##gff-version 3 P61011 UniProtKB Chain 1 504 . . . ID=PRO_0000101192;Note=Signal recognition particle subunit SRP54 P61011 UniProtKB Region 1 295 . . . Note=NG domain;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:34020957;Dbxref=PMID:34020957 P61011 UniProtKB Region 296 504 . . . Note=M-domain;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:34020957;Dbxref=PMID:34020957 P61011 UniProtKB Binding site 108 115 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P61011 UniProtKB Binding site 190 194 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P61011 UniProtKB Binding site 248 251 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P61011 UniProtKB Alternative sequence 1 57 . . . ID=VSP_043696;Note=In isoform 2. MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVK->MPPLSMKR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P61011 UniProtKB Natural variant 113 113 . . . ID=VAR_083566;Note=In SCN8. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29914977;Dbxref=PMID:29914977 P61011 UniProtKB Natural variant 115 115 . . . ID=VAR_083567;Note=In SCN8%3B decreases expression levels%3B decreases GTPase activity%3B decreases neutrophil numbers and migration capacity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28972538;Dbxref=PMID:28972538 P61011 UniProtKB Natural variant 117 117 . . . ID=VAR_083568;Note=In SCN8%3B decreases expression levels%3B slightly decreases GTPase activity%3B decreases neutrophil numbers and migration capacity%3B decreased granulocyte proliferation%3B delayed granulocytic differentiation%3B impaired signaling%3B increased apoptosis%3B induced autophagy. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28972538,ECO:0000269|PubMed:29914977;Dbxref=PMID:28972538,PMID:29914977 P61011 UniProtKB Natural variant 118 118 . . . ID=VAR_083569;Note=In SCN8%3B decreased granulocyte proliferation%3B increased apoptosis. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29914977;Dbxref=PMID:29914977 P61011 UniProtKB Natural variant 136 136 . . . ID=VAR_083570;Note=In SCN8%3B decreased granulocyte proliferation%3B delayed granulocytic differentiation%3B impaired signaling%3B induced autophagy. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29914977;Dbxref=PMID:29914977 P61011 UniProtKB Natural variant 223 223 . . . ID=VAR_083571;Note=In SCN8%3B decreased granulocyte proliferation%3B induced autophagy. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29914977;Dbxref=PMID:29914977 P61011 UniProtKB Natural variant 226 226 . . . ID=VAR_083572;Note=In SCN8%3B decreases expression levels%3B decreases neutrophil numbers and migration capacity%3B faster dissociation of the interaction with the SRP receptor subunit SRPRA%3B reduced SR compaction%3B impaired interaction with SR%3B impaired detachment from ribosome%3B effects on enzymatic activity are unclear as both normal and reduced GTPase activity have been reported. G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:28972538,ECO:0000269|PubMed:29914977,ECO:0000269|PubMed:34020957;Dbxref=PMID:28972538,PMID:29914977,PMID:34020957 P61011 UniProtKB Natural variant 274 274 . . . ID=VAR_083573;Note=In SCN8. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29914977;Dbxref=PMID:29914977 P61011 UniProtKB Helix 4 19 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 25 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Turn 41 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 46 59 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Turn 62 64 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y32 P61011 UniProtKB Helix 71 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 102 108 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 114 127 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 132 136 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 143 155 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 159 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y30 P61011 UniProtKB Helix 168 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 185 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 198 212 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 215 222 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 223 228 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 229 237 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 241 248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 251 254 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 256 265 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 270 274 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 276 278 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Beta strand 282 284 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 287 295 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6Y2Z P61011 UniProtKB Helix 329 341 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QB2 P61011 UniProtKB Helix 343 351 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QB2 P61011 UniProtKB Turn 357 360 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QB2 P61011 UniProtKB Helix 365 379 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QB2 P61011 UniProtKB Helix 384 388 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QB2 P61011 UniProtKB Turn 390 392 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QB2 P61011 UniProtKB Helix 393 398 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QB2 P61011 UniProtKB Helix 401 409 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QB2 P61011 UniProtKB Helix 414 430 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QB2