Cyclin-dependent kinases regulatory subunit 1

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P61024 (CKS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Short name=CKS-1

Gene names

Name:	CKS1B
Synonyms:	CKS1
ORF Names:	PNAS-143, PNAS-16

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	79 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Subunit structure	Forms a homohexamer that can probably bind six kinase subunits.
Sequence similarities	Belongs to the CKS family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1 phase of mitotic cell cycle Traceable author statement. Source: Reactome G1/S transition of mitotic cell cycle Traceable author statement. Source: Reactome S phase of mitotic cell cycle Traceable author statement. Source: Reactome cell division Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Traceable author statement Ref.1. Source: ProtInc regulation of cyclin-dependent protein serine/threonine kinase activity Traceable author statement Ref.7. Source: ProtInc
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SKP2	Q13309	3	EBI-456371,EBI-456291

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 79

Cyclin-dependent kinases regulatory subunit 1

PRO_0000206235

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P61024 [UniParc].

Last modified April 26, 2004. Version 1.
Checksum: E64207B140FA38D5
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FASTA

9,660

        10         20         30         40         50         60 
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ SQGWVHYMIH 

        70 
EPEPHILLFR RPLPKKPKK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe." Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I. Genes Dev. 4:1332-1344(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes." Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Promyelocytic leukemia.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Muscle and Prostate.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain." Arvai A.S., Bourne Y., Hickey M.J., Tainer J.A. J. Mol. Biol. 249:835-842(1995) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
[7]	"Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1." Bourne Y., Watson M.H., Hickey M.J., Holmes W., Rocque W., Reed S.I., Tainer J.A. Cell 84:863-874(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF COMPLEX WITH CDK2.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X54941 mRNA. Translation: CAA38702.1.
AF274941 mRNA. Translation: AAK07518.1.
AF279897 mRNA. Translation: AAK07553.1.
BT007196 mRNA. Translation: AAP35860.1.
BC007751 mRNA. Translation: AAH07751.1.
BC015629 mRNA. Translation: AAH15629.1.
BC070319 mRNA. Translation: AAH70319.1.
BC070320 mRNA. Translation: AAH70320.1.

IPI

IPI00015104.

PIR

A36670.

RefSeq

NP_001817.1. NM_001826.2.

UniGene

Hs.374378.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BUH	X-ray	2.60	B	1-79	[»]
1DKS	X-ray	3.20	A/B	1-79	[»]
1DKT	X-ray	2.90	A/B	1-79	[»]
2ASS	X-ray	3.00	C	5-73	[»]
2AST	X-ray	2.30	C	5-73	[»]

ProteinModelPortal

P61024.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-102N.

IntAct

P61024. 8 interactions.

MINT

MINT-1515264.

STRING

9606.ENSP00000311083.

PTM databases

PhosphoSite

P61024.

Polymorphism databases

DMDM

46577579.

Proteomic databases

PaxDb

P61024.

PRIDE

P61024.

Protocols and materials databases

DNASU

1163.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000308987; ENSP00000311083; ENSG00000173207.

GeneID

1163.

KEGG

hsa:1163.

UCSC

uc001fgb.3. human.

Organism-specific databases

CTD

1163.

GeneCards

GC01P154947.

HGNC

HGNC:19083. CKS1B.

HPA

CAB013284.
HPA030762.

MIM

116900. gene.

neXtProt

NX_P61024.

PharmGKB

PA38791.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG272189.

HOVERGEN

HBG003626.

InParanoid

P61024.

K02219.

OMA

QPEPHIL.

PhylomeDB

P61024.

Enzyme and pathway databases

Pathway_Interaction_DB

foxm1pathway. FOXM1 transcription factor network.

Reactome

REACT_115566. Cell Cycle.

Gene expression databases

ArrayExpress

P61024.

Bgee

P61024.

CleanEx

HS_CKS1B.

Genevestigator

P61024.

GermOnline

ENSG00000173207. Homo sapiens.
ENSG00000187631. Homo sapiens.

Family and domain databases

Gene3D

3.30.170.10. 1 hit.

InterPro

IPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]

Pfam

PF01111. CKS. 1 hit.
[Graphical view]

PRINTS

PR00296. CYCLINKINASE.

SMART

SM01084. CKS. 1 hit.
[Graphical view]

SUPFAM

SSF55637. Cyc_dep_kin_rsub. 1 hit.

PROSITE

PS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P61024.

GenomeRNAi

1163.

NextBio

4830.

SOURCE

Search...

Entry information

Entry name

CKS1_HUMAN

Accession

Primary (citable) accession number: P61024
Secondary accession number(s): P33551

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	May 29, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents