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P60903

- S10AA_HUMAN

UniProt

P60903 - S10AA_HUMAN

Protein

Protein S100-A10

Gene

S100A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. ion channel binding Source: UniProt
    3. protein binding Source: IntAct
    4. protein homodimerization activity Source: UniProt

    GO - Biological processi

    1. cellular response to acid chemical Source: Ensembl
    2. establishment of protein localization to plasma membrane Source: UniProt
    3. membrane budding Source: UniProt
    4. membrane raft assembly Source: UniProt
    5. positive regulation of binding Source: Ensembl
    6. positive regulation of focal adhesion assembly Source: UniProt
    7. positive regulation of Rac GTPase activity Source: UniProt
    8. positive regulation of stress fiber assembly Source: UniProt
    9. positive regulation of substrate adhesion-dependent cell spreading Source: UniProt
    10. protein heterotetramerization Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A10
    Alternative name(s):
    Calpactin I light chain
    Calpactin-1 light chain
    Cellular ligand of annexin II
    S100 calcium-binding protein A10
    p10 protein
    p11
    Gene namesi
    Name:S100A10
    Synonyms:ANX2LG, CAL1L, CLP11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10487. S100A10.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. extrinsic component of plasma membrane Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34899.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 9796Protein S100-A10PRO_0000144002Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231N6-acetyllysine1 Publication
    Modified residuei28 – 281N6-acetyllysine1 Publication
    Modified residuei37 – 371N6-acetyllysine1 Publication
    Modified residuei54 – 541N6-acetyllysine1 Publication
    Modified residuei57 – 571N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP60903.
    PaxDbiP60903.
    PeptideAtlasiP60903.
    PRIDEiP60903.

    2D gel databases

    SWISS-2DPAGEP60903.

    PTM databases

    PhosphoSiteiP60903.

    Expressioni

    Gene expression databases

    ArrayExpressiP60903.
    BgeeiP60903.
    CleanExiHS_S100A10.
    GenevestigatoriP60903.

    Organism-specific databases

    HPAiCAB025484.
    HPA003340.

    Interactioni

    Subunit structurei

    Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HLTFQ145272EBI-717048,EBI-1045161

    Protein-protein interaction databases

    BioGridi112189. 35 interactions.
    IntActiP60903. 7 interactions.
    MINTiMINT-1178035.
    STRINGi9606.ENSP00000357799.

    Structurei

    Secondary structure

    1
    97
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 2017
    Helixi21 – 233
    Beta strandi24 – 263
    Helixi28 – 3811
    Helixi42 – 454
    Helixi51 – 577
    Beta strandi59 – 613
    Beta strandi63 – 653
    Helixi69 – 9022

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A4PX-ray2.25A/B2-97[»]
    1BT6X-ray2.40A/B2-97[»]
    4DRWX-ray3.50A/B/C/D1-93[»]
    4FTGX-ray2.51A/B2-97[»]
    4HREX-ray2.79E/F/I/J2-97[»]
    4HRGX-ray2.00A/B1-93[»]
    4HRHX-ray3.00A/B1-93[»]
    ProteinModelPortaliP60903.
    SMRiP60903. Positions 2-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP60903.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 7112Ancestral calcium siteAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated

    Phylogenomic databases

    eggNOGiNOG26977.
    HOVERGENiHBG001479.
    InParanoidiP60903.
    KOiK17274.
    OMAiAMETLMF.
    OrthoDBiEOG7R833W.
    PhylomeDBiP60903.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR028476. S100-A10.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view]
    PANTHERiPTHR11639:SF56. PTHR11639:SF56. 1 hit.
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60903-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL   50
    AVDKIMKDLD QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK 97
    Length:97
    Mass (Da):11,203
    Last modified:January 23, 2007 - v2
    Checksum:i3E8E03A6E7DD7A8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81457 mRNA. Translation: AAA58404.1.
    M38591 mRNA. Translation: AAA58426.1.
    M77483 Genomic DNA. No translation available.
    AK291073 mRNA. Translation: BAF83762.1.
    AL450992 Genomic DNA. Translation: CAI12164.1.
    BC015973 mRNA. Translation: AAH15973.1.
    BC105786 mRNA. Translation: AAI05787.1.
    CCDSiCCDS1008.1.
    PIRiJC1139.
    RefSeqiNP_002957.1. NM_002966.2.
    UniGeneiHs.143873.

    Genome annotation databases

    EnsembliENST00000368809; ENSP00000357799; ENSG00000197747.
    ENST00000368811; ENSP00000357801; ENSG00000197747.
    GeneIDi6281.
    KEGGihsa:6281.
    UCSCiuc001ezl.3. human.

    Polymorphism databases

    DMDMi46397706.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81457 mRNA. Translation: AAA58404.1 .
    M38591 mRNA. Translation: AAA58426.1 .
    M77483 Genomic DNA. No translation available.
    AK291073 mRNA. Translation: BAF83762.1 .
    AL450992 Genomic DNA. Translation: CAI12164.1 .
    BC015973 mRNA. Translation: AAH15973.1 .
    BC105786 mRNA. Translation: AAI05787.1 .
    CCDSi CCDS1008.1.
    PIRi JC1139.
    RefSeqi NP_002957.1. NM_002966.2.
    UniGenei Hs.143873.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A4P X-ray 2.25 A/B 2-97 [» ]
    1BT6 X-ray 2.40 A/B 2-97 [» ]
    4DRW X-ray 3.50 A/B/C/D 1-93 [» ]
    4FTG X-ray 2.51 A/B 2-97 [» ]
    4HRE X-ray 2.79 E/F/I/J 2-97 [» ]
    4HRG X-ray 2.00 A/B 1-93 [» ]
    4HRH X-ray 3.00 A/B 1-93 [» ]
    ProteinModelPortali P60903.
    SMRi P60903. Positions 2-93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112189. 35 interactions.
    IntActi P60903. 7 interactions.
    MINTi MINT-1178035.
    STRINGi 9606.ENSP00000357799.

    Chemistry

    BindingDBi P60903.
    ChEMBLi CHEMBL2111435.

    PTM databases

    PhosphoSitei P60903.

    Polymorphism databases

    DMDMi 46397706.

    2D gel databases

    SWISS-2DPAGE P60903.

    Proteomic databases

    MaxQBi P60903.
    PaxDbi P60903.
    PeptideAtlasi P60903.
    PRIDEi P60903.

    Protocols and materials databases

    DNASUi 6281.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368809 ; ENSP00000357799 ; ENSG00000197747 .
    ENST00000368811 ; ENSP00000357801 ; ENSG00000197747 .
    GeneIDi 6281.
    KEGGi hsa:6281.
    UCSCi uc001ezl.3. human.

    Organism-specific databases

    CTDi 6281.
    GeneCardsi GC01M151955.
    HGNCi HGNC:10487. S100A10.
    HPAi CAB025484.
    HPA003340.
    MIMi 114085. gene.
    neXtProti NX_P60903.
    PharmGKBi PA34899.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26977.
    HOVERGENi HBG001479.
    InParanoidi P60903.
    KOi K17274.
    OMAi AMETLMF.
    OrthoDBi EOG7R833W.
    PhylomeDBi P60903.
    TreeFami TF332727.

    Miscellaneous databases

    ChiTaRSi S100A10. human.
    EvolutionaryTracei P60903.
    GeneWikii S100A10.
    GenomeRNAii 6281.
    NextBioi 24381.
    PROi P60903.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P60903.
    Bgeei P60903.
    CleanExi HS_S100A10.
    Genevestigatori P60903.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR028476. S100-A10.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view ]
    PANTHERi PTHR11639:SF56. PTHR11639:SF56. 1 hit.
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of human, chicken, and Xenopus laevis p11, a cellular ligand of the Src-kinase substrate, annexin II."
      Kube E., Weber K., Gerke V.
      Gene 102:255-259(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family."
      Harder T., Kube E., Gerke V.
      Gene 113:269-274(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "cDNA sequence of human p11 calpactin I light chain."
      Dooley T.P., Weiland K.L., Simon M.
      Genomics 13:866-868(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Keratinocyte.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23; LYS-28; LYS-37; LYS-54 AND LYS-57, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "The crystal structure of a complex of p11 with the annexin II N-terminal peptide."
      Rety S., Sopkova J., Renouard M., Osterloh D., Gerke V., Tabaries S., Russo-Marie F., Lewit-Bentley A.
      Nat. Struct. Biol. 6:89-95(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).

    Entry informationi

    Entry nameiS10AA_HUMAN
    AccessioniPrimary (citable) accession number: P60903
    Secondary accession number(s): A8K4V8, P08206, Q5T1C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3