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Protein

Destrin

Gene

DSTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.1 Publication

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

  • actin filament depolymerization Source: UniProtKB
  • actin filament fragmentation Source: Ensembl
  • actin filament severing Source: ProtInc
  • actin polymerization or depolymerization Source: ProtInc
  • positive regulation of actin filament depolymerization Source: Ensembl

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SIGNORiP60981.

Names & Taxonomyi

Protein namesi
Recommended name:
Destrin
Alternative name(s):
Actin-depolymerizing factor
Short name:
ADF
Gene namesi
Name:DSTN
Synonyms:ACTDP, DSN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15750. DSTN.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: ProtInc
  • cortical actin cytoskeleton Source: Ensembl
  • extracellular exosome Source: UniProtKB

Pathology & Biotechi

Organism-specific databases

DisGeNETi11034.
OpenTargetsiENSG00000125868.
PharmGKBiPA27509.

Chemistry databases

DrugBankiDB04147. Lauryl Dimethylamine-N-Oxide.

Polymorphism and mutation databases

BioMutaiDSTN.
DMDMi46577586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002149182 – 165DestrinAdd BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei3PhosphoserineCombined sources1
Modified residuei19N6-acetyllysineCombined sources1

Post-translational modificationi

ISGylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP60981.
PaxDbiP60981.
PeptideAtlasiP60981.
PRIDEiP60981.

2D gel databases

OGPiP18282.
REPRODUCTION-2DPAGEiIPI00473014.
UCD-2DPAGEiP60981.

PTM databases

iPTMnetiP60981.
PhosphoSitePlusiP60981.
SwissPalmiP60981.

Expressioni

Tissue specificityi

Widely distributed in various tissues.

Gene expression databases

BgeeiENSG00000125868.
CleanExiHS_DSTN.
ExpressionAtlasiP60981. baseline and differential.
GenevisibleiP60981. HS.

Organism-specific databases

HPAiCAB037094.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116223. 94 interactors.
IntActiP60981. 16 interactors.
MINTiMINT-5001125.
STRINGi9606.ENSP00000246069.

Structurei

3D structure databases

ProteinModelPortaliP60981.
SMRiP60981.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 153ADF-HPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 34Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated

Phylogenomic databases

eggNOGiKOG1735. Eukaryota.
ENOG41122P5. LUCA.
GeneTreeiENSGT00440000033289.
HOGENOMiHOG000039697.
HOVERGENiHBG000381.
InParanoidiP60981.
KOiK10363.
OMAiWIPDTIQ.
OrthoDBiEOG091G0PWC.
PhylomeDBiP60981.
TreeFamiTF328601.

Family and domain databases

CDDicd11286. ADF_cofilin_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiView protein in InterPro
IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin.
IPR029924. Dstn.
PANTHERiPTHR11913. PTHR11913. 1 hit.
PTHR11913:SF39. PTHR11913:SF39. 1 hit.
PfamiView protein in Pfam
PF00241. Cofilin_ADF. 1 hit.
PRINTSiPR00006. COFILIN.
SMARTiView protein in SMART
SM00102. ADF. 1 hit.
PROSITEiView protein in PROSITE
PS51263. ADF_H. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60981-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIIVE
60 70 80 90 100
EGKEILVGDV GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM
110 120 130 140 150
FFLWAPELAP LKSKMIYASS KDAIKKKFQG IKHECQANGP EDLNRACIAE
160
KLGGSLIVAF EGCPV
Length:165
Mass (Da):18,506
Last modified:January 23, 2007 - v3
Checksum:i8868A3167924100E
GO
Isoform 2 (identifier: P60981-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Note: No experimental confirmation available.
Show »
Length:148
Mass (Da):16,621
Checksum:iC61BB699DCA3E508
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036459139G → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430691 – 17Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65738 mRNA. Translation: AAB28361.1.
CR457042 mRNA. Translation: CAG33323.1.
AK302338 mRNA. Translation: BAG63668.1.
AK312645 mRNA. Translation: BAG35529.1.
AL132765 Genomic DNA. Translation: CAC10585.1.
CH471133 Genomic DNA. Translation: EAX10274.1.
CH471133 Genomic DNA. Translation: EAX10275.1.
CH471133 Genomic DNA. Translation: EAX10276.1.
BC009477 mRNA. Translation: AAH09477.1.
CCDSiCCDS13127.1. [P60981-1]
CCDS46580.1. [P60981-2]
PIRiA54184.
RefSeqiNP_001011546.1. NM_001011546.1. [P60981-2]
NP_006861.1. NM_006870.3. [P60981-1]
XP_011527444.1. XM_011529142.1. [P60981-1]
XP_011527445.1. XM_011529143.1. [P60981-1]
XP_011527446.1. XM_011529144.1. [P60981-2]
UniGeneiHs.304192.
Hs.705996.

Genome annotation databases

EnsembliENST00000246069; ENSP00000246069; ENSG00000125868. [P60981-1]
ENST00000474024; ENSP00000476975; ENSG00000125868. [P60981-2]
GeneIDi11034.
KEGGihsa:11034.
UCSCiuc002wpq.4. human. [P60981-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65738 mRNA. Translation: AAB28361.1.
CR457042 mRNA. Translation: CAG33323.1.
AK302338 mRNA. Translation: BAG63668.1.
AK312645 mRNA. Translation: BAG35529.1.
AL132765 Genomic DNA. Translation: CAC10585.1.
CH471133 Genomic DNA. Translation: EAX10274.1.
CH471133 Genomic DNA. Translation: EAX10275.1.
CH471133 Genomic DNA. Translation: EAX10276.1.
BC009477 mRNA. Translation: AAH09477.1.
CCDSiCCDS13127.1. [P60981-1]
CCDS46580.1. [P60981-2]
PIRiA54184.
RefSeqiNP_001011546.1. NM_001011546.1. [P60981-2]
NP_006861.1. NM_006870.3. [P60981-1]
XP_011527444.1. XM_011529142.1. [P60981-1]
XP_011527445.1. XM_011529143.1. [P60981-1]
XP_011527446.1. XM_011529144.1. [P60981-2]
UniGeneiHs.304192.
Hs.705996.

3D structure databases

ProteinModelPortaliP60981.
SMRiP60981.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116223. 94 interactors.
IntActiP60981. 16 interactors.
MINTiMINT-5001125.
STRINGi9606.ENSP00000246069.

Chemistry databases

DrugBankiDB04147. Lauryl Dimethylamine-N-Oxide.

PTM databases

iPTMnetiP60981.
PhosphoSitePlusiP60981.
SwissPalmiP60981.

Polymorphism and mutation databases

BioMutaiDSTN.
DMDMi46577586.

2D gel databases

OGPiP18282.
REPRODUCTION-2DPAGEiIPI00473014.
UCD-2DPAGEiP60981.

Proteomic databases

EPDiP60981.
PaxDbiP60981.
PeptideAtlasiP60981.
PRIDEiP60981.

Protocols and materials databases

DNASUi11034.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246069; ENSP00000246069; ENSG00000125868. [P60981-1]
ENST00000474024; ENSP00000476975; ENSG00000125868. [P60981-2]
GeneIDi11034.
KEGGihsa:11034.
UCSCiuc002wpq.4. human. [P60981-1]

Organism-specific databases

CTDi11034.
DisGeNETi11034.
GeneCardsiDSTN.
HGNCiHGNC:15750. DSTN.
HPAiCAB037094.
MIMi609114. gene.
neXtProtiNX_P60981.
OpenTargetsiENSG00000125868.
PharmGKBiPA27509.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1735. Eukaryota.
ENOG41122P5. LUCA.
GeneTreeiENSGT00440000033289.
HOGENOMiHOG000039697.
HOVERGENiHBG000381.
InParanoidiP60981.
KOiK10363.
OMAiWIPDTIQ.
OrthoDBiEOG091G0PWC.
PhylomeDBiP60981.
TreeFamiTF328601.

Enzyme and pathway databases

SIGNORiP60981.

Miscellaneous databases

ChiTaRSiDSTN. human.
GenomeRNAii11034.
PROiPR:P60981.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125868.
CleanExiHS_DSTN.
ExpressionAtlasiP60981. baseline and differential.
GenevisibleiP60981. HS.

Family and domain databases

CDDicd11286. ADF_cofilin_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiView protein in InterPro
IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin.
IPR029924. Dstn.
PANTHERiPTHR11913. PTHR11913. 1 hit.
PTHR11913:SF39. PTHR11913:SF39. 1 hit.
PfamiView protein in Pfam
PF00241. Cofilin_ADF. 1 hit.
PRINTSiPR00006. COFILIN.
SMARTiView protein in SMART
SM00102. ADF. 1 hit.
PROSITEiView protein in PROSITE
PS51263. ADF_H. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEST_HUMAN
AccessioniPrimary (citable) accession number: P60981
Secondary accession number(s): B2R6N2
, B4DYA6, P18282, Q5W166, Q6IAW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.