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P60939 (UPPP_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:MAP_1575c
OrganismMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) [Complete proteome] [HAMAP]
Taxonomic identifier262316 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence AAS03892.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151165

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane246 – 26621Helical; Potential
Transmembrane284 – 30421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P60939 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: D46F601CC0AB8EE6

FASTA30532,549
        10         20         30         40         50         60 
MTAHLSYVEA VVVGAFQGVT ELFPVSSLGH AVLVPALVGG RWAQDLSVSA HRSPYLAFIV 

        70         80         90        100        110        120 
GLHVATAAAL LVFFWRDWVR ILAGFFSSLR HRRIRTPDER LAWLIVVGTI PVGLAGLALE 

       130        140        150        160        170        180 
QLFRTTLGKP VPAAAFLLLN GVALYAGEVL RRRVAPVADE PAVPDAEQQH GDEASDNRLA 

       190        200        210        220        230        240 
QLPLRRGVLI GAAQILALLP GISRSGITIV AGLWRGLSHE DAARFSFLLA TPIILAAGVY 

       250        260        270        280        290        300 
KIPELFGPLG AGIGGQVLAG SIASFVCAYL AVRYLTRYFQ TRTLTPFAIY CAVAGGASLV 


WLALR 

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016958 Genomic DNA. Translation: AAS03892.1. Different initiation.
RefSeqNP_960509.2. NC_002944.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262316.MAP1575c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS03892; AAS03892; MAP_1575c.
GeneID2720145.
KEGGmpa:MAP1575c.
PATRIC17995680. VBIMycAvi108102_1668.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMANANEAVD.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycMAVI262316:GCQR-1597-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_MYCPA
AccessionPrimary (citable) accession number: P60939
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families