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P60920

- SYH_TREDE

UniProt

P60920 - SYH_TREDE

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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTDEN243275:GJ7G-1465-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:TDE_1442
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000008212: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Histidine--tRNA ligasePRO_0000136285Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243275.TDE1442.

Structurei

3D structure databases

ProteinModelPortaliP60920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiQMSYANA.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60920-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDLIQPKVL KGFRDFLPAD EIERALLMER LVKVFRDYGF VPIDTPALEY
60 70 80 90 100
SEILLRKSGG ETEKQVFRFS DNGGRDVAMR FDLTVPLARF VAEHKSEIYF
110 120 130 140 150
PFKRYHLGKV WRGEKPQAGR YREFLQCDFD TLGSDSAAVD FEILRLIKKA
160 170 180 190 200
LNELGVSNFK IHVSHRGIFN RFLKSLNLSE DSEEVLRIVD KLAKIGEDEV
210 220 230 240 250
LKLLTDISSE ESAKKILAYI SGVSKELKSE DFEKTLSHLE NLAGGPDEDT
260 270 280 290 300
KRMRDIYALV KAVGIEDSIV FDPSITRGLD YYTGVVFETF LNDLPSIGSV
310 320 330 340 350
CSGGRYDNLT ALYMKECITG VGASIGLDRL LAALELLGHQ KTKASFTDLL
360 370 380 390 400
IFSLPEDDLV LSYKIVNFFE AEKINAEVYP EPKKMNHQYT YAEKKDIRWG
410 420 430 440
LFLDKDSCVE EFDKAPQRFK IKLKDMTNRT EDETPLSEAV KKIRASKN
Length:448
Mass (Da):51,014
Last modified:April 13, 2004 - v1
Checksum:i431DDC865468BF21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017226 Genomic DNA. Translation: AAS11959.1.
RefSeqiNP_972048.1. NC_002967.9.

Genome annotation databases

EnsemblBacteriaiAAS11959; AAS11959; TDE_1442.
GeneIDi2741405.
KEGGitde:TDE1442.
PATRICi20525064. VBITreDen445_1383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017226 Genomic DNA. Translation: AAS11959.1 .
RefSeqi NP_972048.1. NC_002967.9.

3D structure databases

ProteinModelPortali P60920.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243275.TDE1442.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS11959 ; AAS11959 ; TDE_1442 .
GeneIDi 2741405.
KEGGi tde:TDE1442.
PATRICi 20525064. VBITreDen445_1383.

Phylogenomic databases

eggNOGi COG0124.
KOi K01892.
OMAi QMSYANA.
OrthoDBi EOG6BPDH4.

Enzyme and pathway databases

BioCyci TDEN243275:GJ7G-1465-MONOMER.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00127. His_tRNA_synth.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Entry informationi

Entry nameiSYH_TREDE
AccessioniPrimary (citable) accession number: P60920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3