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P61021

- RAB5B_MOUSE

UniProt

P61021 - RAB5B_MOUSE

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Protein
Ras-related protein Rab-5B
Gene
Rab5b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic By similarity.

Enzyme regulationi

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 359GTP By similarity
Nucleotide bindingi75 – 795GTP By similarity
Nucleotide bindingi133 – 1364GTP By similarity
Nucleotide bindingi163 – 1653GTP By similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB-KW
  3. GTPase activity Source: MGI
  4. protein binding Source: IntAct

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. endosome organization Source: MGI
  3. protein transport Source: UniProtKB-KW
  4. regulation of endocytosis Source: MGI
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5B
Gene namesi
Name:Rab5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:105938. Rab5b.

Subcellular locationi

GO - Cellular componenti

  1. early endosome membrane Source: UniProtKB-SubCell
  2. endocytic vesicle Source: MGI
  3. melanosome Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 215214Ras-related protein Rab-5B
PRO_0000121108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine By similarity
Lipidationi212 – 2121S-geranylgeranyl cysteine By similarity
Lipidationi213 – 2131S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

MaxQBiP61021.
PaxDbiP61021.
PRIDEiP61021.

PTM databases

PhosphoSiteiP61021.

Expressioni

Gene expression databases

BgeeiP61021.
CleanExiMM_RAB5B.
GenevestigatoriP61021.

Interactioni

Subunit structurei

Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-8320093,EBI-5323863From a different organism.

Protein-protein interaction databases

BioGridi202548. 2 interactions.
IntActiP61021. 3 interactions.
MINTiMINT-1865771.

Structurei

3D structure databases

ProteinModelPortaliP61021.
SMRiP61021. Positions 17-183.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 579Effector region Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00640000091139.
HOVERGENiHBG009351.
InParanoidiP61021.
KOiK07888.
OMAiMENTHFD.
OrthoDBiEOG77DJ7M.
PhylomeDBiP61021.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61021-1 [UniParc]FASTAAdd to Basket

« Hide

MTSRSTARPN GQPQASKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEYQE    50
STIGAAFLTQ SVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY 100
DITNQETFAR AKTWVKELQR QASPSIVIAL AGNKADLANK RMVEYEEAQA 150
YADDNSLLFM ETSAKTAMNV NDLFLAIAKK LPKSEPQNLG GAAGRSRGVD 200
LHEQSQQNKS QCCSN 215
Length:215
Mass (Da):23,707
Last modified:April 26, 2004 - v1
Checksum:iD47AD834BCF8B591
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561A → G in AAK14835. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84239 mRNA. Translation: CAA59016.1.
AK081251 mRNA. Translation: BAC38176.1.
M79311 mRNA. Translation: AAK14835.1.
CCDSiCCDS24287.1.
PIRiJH0640.
S65932.
RefSeqiNP_803130.1. NM_177411.4.
XP_006513447.1. XM_006513384.1.
UniGeneiMm.12815.
Mm.490984.

Genome annotation databases

EnsembliENSMUST00000000727; ENSMUSP00000000727; ENSMUSG00000000711.
GeneIDi19344.
KEGGimmu:19344.
UCSCiuc007hnv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84239 mRNA. Translation: CAA59016.1 .
AK081251 mRNA. Translation: BAC38176.1 .
M79311 mRNA. Translation: AAK14835.1 .
CCDSi CCDS24287.1.
PIRi JH0640.
S65932.
RefSeqi NP_803130.1. NM_177411.4.
XP_006513447.1. XM_006513384.1.
UniGenei Mm.12815.
Mm.490984.

3D structure databases

ProteinModelPortali P61021.
SMRi P61021. Positions 17-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202548. 2 interactions.
IntActi P61021. 3 interactions.
MINTi MINT-1865771.

PTM databases

PhosphoSitei P61021.

Proteomic databases

MaxQBi P61021.
PaxDbi P61021.
PRIDEi P61021.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000727 ; ENSMUSP00000000727 ; ENSMUSG00000000711 .
GeneIDi 19344.
KEGGi mmu:19344.
UCSCi uc007hnv.2. mouse.

Organism-specific databases

CTDi 5869.
MGIi MGI:105938. Rab5b.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00640000091139.
HOVERGENi HBG009351.
InParanoidi P61021.
KOi K07888.
OMAi MENTHFD.
OrthoDBi EOG77DJ7M.
PhylomeDBi P61021.
TreeFami TF300199.

Miscellaneous databases

NextBioi 22794.
PROi P61021.
SOURCEi Search...

Gene expression databases

Bgeei P61021.
CleanExi MM_RAB5B.
Genevestigatori P61021.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpus striatum.
  3. "The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach."
    Chavrier P., Simons K., Zerial M.
    Gene 112:261-264(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-80.
    Tissue: Kidney.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 82-110, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiRAB5B_MOUSE
AccessioniPrimary (citable) accession number: P61021
Secondary accession number(s): P35239, P35277
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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