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P61019

- RAB2A_HUMAN

UniProt

P61019 - RAB2A_HUMAN

Protein

Ras-related protein Rab-2A

Gene

RAB2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    Required for protein transport from the endoplasmic reticulum to the Golgi complex.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 219GTP
    Nucleotide bindingi61 – 655GTPBy similarity
    Nucleotide bindingi119 – 1224GTP
    Nucleotide bindingi149 – 1513GTP

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: UniProtKB
    3. GTP binding Source: UniProtKB

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: ProtInc
    2. GTP catabolic process Source: GOC
    3. mitotic cell cycle Source: Reactome
    4. protein transport Source: UniProtKB-KW
    5. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_1100. Golgi Cisternae Pericentriolar Stack Reorganization.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-2A
    Gene namesi
    Name:RAB2A
    Synonyms:RAB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:9763. RAB2A.

    Subcellular locationi

    Endoplasmic reticulum-Golgi intermediate compartment membrane 1 Publication; Lipid-anchor 1 Publication. Melanosome 1 Publication. Endoplasmic reticulum membrane Curated; Lipid-anchor Curated. Golgi apparatus membrane Curated; Lipid-anchor Curated
    Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

    GO - Cellular componenti

    1. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi membrane Source: Reactome
    5. lysosomal membrane Source: UniProtKB
    6. melanosome Source: UniProtKB-SubCell
    7. nucleus Source: UniProt

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400618.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 212211Ras-related protein Rab-2APRO_0000121066Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Lipidationi211 – 2111S-geranylgeranyl cysteine1 Publication
    Lipidationi212 – 2121S-geranylgeranyl cysteine1 Publication

    Keywords - PTMi

    Acetylation, Lipoprotein, Prenylation

    Proteomic databases

    MaxQBiP61019.
    PaxDbiP61019.
    PRIDEiP61019.

    PTM databases

    PhosphoSiteiP61019.

    Expressioni

    Gene expression databases

    ArrayExpressiP61019.
    BgeeiP61019.
    CleanExiHS_RAB2A.
    GenevestigatoriP61019.

    Organism-specific databases

    HPAiCAB018781.

    Interactioni

    Subunit structurei

    Interacts with PRKCI.2 Publications

    Protein-protein interaction databases

    BioGridi111800. 22 interactions.
    DIPiDIP-316N.
    IntActiP61019. 14 interactions.
    MINTiMINT-5001132.
    STRINGi9606.ENSP00000262646.

    Structurei

    Secondary structure

    1
    212
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 1411
    Helixi19 – 2810
    Beta strandi43 – 508
    Beta strandi53 – 619
    Turni66 – 694
    Helixi73 – 764
    Beta strandi79 – 879
    Helixi91 – 955
    Helixi97 – 10711
    Beta strandi113 – 1197
    Helixi124 – 1263
    Helixi131 – 14111
    Beta strandi144 – 1485
    Turni150 – 1523
    Helixi156 – 16914

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Z0AX-ray2.12A/B/C/D2-170[»]
    ProteinModelPortaliP61019.
    SMRiP61019. Positions 2-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP61019.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 1918Required for interaction with PRKCIAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 439Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    KOiK07877.
    OMAiHPTTNST.
    OrthoDBiEOG7QK0CV.
    PhylomeDBiP61019.
    TreeFamiTF300032.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P61019-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI    50
    DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW 100
    LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA 150
    KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNATHAG 200
    NQGGQQAGGG CC 212
    Length:212
    Mass (Da):23,546
    Last modified:April 26, 2004 - v1
    Checksum:iF8731E3F8FB399A3
    GO
    Isoform 2 (identifier: P61019-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         16-39: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:188
    Mass (Da):20,847
    Checksum:i5B13DD3486CC230F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti144 – 1441I → M in AAA60241. (PubMed:2501306)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei16 – 3924Missing in isoform 2. 1 PublicationVSP_042917Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12953 mRNA. Translation: CAA31411.1.
    M28213 mRNA. Translation: AAA60241.1.
    AF498930 mRNA. Translation: AAM21078.1.
    BT019695 mRNA. Translation: AAV38501.1.
    AK297576 mRNA. Translation: BAG59967.1.
    AK312344 mRNA. Translation: BAG35265.1.
    AC068389 Genomic DNA. No translation available.
    AC079065 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW86827.1.
    BC008929 mRNA. Translation: AAH08929.1.
    CCDSiCCDS56537.1. [P61019-2]
    CCDS6175.1. [P61019-1]
    PIRiB34323.
    RefSeqiNP_001229573.1. NM_001242644.1. [P61019-2]
    NP_002856.1. NM_002865.2. [P61019-1]
    UniGeneiHs.369017.

    Genome annotation databases

    EnsembliENST00000262646; ENSP00000262646; ENSG00000104388. [P61019-1]
    ENST00000531289; ENSP00000431846; ENSG00000104388. [P61019-2]
    GeneIDi5862.
    KEGGihsa:5862.
    UCSCiuc003xud.2. human. [P61019-1]
    uc011lef.2. human. [P61019-2]

    Polymorphism databases

    DMDMi46577636.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12953 mRNA. Translation: CAA31411.1 .
    M28213 mRNA. Translation: AAA60241.1 .
    AF498930 mRNA. Translation: AAM21078.1 .
    BT019695 mRNA. Translation: AAV38501.1 .
    AK297576 mRNA. Translation: BAG59967.1 .
    AK312344 mRNA. Translation: BAG35265.1 .
    AC068389 Genomic DNA. No translation available.
    AC079065 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW86827.1 .
    BC008929 mRNA. Translation: AAH08929.1 .
    CCDSi CCDS56537.1. [P61019-2 ]
    CCDS6175.1. [P61019-1 ]
    PIRi B34323.
    RefSeqi NP_001229573.1. NM_001242644.1. [P61019-2 ]
    NP_002856.1. NM_002865.2. [P61019-1 ]
    UniGenei Hs.369017.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Z0A X-ray 2.12 A/B/C/D 2-170 [» ]
    ProteinModelPortali P61019.
    SMRi P61019. Positions 2-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111800. 22 interactions.
    DIPi DIP-316N.
    IntActi P61019. 14 interactions.
    MINTi MINT-5001132.
    STRINGi 9606.ENSP00000262646.

    Chemistry

    BindingDBi P61019.

    PTM databases

    PhosphoSitei P61019.

    Polymorphism databases

    DMDMi 46577636.

    Proteomic databases

    MaxQBi P61019.
    PaxDbi P61019.
    PRIDEi P61019.

    Protocols and materials databases

    DNASUi 5862.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262646 ; ENSP00000262646 ; ENSG00000104388 . [P61019-1 ]
    ENST00000531289 ; ENSP00000431846 ; ENSG00000104388 . [P61019-2 ]
    GeneIDi 5862.
    KEGGi hsa:5862.
    UCSCi uc003xud.2. human. [P61019-1 ]
    uc011lef.2. human. [P61019-2 ]

    Organism-specific databases

    CTDi 5862.
    GeneCardsi GC08P061429.
    HGNCi HGNC:9763. RAB2A.
    HPAi CAB018781.
    MIMi 179509. gene.
    neXtProti NX_P61019.
    PharmGKBi PA162400618.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    KOi K07877.
    OMAi HPTTNST.
    OrthoDBi EOG7QK0CV.
    PhylomeDBi P61019.
    TreeFami TF300032.

    Enzyme and pathway databases

    Reactomei REACT_1100. Golgi Cisternae Pericentriolar Stack Reorganization.

    Miscellaneous databases

    ChiTaRSi RAB2A. human.
    EvolutionaryTracei P61019.
    GeneWikii RAB2A.
    GenomeRNAii 5862.
    NextBioi 22766.
    PROi P61019.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61019.
    Bgeei P61019.
    CleanExi HS_RAB2A.
    Genevestigatori P61019.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily."
      Tachibana K., Umezawa A., Kato S., Takano T.
      Nucleic Acids Res. 16:10368-10368(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion."
      Zahraoui A., Touchot N., Chardin P., Tavitian A.
      J. Biol. Chem. 264:12394-12401(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Brain cortex.
    6. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    9. Cited for: ISOPRENYLATION AT CYS-211 AND CYS-212.
    10. "Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation."
      Tisdale E.J.
      J. Biol. Chem. 278:52524-52530(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PRKCI.
    11. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."
      Eathiraj S., Pan X., Ritacco C., Lambright D.G.
      Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 2-170 IN COMPLEX WITH GDP.

    Entry informationi

    Entry nameiRAB2A_HUMAN
    AccessioniPrimary (citable) accession number: P61019
    Secondary accession number(s): B2R5W8, B4DMQ5, P08886
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3