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P60985 (KTDAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratinocyte differentiation-associated protein
Gene names
Name:KRTDAP
Synonyms:KDAP
ORF Names:UNQ467/PRO826
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. Ref.1

Subcellular location

Secreted Ref.1.

Tissue specificity

Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not detected in gastrointestinal mucosa. Ref.1

Induction

Up-regulated in situ in psoriatic skin (at protein level). Ref.1

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P60985-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P60985-2)

The sequence of this isoform differs from the canonical sequence as follows:
     45-58: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 9977Keratinocyte differentiation-associated protein
PRO_0000022609

Natural variations

Alternative sequence45 – 5814Missing in isoform 2.
VSP_030856

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 26, 2004. Version 1.
Checksum: 0F966EC142C89838

FASTA9911,050
        10         20         30         40         50         60 
MKIPVLPAVV LLSLLVLHSA QGATLGGPEE ESTIENYASR PEAFNTPFLN IDKLRSAFKA 

        70         80         90 
DEFLNWHALF ESIKRKLPFL NWDAFPKLKG LRSATPDAQ 

« Hide

Isoform 2 [UniParc].

Checksum: F392074ED0B9773E
Show »

FASTA859,432

References

« Hide 'large scale' references
[1]"Characterization of Kdap, a protein secreted by keratinocytes."
Tsuchida S., Bonkobara M., McMillan J.R., Akiyama M., Yudate T., Aragane Y., Tezuka T., Shimizu H., Cruz P.D. Jr., Ariizumi K.
J. Invest. Dermatol. 122:1225-1234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, ALTERNATIVE SPLICING.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY359007 mRNA. Translation: AAQ89366.1.
BC130501 mRNA. Translation: AAI30502.1.
RefSeqNP_001231776.1. NM_001244847.1.
NP_997275.1. NM_207392.2.
UniGeneHs.112457.

3D structure databases

ProteinModelPortalP60985.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000339251.

Proteomic databases

PaxDbP60985.
PeptideAtlasP60985.
PRIDEP60985.

Protocols and materials databases

DNASU388533.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338897; ENSP00000339251; ENSG00000188508. [P60985-1]
ENST00000484218; ENSP00000470713; ENSG00000188508. [P60985-2]
GeneID388533.
KEGGhsa:388533.
UCSCuc002nzh.3. human. [P60985-1]
uc021uso.1. human. [P60985-2]

Organism-specific databases

CTD388533.
GeneCardsGC19M035978.
HGNCHGNC:16313. KRTDAP.
neXtProtNX_P60985.
PharmGKBPA30236.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87660.
HOGENOMHOG000113266.
HOVERGENHBG108078.
InParanoidP60985.
OMAAGPEAFN.
OrthoDBEOG7N0C7M.
PhylomeDBP60985.
TreeFamTF341267.

Gene expression databases

BgeeP60985.
CleanExHS_KRTDAP.
GenevestigatorP60985.

Family and domain databases

InterProIPR028196. KRTDAP.
[Graphical view]
PfamPF15200. KRTDAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKRTDAP.
GenomeRNAi388533.
NextBio102117.
PROP60985.

Entry information

Entry nameKTDAP_HUMAN
AccessionPrimary (citable) accession number: P60985
Secondary accession number(s): A1L4D7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: March 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM