Proteasome subunit alpha type-6 - Rattus norvegicus (Rat)

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P60901 (PSA6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Proteasome subunit alpha type-6
EC=3.4.25.1

Alternative name(s):
Macropain iota chain
Multicatalytic endopeptidase complex iota chain
Proteasome iota chain

Gene names

Name:

Psma6

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Catalytic activity	Cleavage of peptide bonds with very broad specificity.
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.
Subcellular location	Cytoplasm. Nucleus.
Sequence similarities	Belongs to the peptidase T1A family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus Proteasome
Molecular function	Hydrolase Protease Threonine protease
PTM	Acetylation Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of NF-kappaB transcription factor activity Inferred from sequence or structural similarity. Source: BHF-UCL ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	nuclear matrix Inferred from sequence or structural similarity. Source: BHF-UCL polysome Inferred from sequence or structural similarity. Source: BHF-UCL proteasome core complex, alpha-subunit complex Inferred from sequence or structural similarity. Source: BHF-UCL sarcomere Inferred from direct assay. Source: BHF-UCL
Molecular function	RNA binding Inferred from sequence or structural similarity. Source: BHF-UCL threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 246

246

Proteasome subunit alpha type-6

PRO_0000124132

Amino acid modifications

Modified residue

102

N6-acetyllysine By similarity

Modified residue

104

N6-acetyllysine By similarity

Modified residue

159

Phosphotyrosine By similarity

Modified residue

160

Phosphotyrosine By similarity

Cross-link

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P60901 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: 94D1FD3C0A7CC72A
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FASTA

246

27,399

        10         20         30         40         50         60 
MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQGGLTSV AVRGKDCAVI VTQKKVPDKL 

        70         80         90        100        110        120 
LDSSTVTHLF KITENIGCVM TGMTADSRSQ VQRARYEAAN WKYKYGYEIP VDMLCKRIAD 

       130        140        150        160        170        180 
ISQVYTQNAE MRPLGCCMIL IGIDEEQGPQ VYKCDPAGYY CGFKATAAGV KQTESTSFLE 

       190        200        210        220        230        240 
KKVKKKFDWT FEQTVETAIT CLSTVLSIDF KPSEIEVGVV TVENPKFRIL TEAEIDAHLV 


ALAERD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of cDNAs for rat proteasomes: deduced primary structures of four other subunits." Tamura T., Shimbara N., Aki M., Ishida N., Bey F., Scherrer K., Tanaka K., Ichihara A. J. Biochem. 112:530-534(1992) [PubMed: 1491007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	Lubec G., Afjehi-Sadat L. Submitted (NOV-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 12-21; 60-71; 154-164 AND 229-246, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Spinal cord.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10755 mRNA. Translation: BAA01587.1. BC062232 mRNA. Translation: AAH62232.1.
IPI	IPI00191501.
PIR	JX0230.
RefSeq	NP_058979.1. NM_017283.2.
UniGene	Rn.107278.
3D structure databases
ProteinModelPortal	P60901.
SMR	P60901. Positions 2-245.
ModBase	Search...
Protein-protein interaction databases
IntAct	P60901. 1 interaction.
STRING	P60901.
Protein family/group databases
MEROPS	T01.971.
PTM databases
PhosphoSite	P60901.
2D gel databases
World-2DPAGE	0004:P60901.
Proteomic databases
PRIDE	P60901.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000009666; ENSRNOP00000009666; ENSRNOG00000007114.
GeneID	29673.
KEGG	rno:29673.
UCSC	NM_017283. rat.
Organism-specific databases
CTD	5687.
RGD	61849. Psma6.
Phylogenomic databases
eggNOG	roNOG06143.
GeneTree	ENSGT00550000074807.
HOVERGEN	HBG107363.
InParanoid	P60901.
OMA	GKDCAVV.
OrthoDB	EOG4BP1CH.
PhylomeDB	P60901.
Gene expression databases
ArrayExpress	P60901.
Genevestigator	P60901.
GermOnline	ENSRNOG00000007114. Rattus norvegicus.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
KO	K02730.
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMART	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A_1. 1 hit. PS51475. PROTEASOME_A_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610003.

Entry information

Entry name

PSA6_RAT

Accession

Primary (citable) accession number: P60901
Secondary accession number(s): P34062

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	April 13, 2004
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents