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Protein

Keratinocyte differentiation-associated protein

Gene

KRTDAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Keratinocyte differentiation-associated protein
Gene namesi
Name:KRTDAP
Synonyms:KDAP
ORF Names:UNQ467/PRO826
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16313. KRTDAP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30236.

Polymorphism and mutation databases

BioMutaiKRTDAP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 9977Keratinocyte differentiation-associated proteinPRO_0000022609Add
BLAST

Proteomic databases

MaxQBiP60985.
PaxDbiP60985.
PeptideAtlasiP60985.
PRIDEiP60985.

Expressioni

Tissue specificityi

Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not detected in gastrointestinal mucosa.1 Publication

Inductioni

Up-regulated in situ in psoriatic skin (at protein level).1 Publication

Gene expression databases

BgeeiP60985.
CleanExiHS_KRTDAP.
GenevestigatoriP60985.

Organism-specific databases

HPAiHPA063474.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000339251.

Structurei

3D structure databases

ProteinModelPortaliP60985.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG87660.
GeneTreeiENSGT00390000009097.
HOGENOMiHOG000113266.
HOVERGENiHBG108078.
InParanoidiP60985.
OMAiEEFLNWH.
OrthoDBiEOG7N0C7M.
PhylomeDBiP60985.
TreeFamiTF341267.

Family and domain databases

InterProiIPR028196. KRTDAP.
[Graphical view]
PfamiPF15200. KRTDAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60985-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIPVLPAVV LLSLLVLHSA QGATLGGPEE ESTIENYASR PEAFNTPFLN
60 70 80 90
IDKLRSAFKA DEFLNWHALF ESIKRKLPFL NWDAFPKLKG LRSATPDAQ
Length:99
Mass (Da):11,050
Last modified:April 26, 2004 - v1
Checksum:i0F966EC142C89838
GO
Isoform 2 (identifier: P60985-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-58: Missing.

Show »
Length:85
Mass (Da):9,432
Checksum:iF392074ED0B9773E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei45 – 5814Missing in isoform 2. 1 PublicationVSP_030856Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359007 mRNA. Translation: AAQ89366.1.
BC130501 mRNA. Translation: AAI30502.1.
CCDSiCCDS12462.1. [P60985-1]
CCDS59377.1. [P60985-2]
RefSeqiNP_001231776.1. NM_001244847.1. [P60985-2]
NP_997275.1. NM_207392.2. [P60985-1]
UniGeneiHs.112457.

Genome annotation databases

EnsembliENST00000338897; ENSP00000339251; ENSG00000188508. [P60985-1]
ENST00000484218; ENSP00000470713; ENSG00000188508. [P60985-2]
GeneIDi388533.
KEGGihsa:388533.
UCSCiuc002nzh.3. human. [P60985-1]
uc021uso.1. human. [P60985-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359007 mRNA. Translation: AAQ89366.1.
BC130501 mRNA. Translation: AAI30502.1.
CCDSiCCDS12462.1. [P60985-1]
CCDS59377.1. [P60985-2]
RefSeqiNP_001231776.1. NM_001244847.1. [P60985-2]
NP_997275.1. NM_207392.2. [P60985-1]
UniGeneiHs.112457.

3D structure databases

ProteinModelPortaliP60985.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000339251.

Polymorphism and mutation databases

BioMutaiKRTDAP.

Proteomic databases

MaxQBiP60985.
PaxDbiP60985.
PeptideAtlasiP60985.
PRIDEiP60985.

Protocols and materials databases

DNASUi388533.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338897; ENSP00000339251; ENSG00000188508. [P60985-1]
ENST00000484218; ENSP00000470713; ENSG00000188508. [P60985-2]
GeneIDi388533.
KEGGihsa:388533.
UCSCiuc002nzh.3. human. [P60985-1]
uc021uso.1. human. [P60985-2]

Organism-specific databases

CTDi388533.
GeneCardsiGC19M035978.
HGNCiHGNC:16313. KRTDAP.
HPAiHPA063474.
neXtProtiNX_P60985.
PharmGKBiPA30236.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87660.
GeneTreeiENSGT00390000009097.
HOGENOMiHOG000113266.
HOVERGENiHBG108078.
InParanoidiP60985.
OMAiEEFLNWH.
OrthoDBiEOG7N0C7M.
PhylomeDBiP60985.
TreeFamiTF341267.

Miscellaneous databases

GeneWikiiKRTDAP.
GenomeRNAii388533.
NextBioi102117.
PROiP60985.

Gene expression databases

BgeeiP60985.
CleanExiHS_KRTDAP.
GenevestigatoriP60985.

Family and domain databases

InterProiIPR028196. KRTDAP.
[Graphical view]
PfamiPF15200. KRTDAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, ALTERNATIVE SPLICING.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiKTDAP_HUMAN
AccessioniPrimary (citable) accession number: P60985
Secondary accession number(s): A1L4D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: April 29, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.