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Protein

Ras-related protein Rab-2A

Gene

RAB2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21GTPCombined sources9
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPCombined sources4
Nucleotide bindingi149 – 151GTPCombined sources3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: ProtInc
  • Golgi organization Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104388-MONOMER.
ReactomeiR-HSA-162658. Golgi Cisternae Pericentriolar Stack Reorganization.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2A
Gene namesi
Name:RAB2A
Synonyms:RAB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9763. RAB2A.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • Golgi membrane Source: Reactome
  • lysosomal membrane Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5862.
OpenTargetsiENSG00000104388.
PharmGKBiPA162400618.

Polymorphism and mutation databases

BioMutaiRAB2A.
DMDMi46577636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001210662 – 212Ras-related protein Rab-2AAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Lipidationi211S-geranylgeranyl cysteine1 Publication1
Lipidationi212S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

EPDiP61019.
MaxQBiP61019.
PaxDbiP61019.
PeptideAtlasiP61019.
PRIDEiP61019.
TopDownProteomicsiP61019-1. [P61019-1]
P61019-2. [P61019-2]

PTM databases

iPTMnetiP61019.
PhosphoSitePlusiP61019.
SwissPalmiP61019.

Expressioni

Gene expression databases

BgeeiENSG00000104388.
CleanExiHS_RAB2A.
ExpressionAtlasiP61019. baseline and differential.
GenevisibleiP61019. HS.

Organism-specific databases

HPAiCAB018781.

Interactioni

Subunit structurei

Interacts with PRKCI.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BLZF1Q9H2G95EBI-752037,EBI-2548012
FAM114A1Q8IWE25EBI-752037,EBI-2686288
FAM71CQ8NEG08EBI-752037,EBI-752049
GOLGA2Q083794EBI-752037,EBI-618309
ICA1Q050843EBI-752037,EBI-1046751
STAMBPL1Q96FJ06EBI-752037,EBI-745021

Protein-protein interaction databases

BioGridi111800. 106 interactors.
DIPiDIP-316N.
IntActiP61019. 61 interactors.
MINTiMINT-5001132.
STRINGi9606.ENSP00000262646.

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 14Combined sources11
Helixi19 – 28Combined sources10
Beta strandi43 – 50Combined sources8
Beta strandi53 – 61Combined sources9
Turni66 – 69Combined sources4
Helixi73 – 76Combined sources4
Beta strandi79 – 87Combined sources9
Helixi91 – 95Combined sources5
Helixi97 – 107Combined sources11
Beta strandi113 – 119Combined sources7
Helixi124 – 126Combined sources3
Helixi131 – 141Combined sources11
Beta strandi144 – 148Combined sources5
Turni150 – 152Combined sources3
Helixi156 – 169Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z0AX-ray2.12A/B/C/D2-170[»]
ProteinModelPortaliP61019.
SMRiP61019.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61019.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 19Required for interaction with PRKCI1 PublicationAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP61019.
KOiK07877.
OMAiCAFVKCF.
OrthoDBiEOG091G0QOB.
PhylomeDBiP61019.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P61019-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW
110 120 130 140 150
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA
160 170 180 190 200
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNATHAG
210
NQGGQQAGGG CC
Length:212
Mass (Da):23,546
Last modified:April 26, 2004 - v1
Checksum:iF8731E3F8FB399A3
GO
Isoform 2 (identifier: P61019-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-39: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):20,847
Checksum:i5B13DD3486CC230F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144I → M in AAA60241 (PubMed:2501306).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04291716 – 39Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12953 mRNA. Translation: CAA31411.1.
M28213 mRNA. Translation: AAA60241.1.
AF498930 mRNA. Translation: AAM21078.1.
BT019695 mRNA. Translation: AAV38501.1.
AK297576 mRNA. Translation: BAG59967.1.
AK312344 mRNA. Translation: BAG35265.1.
AC068389 Genomic DNA. No translation available.
AC079065 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86827.1.
BC008929 mRNA. Translation: AAH08929.1.
CCDSiCCDS56537.1. [P61019-2]
CCDS6175.1. [P61019-1]
PIRiB34323.
RefSeqiNP_001229573.1. NM_001242644.1. [P61019-2]
NP_002856.1. NM_002865.2. [P61019-1]
UniGeneiHs.369017.

Genome annotation databases

EnsembliENST00000262646; ENSP00000262646; ENSG00000104388. [P61019-1]
ENST00000531289; ENSP00000431846; ENSG00000104388. [P61019-2]
GeneIDi5862.
KEGGihsa:5862.
UCSCiuc003xud.3. human. [P61019-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12953 mRNA. Translation: CAA31411.1.
M28213 mRNA. Translation: AAA60241.1.
AF498930 mRNA. Translation: AAM21078.1.
BT019695 mRNA. Translation: AAV38501.1.
AK297576 mRNA. Translation: BAG59967.1.
AK312344 mRNA. Translation: BAG35265.1.
AC068389 Genomic DNA. No translation available.
AC079065 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86827.1.
BC008929 mRNA. Translation: AAH08929.1.
CCDSiCCDS56537.1. [P61019-2]
CCDS6175.1. [P61019-1]
PIRiB34323.
RefSeqiNP_001229573.1. NM_001242644.1. [P61019-2]
NP_002856.1. NM_002865.2. [P61019-1]
UniGeneiHs.369017.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z0AX-ray2.12A/B/C/D2-170[»]
ProteinModelPortaliP61019.
SMRiP61019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111800. 106 interactors.
DIPiDIP-316N.
IntActiP61019. 61 interactors.
MINTiMINT-5001132.
STRINGi9606.ENSP00000262646.

PTM databases

iPTMnetiP61019.
PhosphoSitePlusiP61019.
SwissPalmiP61019.

Polymorphism and mutation databases

BioMutaiRAB2A.
DMDMi46577636.

Proteomic databases

EPDiP61019.
MaxQBiP61019.
PaxDbiP61019.
PeptideAtlasiP61019.
PRIDEiP61019.
TopDownProteomicsiP61019-1. [P61019-1]
P61019-2. [P61019-2]

Protocols and materials databases

DNASUi5862.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262646; ENSP00000262646; ENSG00000104388. [P61019-1]
ENST00000531289; ENSP00000431846; ENSG00000104388. [P61019-2]
GeneIDi5862.
KEGGihsa:5862.
UCSCiuc003xud.3. human. [P61019-1]

Organism-specific databases

CTDi5862.
DisGeNETi5862.
GeneCardsiRAB2A.
HGNCiHGNC:9763. RAB2A.
HPAiCAB018781.
MIMi179509. gene.
neXtProtiNX_P61019.
OpenTargetsiENSG00000104388.
PharmGKBiPA162400618.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP61019.
KOiK07877.
OMAiCAFVKCF.
OrthoDBiEOG091G0QOB.
PhylomeDBiP61019.
TreeFamiTF300032.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104388-MONOMER.
ReactomeiR-HSA-162658. Golgi Cisternae Pericentriolar Stack Reorganization.

Miscellaneous databases

ChiTaRSiRAB2A. human.
EvolutionaryTraceiP61019.
GeneWikiiRAB2A.
GenomeRNAii5862.
PROiP61019.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104388.
CleanExiHS_RAB2A.
ExpressionAtlasiP61019. baseline and differential.
GenevisibleiP61019. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB2A_HUMAN
AccessioniPrimary (citable) accession number: P61019
Secondary accession number(s): B2R5W8, B4DMQ5, P08886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.