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Protein

Signal peptidase complex subunit 3

Gene

SPCS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein targeting to ER Source: GO_Central
  • proteolysis Source: UniProtKB
  • signal peptide processing Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex subunit 3 (EC:3.4.-.-By similarity)
Alternative name(s):
Microsomal signal peptidase 22/23 kDa subunit
Short name:
SPC22/23
Short name:
SPase 22/23 kDa subunit
Gene namesi
Name:SPCS3
Synonyms:SPC22
ORF Names:UNQ1841/PRO3567
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000129128.12
HGNCiHGNC:26212 SPCS3
neXtProtiNX_P61009

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 180LumenalSequence analysisAdd BLAST148

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi60559
OpenTargetsiENSG00000129128
PharmGKBiPA134910080

Polymorphism and mutation databases

BioMutaiSPCS3
DMDMi46577648

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189381 – 180Signal peptidase complex subunit 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP61009
MaxQBiP61009
PaxDbiP61009
PeptideAtlasiP61009
PRIDEiP61009
TopDownProteomicsiP61009

PTM databases

iPTMnetiP61009
PhosphoSitePlusiP61009
SwissPalmiP61009

Expressioni

Gene expression databases

BgeeiENSG00000129128
CleanExiHS_SPCS3
GenevisibleiP61009 HS

Organism-specific databases

HPAiHPA053180

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

BioGridi121940, 35 interactors
IntActiP61009, 11 interactors
STRINGi9606.ENSP00000427463

Structurei

3D structure databases

ProteinModelPortaliP61009
SMRiP61009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPCS3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3372 Eukaryota
ENOG4110TZP LUCA
GeneTreeiENSGT00390000009223
HOGENOMiHOG000246793
HOVERGENiHBG054497
InParanoidiP61009
KOiK12948
OMAiFKDRRVP
OrthoDBiEOG091G0Q9K
PhylomeDBiP61009
TreeFamiTF300185

Family and domain databases

InterProiView protein in InterPro
IPR007653 SPC3
PANTHERiPTHR12804 PTHR12804, 1 hit
PfamiView protein in Pfam
PF04573 SPC22, 1 hit
PIRSFiPIRSF016089 SPC22, 1 hit

Sequencei

Sequence statusi: Complete.

P61009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTVLSRANS LFAFSLSVMA ALTFGCFITT AFKDRSVPVR LHVSRIMLKN
60 70 80 90 100
VEDFTGPRER SDLGFITFDI TADLENIFDW NVKQLFLYLS AEYSTKNNAL
110 120 130 140 150
NQVVLWDKIV LRGDNPKLLL KDMKTKYFFF DDGNGLKGNR NVTLTLSWNV
160 170 180
VPNAGILPLV TGSGHVSVPF PDTYEITKSY
Length:180
Mass (Da):20,313
Last modified:April 26, 2004 - v1
Checksum:i342AB8E0F3F6D71A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68F → S in CAB66595 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136660 mRNA Translation: CAB66595.1
AK026302 mRNA Translation: BAB15437.1
AY359044 mRNA Translation: AAQ89403.1
BC047290 mRNA Translation: AAH47290.1
CCDSiCCDS54823.1
RefSeqiNP_068747.1, NM_021928.3
UniGeneiHs.42194

Genome annotation databases

EnsembliENST00000503362; ENSP00000427463; ENSG00000129128
GeneIDi60559
KEGGihsa:60559
UCSCiuc003iur.5 human

Similar proteinsi

Entry informationi

Entry nameiSPCS3_HUMAN
AccessioniPrimary (citable) accession number: P61009
Secondary accession number(s): P12280, Q9H0S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health