Reviewed, UniProtKB/Swiss-Prot P60934 (UPPP_STRPN)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase
    Bacitracin resistance protein

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	SP_0457

Organism

Streptococcus pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) By similarity. Confers resistance to bacitracin. Is also required for virulence.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Undecaprenyl-diphosphatase HAMAP MF_01006		PRO_0000151214
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	45 – 65	21	Potential
	Transmembrane	89 – 109	21	Potential
	Transmembrane	113 – 133	21	Potential
	Transmembrane	152 – 172	21	Potential
	Transmembrane	190 – 210	21	Potential
	Transmembrane	225 – 245	21	Potential
	Transmembrane	257 – 277	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P60934-1 [UniParc]. Last modified April 13, 2004. Version 1. Checksum: 0575353B1BDF97C2	FASTA	281	31,810
	10 20 30 40 50 60 MYLIEILKSI FFGIVEGITE WLPISSTGHL ILAEEFIQYQ NQNEAFMSMF NVVIQLGAIL 70 80 90 100 110 120 AVMVIYFNKL NPFKPTKDKQ EVRKTWRLWL KVLIATLPLL GVFKFDDWFD THFHNMVSVA 130 140 150 160 170 180 LMLIIYGVAF IYLEKRNKAR AIEPSVTELD KLPYTTAFYI GLFQVLALLP GTSRSGATIV 190 200 210 220 230 240 GGLLNGTSRS VVTEFTFYLG IPVMFGASAL KIFKFVKAGE LLSFGQLFLL LVAMGVAFAV 250 260 270 280 SMVAIRFLTS YVKKHDFTLF GKYRIVLGSV LLLYSFVRLF V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.
[2]	"The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence." Chalker A.F., Ingraham K.A., Lunsford R.D., Bryant A.P., Bryant J., Wallis N.G., Broskey J.P., Pearson S.C., Holmes D.J. Microbiology 146:1547-1553(2000) [PubMed: 10878119] [Abstract] Cited for: FUNCTION. Strain: 0100993 / NCIMB 40794 / Serotype 3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005672 Genomic DNA. Translation: AAK74617.1.
PIR	H95052.
RefSeq	NP_344977.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	930395.
GenomeReviews	Gene locus SP_0457 in contig AE005672_GR.
KEGG	spn:SP_0457.
TIGR	SP_0457.
Phylogenomic databases
HOGENOM	P60934.
OMA	QVLSIIP.
Enzyme and pathway databases
BRENDA	3.6.1.27. 600.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_STRPN

Accession

Primary (citable) accession number: P60934
Secondary accession number(s): Q97SC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	April 13, 2004
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)