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Protein

Destrin

Gene

DSTN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Destrin
Alternative name(s):
Actin-depolymerizing factor
Short name:
ADF
Gene namesi
Name:DSTN
Synonyms:DSN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002149202 – 165DestrinAdd BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei19N6-acetyllysineBy similarity1

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP60982
PeptideAtlasiP60982
PRIDEiP60982

Expressioni

Tissue specificityi

Widely distributed in various tissues.

Gene expression databases

ExpressionAtlasiP60982 baseline and differential
GenevisibleiP60982 SS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007548

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 17Combined sources8
Beta strandi19 – 21Combined sources3
Helixi26 – 29Combined sources4
Helixi30 – 32Combined sources3
Beta strandi35 – 38Combined sources4
Beta strandi42 – 44Combined sources3
Beta strandi57 – 59Combined sources3
Turni60 – 63Combined sources4
Beta strandi66 – 68Combined sources3
Helixi69 – 73Combined sources5
Beta strandi77 – 79Combined sources3
Beta strandi82 – 85Combined sources4
Beta strandi91 – 93Combined sources3
Beta strandi101 – 104Combined sources4
Beta strandi107 – 109Combined sources3
Helixi111 – 115Combined sources5
Helixi117 – 127Combined sources11
Beta strandi135 – 139Combined sources5
Turni140 – 143Combined sources4
Helixi145 – 151Combined sources7
Turni152 – 155Combined sources4
Beta strandi156 – 158Combined sources3
Turni159 – 162Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AK6NMR-A2-165[»]
1AK7NMR-A2-165[»]
ProteinModelPortaliP60982
SMRiP60982
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60982

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 153ADF-HPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 34Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated

Phylogenomic databases

eggNOGiKOG1735 Eukaryota
ENOG41122P5 LUCA
GeneTreeiENSGT00440000033289
HOGENOMiHOG000039697
HOVERGENiHBG000381
InParanoidiP60982
KOiK10363
OrthoDBiEOG091G0PWC

Family and domain databases

CDDicd11286 ADF_cofilin_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR017904 ADF/Cofilin
IPR029924 Dstn
PANTHERiPTHR11913 PTHR11913, 1 hit
PTHR11913:SF18 PTHR11913:SF18, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PRINTSiPR00006 COFILIN
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60982-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIIVE
60 70 80 90 100
EGKEILVGDV GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM
110 120 130 140 150
FFLWAPELAP LKSKMIYASS KDAIKKKFQG IKHECQANGP EDLNRACIAE
160
KLGGSLIVAF EGCPV
Length:165
Mass (Da):18,506
Last modified:January 23, 2007 - v3
Checksum:i8868A3167924100E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90053 mRNA Translation: BAA14105.1
PIRiA35179
RefSeqiNP_001004031.1, NM_001004031.1
UniGeneiSsc.10583

Genome annotation databases

EnsembliENSSSCT00000007757; ENSSSCP00000007548; ENSSSCG00000007085
ENSSSCT00000049626; ENSSSCP00000056780; ENSSSCG00000007085
GeneIDi445516
KEGGissc:445516

Similar proteinsi

Entry informationi

Entry nameiDEST_PIG
AccessioniPrimary (citable) accession number: P60982
Secondary accession number(s): P18282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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