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Protein

Glia maturation factor beta

Gene

GMFB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

GO - Molecular functioni

  • actin binding Source: InterPro
  • Arp2/3 complex binding Source: InterPro
  • enzyme activator activity Source: ProtInc
  • growth factor activity Source: UniProtKB-KW
  • protein kinase inhibitor activity Source: ProtInc
  • signal transducer activity Source: ProtInc

GO - Biological processi

  • learning Source: Ensembl
  • locomotory behavior Source: Ensembl
  • negative regulation of Arp2/3 complex-mediated actin nucleation Source: InterPro
  • nervous system development Source: ProtInc
  • protein phosphorylation Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

SignaLinkiP60983.
SIGNORiP60983.

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor beta
Short name:
GMF-beta
Gene namesi
Name:GMFB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:4373. GMFB.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi2764.
OpenTargetsiENSG00000197045.
PharmGKBiPA28758.

Polymorphism and mutation databases

BioMutaiGMFB.
DMDMi46577593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002149432 – 142Glia maturation factor betaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Post-translational modificationi

Phosphorylated; stimulated by phorbol ester.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP60983.
MaxQBiP60983.
PaxDbiP60983.
PeptideAtlasiP60983.
PRIDEiP60983.
TopDownProteomicsiP60983.

2D gel databases

OGPiP17774.

PTM databases

iPTMnetiP60983.
PhosphoSitePlusiP60983.

Expressioni

Gene expression databases

BgeeiENSG00000197045.
CleanExiHS_GMFB.
ExpressionAtlasiP60983. baseline and differential.
GenevisibleiP60983. HS.

Organism-specific databases

HPAiHPA002954.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109026. 9 interactors.
IntActiP60983. 1 interactor.
STRINGi9606.ENSP00000350757.

Structurei

3D structure databases

ProteinModelPortaliP60983.
SMRiP60983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 139ADF-HPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1736. Eukaryota.
ENOG4111RK6. LUCA.
GeneTreeiENSGT00390000008920.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiP60983.
PhylomeDBiP60983.
TreeFamiTF315147.

Family and domain databases

CDDicd11283. ADF_GMF-beta_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiView protein in InterPro
IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
PANTHERiPTHR11249. PTHR11249. 1 hit.
PfamiView protein in Pfam
PF00241. Cofilin_ADF. 1 hit.
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiView protein in SMART
SM00102. ADF. 1 hit.
PROSITEiView protein in PROSITE
PS51263. ADF_H. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE
60 70 80 90 100
GISPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH
Length:142
Mass (Da):16,713
Last modified:January 23, 2007 - v2
Checksum:iCF2D4A8CB1F37B1F
GO

Sequence cautioni

The sequence AAH05359 differs from that shown. Reason: Frameshift at position 142.Curated
The sequence AAP35430 differs from that shown. Reason: Frameshift at position 142.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86492 mRNA. Translation: AAA58614.1.
AB001106 mRNA. Translation: BAA19232.1.
BT006784 mRNA. Translation: AAP35430.1. Frameshift.
CR542113 mRNA. Translation: CAG46910.1.
AK311753 mRNA. Translation: BAG34696.1.
CH471061 Genomic DNA. Translation: EAW80638.1.
BC005359 mRNA. Translation: AAH05359.1. Frameshift.
CCDSiCCDS9718.1.
PIRiPT0410.
RefSeqiNP_004115.1. NM_004124.2.
UniGeneiHs.151413.

Genome annotation databases

EnsembliENST00000358056; ENSP00000350757; ENSG00000197045.
ENST00000616146; ENSP00000479543; ENSG00000197045.
GeneIDi2764.
KEGGihsa:2764.
UCSCiuc021rtf.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGMFB_HUMAN
AccessioniPrimary (citable) accession number: P60983
Secondary accession number(s): B2R499, P17774, Q9BS35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families