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P60938 (UPPP_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:GSU0387
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP]
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151154

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane40 – 5920Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane147 – 16620Helical; Potential
Transmembrane188 – 20821Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane248 – 26821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P60938 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: A1740BFD5392088D

FASTA26928,742
        10         20         30         40         50         60 
MDIMHAAVLG ILQGLTEILP ISSSAHLILV PWLLGWPESG LTFDVGLHVG TLIALCVYFR 

        70         80         90        100        110        120 
RDIAYLISDA ITGLREGFGS QTSRLPFFII AGTVPAAIAG KTLEKPIEEF FRGSHTLIAL 

       130        140        150        160        170        180 
LLIAFGLLLA LADTTGPKRW RMDRVDLRGA LLIGLAQCLA LIPGVSRSGI TITAALFLGF 

       190        200        210        220        230        240 
TRDTAARFSF LLSLPIVAGA GILKMGELAR HGIPAGELAP LLAGMATSAV SGYLGVALLL 

       250        260 
RLVQRYSLYP FVWYRLLAGG AVLAYLFAR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017180 Genomic DNA. Translation: AAR33719.1.
RefSeqNP_951446.1. NC_002939.5.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243231.GSU0387.

Protocols and materials databases

DNASU2686573.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAR33719; AAR33719; GSU0387.
GeneID2686573.
KEGGgsu:GSU0387.
PATRIC22023518. VBIGeoSul17553_0385.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMALVGCFQC.
OrthoDBEOG6QP13M.
ProtClustDBCLSK827794.

Enzyme and pathway databases

BioCycGSUL243231:GH27-392-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_GEOSL
AccessionPrimary (citable) accession number: P60938
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families