Cyclin-dependent kinases regulatory subunit 1

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Reviewed, UniProtKB/Swiss-Prot P61024 (CKS1_HUMAN)

Last modified July 7, 2009. Version 64. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Short name=CKS-1

Gene names

Name:	CKS1B
Synonyms:	CKS1
ORF Names:	PNAS-16, PNAS-143

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	79 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Subunit structure	Forms a homohexamer that can probably bind six kinase subunits.
Sequence similarities	Belongs to the CKS family.

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Ontologies

Keywords
Biological process	Cell cycle Cell division
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Ref.1 Traceable author statement. Source: ProtInc regulation of cyclin-dependent protein kinase activity Ref.7 Traceable author statement. Source: ProtInc
Cellular component	nucleoplasm Inferred from Experiment. Source: Reactome
Molecular function	cyclin-dependent protein kinase regulator activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDKA-1	P24100	1	EBI-456371,EBI-371713	From a different organism.
SKP2	Q13309	2	EBI-456371,EBI-456291

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 79

Cyclin-dependent kinases regulatory subunit 1

PRO_0000206235

Secondary structure

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P61024-1 [UniParc].

Last modified April 26, 2004. Version 1.
Checksum: E64207B140FA38D5
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FASTA

9,660

        10         20         30         40         50         60 
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ SQGWVHYMIH 

        70 
EPEPHILLFR RPLPKKPKK

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe." Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I. Genes Dev. 4:1332-1344(1990) [PubMed: 2227411] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes." Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Promyelocytic leukemia.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Muscle and Prostate.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain." Arvai A.S., Bourne Y., Hickey M.J., Tainer J.A. J. Mol. Biol. 249:835-842(1995) [PubMed: 7791211] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
[7]	"Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1." Bourne Y., Watson M.H., Hickey M.J., Holmes W., Rocque W., Reed S.I., Tainer J.A. Cell 84:863-874(1996) [PubMed: 8601310] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF COMPLEX WITH CDK2.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

X54941 mRNA. Translation: CAA38702.1.
AF274941 mRNA. Translation: AAK07518.1.
AF279897 mRNA. Translation: AAK07553.1.
BT007196 mRNA. Translation: AAP35860.1.
BC007751 mRNA. Translation: AAH07751.1.
BC015629 mRNA. Translation: AAH15629.1.
BC070319 mRNA. Translation: AAH70319.1.
BC070320 mRNA. Translation: AAH70320.1.

IPI

IPI00015104.

PIR

A36670.

RefSeq

NP_001817.1.

UniGene

Hs.374378

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BUH	X-ray	2.60	B	1-79	[»]
1DKS	X-ray	3.20	A/B	1-79	[»]
1DKT	X-ray	2.90	A/B	1-79	[»]
2ASS	X-ray	3.00	C	5-73	[»]
2AST	X-ray	2.30	C	5-73	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P61024. 6 interactions.

PTM databases

PhosphoSite

P61024.

Proteomic databases

PRIDE

P61024.

Genome annotation databases

Ensembl

ENSG00000173207. Homo sapiens. [Contig view]

GeneID

1163.

KEGG

hsa:1163.

UCSC

uc001fgb.1. human.

Organism-specific databases

GeneCards

GC01P153213.
GC11P082598.

H-InvDB

HIX0001021.
HIX0032135.
HIX0056525.
HIX0057550.

HGNC

HGNC:19083. CKS1B.

HPA

CAB013284.

MIM

116900. gene.

PharmGKB

PA38791.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P61024.

HOVERGEN

P61024.

OMA

P61024. LMSETEW.

Enzyme and pathway databases

Pathway_Interaction_DB

foxm1pathway. FOXM1 transcription factor network.

Reactome

REACT_152. Cell Cycle, Mitotic.

Gene expression databases

Bgee

P61024.

CleanEx

HS_CKS1B.

GermOnline

ENSG00000173207. Homo sapiens.
ENSG00000187631. Homo sapiens.

Family and domain databases

InterPro

IPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]

Gene3D

G3DSA:3.30.170.10. Cyclin-dep_kinase_reg-sub. 1 hit.

Pfam

PF01111. CKS. 1 hit.
[Graphical view]

PRINTS

PR00296. CYCLINKINASE.

ProDom

PD005152. Cyc_dep_kin_rsub. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

4830.

SOURCE

Search...

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Entry information

Entry name

CKS1_HUMAN

Accession

Primary (citable) accession number: P61024
Secondary accession number(s): P33551

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	July 7, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents