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P61024

- CKS1_HUMAN

UniProt

P61024 - CKS1_HUMAN

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Protein
Cyclin-dependent kinases regulatory subunit 1
Gene
CKS1B, CKS1, PNAS-143, PNAS-16
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro
  2. protein binding Source: IntAct

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: Reactome
  2. cell division Source: UniProtKB-KW
  3. cell proliferation Source: ProtInc
  4. mitotic cell cycle Source: Reactome
  5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_821. Cyclin D associated events in G1.
REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Short name:
CKS-1
Gene namesi
Name:CKS1B
Synonyms:CKS1
ORF Names:PNAS-143, PNAS-16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19083. CKS1B.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 1
PRO_0000206235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP61024.
PaxDbiP61024.
PRIDEiP61024.

PTM databases

PhosphoSiteiP61024.

Expressioni

Gene expression databases

ArrayExpressiP61024.
BgeeiP61024.
CleanExiHS_CKS1B.
GenevestigatoriP61024.

Organism-specific databases

HPAiCAB013284.
HPA030762.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK2P249413EBI-456371,EBI-375096
SKP2Q133096EBI-456371,EBI-456291

Protein-protein interaction databases

BioGridi107582. 27 interactions.
DIPiDIP-102N.
IntActiP61024. 11 interactions.
MINTiMINT-1515264.
STRINGi9606.ENSP00000311083.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 93
Beta strandi15 – 239
Helixi26 – 294
Beta strandi34 – 363
Helixi40 – 467
Beta strandi55 – 595
Beta strandi61 – 633
Beta strandi66 – 727

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BUHX-ray2.60B1-79[»]
1DKSX-ray3.20A/B1-79[»]
1DKTX-ray2.90A/B1-79[»]
2ASSX-ray3.00C5-73[»]
2ASTX-ray2.30C5-73[»]
ProteinModelPortaliP61024.
SMRiP61024. Positions 5-74.

Miscellaneous databases

EvolutionaryTraceiP61024.

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.

Phylogenomic databases

eggNOGiNOG272189.
HOVERGENiHBG003626.
InParanoidiP61024.
KOiK02219.
OMAiRGWIHYM.
PhylomeDBiP61024.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61024-1 [UniParc]FASTAAdd to Basket

« Hide

MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ   50
SQGWVHYMIH EPEPHILLFR RPLPKKPKK 79
Length:79
Mass (Da):9,660
Last modified:April 26, 2004 - v1
Checksum:iE64207B140FA38D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54941 mRNA. Translation: CAA38702.1.
AF274941 mRNA. Translation: AAK07518.1.
AF279897 mRNA. Translation: AAK07553.1.
BT007196 mRNA. Translation: AAP35860.1.
BC007751 mRNA. Translation: AAH07751.1.
BC015629 mRNA. Translation: AAH15629.1.
BC070319 mRNA. Translation: AAH70319.1.
BC070320 mRNA. Translation: AAH70320.1.
CCDSiCCDS1077.1.
PIRiA36670.
RefSeqiNP_001817.1. NM_001826.2.
UniGeneiHs.374378.

Genome annotation databases

EnsembliENST00000308987; ENSP00000311083; ENSG00000173207.
GeneIDi1163.
KEGGihsa:1163.
UCSCiuc001fgb.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54941 mRNA. Translation: CAA38702.1 .
AF274941 mRNA. Translation: AAK07518.1 .
AF279897 mRNA. Translation: AAK07553.1 .
BT007196 mRNA. Translation: AAP35860.1 .
BC007751 mRNA. Translation: AAH07751.1 .
BC015629 mRNA. Translation: AAH15629.1 .
BC070319 mRNA. Translation: AAH70319.1 .
BC070320 mRNA. Translation: AAH70320.1 .
CCDSi CCDS1077.1.
PIRi A36670.
RefSeqi NP_001817.1. NM_001826.2.
UniGenei Hs.374378.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BUH X-ray 2.60 B 1-79 [» ]
1DKS X-ray 3.20 A/B 1-79 [» ]
1DKT X-ray 2.90 A/B 1-79 [» ]
2ASS X-ray 3.00 C 5-73 [» ]
2AST X-ray 2.30 C 5-73 [» ]
ProteinModelPortali P61024.
SMRi P61024. Positions 5-74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107582. 27 interactions.
DIPi DIP-102N.
IntActi P61024. 11 interactions.
MINTi MINT-1515264.
STRINGi 9606.ENSP00000311083.

PTM databases

PhosphoSitei P61024.

Proteomic databases

MaxQBi P61024.
PaxDbi P61024.
PRIDEi P61024.

Protocols and materials databases

DNASUi 1163.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308987 ; ENSP00000311083 ; ENSG00000173207 .
GeneIDi 1163.
KEGGi hsa:1163.
UCSCi uc001fgb.3. human.

Organism-specific databases

CTDi 1163.
GeneCardsi GC01P154947.
HGNCi HGNC:19083. CKS1B.
HPAi CAB013284.
HPA030762.
MIMi 116900. gene.
neXtProti NX_P61024.
PharmGKBi PA38791.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272189.
HOVERGENi HBG003626.
InParanoidi P61024.
KOi K02219.
OMAi RGWIHYM.
PhylomeDBi P61024.
TreeFami TF101142.

Enzyme and pathway databases

Reactomei REACT_821. Cyclin D associated events in G1.
REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.

Miscellaneous databases

EvolutionaryTracei P61024.
GeneWikii CKS1B.
GenomeRNAii 1163.
NextBioi 4830.
PROi P61024.
SOURCEi Search...

Gene expression databases

ArrayExpressi P61024.
Bgeei P61024.
CleanExi HS_CKS1B.
Genevestigatori P61024.

Family and domain databases

Gene3Di 3.30.170.10. 1 hit.
InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view ]
Pfami PF01111. CKS. 1 hit.
[Graphical view ]
PRINTSi PR00296. CYCLINKINASE.
SMARTi SM01084. CKS. 1 hit.
[Graphical view ]
SUPFAMi SSF55637. SSF55637. 1 hit.
PROSITEi PS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I.
    Genes Dev. 4:1332-1344(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Promyelocytic leukemia.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Muscle and Prostate.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain."
    Arvai A.S., Bourne Y., Hickey M.J., Tainer J.A.
    J. Mol. Biol. 249:835-842(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
  8. "Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1."
    Bourne Y., Watson M.H., Hickey M.J., Holmes W., Rocque W., Reed S.I., Tainer J.A.
    Cell 84:863-874(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF COMPLEX WITH CDK2.

Entry informationi

Entry nameiCKS1_HUMAN
AccessioniPrimary (citable) accession number: P61024
Secondary accession number(s): P33551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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