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P60904

- DNJC5_MOUSE

UniProt

P60904 - DNJC5_MOUSE

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Protein

DnaJ homolog subfamily C member 5

Gene

Dnajc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).By similarity

GO - Biological processi

  1. negative regulation of neuron apoptotic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_245631. GABA synthesis, release, reuptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 5
Alternative name(s):
Cysteine string protein
Short name:
CSP
Gene namesi
Name:Dnajc5
Synonyms:Csp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:892995. Dnajc5.

Subcellular locationi

Membrane 1 Publication; Lipid-anchor 1 Publication. Melanosome By similarity. Cell membrane By similarity
Note: Colocalizes with insulin granules, when overexpressed in a islet cell line.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. lysosomal membrane Source: Ensembl
  3. mitochondrion Source: Ensembl
  4. plasma membrane Source: UniProtKB
  5. synaptic vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi113 – 1131C → V: No change in subcellular location; when associated with G-118 and F-121. 1 Publication
Mutagenesisi118 – 1181C → G: No change in subcellular location; when associated with V-113 and F-121. 1 Publication
Mutagenesisi121 – 1211C → F: No change in subcellular location; when associated with V-113 and G-118. 1 Publication
Mutagenesisi129 – 1291F → C: No change in subcellular location; when associated with H-135. 1 Publication
Mutagenesisi135 – 1351K → H: No change in subcellular location; when associated with C-129. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198DnaJ homolog subfamily C member 5PRO_0000071053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei10 – 101Phosphoserine1 Publication
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei56 – 561N6-acetyllysineBy similarity

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif. Palmitoylation is not required for membrane association.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP60904.
PaxDbiP60904.
PRIDEiP60904.

PTM databases

PhosphoSiteiP60904.

Expressioni

Gene expression databases

BgeeiP60904.
CleanExiMM_DNAJC5.
ExpressionAtlasiP60904. baseline and differential.
GenevestigatoriP60904.

Interactioni

Subunit structurei

Homodimer (Probable). Interacts with the chaperone complex consisting of HSC70 and SGTA.1 PublicationCurated

Protein-protein interaction databases

BioGridi198948. 5 interactions.
IntActiP60904. 2 interactions.
MINTiMINT-4093239.
STRINGi10090.ENSMUSP00000104426.

Structurei

Secondary structure

1
198
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 205Combined sources
Helixi28 – 4114Combined sources
Turni44 – 463Combined sources
Helixi51 – 6717Combined sources
Helixi70 – 789Combined sources
Helixi81 – 899Combined sources
Helixi94 – 1007Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CTWNMR-A5-100[»]
ProteinModelPortaliP60904.
SMRiP60904. Positions 5-100.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60904.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 8270JPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi118 – 12811Poly-CysAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000231969.
HOVERGENiHBG005414.
InParanoidiP60904.
KOiK09525.
OMAiCCCGRCK.
OrthoDBiEOG7WHHBD.
PhylomeDBiP60904.
TreeFamiTF105164.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60904-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADQRQRSLS TSGESLYHVL GLDKNATSDD IKKSYRKLAL KYHPDKNPDN
60 70 80 90 100
PEAADKFKEI NNAHAILTDA TKRNIYDKYG SLGLYVAEQF GEENVNTYFV
110 120 130 140 150
LSSWWAKALF VVCGLLTCCY CCCCLCCCFN CCCGKCKPKA PEGEETEFYV
160 170 180 190
SPEDLEAQLQ SDEREATDTP IVIQPASATE TTQLTADSHP SYHTDGFN
Length:198
Mass (Da):22,101
Last modified:April 13, 2004 - v1
Checksum:i52F98261FBAD978F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032115 mRNA. Translation: AAB87080.1.
AK029006 mRNA. Translation: BAC26236.1.
AK032373 mRNA. Translation: BAC27841.1.
CCDSiCCDS17215.1.
RefSeqiNP_001258513.1. NM_001271584.1.
NP_001258514.1. NM_001271585.1.
NP_058055.1. NM_016775.3.
UniGeneiMm.140761.
Mm.391807.
Mm.491282.

Genome annotation databases

EnsembliENSMUST00000072334; ENSMUSP00000072175; ENSMUSG00000000826.
ENSMUST00000108796; ENSMUSP00000104424; ENSMUSG00000000826.
ENSMUST00000108797; ENSMUSP00000104425; ENSMUSG00000000826.
GeneIDi13002.
KEGGimmu:13002.
UCSCiuc008omp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032115 mRNA. Translation: AAB87080.1 .
AK029006 mRNA. Translation: BAC26236.1 .
AK032373 mRNA. Translation: BAC27841.1 .
CCDSi CCDS17215.1.
RefSeqi NP_001258513.1. NM_001271584.1.
NP_001258514.1. NM_001271585.1.
NP_058055.1. NM_016775.3.
UniGenei Mm.140761.
Mm.391807.
Mm.491282.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CTW NMR - A 5-100 [» ]
ProteinModelPortali P60904.
SMRi P60904. Positions 5-100.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198948. 5 interactions.
IntActi P60904. 2 interactions.
MINTi MINT-4093239.
STRINGi 10090.ENSMUSP00000104426.

PTM databases

PhosphoSitei P60904.

Proteomic databases

MaxQBi P60904.
PaxDbi P60904.
PRIDEi P60904.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072334 ; ENSMUSP00000072175 ; ENSMUSG00000000826 .
ENSMUST00000108796 ; ENSMUSP00000104424 ; ENSMUSG00000000826 .
ENSMUST00000108797 ; ENSMUSP00000104425 ; ENSMUSG00000000826 .
GeneIDi 13002.
KEGGi mmu:13002.
UCSCi uc008omp.1. mouse.

Organism-specific databases

CTDi 80331.
MGIi MGI:892995. Dnajc5.

Phylogenomic databases

eggNOGi COG0484.
GeneTreei ENSGT00760000118947.
HOGENOMi HOG000231969.
HOVERGENi HBG005414.
InParanoidi P60904.
KOi K09525.
OMAi CCCGRCK.
OrthoDBi EOG7WHHBD.
PhylomeDBi P60904.
TreeFami TF105164.

Enzyme and pathway databases

Reactomei REACT_245631. GABA synthesis, release, reuptake and degradation.

Miscellaneous databases

EvolutionaryTracei P60904.
NextBioi 282820.
PROi P60904.
SOURCEi Search...

Gene expression databases

Bgeei P60904.
CleanExi MM_DNAJC5.
ExpressionAtlasi P60904. baseline and differential.
Genevestigatori P60904.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
PROSITEi PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Qin N., Lin T., Birnbaumer L.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb and Skin.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 8-24 AND 42-72, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells."
    Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J.
    Biochim. Biophys. Acta 1773:109-119(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HSC70 AND SGTA, SUBCELLULAR LOCATION, PALMITOYLATION, MUTAGENESIS OF CYS-113; CYS-118; CYS-121; PHE-129 AND LYS-135.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  9. "Solution structure of J-domain from mouse DnaJ subfamily C member 5."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 5-100.

Entry informationi

Entry nameiDNJC5_MOUSE
AccessioniPrimary (citable) accession number: P60904
Secondary accession number(s): P54101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3