Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P61024

- CKS1_HUMAN

UniProt

P61024 - CKS1_HUMAN

Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

CKS1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. cell proliferation Source: ProtInc
    3. G1/S transition of mitotic cell cycle Source: Reactome
    4. mitotic cell cycle Source: Reactome
    5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_821. Cyclin D associated events in G1.
    REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 1
    Short name:
    CKS-1
    Gene namesi
    Name:CKS1B
    Synonyms:CKS1
    ORF Names:PNAS-143, PNAS-16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19083. CKS1B.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38791.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 1PRO_0000206235Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP61024.
    PaxDbiP61024.
    PRIDEiP61024.

    PTM databases

    PhosphoSiteiP61024.

    Expressioni

    Gene expression databases

    ArrayExpressiP61024.
    BgeeiP61024.
    CleanExiHS_CKS1B.
    GenevestigatoriP61024.

    Organism-specific databases

    HPAiCAB013284.
    HPA030762.

    Interactioni

    Subunit structurei

    Forms a homohexamer that can probably bind six kinase subunits.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK2P249413EBI-456371,EBI-375096
    SKP2Q133096EBI-456371,EBI-456291

    Protein-protein interaction databases

    BioGridi107582. 27 interactions.
    DIPiDIP-102N.
    IntActiP61024. 11 interactions.
    MINTiMINT-1515264.
    STRINGi9606.ENSP00000311083.

    Structurei

    Secondary structure

    1
    79
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 93
    Beta strandi15 – 239
    Helixi26 – 294
    Beta strandi34 – 363
    Helixi40 – 467
    Beta strandi55 – 595
    Beta strandi61 – 633
    Beta strandi66 – 727

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BUHX-ray2.60B1-79[»]
    1DKSX-ray3.20A/B1-79[»]
    1DKTX-ray2.90A/B1-79[»]
    2ASSX-ray3.00C5-73[»]
    2ASTX-ray2.30C5-73[»]
    ProteinModelPortaliP61024.
    SMRiP61024. Positions 5-74.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP61024.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CKS family.Curated

    Phylogenomic databases

    eggNOGiNOG272189.
    HOVERGENiHBG003626.
    InParanoidiP61024.
    KOiK02219.
    OMAiRGWIHYM.
    PhylomeDBiP61024.
    TreeFamiTF101142.

    Family and domain databases

    Gene3Di3.30.170.10. 1 hit.
    InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view]
    PfamiPF01111. CKS. 1 hit.
    [Graphical view]
    PRINTSiPR00296. CYCLINKINASE.
    SMARTiSM01084. CKS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55637. SSF55637. 1 hit.
    PROSITEiPS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61024-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ   50
    SQGWVHYMIH EPEPHILLFR RPLPKKPKK 79
    Length:79
    Mass (Da):9,660
    Last modified:April 26, 2004 - v1
    Checksum:iE64207B140FA38D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54941 mRNA. Translation: CAA38702.1.
    AF274941 mRNA. Translation: AAK07518.1.
    AF279897 mRNA. Translation: AAK07553.1.
    BT007196 mRNA. Translation: AAP35860.1.
    BC007751 mRNA. Translation: AAH07751.1.
    BC015629 mRNA. Translation: AAH15629.1.
    BC070319 mRNA. Translation: AAH70319.1.
    BC070320 mRNA. Translation: AAH70320.1.
    CCDSiCCDS1077.1.
    PIRiA36670.
    RefSeqiNP_001817.1. NM_001826.2.
    UniGeneiHs.374378.

    Genome annotation databases

    EnsembliENST00000308987; ENSP00000311083; ENSG00000173207.
    GeneIDi1163.
    KEGGihsa:1163.
    UCSCiuc001fgb.3. human.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54941 mRNA. Translation: CAA38702.1 .
    AF274941 mRNA. Translation: AAK07518.1 .
    AF279897 mRNA. Translation: AAK07553.1 .
    BT007196 mRNA. Translation: AAP35860.1 .
    BC007751 mRNA. Translation: AAH07751.1 .
    BC015629 mRNA. Translation: AAH15629.1 .
    BC070319 mRNA. Translation: AAH70319.1 .
    BC070320 mRNA. Translation: AAH70320.1 .
    CCDSi CCDS1077.1.
    PIRi A36670.
    RefSeqi NP_001817.1. NM_001826.2.
    UniGenei Hs.374378.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BUH X-ray 2.60 B 1-79 [» ]
    1DKS X-ray 3.20 A/B 1-79 [» ]
    1DKT X-ray 2.90 A/B 1-79 [» ]
    2ASS X-ray 3.00 C 5-73 [» ]
    2AST X-ray 2.30 C 5-73 [» ]
    ProteinModelPortali P61024.
    SMRi P61024. Positions 5-74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107582. 27 interactions.
    DIPi DIP-102N.
    IntActi P61024. 11 interactions.
    MINTi MINT-1515264.
    STRINGi 9606.ENSP00000311083.

    PTM databases

    PhosphoSitei P61024.

    Proteomic databases

    MaxQBi P61024.
    PaxDbi P61024.
    PRIDEi P61024.

    Protocols and materials databases

    DNASUi 1163.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308987 ; ENSP00000311083 ; ENSG00000173207 .
    GeneIDi 1163.
    KEGGi hsa:1163.
    UCSCi uc001fgb.3. human.

    Organism-specific databases

    CTDi 1163.
    GeneCardsi GC01P154947.
    HGNCi HGNC:19083. CKS1B.
    HPAi CAB013284.
    HPA030762.
    MIMi 116900. gene.
    neXtProti NX_P61024.
    PharmGKBi PA38791.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272189.
    HOVERGENi HBG003626.
    InParanoidi P61024.
    KOi K02219.
    OMAi RGWIHYM.
    PhylomeDBi P61024.
    TreeFami TF101142.

    Enzyme and pathway databases

    Reactomei REACT_821. Cyclin D associated events in G1.
    REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.

    Miscellaneous databases

    EvolutionaryTracei P61024.
    GeneWikii CKS1B.
    GenomeRNAii 1163.
    NextBioi 4830.
    PROi P61024.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61024.
    Bgeei P61024.
    CleanExi HS_CKS1B.
    Genevestigatori P61024.

    Family and domain databases

    Gene3Di 3.30.170.10. 1 hit.
    InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view ]
    Pfami PF01111. CKS. 1 hit.
    [Graphical view ]
    PRINTSi PR00296. CYCLINKINASE.
    SMARTi SM01084. CKS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55637. SSF55637. 1 hit.
    PROSITEi PS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
      Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I.
      Genes Dev. 4:1332-1344(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
      Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Promyelocytic leukemia.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Muscle and Prostate.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. "Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain."
      Arvai A.S., Bourne Y., Hickey M.J., Tainer J.A.
      J. Mol. Biol. 249:835-842(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    8. "Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1."
      Bourne Y., Watson M.H., Hickey M.J., Holmes W., Rocque W., Reed S.I., Tainer J.A.
      Cell 84:863-874(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF COMPLEX WITH CDK2.

    Entry informationi

    Entry nameiCKS1_HUMAN
    AccessioniPrimary (citable) accession number: P61024
    Secondary accession number(s): P33551
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3