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P60904

- DNJC5_MOUSE

UniProt

P60904 - DNJC5_MOUSE

Protein

DnaJ homolog subfamily C member 5

Gene

Dnajc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings By similarity.By similarity

    GO - Biological processi

    1. negative regulation of neuron apoptotic process Source: MGI

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily C member 5
    Alternative name(s):
    Cysteine string protein
    Short name:
    CSP
    Gene namesi
    Name:Dnajc5
    Synonyms:Csp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:892995. Dnajc5.

    Subcellular locationi

    Membrane 1 Publication; Lipid-anchor 1 Publication. Melanosome By similarity. Cell membrane By similarity
    Note: Colocalizes with insulin granules, when overexpressed in a islet cell line.

    GO - Cellular componenti

    1. lysosomal membrane Source: Ensembl
    2. melanosome Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB
    4. synaptic vesicle Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi113 – 1131C → V: No change in subcellular location; when associated with G-118 and F-121. 1 Publication
    Mutagenesisi118 – 1181C → G: No change in subcellular location; when associated with V-113 and F-121. 1 Publication
    Mutagenesisi121 – 1211C → F: No change in subcellular location; when associated with V-113 and G-118. 1 Publication
    Mutagenesisi129 – 1291F → C: No change in subcellular location; when associated with H-135. 1 Publication
    Mutagenesisi135 – 1351K → H: No change in subcellular location; when associated with C-129. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198DnaJ homolog subfamily C member 5PRO_0000071053Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81PhosphoserineBy similarity
    Modified residuei10 – 101Phosphoserine1 Publication
    Modified residuei15 – 151PhosphoserineBy similarity
    Modified residuei56 – 561N6-acetyllysineBy similarity

    Post-translational modificationi

    Fatty acylated. Heavily palmitoylated in the cysteine string motif. Palmitoylation is not required for membrane association.1 Publication

    Keywords - PTMi

    Acetylation, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiP60904.
    PaxDbiP60904.
    PRIDEiP60904.

    PTM databases

    PhosphoSiteiP60904.

    Expressioni

    Gene expression databases

    ArrayExpressiP60904.
    BgeeiP60904.
    CleanExiMM_DNAJC5.
    GenevestigatoriP60904.

    Interactioni

    Subunit structurei

    Homodimer Probable. Interacts with the chaperone complex consisting of HSC70 and SGTA.1 PublicationCurated

    Protein-protein interaction databases

    BioGridi198948. 5 interactions.
    IntActiP60904. 2 interactions.
    MINTiMINT-4093239.
    STRINGi10090.ENSMUSP00000104426.

    Structurei

    Secondary structure

    1
    198
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 205
    Helixi28 – 4114
    Turni44 – 463
    Helixi51 – 6717
    Helixi70 – 789
    Helixi81 – 899
    Helixi94 – 1007

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CTWNMR-A5-100[»]
    ProteinModelPortaliP60904.
    SMRiP60904. Positions 5-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP60904.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 8270JPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi118 – 12811Poly-CysAdd
    BLAST

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0484.
    GeneTreeiENSGT00730000110742.
    HOGENOMiHOG000231969.
    HOVERGENiHBG005414.
    KOiK09525.
    OMAiCCCGRCK.
    OrthoDBiEOG7WHHBD.
    PhylomeDBiP60904.
    TreeFamiTF105164.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60904-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADQRQRSLS TSGESLYHVL GLDKNATSDD IKKSYRKLAL KYHPDKNPDN    50
    PEAADKFKEI NNAHAILTDA TKRNIYDKYG SLGLYVAEQF GEENVNTYFV 100
    LSSWWAKALF VVCGLLTCCY CCCCLCCCFN CCCGKCKPKA PEGEETEFYV 150
    SPEDLEAQLQ SDEREATDTP IVIQPASATE TTQLTADSHP SYHTDGFN 198
    Length:198
    Mass (Da):22,101
    Last modified:April 13, 2004 - v1
    Checksum:i52F98261FBAD978F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF032115 mRNA. Translation: AAB87080.1.
    AK029006 mRNA. Translation: BAC26236.1.
    AK032373 mRNA. Translation: BAC27841.1.
    CCDSiCCDS17215.1.
    RefSeqiNP_001258513.1. NM_001271584.1.
    NP_001258514.1. NM_001271585.1.
    NP_058055.1. NM_016775.3.
    UniGeneiMm.140761.
    Mm.391807.
    Mm.491282.

    Genome annotation databases

    EnsembliENSMUST00000072334; ENSMUSP00000072175; ENSMUSG00000000826.
    ENSMUST00000108796; ENSMUSP00000104424; ENSMUSG00000000826.
    ENSMUST00000108797; ENSMUSP00000104425; ENSMUSG00000000826.
    GeneIDi13002.
    KEGGimmu:13002.
    UCSCiuc008omp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF032115 mRNA. Translation: AAB87080.1 .
    AK029006 mRNA. Translation: BAC26236.1 .
    AK032373 mRNA. Translation: BAC27841.1 .
    CCDSi CCDS17215.1.
    RefSeqi NP_001258513.1. NM_001271584.1.
    NP_001258514.1. NM_001271585.1.
    NP_058055.1. NM_016775.3.
    UniGenei Mm.140761.
    Mm.391807.
    Mm.491282.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CTW NMR - A 5-100 [» ]
    ProteinModelPortali P60904.
    SMRi P60904. Positions 5-100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198948. 5 interactions.
    IntActi P60904. 2 interactions.
    MINTi MINT-4093239.
    STRINGi 10090.ENSMUSP00000104426.

    PTM databases

    PhosphoSitei P60904.

    Proteomic databases

    MaxQBi P60904.
    PaxDbi P60904.
    PRIDEi P60904.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072334 ; ENSMUSP00000072175 ; ENSMUSG00000000826 .
    ENSMUST00000108796 ; ENSMUSP00000104424 ; ENSMUSG00000000826 .
    ENSMUST00000108797 ; ENSMUSP00000104425 ; ENSMUSG00000000826 .
    GeneIDi 13002.
    KEGGi mmu:13002.
    UCSCi uc008omp.1. mouse.

    Organism-specific databases

    CTDi 80331.
    MGIi MGI:892995. Dnajc5.

    Phylogenomic databases

    eggNOGi COG0484.
    GeneTreei ENSGT00730000110742.
    HOGENOMi HOG000231969.
    HOVERGENi HBG005414.
    KOi K09525.
    OMAi CCCGRCK.
    OrthoDBi EOG7WHHBD.
    PhylomeDBi P60904.
    TreeFami TF105164.

    Miscellaneous databases

    EvolutionaryTracei P60904.
    NextBioi 282820.
    PROi P60904.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P60904.
    Bgeei P60904.
    CleanExi MM_DNAJC5.
    Genevestigatori P60904.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Qin N., Lin T., Birnbaumer L.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Olfactory bulb and Skin.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 8-24 AND 42-72, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells."
      Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J.
      Biochim. Biophys. Acta 1773:109-119(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HSC70 AND SGTA, SUBCELLULAR LOCATION, PALMITOYLATION, MUTAGENESIS OF CYS-113; CYS-118; CYS-121; PHE-129 AND LYS-135.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    9. "Solution structure of J-domain from mouse DnaJ subfamily C member 5."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 5-100.

    Entry informationi

    Entry nameiDNJC5_MOUSE
    AccessioniPrimary (citable) accession number: P60904
    Secondary accession number(s): P54101
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3