P61001 (HIS8_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	MAP_1294

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_0000153395
Amino acid modifications
	Modified residue	234	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61001 [UniParc]. Last modified April 26, 2004. Version 1. Checksum: FBD36528B9343FC7	FASTA	398	42,212
	10 20 30 40 50 60 MTGQRATPQP TLDDLPLRDD LRGKSPYGAP QLAVPVRLNT NENPHPPSRA LVDDVVRSVA 70 80 90 100 110 120 RAAADLHRYP DRDAVQLRSD LARYLTAQTG VQLGVENLWA ANGSNEILQQ LLQAFGGPGR 130 140 150 160 170 180 SAIGFVPSYS MHPIISDGTR TEWLQAARAD DFSLDVDAAV AAVTERTPDV VFVASPNNPS 190 200 210 220 230 240 GQSVSLSGLR RLLDAAPGIV IVDEAYGEFS SQPSAVQLVG EYPTKLVVTR TMSKAFAFAG 250 260 270 280 290 300 GRLGYLIATP AVIEAMLLVR LPYHLSSVTQ AAARAALRHA DDTLGSVAAL IAERERVSTA 310 320 330 340 350 360 LTGMGFRVIP SDANFVLFGE FTDAPASWQR YLDAGVLIRD VGIPGYLRAT TGLAEENDAF 370 380 390 LRASAQLAAT ELAPVNVGAI ANAAEPRAAG RDRVLGAP

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS03611.1.
RefSeq	NP_960228.1. NC_002944.2.
3D structure databases
ProteinModelPortal	P61001.
SMR	P61001. Positions 11-372.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000038451; EBMYCP00000036840; EBMYCG00000038446.
GeneID	2718366.
GenomeReviews	Gene locus MAP_1294 in contig AE016958_GR.
KEGG	mpa:MAP1294.
NMPDR	fig|262316.1.peg.1294.
PATRIC	17995065. VBIMycAvi108102_1363.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00070000031717.
HOGENOM	HBG646350.
OMA	GRTAIGF.
ProtClustDB	PRK03317.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_MYCPA

Accession

Primary (citable) accession number: P61001

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 26, 2004
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program