Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P60920 (SYH_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase

EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:TDE_1442
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Histidine--tRNA ligase HAMAP-Rule MF_00127
PRO_0000136285

Sequences

Sequence LengthMass (Da)Tools
P60920 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: 431DDC865468BF21

FASTA44851,014
        10         20         30         40         50         60 
MSDLIQPKVL KGFRDFLPAD EIERALLMER LVKVFRDYGF VPIDTPALEY SEILLRKSGG 

        70         80         90        100        110        120 
ETEKQVFRFS DNGGRDVAMR FDLTVPLARF VAEHKSEIYF PFKRYHLGKV WRGEKPQAGR 

       130        140        150        160        170        180 
YREFLQCDFD TLGSDSAAVD FEILRLIKKA LNELGVSNFK IHVSHRGIFN RFLKSLNLSE 

       190        200        210        220        230        240 
DSEEVLRIVD KLAKIGEDEV LKLLTDISSE ESAKKILAYI SGVSKELKSE DFEKTLSHLE 

       250        260        270        280        290        300 
NLAGGPDEDT KRMRDIYALV KAVGIEDSIV FDPSITRGLD YYTGVVFETF LNDLPSIGSV 

       310        320        330        340        350        360 
CSGGRYDNLT ALYMKECITG VGASIGLDRL LAALELLGHQ KTKASFTDLL IFSLPEDDLV 

       370        380        390        400        410        420 
LSYKIVNFFE AEKINAEVYP EPKKMNHQYT YAEKKDIRWG LFLDKDSCVE EFDKAPQRFK 

       430        440 
IKLKDMTNRT EDETPLSEAV KKIRASKN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017226 Genomic DNA. Translation: AAS11959.1.
RefSeqNP_972048.1. NC_002967.9.

3D structure databases

ProteinModelPortalP60920.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243275.TDE1442.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS11959; AAS11959; TDE_1442.
GeneID2741405.
KEGGtde:TDE1442.
PATRIC20525064. VBITreDen445_1383.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
KOK01892.
OMAQMSYANA.
OrthoDBEOG6BPDH4.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-1465-MONOMER.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. SSF52954. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_TREDE
AccessionPrimary (citable) accession number: P60920
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries