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Protein

Probable G-protein coupled receptor 85

Gene

Gpr85

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 85
Alternative name(s):
PKrCx1
Super conserved receptor expressed in brain 2
Gene namesi
Name:Gpr85
Synonyms:Sreb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi71011. Gpr85.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 57CytoplasmicSequence analysisAdd BLAST11
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 96ExtracellularSequence analysisAdd BLAST18
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 137CytoplasmicSequence analysisAdd BLAST20
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 188ExtracellularSequence analysisAdd BLAST30
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 286CytoplasmicSequence analysisAdd BLAST77
Transmembranei287 – 307Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini308 – 313ExtracellularSequence analysis6
Transmembranei314 – 334Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini335 – 370CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695931 – 370Probable G-protein coupled receptor 85Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60895.

PTM databases

PhosphoSitePlusiP60895.

Expressioni

Gene expression databases

BgeeiENSRNOG00000024636.
GenevisibleiP60895. RN.

Interactioni

Subunit structurei

Interacts with DLG4 AND DLG3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031780.

Structurei

3D structure databases

ProteinModelPortaliP60895.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60895.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG091G0AOZ.
PhylomeDBiP60895.
TreeFamiTF331163.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT
60 70 80 90 100
LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL
110 120 130 140 150
GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV
160 170 180 190 200
AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL
210 220 230 240 250
VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG
260 270 280 290 300
PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP
310 320 330 340 350
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF
360 370
STTLLYCRKS RLPREPYCVI
Length:370
Mass (Da):41,995
Last modified:April 13, 2004 - v1
Checksum:i7B67A39F6166AAEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040803 mRNA. Translation: BAA96649.1.
AF203907 mRNA. Translation: AAG42284.1.
BC087727 mRNA. Translation: AAH87727.1.
RefSeqiNP_071590.1. NM_022254.3.
XP_006236186.1. XM_006236124.3.
XP_006236188.1. XM_006236126.3.
XP_017448349.1. XM_017592860.1.
XP_017448350.1. XM_017592861.1.
UniGeneiRn.53985.

Genome annotation databases

EnsembliENSRNOT00000039005; ENSRNOP00000031780; ENSRNOG00000024636.
GeneIDi64020.
KEGGirno:64020.
UCSCiRGD:71011. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040803 mRNA. Translation: BAA96649.1.
AF203907 mRNA. Translation: AAG42284.1.
BC087727 mRNA. Translation: AAH87727.1.
RefSeqiNP_071590.1. NM_022254.3.
XP_006236186.1. XM_006236124.3.
XP_006236188.1. XM_006236126.3.
XP_017448349.1. XM_017592860.1.
XP_017448350.1. XM_017592861.1.
UniGeneiRn.53985.

3D structure databases

ProteinModelPortaliP60895.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031780.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP60895.

Proteomic databases

PaxDbiP60895.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039005; ENSRNOP00000031780; ENSRNOG00000024636.
GeneIDi64020.
KEGGirno:64020.
UCSCiRGD:71011. rat.

Organism-specific databases

CTDi54329.
RGDi71011. Gpr85.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60895.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG091G0AOZ.
PhylomeDBiP60895.
TreeFamiTF331163.

Miscellaneous databases

PROiP60895.

Gene expression databases

BgeeiENSRNOG00000024636.
GenevisibleiP60895. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR85_RAT
AccessioniPrimary (citable) accession number: P60895
Secondary accession number(s): Q9JHI6, Q9NPD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.