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Protein

Destrin

Gene

DSTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.1 Publication

Caution

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

  • actin filament depolymerization Source: UniProtKB
  • actin filament fragmentation Source: Ensembl
  • actin filament severing Source: ProtInc
  • actin polymerization or depolymerization Source: ProtInc
  • positive regulation of actin filament depolymerization Source: Ensembl

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SIGNORiP60981

Names & Taxonomyi

Protein namesi
Recommended name:
Destrin
Alternative name(s):
Actin-depolymerizing factor
Short name:
ADF
Gene namesi
Name:DSTN
Synonyms:ACTDP, DSN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125868.15
HGNCiHGNC:15750 DSTN
MIMi609114 gene
neXtProtiNX_P60981

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi11034
OpenTargetsiENSG00000125868
PharmGKBiPA27509

Chemistry databases

DrugBankiDB04147 Lauryl Dimethylamine-N-Oxide

Polymorphism and mutation databases

BioMutaiDSTN
DMDMi46577586

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002149182 – 165DestrinAdd BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei3PhosphoserineCombined sources1
Modified residuei19N6-acetyllysineCombined sources1

Post-translational modificationi

ISGylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP60981
PaxDbiP60981
PeptideAtlasiP60981
PRIDEiP60981

2D gel databases

OGPiP18282
REPRODUCTION-2DPAGEiIPI00473014
UCD-2DPAGEiP60981

PTM databases

iPTMnetiP60981
PhosphoSitePlusiP60981
SwissPalmiP60981

Expressioni

Tissue specificityi

Widely distributed in various tissues.

Gene expression databases

BgeeiENSG00000125868
CleanExiHS_DSTN
ExpressionAtlasiP60981 baseline and differential
GenevisibleiP60981 HS

Organism-specific databases

HPAiCAB037094

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

Protein-protein interaction databases

BioGridi11622396 interactors.
IntActiP60981 22 interactors.
MINTiP60981
STRINGi9606.ENSP00000246069

Structurei

3D structure databases

ProteinModelPortaliP60981
SMRiP60981
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 153ADF-HPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 34Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated

Phylogenomic databases

eggNOGiKOG1735 Eukaryota
ENOG41122P5 LUCA
GeneTreeiENSGT00440000033289
HOGENOMiHOG000039697
HOVERGENiHBG000381
InParanoidiP60981
KOiK10363
OMAiQMLPEKD
OrthoDBiEOG091G0PWC
PhylomeDBiP60981
TreeFamiTF328601

Family and domain databases

CDDicd11286 ADF_cofilin_like, 1 hit
Gene3Di3.40.20.101 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR017904 ADF/Cofilin
IPR029924 Dstn
PANTHERiPTHR11913 PTHR11913, 1 hit
PTHR11913:SF18 PTHR11913:SF18, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PRINTSiPR00006 COFILIN
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60981-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIIVE
60 70 80 90 100
EGKEILVGDV GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM
110 120 130 140 150
FFLWAPELAP LKSKMIYASS KDAIKKKFQG IKHECQANGP EDLNRACIAE
160
KLGGSLIVAF EGCPV
Length:165
Mass (Da):18,506
Last modified:January 23, 2007 - v3
Checksum:i8868A3167924100E
GO
Isoform 2 (identifier: P60981-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Note: No experimental confirmation available.
Show »
Length:148
Mass (Da):16,621
Checksum:iC61BB699DCA3E508
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036459139G → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430691 – 17Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65738 mRNA Translation: AAB28361.1
CR457042 mRNA Translation: CAG33323.1
AK302338 mRNA Translation: BAG63668.1
AK312645 mRNA Translation: BAG35529.1
AL132765 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10274.1
CH471133 Genomic DNA Translation: EAX10275.1
CH471133 Genomic DNA Translation: EAX10276.1
BC009477 mRNA Translation: AAH09477.1
CCDSiCCDS13127.1 [P60981-1]
CCDS46580.1 [P60981-2]
PIRiA54184
RefSeqiNP_001011546.1, NM_001011546.1 [P60981-2]
NP_006861.1, NM_006870.3 [P60981-1]
XP_011527444.1, XM_011529142.1 [P60981-1]
XP_011527445.1, XM_011529143.1 [P60981-1]
XP_011527446.1, XM_011529144.1 [P60981-2]
UniGeneiHs.304192
Hs.705996

Genome annotation databases

EnsembliENST00000246069; ENSP00000246069; ENSG00000125868 [P60981-1]
ENST00000474024; ENSP00000476975; ENSG00000125868 [P60981-2]
GeneIDi11034
KEGGihsa:11034
UCSCiuc002wpq.4 human [P60981-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDEST_HUMAN
AccessioniPrimary (citable) accession number: P60981
Secondary accession number(s): B2R6N2
, B4DYA6, P18282, Q5W166, Q6IAW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome