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P60936 (UPPP_BDEBA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:Bd2694
OrganismBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) [Complete proteome] [HAMAP]
Taxonomic identifier264462 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151111

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane69 – 8921Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane177 – 19721Helical; Potential
Transmembrane208 – 22821Helical; Potential
Transmembrane238 – 25821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P60936 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: F42944FD037BA0C7

FASTA26328,996
        10         20         30         40         50         60 
MSYLHAIILG IVEGITEFLP ISSTGHMIIA SSMMGIEDSS FTKAFEVIIQ FGAIMSVLVL 

        70         80         90        100        110        120 
YWKRFLPHWG FYRKLFVAFL PTAIIGFVVK DVVEHLMGSV QVVAWSLIIG GVILIWADKA 

       130        140        150        160        170        180 
FAHLTMMGRK TDDLTYKDSV KLGLFQAIAM IPGVSRSGAT IMGGLTLGMN KKEAAEFSFF 

       190        200        210        220        230        240 
LAVPTMAAAT LYKLLKIYKT IEPAQINLLL VGCAVAFVVA MIAIKFFIGI VSRYGFRGFG 

       250        260 
YYRIVLGLVI LILLYTGHDL QMV 

« Hide

References

[1]"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX842653 Genomic DNA. Translation: CAE80485.1.
RefSeqNP_969492.1. NC_005363.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264462.Bd2694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE80485; CAE80485; Bd2694.
GeneID2736208.
KEGGbba:Bd2694.
PATRIC21079804. VBIBdeBac73187_2464.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_BDEBA
AccessionPrimary (citable) accession number: P60936
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families