P60936 (UPPP_BDEBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	Bd2694

Organism

Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) [Complete proteome] [HAMAP]

Taxonomic identifier

264462 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Bdellovibrionales › Bdellovibrionaceae › Bdellovibrio › Bdellovibrio bacteriovorus

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151111
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	69 – 89	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	147 – 167	21	Helical; Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Transmembrane	208 – 228	21	Helical; Potential
	Transmembrane	238 – 258	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P60936 [UniParc]. Last modified April 13, 2004. Version 1. Checksum: F42944FD037BA0C7	FASTA	263	28,996
	10 20 30 40 50 60 MSYLHAIILG IVEGITEFLP ISSTGHMIIA SSMMGIEDSS FTKAFEVIIQ FGAIMSVLVL 70 80 90 100 110 120 YWKRFLPHWG FYRKLFVAFL PTAIIGFVVK DVVEHLMGSV QVVAWSLIIG GVILIWADKA 130 140 150 160 170 180 FAHLTMMGRK TDDLTYKDSV KLGLFQAIAM IPGVSRSGAT IMGGLTLGMN KKEAAEFSFF 190 200 210 220 230 240 LAVPTMAAAT LYKLLKIYKT IEPAQINLLL VGCAVAFVVA MIAIKFFIGI VSRYGFRGFG 250 260 YYRIVLGLVI LILLYTGHDL QMV

References

[1]

"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective." Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C. Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842653 Genomic DNA. Translation: CAE80485.1.
RefSeq	NP_969492.1. NC_005363.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	264462.Bd2694.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE80485; CAE80485; Bd2694.
GeneID	2736208.
KEGG	bba:Bd2694.
PATRIC	21079804. VBIBdeBac73187_2464.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	RWLLRYI.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_BDEBA

Accession

Primary (citable) accession number: P60936

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	April 13, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program