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P60983

- GMFB_HUMAN

UniProt

P60983 - GMFB_HUMAN

Protein

Glia maturation factor beta

Gene

GMFB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

    GO - Molecular functioni

    1. enzyme activator activity Source: ProtInc
    2. protein kinase inhibitor activity Source: ProtInc
    3. signal transducer activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of protein kinase activity Source: GOC
    2. nervous system development Source: ProtInc
    3. positive regulation of catalytic activity Source: GOC
    4. protein phosphorylation Source: ProtInc
    5. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    SignaLinkiP60983.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glia maturation factor beta
    Short name:
    GMF-beta
    Gene namesi
    Name:GMFB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:4373. GMFB.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28758.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 142141Glia maturation factor betaPRO_0000214943Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications

    Post-translational modificationi

    Phosphorylated; stimulated by phorbol ester.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP60983.
    PaxDbiP60983.
    PRIDEiP60983.

    2D gel databases

    OGPiP17774.

    PTM databases

    PhosphoSiteiP60983.

    Expressioni

    Gene expression databases

    ArrayExpressiP60983.
    BgeeiP60983.
    CleanExiHS_GMFB.
    GenevestigatoriP60983.

    Organism-specific databases

    HPAiHPA002954.

    Interactioni

    Protein-protein interaction databases

    BioGridi109026. 4 interactions.
    IntActiP60983. 1 interaction.
    STRINGi9606.ENSP00000350757.

    Structurei

    3D structure databases

    ProteinModelPortaliP60983.
    SMRiP60983. Positions 5-139.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 139136ADF-HPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ADF-H domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG268251.
    HOGENOMiHOG000175654.
    HOVERGENiHBG003045.
    OrthoDBiEOG78D7MR.
    PhylomeDBiP60983.
    TreeFamiTF315147.

    Family and domain databases

    Gene3Di3.40.20.10. 1 hit.
    InterProiIPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR011171. GMF-beta.
    [Graphical view]
    PANTHERiPTHR11249. PTHR11249. 1 hit.
    PfamiPF00241. Cofilin_ADF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001788. GMF-beta. 1 hit.
    SMARTiSM00102. ADF. 1 hit.
    [Graphical view]
    PROSITEiPS51263. ADF_H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60983-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE    50
    GISPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ 100
    QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH 142
    Length:142
    Mass (Da):16,713
    Last modified:January 23, 2007 - v2
    Checksum:iCF2D4A8CB1F37B1F
    GO

    Sequence cautioni

    The sequence AAH05359.1 differs from that shown. Reason: Frameshift at position 142.
    The sequence AAP35430.1 differs from that shown. Reason: Frameshift at position 142.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86492 mRNA. Translation: AAA58614.1.
    AB001106 mRNA. Translation: BAA19232.1.
    BT006784 mRNA. Translation: AAP35430.1. Frameshift.
    CR542113 mRNA. Translation: CAG46910.1.
    AK311753 mRNA. Translation: BAG34696.1.
    CH471061 Genomic DNA. Translation: EAW80638.1.
    BC005359 mRNA. Translation: AAH05359.1. Frameshift.
    CCDSiCCDS9718.1.
    PIRiPT0410.
    RefSeqiNP_004115.1. NM_004124.2.
    UniGeneiHs.151413.

    Genome annotation databases

    EnsembliENST00000358056; ENSP00000350757; ENSG00000197045.
    GeneIDi2764.
    KEGGihsa:2764.
    UCSCiuc021rtf.1. human.

    Polymorphism databases

    DMDMi46577593.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86492 mRNA. Translation: AAA58614.1 .
    AB001106 mRNA. Translation: BAA19232.1 .
    BT006784 mRNA. Translation: AAP35430.1 . Frameshift.
    CR542113 mRNA. Translation: CAG46910.1 .
    AK311753 mRNA. Translation: BAG34696.1 .
    CH471061 Genomic DNA. Translation: EAW80638.1 .
    BC005359 mRNA. Translation: AAH05359.1 . Frameshift.
    CCDSi CCDS9718.1.
    PIRi PT0410.
    RefSeqi NP_004115.1. NM_004124.2.
    UniGenei Hs.151413.

    3D structure databases

    ProteinModelPortali P60983.
    SMRi P60983. Positions 5-139.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109026. 4 interactions.
    IntActi P60983. 1 interaction.
    STRINGi 9606.ENSP00000350757.

    PTM databases

    PhosphoSitei P60983.

    Polymorphism databases

    DMDMi 46577593.

    2D gel databases

    OGPi P17774.

    Proteomic databases

    MaxQBi P60983.
    PaxDbi P60983.
    PRIDEi P60983.

    Protocols and materials databases

    DNASUi 2764.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358056 ; ENSP00000350757 ; ENSG00000197045 .
    GeneIDi 2764.
    KEGGi hsa:2764.
    UCSCi uc021rtf.1. human.

    Organism-specific databases

    CTDi 2764.
    GeneCardsi GC14M054941.
    HGNCi HGNC:4373. GMFB.
    HPAi HPA002954.
    MIMi 601713. gene.
    neXtProti NX_P60983.
    PharmGKBi PA28758.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268251.
    HOGENOMi HOG000175654.
    HOVERGENi HBG003045.
    OrthoDBi EOG78D7MR.
    PhylomeDBi P60983.
    TreeFami TF315147.

    Enzyme and pathway databases

    SignaLinki P60983.

    Miscellaneous databases

    ChiTaRSi GMFB. human.
    GenomeRNAii 2764.
    NextBioi 10872.
    PROi P60983.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P60983.
    Bgeei P60983.
    CleanExi HS_GMFB.
    Genevestigatori P60983.

    Family and domain databases

    Gene3Di 3.40.20.10. 1 hit.
    InterProi IPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR011171. GMF-beta.
    [Graphical view ]
    PANTHERi PTHR11249. PTHR11249. 1 hit.
    Pfami PF00241. Cofilin_ADF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001788. GMF-beta. 1 hit.
    SMARTi SM00102. ADF. 1 hit.
    [Graphical view ]
    PROSITEi PS51263. ADF_H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of biologically active human glia maturation factor-beta."
      Kaplan R., Zaheer A., Jaye M., Lim R.
      J. Neurochem. 57:483-490(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Saito T., Tanaka N., Toyomasu T.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Urinary bladder.
    8. "Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor."
      Lim R., Zaheer A.
      Biochem. Biophys. Res. Commun. 211:928-934(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGMFB_HUMAN
    AccessioniPrimary (citable) accession number: P60983
    Secondary accession number(s): B2R499, P17774, Q9BS35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3