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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1597-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:MAP_1575c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalUniRule annotationAdd
BLAST
Transmembranei55 – 7521HelicalUniRule annotationAdd
BLAST
Transmembranei103 – 12321HelicalUniRule annotationAdd
BLAST
Transmembranei130 – 15021HelicalUniRule annotationAdd
BLAST
Transmembranei187 – 20721HelicalUniRule annotationAdd
BLAST
Transmembranei225 – 24521HelicalUniRule annotationAdd
BLAST
Transmembranei246 – 26621HelicalUniRule annotationAdd
BLAST
Transmembranei284 – 30421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Undecaprenyl-diphosphatasePRO_0000151165Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP1575c.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiHMMWALI.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60939-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAHLSYVEA VVVGAFQGVT ELFPVSSLGH AVLVPALVGG RWAQDLSVSA
60 70 80 90 100
HRSPYLAFIV GLHVATAAAL LVFFWRDWVR ILAGFFSSLR HRRIRTPDER
110 120 130 140 150
LAWLIVVGTI PVGLAGLALE QLFRTTLGKP VPAAAFLLLN GVALYAGEVL
160 170 180 190 200
RRRVAPVADE PAVPDAEQQH GDEASDNRLA QLPLRRGVLI GAAQILALLP
210 220 230 240 250
GISRSGITIV AGLWRGLSHE DAARFSFLLA TPIILAAGVY KIPELFGPLG
260 270 280 290 300
AGIGGQVLAG SIASFVCAYL AVRYLTRYFQ TRTLTPFAIY CAVAGGASLV

WLALR
Length:305
Mass (Da):32,549
Last modified:April 13, 2004 - v1
Checksum:iD46F601CC0AB8EE6
GO

Sequence cautioni

The sequence AAS03892.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS03892.1. Different initiation.
RefSeqiNP_960509.2. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS03892; AAS03892; MAP_1575c.
GeneIDi2720145.
KEGGimpa:MAP1575c.
PATRICi17995680. VBIMycAvi108102_1668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS03892.1. Different initiation.
RefSeqiNP_960509.2. NC_002944.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262316.MAP1575c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS03892; AAS03892; MAP_1575c.
GeneIDi2720145.
KEGGimpa:MAP1575c.
PATRICi17995680. VBIMycAvi108102_1668.

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiHMMWALI.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1597-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiUPPP_MYCPA
AccessioniPrimary (citable) accession number: P60939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.