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P61021

- RAB5B_MOUSE

UniProt

P61021 - RAB5B_MOUSE

Protein

Ras-related protein Rab-5B

Gene

Rab5b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    Protein transport. Probably involved in vesicular traffic By similarity.By similarity

    Enzyme regulationi

    Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 359GTPBy similarity
    Nucleotide bindingi75 – 795GTPBy similarity
    Nucleotide bindingi133 – 1364GTPBy similarity
    Nucleotide bindingi163 – 1653GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: MGI
    3. GTP binding Source: UniProtKB-KW
    4. protein binding Source: IntAct

    GO - Biological processi

    1. endosome organization Source: MGI
    2. GTP catabolic process Source: GOC
    3. protein transport Source: UniProtKB-KW
    4. regulation of endocytosis Source: MGI
    5. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-5B
    Gene namesi
    Name:Rab5b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:105938. Rab5b.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome membrane Source: UniProtKB-SubCell
    2. endocytic vesicle Source: MGI
    3. melanosome Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 215214Ras-related protein Rab-5BPRO_0000121108Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonineBy similarity
    Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity
    Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Prenylation

    Proteomic databases

    MaxQBiP61021.
    PaxDbiP61021.
    PRIDEiP61021.

    PTM databases

    PhosphoSiteiP61021.

    Expressioni

    Gene expression databases

    BgeeiP61021.
    CleanExiMM_RAB5B.
    GenevestigatoriP61021.

    Interactioni

    Subunit structurei

    Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LRRK2Q5S0072EBI-8320093,EBI-5323863From a different organism.

    Protein-protein interaction databases

    BioGridi202548. 2 interactions.
    IntActiP61021. 3 interactions.
    MINTiMINT-1865771.

    Structurei

    3D structure databases

    ProteinModelPortaliP61021.
    SMRiP61021. Positions 17-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 579Effector regionSequence Analysis

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00640000091139.
    HOVERGENiHBG009351.
    InParanoidiP61021.
    KOiK07888.
    OMAiMENTHFD.
    OrthoDBiEOG77DJ7M.
    PhylomeDBiP61021.
    TreeFamiTF300199.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61021-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSRSTARPN GQPQASKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEYQE    50
    STIGAAFLTQ SVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY 100
    DITNQETFAR AKTWVKELQR QASPSIVIAL AGNKADLANK RMVEYEEAQA 150
    YADDNSLLFM ETSAKTAMNV NDLFLAIAKK LPKSEPQNLG GAAGRSRGVD 200
    LHEQSQQNKS QCCSN 215
    Length:215
    Mass (Da):23,707
    Last modified:April 26, 2004 - v1
    Checksum:iD47AD834BCF8B591
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561A → G in AAK14835. (PubMed:1555775)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84239 mRNA. Translation: CAA59016.1.
    AK081251 mRNA. Translation: BAC38176.1.
    M79311 mRNA. Translation: AAK14835.1.
    CCDSiCCDS24287.1.
    PIRiJH0640.
    S65932.
    RefSeqiNP_803130.1. NM_177411.4.
    XP_006513447.1. XM_006513384.1.
    UniGeneiMm.12815.
    Mm.490984.

    Genome annotation databases

    EnsembliENSMUST00000000727; ENSMUSP00000000727; ENSMUSG00000000711.
    GeneIDi19344.
    KEGGimmu:19344.
    UCSCiuc007hnv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84239 mRNA. Translation: CAA59016.1 .
    AK081251 mRNA. Translation: BAC38176.1 .
    M79311 mRNA. Translation: AAK14835.1 .
    CCDSi CCDS24287.1.
    PIRi JH0640.
    S65932.
    RefSeqi NP_803130.1. NM_177411.4.
    XP_006513447.1. XM_006513384.1.
    UniGenei Mm.12815.
    Mm.490984.

    3D structure databases

    ProteinModelPortali P61021.
    SMRi P61021. Positions 17-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202548. 2 interactions.
    IntActi P61021. 3 interactions.
    MINTi MINT-1865771.

    PTM databases

    PhosphoSitei P61021.

    Proteomic databases

    MaxQBi P61021.
    PaxDbi P61021.
    PRIDEi P61021.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000727 ; ENSMUSP00000000727 ; ENSMUSG00000000711 .
    GeneIDi 19344.
    KEGGi mmu:19344.
    UCSCi uc007hnv.2. mouse.

    Organism-specific databases

    CTDi 5869.
    MGIi MGI:105938. Rab5b.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00640000091139.
    HOVERGENi HBG009351.
    InParanoidi P61021.
    KOi K07888.
    OMAi MENTHFD.
    OrthoDBi EOG77DJ7M.
    PhylomeDBi P61021.
    TreeFami TF300199.

    Miscellaneous databases

    NextBioi 22794.
    PROi P61021.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61021.
    CleanExi MM_RAB5B.
    Genevestigatori P61021.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Corpus striatum.
    3. "The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach."
      Chavrier P., Simons K., Zerial M.
      Gene 112:261-264(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-80.
      Tissue: Kidney.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 82-110, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiRAB5B_MOUSE
    AccessioniPrimary (citable) accession number: P61021
    Secondary accession number(s): P35239, P35277
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3