.1.
UniGenei Mm.3049.

3D structure databases

ProteinModelPortali P61025.
SMRi P61025. Positions 5-74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207564. 1 interaction.
MINTi MINT-255215.

PTM databases

PhosphoSitei P61025.

Proteomic databases

MaxQBi P61025.
PaxDbi P61025.
PRIDEi P61025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029679 ; ENSMUSP00000029679 ; ENSMUSG00000028044 .
GeneIDi 54124.
KEGGi mmu:54124.
UCSCi uc008pzl.1. mouse.

Organism-specific databases

CTDi 1163.
MGIi MGI:1889208. Cks1b.

Phylogenomic databases

eggNOGi NOG272189.
GeneTreei ENSGT00390000011006.
HOVERGENi HBG003626.
InParanoidi P61025.
KOi K02219.
OMAi RGWIHYM.
OrthoDBi EOG735413.
PhylomeDBi P61025.
TreeFami TF101142.

Enzyme and pathway databases

Reactomei REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.

Miscellaneous databases

NextBioi 310913.
PROi P61025.
SOURCEi Search...

Gene expression databases

Bgeei P61025.
CleanExi MM_CKS1B.
ExpressionAtlasi P61025. baseline and differential.
Genevestigatori P61025.

Family and domain databases

Gene3Di 3.30.170.10. 1 hit.
InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view ]
Pfami PF01111. CKS. 1 hit.
[Graphical view ]
PRINTSi PR00296. CYCLINKINASE.
SMARTi SM01084. CKS. 1 hit.
[Graphical view ]
SUPFAMi SSF55637. SSF55637. 1 hit.
PROSITEi PS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse cks1 sid1334."
    Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Saito T.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCKS1_MOUSE
AccessioniPrimary (citable) accession number: P61025
Secondary accession number(s): P33551, Q6ZWX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3