ID GPR85_MOUSE Reviewed; 370 AA. AC P60894; Q9JHI6; Q9NPD1; DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot. DT 13-APR-2004, sequence version 1. DT 24-JAN-2024, entry version 141. DE RecName: Full=Probable G-protein coupled receptor 85; DE AltName: Full=Super conserved receptor expressed in brain 2; GN Name=Gpr85; Synonyms=Sreb2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC STRAIN=CD-1; TISSUE=Fetal brain; RX PubMed=10978537; DOI=10.1016/s0167-4781(00)00182-2; RA Hellebrand S., Schaller H.C., Wittenberger T.; RT "The brain-specific G-protein coupled receptor GPR85 with identical protein RT sequence in man and mouse maps to human chromosome 7q31."; RL Biochim. Biophys. Acta 1493:269-272(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Orphan receptor. CC -!- SUBUNIT: Interacts with DLG4 and DLG3. {ECO:0000250|UniProtKB:P60893}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane CC protein {ECO:0000250}. Endoplasmic reticulum CC {ECO:0000250|UniProtKB:P60893}. CC -!- TISSUE SPECIFICITY: Exclusively expressed in brain. CC {ECO:0000269|PubMed:10978537}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF254416; AAF79959.1; -; mRNA. DR EMBL; BC026975; AAH26975.1; -; mRNA. DR EMBL; BC065154; AAH65154.1; -; mRNA. DR CCDS; CCDS19916.1; -. DR RefSeq; NP_001317595.1; NM_001330666.1. DR RefSeq; NP_001317596.1; NM_001330667.1. DR RefSeq; NP_659503.1; NM_145066.5. DR RefSeq; XP_006505221.1; XM_006505158.3. DR RefSeq; XP_011239381.1; XM_011241079.2. DR RefSeq; XP_017177194.1; XM_017321705.1. DR AlphaFoldDB; P60894; -. DR SMR; P60894; -. DR BioGRID; 211078; 1. DR STRING; 10090.ENSMUSP00000053837; -. DR GlyCosmos; P60894; 3 sites, No reported glycans. DR GlyGen; P60894; 3 sites. DR PhosphoSitePlus; P60894; -. DR PaxDb; 10090-ENSMUSP00000053837; -. DR Antibodypedia; 17381; 182 antibodies from 26 providers. DR DNASU; 64450; -. DR Ensembl; ENSMUST00000060442.14; ENSMUSP00000053837.8; ENSMUSG00000048216.14. DR Ensembl; ENSMUST00000115491.2; ENSMUSP00000111154.2; ENSMUSG00000048216.14. DR Ensembl; ENSMUST00000115492.2; ENSMUSP00000111155.2; ENSMUSG00000048216.14. DR GeneID; 64450; -. DR KEGG; mmu:64450; -. DR UCSC; uc009ayr.1; mouse. DR AGR; MGI:1927851; -. DR CTD; 54329; -. DR MGI; MGI:1927851; Gpr85. DR VEuPathDB; HostDB:ENSMUSG00000048216; -. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT00890000139436; -. DR HOGENOM; CLU_055518_0_0_1; -. DR InParanoid; P60894; -. DR OMA; WCPYLVA; -. DR OrthoDB; 2962814at2759; -. DR PhylomeDB; P60894; -. DR TreeFam; TF331163; -. DR BioGRID-ORCS; 64450; 4 hits in 77 CRISPR screens. DR ChiTaRS; Gpr85; mouse. DR PRO; PR:P60894; -. DR Proteomes; UP000000589; Chromosome 6. DR RNAct; P60894; Protein. DR Bgee; ENSMUSG00000048216; Expressed in barrel cortex and 212 other cell types or tissues. DR ExpressionAtlas; P60894; baseline and differential. DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; ISA:MGI. DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central. DR CDD; cd15218; 7tmA_SREB2_GPR85; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR19268; G PROTEIN-COUPLED RECEPTOR; 1. DR PANTHER; PTHR19268:SF7; G-PROTEIN COUPLED RECEPTOR 85-RELATED; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; P60894; MM. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; Endoplasmic reticulum; KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Reference proteome; Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..370 FT /note="Probable G-protein coupled receptor 85" FT /id="PRO_0000069592" FT TOPO_DOM 1..25 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 26..46 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 47..57 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 58..78 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 79..96 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 97..117 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 118..137 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 138..158 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 159..188 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 189..209 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 210..286 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 287..307 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 308..313 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 314..334 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 335..370 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 3 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 83 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 182 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 94..172 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 370 AA; 41995 MW; 7B67A39F6166AAEB CRC64; MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF STTLLYCRKS RLPREPYCVI //