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P60983

- GMFB_HUMAN

UniProt

P60983 - GMFB_HUMAN

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Protein
Glia maturation factor beta
Gene
GMFB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

GO - Molecular functioni

  1. enzyme activator activity Source: ProtInc
  2. protein kinase inhibitor activity Source: ProtInc
  3. signal transducer activity Source: ProtInc

GO - Biological processi

  1. negative regulation of protein kinase activity Source: GOC
  2. nervous system development Source: ProtInc
  3. positive regulation of catalytic activity Source: GOC
  4. protein phosphorylation Source: ProtInc
  5. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

SignaLinkiP60983.

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor beta
Short name:
GMF-beta
Gene namesi
Name:GMFB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:4373. GMFB.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28758.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 142141Glia maturation factor beta
PRO_0000214943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications

Post-translational modificationi

Phosphorylated; stimulated by phorbol ester.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP60983.
PaxDbiP60983.
PRIDEiP60983.

2D gel databases

OGPiP17774.

PTM databases

PhosphoSiteiP60983.

Expressioni

Gene expression databases

ArrayExpressiP60983.
BgeeiP60983.
CleanExiHS_GMFB.
GenevestigatoriP60983.

Organism-specific databases

HPAiHPA002954.

Interactioni

Protein-protein interaction databases

BioGridi109026. 4 interactions.
IntActiP60983. 1 interaction.
STRINGi9606.ENSP00000350757.

Structurei

3D structure databases

ProteinModelPortaliP60983.
SMRiP60983. Positions 5-139.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 139136ADF-H
Add
BLAST

Sequence similaritiesi

Contains 1 ADF-H domain.

Phylogenomic databases

eggNOGiNOG268251.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
OrthoDBiEOG78D7MR.
PhylomeDBiP60983.
TreeFamiTF315147.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF-beta.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60983-1 [UniParc]FASTAAdd to Basket

« Hide

MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE    50
GISPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ 100
QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH 142
Length:142
Mass (Da):16,713
Last modified:January 23, 2007 - v2
Checksum:iCF2D4A8CB1F37B1F
GO

Sequence cautioni

The sequence AAH05359.1 differs from that shown. Reason: Frameshift at position 142.
The sequence AAP35430.1 differs from that shown. Reason: Frameshift at position 142.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86492 mRNA. Translation: AAA58614.1.
AB001106 mRNA. Translation: BAA19232.1.
BT006784 mRNA. Translation: AAP35430.1. Frameshift.
CR542113 mRNA. Translation: CAG46910.1.
AK311753 mRNA. Translation: BAG34696.1.
CH471061 Genomic DNA. Translation: EAW80638.1.
BC005359 mRNA. Translation: AAH05359.1. Frameshift.
CCDSiCCDS9718.1.
PIRiPT0410.
RefSeqiNP_004115.1. NM_004124.2.
UniGeneiHs.151413.

Genome annotation databases

EnsembliENST00000358056; ENSP00000350757; ENSG00000197045.
GeneIDi2764.
KEGGihsa:2764.
UCSCiuc021rtf.1. human.

Polymorphism databases

DMDMi46577593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86492 mRNA. Translation: AAA58614.1 .
AB001106 mRNA. Translation: BAA19232.1 .
BT006784 mRNA. Translation: AAP35430.1 . Frameshift.
CR542113 mRNA. Translation: CAG46910.1 .
AK311753 mRNA. Translation: BAG34696.1 .
CH471061 Genomic DNA. Translation: EAW80638.1 .
BC005359 mRNA. Translation: AAH05359.1 . Frameshift.
CCDSi CCDS9718.1.
PIRi PT0410.
RefSeqi NP_004115.1. NM_004124.2.
UniGenei Hs.151413.

3D structure databases

ProteinModelPortali P60983.
SMRi P60983. Positions 5-139.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109026. 4 interactions.
IntActi P60983. 1 interaction.
STRINGi 9606.ENSP00000350757.

PTM databases

PhosphoSitei P60983.

Polymorphism databases

DMDMi 46577593.

2D gel databases

OGPi P17774.

Proteomic databases

MaxQBi P60983.
PaxDbi P60983.
PRIDEi P60983.

Protocols and materials databases

DNASUi 2764.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358056 ; ENSP00000350757 ; ENSG00000197045 .
GeneIDi 2764.
KEGGi hsa:2764.
UCSCi uc021rtf.1. human.

Organism-specific databases

CTDi 2764.
GeneCardsi GC14M054941.
HGNCi HGNC:4373. GMFB.
HPAi HPA002954.
MIMi 601713. gene.
neXtProti NX_P60983.
PharmGKBi PA28758.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG268251.
HOGENOMi HOG000175654.
HOVERGENi HBG003045.
OrthoDBi EOG78D7MR.
PhylomeDBi P60983.
TreeFami TF315147.

Enzyme and pathway databases

SignaLinki P60983.

Miscellaneous databases

ChiTaRSi GMFB. human.
GenomeRNAii 2764.
NextBioi 10872.
PROi P60983.
SOURCEi Search...

Gene expression databases

ArrayExpressi P60983.
Bgeei P60983.
CleanExi HS_GMFB.
Genevestigatori P60983.

Family and domain databases

Gene3Di 3.40.20.10. 1 hit.
InterProi IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF-beta.
[Graphical view ]
PANTHERi PTHR11249. PTHR11249. 1 hit.
Pfami PF00241. Cofilin_ADF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001788. GMF-beta. 1 hit.
SMARTi SM00102. ADF. 1 hit.
[Graphical view ]
PROSITEi PS51263. ADF_H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of biologically active human glia maturation factor-beta."
    Kaplan R., Zaheer A., Jaye M., Lim R.
    J. Neurochem. 57:483-490(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Saito T., Tanaka N., Toyomasu T.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Urinary bladder.
  8. "Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor."
    Lim R., Zaheer A.
    Biochem. Biophys. Res. Commun. 211:928-934(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGMFB_HUMAN
AccessioniPrimary (citable) accession number: P60983
Secondary accession number(s): B2R499, P17774, Q9BS35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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