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Protein

Glia maturation factor beta

Gene

GMFB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

GO - Molecular functioni

  1. enzyme activator activity Source: ProtInc
  2. protein kinase inhibitor activity Source: ProtInc
  3. signal transducer activity Source: ProtInc

GO - Biological processi

  1. learning Source: Ensembl
  2. locomotory behavior Source: Ensembl
  3. negative regulation of Arp2/3 complex-mediated actin nucleation Source: InterPro
  4. negative regulation of protein kinase activity Source: GOC
  5. nervous system development Source: ProtInc
  6. positive regulation of catalytic activity Source: GOC
  7. protein phosphorylation Source: ProtInc
  8. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

SignaLinkiP60983.

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor beta
Short name:
GMF-beta
Gene namesi
Name:GMFB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:4373. GMFB.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28758.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 142141Glia maturation factor betaPRO_0000214943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications

Post-translational modificationi

Phosphorylated; stimulated by phorbol ester.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP60983.
PaxDbiP60983.
PRIDEiP60983.

2D gel databases

OGPiP17774.

PTM databases

PhosphoSiteiP60983.

Expressioni

Gene expression databases

BgeeiP60983.
CleanExiHS_GMFB.
ExpressionAtlasiP60983. baseline and differential.
GenevestigatoriP60983.

Organism-specific databases

HPAiHPA002954.

Interactioni

Protein-protein interaction databases

BioGridi109026. 4 interactions.
IntActiP60983. 1 interaction.
STRINGi9606.ENSP00000350757.

Structurei

3D structure databases

ProteinModelPortaliP60983.
SMRiP60983. Positions 5-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 139136ADF-HPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG268251.
GeneTreeiENSGT00390000008920.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiP60983.
OrthoDBiEOG78D7MR.
PhylomeDBiP60983.
TreeFamiTF315147.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE
60 70 80 90 100
GISPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH
Length:142
Mass (Da):16,713
Last modified:January 22, 2007 - v2
Checksum:iCF2D4A8CB1F37B1F
GO

Sequence cautioni

The sequence AAH05359.1 differs from that shown. Reason: Frameshift at position 142. Curated
The sequence AAP35430.1 differs from that shown. Reason: Frameshift at position 142. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86492 mRNA. Translation: AAA58614.1.
AB001106 mRNA. Translation: BAA19232.1.
BT006784 mRNA. Translation: AAP35430.1. Frameshift.
CR542113 mRNA. Translation: CAG46910.1.
AK311753 mRNA. Translation: BAG34696.1.
CH471061 Genomic DNA. Translation: EAW80638.1.
BC005359 mRNA. Translation: AAH05359.1. Frameshift.
CCDSiCCDS9718.1.
PIRiPT0410.
RefSeqiNP_004115.1. NM_004124.2.
UniGeneiHs.151413.

Genome annotation databases

EnsembliENST00000358056; ENSP00000350757; ENSG00000197045.
ENST00000616146; ENSP00000479543; ENSG00000197045.
GeneIDi2764.
KEGGihsa:2764.
UCSCiuc021rtf.1. human.

Polymorphism databases

DMDMi46577593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86492 mRNA. Translation: AAA58614.1.
AB001106 mRNA. Translation: BAA19232.1.
BT006784 mRNA. Translation: AAP35430.1. Frameshift.
CR542113 mRNA. Translation: CAG46910.1.
AK311753 mRNA. Translation: BAG34696.1.
CH471061 Genomic DNA. Translation: EAW80638.1.
BC005359 mRNA. Translation: AAH05359.1. Frameshift.
CCDSiCCDS9718.1.
PIRiPT0410.
RefSeqiNP_004115.1. NM_004124.2.
UniGeneiHs.151413.

3D structure databases

ProteinModelPortaliP60983.
SMRiP60983. Positions 5-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109026. 4 interactions.
IntActiP60983. 1 interaction.
STRINGi9606.ENSP00000350757.

PTM databases

PhosphoSiteiP60983.

Polymorphism databases

DMDMi46577593.

2D gel databases

OGPiP17774.

Proteomic databases

MaxQBiP60983.
PaxDbiP60983.
PRIDEiP60983.

Protocols and materials databases

DNASUi2764.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358056; ENSP00000350757; ENSG00000197045.
ENST00000616146; ENSP00000479543; ENSG00000197045.
GeneIDi2764.
KEGGihsa:2764.
UCSCiuc021rtf.1. human.

Organism-specific databases

CTDi2764.
GeneCardsiGC14M054941.
HGNCiHGNC:4373. GMFB.
HPAiHPA002954.
MIMi601713. gene.
neXtProtiNX_P60983.
PharmGKBiPA28758.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG268251.
GeneTreeiENSGT00390000008920.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiP60983.
OrthoDBiEOG78D7MR.
PhylomeDBiP60983.
TreeFamiTF315147.

Enzyme and pathway databases

SignaLinkiP60983.

Miscellaneous databases

ChiTaRSiGMFB. human.
GenomeRNAii2764.
NextBioi10872.
PROiP60983.
SOURCEiSearch...

Gene expression databases

BgeeiP60983.
CleanExiHS_GMFB.
ExpressionAtlasiP60983. baseline and differential.
GenevestigatoriP60983.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of biologically active human glia maturation factor-beta."
    Kaplan R., Zaheer A., Jaye M., Lim R.
    J. Neurochem. 57:483-490(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Saito T., Tanaka N., Toyomasu T.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Urinary bladder.
  8. "Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor."
    Lim R., Zaheer A.
    Biochem. Biophys. Res. Commun. 211:928-934(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGMFB_HUMAN
AccessioniPrimary (citable) accession number: P60983
Secondary accession number(s): B2R499, P17774, Q9BS35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 25, 2004
Last sequence update: January 22, 2007
Last modified: March 3, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.