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Protein

26S proteasome complex subunit DSS1

Gene

Shfm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Prevents accumulation of R-loops independently of the RAD51 homologous recombination function (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.By similarity

GO - Biological processi

  • double-strand break repair via homologous recombination Source: MGI
  • mRNA export from nucleus Source: InterPro
  • proteasome assembly Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome complex subunit DSS1
Alternative name(s):
Deleted in split hand/split foot protein 1 homolog
Split hand/foot deleted protein 1 homolog
Split hand/foot malformation type 1 protein homolog
Gene namesi
Name:Shfm1
Synonyms:Dss1, Shfdg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:109238. Shfm1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707026S proteasome complex subunit DSS1PRO_0000122962Add
BLAST

Proteomic databases

PaxDbiP60897.

PTM databases

PhosphoSiteiP60897.

Expressioni

Gene expression databases

BgeeiP60897.
ExpressionAtlasiP60897. baseline and differential.
GenevisibleiP60897. MM.

Interactioni

Subunit structurei

Part of the 26S proteasome (By similarity). Belongs to the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. Interacts with the C-terminal of BRCA2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi203219. 1 interaction.
STRINGi10090.ENSMUSP00000040741.

Structurei

3D structure databases

ProteinModelPortaliP60897.
SMRiP60897. Positions 6-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 218Asp/Glu-rich (highly acidic)
Compositional biasi31 – 355Asp/Glu-rich (highly acidic)
Compositional biasi40 – 5112Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Belongs to the DSS1/SEM1 family.Curated

Phylogenomic databases

eggNOGiKOG4764. Eukaryota.
ENOG41126I3. LUCA.
HOVERGENiHBG005536.
InParanoidiP60897.
KOiK10881.
OMAiINEEWKE.
OrthoDBiEOG7HF1NR.
PhylomeDBiP60897.
TreeFamiTF314699.

Family and domain databases

InterProiIPR007834. DSS1_SEM1.
[Graphical view]
PfamiPF05160. DSS1_SEM1. 1 hit.
[Graphical view]
SMARTiSM01385. DSS1_SEM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKKQPVDL GLLEEDDEFE EFPAEDWAGL DEDEDAHVWE DNWDDDNVED
60 70
DFSNQLRAEL EKHGYKMETS
Length:70
Mass (Da):8,278
Last modified:April 13, 2004 - v1
Checksum:i0E0F58D2F3D9F723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41626 mRNA. Translation: AAA91180.1.
BC023490 mRNA. Translation: AAH23490.1.
BC058117 mRNA. Translation: AAH58117.1.
CCDSiCCDS39422.1.
RefSeqiNP_033195.1. NM_009169.2.
UniGeneiMm.2469.

Genome annotation databases

EnsembliENSMUST00000041111; ENSMUSP00000040741; ENSMUSG00000042541.
GeneIDi20422.
KEGGimmu:20422.
UCSCiuc009aws.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41626 mRNA. Translation: AAA91180.1.
BC023490 mRNA. Translation: AAH23490.1.
BC058117 mRNA. Translation: AAH58117.1.
CCDSiCCDS39422.1.
RefSeqiNP_033195.1. NM_009169.2.
UniGeneiMm.2469.

3D structure databases

ProteinModelPortaliP60897.
SMRiP60897. Positions 6-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203219. 1 interaction.
STRINGi10090.ENSMUSP00000040741.

PTM databases

PhosphoSiteiP60897.

Proteomic databases

PaxDbiP60897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041111; ENSMUSP00000040741; ENSMUSG00000042541.
GeneIDi20422.
KEGGimmu:20422.
UCSCiuc009aws.1. mouse.

Organism-specific databases

CTDi7979.
MGIiMGI:109238. Shfm1.

Phylogenomic databases

eggNOGiKOG4764. Eukaryota.
ENOG41126I3. LUCA.
HOVERGENiHBG005536.
InParanoidiP60897.
KOiK10881.
OMAiINEEWKE.
OrthoDBiEOG7HF1NR.
PhylomeDBiP60897.
TreeFamiTF314699.

Miscellaneous databases

PROiP60897.
SOURCEiSearch...

Gene expression databases

BgeeiP60897.
ExpressionAtlasiP60897. baseline and differential.
GenevisibleiP60897. MM.

Family and domain databases

InterProiIPR007834. DSS1_SEM1.
[Graphical view]
PfamiPF05160. DSS1_SEM1. 1 hit.
[Graphical view]
SMARTiSM01385. DSS1_SEM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development."
    Crackower M.A., Scherer S.W., Rommens J.M., Hui C.-C., Poorkaj P., Soder S., Cobben J.M., Hudgins L., Evans J.P., Tsui L.-C.
    Hum. Mol. Genet. 5:571-579(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiDSS1_MOUSE
AccessioniPrimary (citable) accession number: P60897
Secondary accession number(s): Q13437, Q61067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.