Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Death ligand signal enhancer

Gene

Dele

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Death ligand signal enhancer
Gene namesi
Name:Dele
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi735029 RGD735029

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 101MitochondrionSequence analysisAdd BLAST101
ChainiPRO_0000050723102 – 509Death ligand signal enhancerAdd BLAST408

Proteomic databases

PaxDbiP60924
PRIDEiP60924

PTM databases

iPTMnetiP60924
PhosphoSitePlusiP60924

Interactioni

Subunit structurei

Interacts with DAP3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026273

Structurei

3D structure databases

ProteinModelPortaliP60924
SMRiP60924
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati213 – 245TPR 1Add BLAST33
Repeati246 – 278TPR 2Add BLAST33
Repeati279 – 313TPR 3Add BLAST35
Repeati314 – 351TPR 4Add BLAST38
Repeati352 – 385TPR 5Add BLAST34
Repeati386 – 423TPR 6Add BLAST38
Repeati470 – 498TPR 7Add BLAST29

Keywords - Domaini

Repeat, TPR repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1550 Eukaryota
COG0790 LUCA
HOVERGENiHBG052169
InParanoidiP60924
PhylomeDBiP60924

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006597 Sel1-like
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF08238 Sel1, 5 hits
SMARTiView protein in SMART
SM00671 SEL1, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLTGILGR ALPRLLGPGF RGITPKPTSS DGPQTTSTTL LLPRVNFDRS
60 70 80 90 100
GSHGSKRNRD PKCCGWKEAF HWMSAHVSPN TLRDAVSWGT LAVLALHLAR
110 120 130 140 150
QIHFHAPLVA GPQSAERCSW HSPLYRFLSS SWWHPHSSLR RYVLPSPDCP
160 170 180 190 200
APRNTGLREP RLGQEEPAAR SQGLPSDSSL KPGLLNLPEE EPSDFGFLNA
210 220 230 240 250
SRDFTSQAKA AEAGPPGGKN EQDKPKALPL EEAVTSIQQL FQLSVAIAFN
260 270 280 290 300
FLGTENIKTG DYTAAFSYFQ KAADRGYSKA QYNVGLCLEH GRGTPRDLSK
310 320 330 340 350
AVLFYHLAAV QGHSLAQYRY ARCLLQSPGS MSDPERQRAV SLLKQAADSG
360 370 380 390 400
LTEAQAFLGV LFTKEPHLDE QKAVKYFWLA ASNGDSQSRF HLGICYEKGL
410 420 430 440 450
GVQRNLGEAV KCYQKSAAMG NEPAQERLRT LFNVEAAGPS HLAIGLKSFS
460 470 480 490 500
SPSLCSLNTF LAGASGLPHA SSTGNLGLLC RSGHLGTSHG APSRAMPSLE

RSLVRLGFG
Length:509
Mass (Da):55,250
Last modified:April 13, 2004 - v1
Checksum:i10E508B95EA0E8DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC064660 mRNA Translation: AAH64660.1
RefSeqiNP_955787.1, NM_199493.1
UniGeneiRn.12899

Genome annotation databases

GeneIDi307480
KEGGirno:307480
UCSCiRGD:735029 rat

Entry informationi

Entry nameiDELE_RAT
AccessioniPrimary (citable) accession number: P60924
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health