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Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

CKS1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciZFISH:HS11295-MONOMER.
ReactomeiR-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-HSA-69231. Cyclin D associated events in G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Short name:
CKS-1
Gene namesi
Name:CKS1B
Synonyms:CKS1
ORF Names:PNAS-143, PNAS-16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19083. CKS1B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi1163.
OpenTargetsiENSG00000173207.
PharmGKBiPA38791.

Polymorphism and mutation databases

BioMutaiCKS1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002062352 – 79Cyclin-dependent kinases regulatory subunit 1Add BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61024.
PaxDbiP61024.
PeptideAtlasiP61024.
PRIDEiP61024.
TopDownProteomicsiP61024.

PTM databases

iPTMnetiP61024.
PhosphoSitePlusiP61024.

Expressioni

Gene expression databases

BgeeiENSG00000173207.
CleanExiHS_CKS1B.
ExpressionAtlasiP61024. baseline and differential.
GenevisibleiP61024. HS.

Organism-specific databases

HPAiCAB013284.
HPA030762.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-456371,EBI-10175576
ARID5AC9J1Q03EBI-456371,EBI-10176351
CDK1P064938EBI-456371,EBI-444308
CDK2P249416EBI-456371,EBI-375096
CDK3Q005263EBI-456371,EBI-1245761
CDX4O146273EBI-456371,EBI-10181162
IKZF1Q134223EBI-456371,EBI-745305
KRTAP10-9P604113EBI-456371,EBI-10172052
KRTAP5-9P263713EBI-456371,EBI-3958099
MEOX1P502215EBI-456371,EBI-2864512
MIPOL1Q8TD103EBI-456371,EBI-2548751
RELQ048643EBI-456371,EBI-307352
ROPN1Q9HAT03EBI-456371,EBI-1378139
SEPT3Q9UH035EBI-456371,EBI-727037
SKP2Q133096EBI-456371,EBI-456291
SPERTQ8NA613EBI-456371,EBI-741724
TCF4P158843EBI-456371,EBI-533224
TRIM27P143733EBI-456371,EBI-719493
XIAPP981705EBI-456371,EBI-517127

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107582. 55 interactors.
DIPiDIP-102N.
IntActiP61024. 51 interactors.
MINTiMINT-1515264.
STRINGi9606.ENSP00000471505.

Structurei

Secondary structure

179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Beta strandi15 – 23Combined sources9
Helixi26 – 29Combined sources4
Beta strandi34 – 36Combined sources3
Helixi40 – 46Combined sources7
Beta strandi55 – 59Combined sources5
Beta strandi61 – 63Combined sources3
Beta strandi66 – 72Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BUHX-ray2.60B1-79[»]
1DKSX-ray3.20A/B1-79[»]
1DKTX-ray2.90A/B1-79[»]
2ASSX-ray3.00C5-73[»]
2ASTX-ray2.30C5-73[»]
4YC6X-ray2.60B/D/F/H1-79[»]
ProteinModelPortaliP61024.
SMRiP61024.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61024.

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP61024.
KOiK02219.
OMAiIPKNRLM.
OrthoDBiEOG091G18GQ.
PhylomeDBiP61024.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ
60 70
SQGWVHYMIH EPEPHILLFR RPLPKKPKK
Length:79
Mass (Da):9,660
Last modified:April 26, 2004 - v1
Checksum:iE64207B140FA38D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54941 mRNA. Translation: CAA38702.1.
AF274941 mRNA. Translation: AAK07518.1.
AF279897 mRNA. Translation: AAK07553.1.
BT007196 mRNA. Translation: AAP35860.1.
BC007751 mRNA. Translation: AAH07751.1.
BC015629 mRNA. Translation: AAH15629.1.
BC070319 mRNA. Translation: AAH70319.1.
BC070320 mRNA. Translation: AAH70320.1.
CCDSiCCDS1077.1.
PIRiA36670.
RefSeqiNP_001817.1. NM_001826.2.
UniGeneiHs.374378.

Genome annotation databases

EnsembliENST00000308987; ENSP00000311083; ENSG00000173207.
GeneIDi1163.
KEGGihsa:1163.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54941 mRNA. Translation: CAA38702.1.
AF274941 mRNA. Translation: AAK07518.1.
AF279897 mRNA. Translation: AAK07553.1.
BT007196 mRNA. Translation: AAP35860.1.
BC007751 mRNA. Translation: AAH07751.1.
BC015629 mRNA. Translation: AAH15629.1.
BC070319 mRNA. Translation: AAH70319.1.
BC070320 mRNA. Translation: AAH70320.1.
CCDSiCCDS1077.1.
PIRiA36670.
RefSeqiNP_001817.1. NM_001826.2.
UniGeneiHs.374378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BUHX-ray2.60B1-79[»]
1DKSX-ray3.20A/B1-79[»]
1DKTX-ray2.90A/B1-79[»]
2ASSX-ray3.00C5-73[»]
2ASTX-ray2.30C5-73[»]
4YC6X-ray2.60B/D/F/H1-79[»]
ProteinModelPortaliP61024.
SMRiP61024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107582. 55 interactors.
DIPiDIP-102N.
IntActiP61024. 51 interactors.
MINTiMINT-1515264.
STRINGi9606.ENSP00000471505.

PTM databases

iPTMnetiP61024.
PhosphoSitePlusiP61024.

Polymorphism and mutation databases

BioMutaiCKS1B.

Proteomic databases

EPDiP61024.
PaxDbiP61024.
PeptideAtlasiP61024.
PRIDEiP61024.
TopDownProteomicsiP61024.

Protocols and materials databases

DNASUi1163.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308987; ENSP00000311083; ENSG00000173207.
GeneIDi1163.
KEGGihsa:1163.

Organism-specific databases

CTDi1163.
DisGeNETi1163.
GeneCardsiCKS1B.
HGNCiHGNC:19083. CKS1B.
HPAiCAB013284.
HPA030762.
MIMi116900. gene.
neXtProtiNX_P61024.
OpenTargetsiENSG00000173207.
PharmGKBiPA38791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP61024.
KOiK02219.
OMAiIPKNRLM.
OrthoDBiEOG091G18GQ.
PhylomeDBiP61024.
TreeFamiTF101142.

Enzyme and pathway databases

BioCyciZFISH:HS11295-MONOMER.
ReactomeiR-HSA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-HSA-69231. Cyclin D associated events in G1.

Miscellaneous databases

EvolutionaryTraceiP61024.
GeneWikiiCKS1B.
GenomeRNAii1163.
PROiP61024.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173207.
CleanExiHS_CKS1B.
ExpressionAtlasiP61024. baseline and differential.
GenevisibleiP61024. HS.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKS1_HUMAN
AccessioniPrimary (citable) accession number: P61024
Secondary accession number(s): P33551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.