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Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

CKS1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: ProtInc
  • G1/S transition of mitotic cell cycle Source: Reactome
  • mitotic cell cycle Source: Reactome
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_821. Cyclin D associated events in G1.
REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Short name:
CKS-1
Gene namesi
Name:CKS1B
Synonyms:CKS1
ORF Names:PNAS-143, PNAS-16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19083. CKS1B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38791.

Polymorphism and mutation databases

BioMutaiCKS1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 1PRO_0000206235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP61024.
PaxDbiP61024.
PRIDEiP61024.

PTM databases

PhosphoSiteiP61024.

Expressioni

Gene expression databases

BgeeiP61024.
CleanExiHS_CKS1B.
ExpressionAtlasiP61024. baseline and differential.
GenevisibleiP61024. HS.

Organism-specific databases

HPAiCAB013284.
HPA030762.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-456371,EBI-10175576
ARID5AC9J1Q03EBI-456371,EBI-10176351
CDK1P064936EBI-456371,EBI-444308
CDK2P249415EBI-456371,EBI-375096
CDX4O146273EBI-456371,EBI-10181162
IKZF1Q134223EBI-456371,EBI-745305
KRTAP10-9P604113EBI-456371,EBI-10172052
KRTAP5-9P263713EBI-456371,EBI-3958099
MEOX1P502213EBI-456371,EBI-2864512
MIPOL1Q8TD103EBI-456371,EBI-2548751
RELQ048643EBI-456371,EBI-307352
ROPN1Q9HAT03EBI-456371,EBI-1378139
SEPT3Q9UH033EBI-456371,EBI-727037
SKP2Q133096EBI-456371,EBI-456291
SPERTQ8NA613EBI-456371,EBI-741724
TCF4P158843EBI-456371,EBI-533224
TRIM27P143733EBI-456371,EBI-719493
XIAPP981703EBI-456371,EBI-517127

Protein-protein interaction databases

BioGridi107582. 43 interactions.
DIPiDIP-102N.
IntActiP61024. 26 interactions.
MINTiMINT-1515264.
STRINGi9606.ENSP00000471505.

Structurei

Secondary structure

1
79
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 93Combined sources
Beta strandi15 – 239Combined sources
Helixi26 – 294Combined sources
Beta strandi34 – 363Combined sources
Helixi40 – 467Combined sources
Beta strandi55 – 595Combined sources
Beta strandi61 – 633Combined sources
Beta strandi66 – 727Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BUHX-ray2.60B1-79[»]
1DKSX-ray3.20A/B1-79[»]
1DKTX-ray2.90A/B1-79[»]
2ASSX-ray3.00C5-73[»]
2ASTX-ray2.30C5-73[»]
4YC6X-ray2.60B/D/F/H1-79[»]
ProteinModelPortaliP61024.
SMRiP61024. Positions 5-74.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61024.

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiNOG272189.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP61024.
KOiK02219.
OMAiIPKNRLM.
PhylomeDBiP61024.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ
60 70
SQGWVHYMIH EPEPHILLFR RPLPKKPKK
Length:79
Mass (Da):9,660
Last modified:April 26, 2004 - v1
Checksum:iE64207B140FA38D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54941 mRNA. Translation: CAA38702.1.
AF274941 mRNA. Translation: AAK07518.1.
AF279897 mRNA. Translation: AAK07553.1.
BT007196 mRNA. Translation: AAP35860.1.
BC007751 mRNA. Translation: AAH07751.1.
BC015629 mRNA. Translation: AAH15629.1.
BC070319 mRNA. Translation: AAH70319.1.
BC070320 mRNA. Translation: AAH70320.1.
CCDSiCCDS1077.1.
PIRiA36670.
RefSeqiNP_001817.1. NM_001826.2.
UniGeneiHs.374378.

Genome annotation databases

EnsembliENST00000308987; ENSP00000311083; ENSG00000173207.
GeneIDi1163.
KEGGihsa:1163.
UCSCiuc001fgb.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54941 mRNA. Translation: CAA38702.1.
AF274941 mRNA. Translation: AAK07518.1.
AF279897 mRNA. Translation: AAK07553.1.
BT007196 mRNA. Translation: AAP35860.1.
BC007751 mRNA. Translation: AAH07751.1.
BC015629 mRNA. Translation: AAH15629.1.
BC070319 mRNA. Translation: AAH70319.1.
BC070320 mRNA. Translation: AAH70320.1.
CCDSiCCDS1077.1.
PIRiA36670.
RefSeqiNP_001817.1. NM_001826.2.
UniGeneiHs.374378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BUHX-ray2.60B1-79[»]
1DKSX-ray3.20A/B1-79[»]
1DKTX-ray2.90A/B1-79[»]
2ASSX-ray3.00C5-73[»]
2ASTX-ray2.30C5-73[»]
4YC6X-ray2.60B/D/F/H1-79[»]
ProteinModelPortaliP61024.
SMRiP61024. Positions 5-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107582. 43 interactions.
DIPiDIP-102N.
IntActiP61024. 26 interactions.
MINTiMINT-1515264.
STRINGi9606.ENSP00000471505.

PTM databases

PhosphoSiteiP61024.

Polymorphism and mutation databases

BioMutaiCKS1B.

Proteomic databases

MaxQBiP61024.
PaxDbiP61024.
PRIDEiP61024.

Protocols and materials databases

DNASUi1163.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308987; ENSP00000311083; ENSG00000173207.
GeneIDi1163.
KEGGihsa:1163.
UCSCiuc001fgb.3. human.

Organism-specific databases

CTDi1163.
GeneCardsiGC01P154947.
HGNCiHGNC:19083. CKS1B.
HPAiCAB013284.
HPA030762.
MIMi116900. gene.
neXtProtiNX_P61024.
PharmGKBiPA38791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272189.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP61024.
KOiK02219.
OMAiIPKNRLM.
PhylomeDBiP61024.
TreeFamiTF101142.

Enzyme and pathway databases

ReactomeiREACT_821. Cyclin D associated events in G1.
REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.

Miscellaneous databases

EvolutionaryTraceiP61024.
GeneWikiiCKS1B.
GenomeRNAii1163.
NextBioi4830.
PROiP61024.
SOURCEiSearch...

Gene expression databases

BgeeiP61024.
CleanExiHS_CKS1B.
ExpressionAtlasiP61024. baseline and differential.
GenevisibleiP61024. HS.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I.
    Genes Dev. 4:1332-1344(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Promyelocytic leukemia.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Muscle and Prostate.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain."
    Arvai A.S., Bourne Y., Hickey M.J., Tainer J.A.
    J. Mol. Biol. 249:835-842(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
  8. "Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1."
    Bourne Y., Watson M.H., Hickey M.J., Holmes W., Rocque W., Reed S.I., Tainer J.A.
    Cell 84:863-874(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF COMPLEX WITH CDK2.

Entry informationi

Entry nameiCKS1_HUMAN
AccessioniPrimary (citable) accession number: P61024
Secondary accession number(s): P33551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: July 22, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.