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Protein

Cardiac phospholamban

Gene

PLN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-5578775 Ion homeostasis
R-SSC-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiac phospholamban
Short name:
PLB
Gene namesi
Name:PLN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912461 – 52Cardiac phospholambanAdd BLAST52

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei16Phosphoserine; by PKA and DMPKBy similarity1
Modified residuei17Phosphothreonine; by CaMK2By similarity1
Lipidationi36S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity).By similarity
Palmitoylated by ZDHHC16, promoting formation of the homopentamer.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP61013
PeptideAtlasiP61013
PRIDEiP61013

PTM databases

iPTMnetiP61013

Expressioni

Gene expression databases

BgeeiENSSSCG00000004248
GenevisibleiP61013 SS

Interactioni

Subunit structurei

Homopentamer (By similarity). Interacts with HAX1 and ATP2A2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004587

Structurei

Secondary structure

152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Beta strandi17 – 20Combined sources4
Helixi21 – 49Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FJKNMR-A1-52[»]
1FJPNMR-A1-52[»]
ProteinModelPortaliP61013
SMRiP61013
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61013

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholamban family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J7H0 Eukaryota
ENOG4111BFT LUCA
GeneTreeiENSGT00390000002403
HOGENOMiHOG000115660
HOVERGENiHBG008240
InParanoidiP61013
KOiK05852
OMAiMERVQHM
TreeFamiTF330750

Family and domain databases

InterProiView protein in InterPro
IPR005984 PLB
PANTHERiPTHR21194 PTHR21194, 1 hit
PfamiView protein in Pfam
PF04272 Phospholamban, 1 hit
PIRSFiPIRSF001665 PLB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014689 P_lamban, 1 hit
TIGRFAMsiTIGR01294 P_lamban, 1 hit

Sequencei

Sequence statusi: Complete.

P61013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKVQYLTRS AIRRASTIEM PQQARQNLQN LFINFCLILI CLLLICIIVM

LL
Length:52
Mass (Da):6,080
Last modified:April 1, 1988 - v1
Checksum:i076361D9ADC424D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15075 mRNA Translation: CAA33171.1
PIRiS05540
RefSeqiNP_999378.1, NM_214213.1
UniGeneiSsc.5227

Genome annotation databases

EnsembliENSSSCT00000055657; ENSSSCP00000045624; ENSSSCG00000034163
GeneIDi397421
KEGGissc:397421

Similar proteinsi

Entry informationi

Entry nameiPPLA_PIG
AccessioniPrimary (citable) accession number: P61013
Secondary accession number(s): P07473
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome