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Protein

DnaJ homolog subfamily C member 5

Gene

Dnajc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of neuron apoptotic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-888590. GABA synthesis, release, reuptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 5Curated
Alternative name(s):
Cysteine string proteinBy similarity
Short name:
CSPBy similarity
Gene namesi
Name:Dnajc5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:892995. Dnajc5.

Subcellular locationi

  • Membrane 1 Publication; Lipid-anchor 1 Publication
  • Melanosome By similarity
  • Cell membrane By similarity

  • Note: Colocalizes with insulin granules, when overexpressed in a islet cell line.1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi113C → V: No change in subcellular location; when associated with G-118 and F-121. 1 Publication1
Mutagenesisi118C → G: No change in subcellular location; when associated with V-113 and F-121. 1 Publication1
Mutagenesisi121C → F: No change in subcellular location; when associated with V-113 and G-118. 1 Publication1
Mutagenesisi129F → C: No change in subcellular location; when associated with H-135. 1 Publication1
Mutagenesisi135K → H: No change in subcellular location; when associated with C-129. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710531 – 198DnaJ homolog subfamily C member 5Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei10PhosphoserineCombined sources1
Modified residuei12PhosphoserineBy similarity1
Modified residuei15PhosphoserineCombined sources1
Modified residuei17PhosphotyrosineBy similarity1
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei151PhosphoserineCombined sources1

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif. Palmitoylation is not required for membrane association.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP60904.
MaxQBiP60904.
PaxDbiP60904.
PeptideAtlasiP60904.
PRIDEiP60904.

PTM databases

iPTMnetiP60904.
PhosphoSitePlusiP60904.
SwissPalmiP60904.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000826.
CleanExiMM_DNAJC5.
ExpressionAtlasiP60904. baseline and differential.
GenevisibleiP60904. MM.

Interactioni

Subunit structurei

Homodimer (Probable). Interacts with the chaperone complex consisting of HSC70 and SGTA (PubMed:17034881). Interacts with ZDHHC13 (via ANK repeats) (PubMed:25253725, PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:25253725, PubMed:26198635).Curated3 Publications

Protein-protein interaction databases

BioGridi198948. 5 interactors.
IntActiP60904. 2 interactors.
MINTiMINT-4093239.
STRINGi10090.ENSMUSP00000072175.

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 20Combined sources5
Helixi28 – 41Combined sources14
Turni44 – 46Combined sources3
Helixi51 – 67Combined sources17
Helixi70 – 78Combined sources9
Helixi81 – 89Combined sources9
Helixi94 – 100Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CTWNMR-A5-100[»]
ProteinModelPortaliP60904.
SMRiP60904.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60904.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 82JPROSITE-ProRule annotationAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 128Poly-CysAdd BLAST11

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0716. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000231969.
HOVERGENiHBG005414.
InParanoidiP60904.
KOiK09525.
OMAiCGRCKPR.
OrthoDBiEOG091G0QJP.
PhylomeDBiP60904.
TreeFamiTF105164.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQRQRSLS TSGESLYHVL GLDKNATSDD IKKSYRKLAL KYHPDKNPDN
60 70 80 90 100
PEAADKFKEI NNAHAILTDA TKRNIYDKYG SLGLYVAEQF GEENVNTYFV
110 120 130 140 150
LSSWWAKALF VVCGLLTCCY CCCCLCCCFN CCCGKCKPKA PEGEETEFYV
160 170 180 190
SPEDLEAQLQ SDEREATDTP IVIQPASATE TTQLTADSHP SYHTDGFN
Length:198
Mass (Da):22,101
Last modified:April 13, 2004 - v1
Checksum:i52F98261FBAD978F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032115 mRNA. Translation: AAB87080.1.
AK029006 mRNA. Translation: BAC26236.1.
AK032373 mRNA. Translation: BAC27841.1.
CCDSiCCDS17215.1.
RefSeqiNP_001258513.1. NM_001271584.1.
NP_001258514.1. NM_001271585.1.
NP_058055.1. NM_016775.3.
XP_011238225.1. XM_011239923.2.
UniGeneiMm.140761.
Mm.391807.
Mm.491282.

Genome annotation databases

EnsembliENSMUST00000072334; ENSMUSP00000072175; ENSMUSG00000000826.
ENSMUST00000108796; ENSMUSP00000104424; ENSMUSG00000000826.
ENSMUST00000108797; ENSMUSP00000104425; ENSMUSG00000000826.
GeneIDi13002.
KEGGimmu:13002.
UCSCiuc008omp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032115 mRNA. Translation: AAB87080.1.
AK029006 mRNA. Translation: BAC26236.1.
AK032373 mRNA. Translation: BAC27841.1.
CCDSiCCDS17215.1.
RefSeqiNP_001258513.1. NM_001271584.1.
NP_001258514.1. NM_001271585.1.
NP_058055.1. NM_016775.3.
XP_011238225.1. XM_011239923.2.
UniGeneiMm.140761.
Mm.391807.
Mm.491282.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CTWNMR-A5-100[»]
ProteinModelPortaliP60904.
SMRiP60904.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198948. 5 interactors.
IntActiP60904. 2 interactors.
MINTiMINT-4093239.
STRINGi10090.ENSMUSP00000072175.

PTM databases

iPTMnetiP60904.
PhosphoSitePlusiP60904.
SwissPalmiP60904.

Proteomic databases

EPDiP60904.
MaxQBiP60904.
PaxDbiP60904.
PeptideAtlasiP60904.
PRIDEiP60904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072334; ENSMUSP00000072175; ENSMUSG00000000826.
ENSMUST00000108796; ENSMUSP00000104424; ENSMUSG00000000826.
ENSMUST00000108797; ENSMUSP00000104425; ENSMUSG00000000826.
GeneIDi13002.
KEGGimmu:13002.
UCSCiuc008omp.2. mouse.

Organism-specific databases

CTDi80331.
MGIiMGI:892995. Dnajc5.

Phylogenomic databases

eggNOGiKOG0716. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000231969.
HOVERGENiHBG005414.
InParanoidiP60904.
KOiK09525.
OMAiCGRCKPR.
OrthoDBiEOG091G0QJP.
PhylomeDBiP60904.
TreeFamiTF105164.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-888590. GABA synthesis, release, reuptake and degradation.

Miscellaneous databases

EvolutionaryTraceiP60904.
PROiP60904.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000826.
CleanExiMM_DNAJC5.
ExpressionAtlasiP60904. baseline and differential.
GenevisibleiP60904. MM.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJC5_MOUSE
AccessioniPrimary (citable) accession number: P60904
Secondary accession number(s): P54101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.