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P60920

- SYH_TREDE

UniProt

P60920 - SYH_TREDE

Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. histidine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTDEN243275:GJ7G-1465-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
    Alternative name(s):
    Histidyl-tRNA synthetaseUniRule annotation
    Short name:
    HisRSUniRule annotation
    Gene namesi
    Name:hisSUniRule annotation
    Ordered Locus Names:TDE_1442
    OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
    Taxonomic identifieri243275 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000008212: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Histidine--tRNA ligasePRO_0000136285Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243275.TDE1442.

    Structurei

    3D structure databases

    ProteinModelPortaliP60920.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0124.
    KOiK01892.
    OMAiQMSYANA.
    OrthoDBiEOG6BPDH4.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_00127. His_tRNA_synth.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view]
    PANTHERiPTHR11476. PTHR11476. 1 hit.
    PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00442. hisS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60920-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDLIQPKVL KGFRDFLPAD EIERALLMER LVKVFRDYGF VPIDTPALEY    50
    SEILLRKSGG ETEKQVFRFS DNGGRDVAMR FDLTVPLARF VAEHKSEIYF 100
    PFKRYHLGKV WRGEKPQAGR YREFLQCDFD TLGSDSAAVD FEILRLIKKA 150
    LNELGVSNFK IHVSHRGIFN RFLKSLNLSE DSEEVLRIVD KLAKIGEDEV 200
    LKLLTDISSE ESAKKILAYI SGVSKELKSE DFEKTLSHLE NLAGGPDEDT 250
    KRMRDIYALV KAVGIEDSIV FDPSITRGLD YYTGVVFETF LNDLPSIGSV 300
    CSGGRYDNLT ALYMKECITG VGASIGLDRL LAALELLGHQ KTKASFTDLL 350
    IFSLPEDDLV LSYKIVNFFE AEKINAEVYP EPKKMNHQYT YAEKKDIRWG 400
    LFLDKDSCVE EFDKAPQRFK IKLKDMTNRT EDETPLSEAV KKIRASKN 448
    Length:448
    Mass (Da):51,014
    Last modified:April 13, 2004 - v1
    Checksum:i431DDC865468BF21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS11959.1.
    RefSeqiNP_972048.1. NC_002967.9.

    Genome annotation databases

    EnsemblBacteriaiAAS11959; AAS11959; TDE_1442.
    GeneIDi2741405.
    KEGGitde:TDE1442.
    PATRICi20525064. VBITreDen445_1383.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS11959.1 .
    RefSeqi NP_972048.1. NC_002967.9.

    3D structure databases

    ProteinModelPortali P60920.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243275.TDE1442.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS11959 ; AAS11959 ; TDE_1442 .
    GeneIDi 2741405.
    KEGGi tde:TDE1442.
    PATRICi 20525064. VBITreDen445_1383.

    Phylogenomic databases

    eggNOGi COG0124.
    KOi K01892.
    OMAi QMSYANA.
    OrthoDBi EOG6BPDH4.

    Enzyme and pathway databases

    BioCyci TDEN243275:GJ7G-1465-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_00127. His_tRNA_synth.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view ]
    PANTHERi PTHR11476. PTHR11476. 1 hit.
    PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00442. hisS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35405 / CIP 103919 / DSM 14222.

    Entry informationi

    Entry nameiSYH_TREDE
    AccessioniPrimary (citable) accession number: P60920
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3