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Protein

Cardiac phospholamban

Gene

PLN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-5578775. Ion homeostasis.
R-SSC-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiac phospholamban
Short name:
PLB
Gene namesi
Name:PLN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912461 – 52Cardiac phospholambanAdd BLAST52

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei16Phosphoserine; by PKA and DMPKBy similarity1
Modified residuei17Phosphothreonine; by CaMK2By similarity1

Post-translational modificationi

Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP61013.
PeptideAtlasiP61013.
PRIDEiP61013.

PTM databases

iPTMnetiP61013.

Expressioni

Gene expression databases

BgeeiENSSSCG00000004248.
GenevisibleiP61013. SS.

Interactioni

Subunit structurei

Homopentamer (By similarity). Interacts with HAX1 and ATP2A2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004587.

Structurei

Secondary structure

152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Beta strandi17 – 20Combined sources4
Helixi21 – 49Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FJKNMR-A1-52[»]
1FJPNMR-A1-52[»]
ProteinModelPortaliP61013.
SMRiP61013.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61013.

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholamban family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J7H0. Eukaryota.
ENOG4111BFT. LUCA.
HOGENOMiHOG000115660.
HOVERGENiHBG008240.
InParanoidiP61013.
KOiK05852.
OMAiMERVQHM.
TreeFamiTF330750.

Family and domain databases

InterProiView protein in InterPro
IPR005984. PLB.
PANTHERiPTHR21194. PTHR21194. 1 hit.
PfamiView protein in Pfam
PF04272. Phospholamban. 1 hit.
PIRSFiPIRSF001665. PLB. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014689. P_lamban. 1 hit.
TIGRFAMsiTIGR01294. P_lamban. 1 hit.

Sequencei

Sequence statusi: Complete.

P61013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKVQYLTRS AIRRASTIEM PQQARQNLQN LFINFCLILI CLLLICIIVM

LL
Length:52
Mass (Da):6,080
Last modified:April 1, 1988 - v1
Checksum:i076361D9ADC424D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15075 mRNA. Translation: CAA33171.1.
PIRiS05540.
RefSeqiNP_999378.1. NM_214213.1.
UniGeneiSsc.5227.

Genome annotation databases

GeneIDi397421.
KEGGissc:397421.

Similar proteinsi

Entry informationi

Entry nameiPPLA_PIG
AccessioniPrimary (citable) accession number: P61013
Secondary accession number(s): P07473
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families