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Protein

Death ligand signal enhancer

Gene

Dele

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Death ligand signal enhancer
Gene namesi
Name:Dele
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735029. RGD735029.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 101101MitochondrionSequence analysisAdd
BLAST
Chaini102 – 509408Death ligand signal enhancerPRO_0000050723Add
BLAST

Proteomic databases

PaxDbiP60924.
PRIDEiP60924.

PTM databases

PhosphoSiteiP60924.

Interactioni

Subunit structurei

Interacts with DAP3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026273.

Structurei

3D structure databases

ProteinModelPortaliP60924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati213 – 24533TPR 1Add
BLAST
Repeati246 – 27833TPR 2Add
BLAST
Repeati279 – 31335TPR 3Add
BLAST
Repeati314 – 35138TPR 4Add
BLAST
Repeati352 – 38534TPR 5Add
BLAST
Repeati386 – 42338TPR 6Add
BLAST
Repeati470 – 49829TPR 7Add
BLAST

Sequence similaritiesi

Contains 7 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
HOVERGENiHBG052169.
InParanoidiP60924.
PhylomeDBiP60924.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 5 hits.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLTGILGR ALPRLLGPGF RGITPKPTSS DGPQTTSTTL LLPRVNFDRS
60 70 80 90 100
GSHGSKRNRD PKCCGWKEAF HWMSAHVSPN TLRDAVSWGT LAVLALHLAR
110 120 130 140 150
QIHFHAPLVA GPQSAERCSW HSPLYRFLSS SWWHPHSSLR RYVLPSPDCP
160 170 180 190 200
APRNTGLREP RLGQEEPAAR SQGLPSDSSL KPGLLNLPEE EPSDFGFLNA
210 220 230 240 250
SRDFTSQAKA AEAGPPGGKN EQDKPKALPL EEAVTSIQQL FQLSVAIAFN
260 270 280 290 300
FLGTENIKTG DYTAAFSYFQ KAADRGYSKA QYNVGLCLEH GRGTPRDLSK
310 320 330 340 350
AVLFYHLAAV QGHSLAQYRY ARCLLQSPGS MSDPERQRAV SLLKQAADSG
360 370 380 390 400
LTEAQAFLGV LFTKEPHLDE QKAVKYFWLA ASNGDSQSRF HLGICYEKGL
410 420 430 440 450
GVQRNLGEAV KCYQKSAAMG NEPAQERLRT LFNVEAAGPS HLAIGLKSFS
460 470 480 490 500
SPSLCSLNTF LAGASGLPHA SSTGNLGLLC RSGHLGTSHG APSRAMPSLE

RSLVRLGFG
Length:509
Mass (Da):55,250
Last modified:April 13, 2004 - v1
Checksum:i10E508B95EA0E8DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064660 mRNA. Translation: AAH64660.1.
RefSeqiNP_955787.1. NM_199493.1.
UniGeneiRn.12899.

Genome annotation databases

GeneIDi307480.
KEGGirno:307480.
UCSCiRGD:735029. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064660 mRNA. Translation: AAH64660.1.
RefSeqiNP_955787.1. NM_199493.1.
UniGeneiRn.12899.

3D structure databases

ProteinModelPortaliP60924.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026273.

PTM databases

PhosphoSiteiP60924.

Proteomic databases

PaxDbiP60924.
PRIDEiP60924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi307480.
KEGGirno:307480.
UCSCiRGD:735029. rat.

Organism-specific databases

CTDi307480.
RGDi735029. RGD735029.

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
HOVERGENiHBG052169.
InParanoidiP60924.
PhylomeDBiP60924.

Miscellaneous databases

NextBioi657432.
PROiP60924.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 5 hits.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiDELE_RAT
AccessioniPrimary (citable) accession number: P60924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 11, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.