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Protein

Signal peptidase complex subunit 3

Gene

SPCS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein targeting to ER Source: GO_Central
  • proteolysis Source: UniProtKB
  • signal peptide processing Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex subunit 3 (EC:3.4.-.-By similarity)
Alternative name(s):
Microsomal signal peptidase 22/23 kDa subunit
Short name:
SPC22/23
Short name:
SPase 22/23 kDa subunit
Gene namesi
Name:SPCS3
Synonyms:SPC22
ORF Names:UNQ1841/PRO3567
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000129128.12.
HGNCiHGNC:26212. SPCS3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 180LumenalSequence analysisAdd BLAST148

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi60559.
OpenTargetsiENSG00000129128.
PharmGKBiPA134910080.

Polymorphism and mutation databases

BioMutaiSPCS3.
DMDMi46577648.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189381 – 180Signal peptidase complex subunit 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP61009.
MaxQBiP61009.
PaxDbiP61009.
PeptideAtlasiP61009.
PRIDEiP61009.
TopDownProteomicsiP61009.

PTM databases

iPTMnetiP61009.
PhosphoSitePlusiP61009.
SwissPalmiP61009.

Expressioni

Gene expression databases

BgeeiENSG00000129128.
CleanExiHS_SPCS3.
GenevisibleiP61009. HS.

Organism-specific databases

HPAiHPA053180.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

BioGridi121940. 34 interactors.
IntActiP61009. 10 interactors.
MINTiMINT-3022145.
STRINGi9606.ENSP00000427463.

Structurei

3D structure databases

ProteinModelPortaliP61009.
SMRiP61009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPCS3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3372. Eukaryota.
ENOG4110TZP. LUCA.
GeneTreeiENSGT00390000009223.
HOGENOMiHOG000246793.
HOVERGENiHBG054497.
InParanoidiP61009.
KOiK12948.
OMAiVDDFTGP.
OrthoDBiEOG091G0Q9K.
PhylomeDBiP61009.
TreeFamiTF300185.

Family and domain databases

InterProiView protein in InterPro
IPR007653. SPC3.
PANTHERiPTHR12804. PTHR12804. 1 hit.
PfamiView protein in Pfam
PF04573. SPC22. 1 hit.
PIRSFiPIRSF016089. SPC22. 1 hit.

Sequencei

Sequence statusi: Complete.

P61009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTVLSRANS LFAFSLSVMA ALTFGCFITT AFKDRSVPVR LHVSRIMLKN
60 70 80 90 100
VEDFTGPRER SDLGFITFDI TADLENIFDW NVKQLFLYLS AEYSTKNNAL
110 120 130 140 150
NQVVLWDKIV LRGDNPKLLL KDMKTKYFFF DDGNGLKGNR NVTLTLSWNV
160 170 180
VPNAGILPLV TGSGHVSVPF PDTYEITKSY
Length:180
Mass (Da):20,313
Last modified:April 26, 2004 - v1
Checksum:i342AB8E0F3F6D71A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68F → S in CAB66595 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136660 mRNA. Translation: CAB66595.1.
AK026302 mRNA. Translation: BAB15437.1.
AY359044 mRNA. Translation: AAQ89403.1.
BC047290 mRNA. Translation: AAH47290.1.
CCDSiCCDS54823.1.
RefSeqiNP_068747.1. NM_021928.3.
UniGeneiHs.42194.

Genome annotation databases

EnsembliENST00000503362; ENSP00000427463; ENSG00000129128.
GeneIDi60559.
KEGGihsa:60559.
UCSCiuc003iur.5. human.

Similar proteinsi

Entry informationi

Entry nameiSPCS3_HUMAN
AccessioniPrimary (citable) accession number: P61009
Secondary accession number(s): P12280, Q9H0S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: September 27, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families