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P60934 (UPPP_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:SP_0457
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) By similarity. Confers resistance to bacitracin. Is also required for virulence. Ref.2

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151214

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane257 – 27721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P60934 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: 0575353B1BDF97C2

FASTA28131,810
        10         20         30         40         50         60 
MYLIEILKSI FFGIVEGITE WLPISSTGHL ILAEEFIQYQ NQNEAFMSMF NVVIQLGAIL 

        70         80         90        100        110        120 
AVMVIYFNKL NPFKPTKDKQ EVRKTWRLWL KVLIATLPLL GVFKFDDWFD THFHNMVSVA 

       130        140        150        160        170        180 
LMLIIYGVAF IYLEKRNKAR AIEPSVTELD KLPYTTAFYI GLFQVLALLP GTSRSGATIV 

       190        200        210        220        230        240 
GGLLNGTSRS VVTEFTFYLG IPVMFGASAL KIFKFVKAGE LLSFGQLFLL LVAMGVAFAV 

       250        260        270        280 
SMVAIRFLTS YVKKHDFTLF GKYRIVLGSV LLLYSFVRLF V 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005672 Genomic DNA. Translation: AAK74617.1.
PIRH95052.
RefSeqNP_344977.1. NC_003028.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING170187.SP_0457.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK74617; AAK74617; SP_0457.
GeneID930395.
KEGGspn:SP_0457.
PATRIC19705265. VBIStrPne105772_0478.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSPNE170187:GHGN-463-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_STRPN
AccessionPrimary (citable) accession number: P60934
Secondary accession number(s): Q97SC8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families