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Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

CKS1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-69231 Cyclin D associated events in G1

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Short name:
CKS-1
Gene namesi
Name:CKS1B
Synonyms:CKS1
ORF Names:PNAS-143, PNAS-16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000173207.12
HGNCiHGNC:19083 CKS1B
MIMi116900 gene
neXtProtiNX_P61024

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1163
OpenTargetsiENSG00000173207
PharmGKBiPA38791

Chemistry databases

DrugBankiDB02681 Meta Vanadate

Polymorphism and mutation databases

BioMutaiCKS1B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002062352 – 79Cyclin-dependent kinases regulatory subunit 1Add BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61024
PaxDbiP61024
PeptideAtlasiP61024
PRIDEiP61024
TopDownProteomicsiP61024

PTM databases

iPTMnetiP61024
PhosphoSitePlusiP61024

Expressioni

Gene expression databases

BgeeiENSG00000173207
CleanExiHS_CKS1B
ExpressionAtlasiP61024 baseline and differential
GenevisibleiP61024 HS

Organism-specific databases

HPAiHPA003424
HPA030762

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107582, 58 interactors
CORUMiP61024
DIPiDIP-102N
IntActiP61024, 58 interactors
MINTiP61024
STRINGi9606.ENSP00000471505

Structurei

Secondary structure

179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Beta strandi15 – 23Combined sources9
Helixi26 – 29Combined sources4
Beta strandi34 – 36Combined sources3
Helixi40 – 46Combined sources7
Beta strandi55 – 59Combined sources5
Beta strandi61 – 63Combined sources3
Beta strandi66 – 72Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BUHX-ray2.60B1-79[»]
1DKSX-ray3.20A/B1-79[»]
1DKTX-ray2.90A/B1-79[»]
2ASSX-ray3.00C5-73[»]
2ASTX-ray2.30C5-73[»]
4YC6X-ray2.60B/D/F/H1-79[»]
ProteinModelPortaliP61024
SMRiP61024
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61024

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484 Eukaryota
ENOG4111UAN LUCA
GeneTreeiENSGT00390000011006
HOVERGENiHBG003626
InParanoidiP61024
KOiK02219
OMAiIHYSSRY
OrthoDBiEOG091G18GQ
PhylomeDBiP61024
TreeFamiTF101142

Family and domain databases

Gene3Di3.30.170.10, 1 hit
InterProiView protein in InterPro
IPR000789 Cyclin-dep_kinase_reg-sub
IPR036858 Cyclin-dep_kinase_reg-sub_sf
PfamiView protein in Pfam
PF01111 CKS, 1 hit
PRINTSiPR00296 CYCLINKINASE
SMARTiView protein in SMART
SM01084 CKS, 1 hit
SUPFAMiSSF55637 SSF55637, 1 hit
PROSITEiView protein in PROSITE
PS00944 CKS_1, 1 hit
PS00945 CKS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ
60 70
SQGWVHYMIH EPEPHILLFR RPLPKKPKK
Length:79
Mass (Da):9,660
Last modified:April 26, 2004 - v1
Checksum:iE64207B140FA38D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54941 mRNA Translation: CAA38702.1
AF274941 mRNA Translation: AAK07518.1
AF279897 mRNA Translation: AAK07553.1
BT007196 mRNA Translation: AAP35860.1
BC007751 mRNA Translation: AAH07751.1
BC015629 mRNA Translation: AAH15629.1
BC070319 mRNA Translation: AAH70319.1
BC070320 mRNA Translation: AAH70320.1
CCDSiCCDS1077.1
PIRiA36670
RefSeqiNP_001817.1, NM_001826.2
UniGeneiHs.374378

Genome annotation databases

EnsembliENST00000308987; ENSP00000311083; ENSG00000173207
GeneIDi1163
KEGGihsa:1163

Similar proteinsi

Entry informationi

Entry nameiCKS1_HUMAN
AccessioniPrimary (citable) accession number: P61024
Secondary accession number(s): P33551
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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