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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:Z4410, ECs3940
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei45 – 65HelicalUniRule annotationAdd BLAST21
Transmembranei90 – 110HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Transmembranei190 – 210HelicalUniRule annotationAdd BLAST21
Transmembranei222 – 242HelicalUniRule annotationAdd BLAST21
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001511471 – 273Undecaprenyl-diphosphataseAdd BLAST273

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4410

Structurei

3D structure databases

ProteinModelPortaliP60933
SMRiP60933
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiPDARMGW

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

P60933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDMHSLLIA AILGVVEGLT EFLPVSSTGH MIIVGHLLGF EGDTAKTFEV
60 70 80 90 100
VIQLGSILAV VVMFWRRLFG LIGIHFGRPL QHEGESKGRL TLIHILLGMI
110 120 130 140 150
PAVVLGLLFH DTIKSLFNPI NVMYALVVGG LLLIAAECLK PKEPRAPGLD
160 170 180 190 200
DMTYRQAFMI GCFQCLALWP GFSRSGATIS GGMLMGVSRY AASEFSFLLA
210 220 230 240 250
VPMMMGATAL DLYKSWGFLT SGDIPMFAVG FITAFVVALI AIKTFLQLIK
260 270
RISFIPFAIY RFIVAAAVYV VFF
Length:273
Mass (Da):29,759
Last modified:April 13, 2004 - v1
Checksum:i6BFAC099D5163352
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58191.1
BA000007 Genomic DNA Translation: BAB37363.1
PIRiD91121
RefSeqiNP_311967.1, NC_002695.1
WP_001281927.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58191; AAG58191; Z4410
BAB37363; BAB37363; BAB37363
GeneIDi916234
KEGGiece:Z4410
ecs:ECs3940
PATRICifig|386585.9.peg.4109

Similar proteinsi

Entry informationi

Entry nameiUPPP_ECO57
AccessioniPrimary (citable) accession number: P60933
Secondary accession number(s): P31054, P39203
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: April 25, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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