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P60937 (UPPP_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:DIP1262
OrganismCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]
Taxonomic identifier257309 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151138

Regions

Transmembrane96 – 11621Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane198 – 21821Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane260 – 28021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P60937 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: DFCB3922D78BDBF2

FASTA28230,248
        10         20         30         40         50         60 
MTQDPSSQIS WSQTIVLSIV QGLTEFLPIS SSGHLRIVSE LFWGKDAGAS FTAVVQLGTE 

        70         80         90        100        110        120 
AAVLVYFAKD IAKILTGWFR GLFDKKQRGF DYRMGWMVIV GTLPVSIVGL LAKDIIRDNL 

       130        140        150        160        170        180 
RNMWITASVL IAFSFVFIAA EKWGSKRRSF DQLTMRDAVI MGCAQCLALI PGVSRSGGTV 

       190        200        210        220        230        240 
SAGLFVGLDR EVATRFSFLL AIPAVLASGL FSLPDAFAPD AGQAASGMQL AVGTGIAFAL 

       250        260        270        280 
GYASIAWLLK FVGSHSFSWF AAYRIPVGLL VMALLATGML TA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248357 Genomic DNA. Translation: CAE49791.1.
RefSeqNP_939617.1. NC_002935.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257309.DIP1262.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE49791; CAE49791; DIP1262.
GeneID2649816.
KEGGcdi:DIP1262.
PATRIC21483720. VBICorDip47633_1244.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CORDI
AccessionPrimary (citable) accession number: P60937
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families