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P60985

- KTDAP_HUMAN

UniProt

P60985 - KTDAP_HUMAN

Protein

Keratinocyte differentiation-associated protein

Gene

KRTDAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.1 Publication

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratinocyte differentiation-associated protein
    Gene namesi
    Name:KRTDAP
    Synonyms:KDAP
    ORF Names:UNQ467/PRO826
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16313. KRTDAP.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30236.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 9977Keratinocyte differentiation-associated proteinPRO_0000022609Add
    BLAST

    Proteomic databases

    PaxDbiP60985.
    PeptideAtlasiP60985.
    PRIDEiP60985.

    Expressioni

    Tissue specificityi

    Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not detected in gastrointestinal mucosa.1 Publication

    Inductioni

    Up-regulated in situ in psoriatic skin (at protein level).1 Publication

    Gene expression databases

    BgeeiP60985.
    CleanExiHS_KRTDAP.
    GenevestigatoriP60985.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000339251.

    Structurei

    3D structure databases

    ProteinModelPortaliP60985.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG87660.
    HOGENOMiHOG000113266.
    HOVERGENiHBG108078.
    InParanoidiP60985.
    OMAiLTINIAV.
    OrthoDBiEOG7N0C7M.
    PhylomeDBiP60985.
    TreeFamiTF341267.

    Family and domain databases

    InterProiIPR028196. KRTDAP.
    [Graphical view]
    PfamiPF15200. KRTDAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P60985-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKIPVLPAVV LLSLLVLHSA QGATLGGPEE ESTIENYASR PEAFNTPFLN   50
    IDKLRSAFKA DEFLNWHALF ESIKRKLPFL NWDAFPKLKG LRSATPDAQ 99
    Length:99
    Mass (Da):11,050
    Last modified:April 26, 2004 - v1
    Checksum:i0F966EC142C89838
    GO
    Isoform 2 (identifier: P60985-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         45-58: Missing.

    Show »
    Length:85
    Mass (Da):9,432
    Checksum:iF392074ED0B9773E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei45 – 5814Missing in isoform 2. 1 PublicationVSP_030856Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359007 mRNA. Translation: AAQ89366.1.
    BC130501 mRNA. Translation: AAI30502.1.
    CCDSiCCDS12462.1. [P60985-1]
    CCDS59377.1. [P60985-2]
    RefSeqiNP_001231776.1. NM_001244847.1. [P60985-2]
    NP_997275.1. NM_207392.2. [P60985-1]
    UniGeneiHs.112457.

    Genome annotation databases

    EnsembliENST00000338897; ENSP00000339251; ENSG00000188508. [P60985-1]
    ENST00000484218; ENSP00000470713; ENSG00000188508. [P60985-2]
    GeneIDi388533.
    KEGGihsa:388533.
    UCSCiuc002nzh.3. human. [P60985-1]
    uc021uso.1. human. [P60985-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359007 mRNA. Translation: AAQ89366.1 .
    BC130501 mRNA. Translation: AAI30502.1 .
    CCDSi CCDS12462.1. [P60985-1 ]
    CCDS59377.1. [P60985-2 ]
    RefSeqi NP_001231776.1. NM_001244847.1. [P60985-2 ]
    NP_997275.1. NM_207392.2. [P60985-1 ]
    UniGenei Hs.112457.

    3D structure databases

    ProteinModelPortali P60985.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000339251.

    Proteomic databases

    PaxDbi P60985.
    PeptideAtlasi P60985.
    PRIDEi P60985.

    Protocols and materials databases

    DNASUi 388533.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338897 ; ENSP00000339251 ; ENSG00000188508 . [P60985-1 ]
    ENST00000484218 ; ENSP00000470713 ; ENSG00000188508 . [P60985-2 ]
    GeneIDi 388533.
    KEGGi hsa:388533.
    UCSCi uc002nzh.3. human. [P60985-1 ]
    uc021uso.1. human. [P60985-2 ]

    Organism-specific databases

    CTDi 388533.
    GeneCardsi GC19M035978.
    HGNCi HGNC:16313. KRTDAP.
    neXtProti NX_P60985.
    PharmGKBi PA30236.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87660.
    HOGENOMi HOG000113266.
    HOVERGENi HBG108078.
    InParanoidi P60985.
    OMAi LTINIAV.
    OrthoDBi EOG7N0C7M.
    PhylomeDBi P60985.
    TreeFami TF341267.

    Miscellaneous databases

    GeneWikii KRTDAP.
    GenomeRNAii 388533.
    NextBioi 102117.
    PROi P60985.

    Gene expression databases

    Bgeei P60985.
    CleanExi HS_KRTDAP.
    Genevestigatori P60985.

    Family and domain databases

    InterProi IPR028196. KRTDAP.
    [Graphical view ]
    Pfami PF15200. KRTDAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, ALTERNATIVE SPLICING.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiKTDAP_HUMAN
    AccessioniPrimary (citable) accession number: P60985
    Secondary accession number(s): A1L4D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM

    External Data

    Dasty 3