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P60894

- GPR85_MOUSE

UniProt

P60894 - GPR85_MOUSE

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Protein

Probable G-protein coupled receptor 85

Gene

Gpr85

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. receptor signaling protein activity Source: MGI

GO - Biological processi

  1. intracellular signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 85
Alternative name(s):
Super conserved receptor expressed in brain 2
Gene namesi
Name:Gpr85
Synonyms:Sreb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1927851. Gpr85.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 5711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini118 – 13720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 18830ExtracellularSequence AnalysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini210 – 28677CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini308 – 3136ExtracellularSequence Analysis
Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini335 – 37036CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Probable G-protein coupled receptor 85PRO_0000069592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP60894.

PTM databases

PhosphoSiteiP60894.

Expressioni

Tissue specificityi

Exclusively expressed in brain.1 Publication

Gene expression databases

BgeeiP60894.
CleanExiMM_GPR85.
ExpressionAtlasiP60894. baseline and differential.
GenevestigatoriP60894.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996893.

Structurei

3D structure databases

ProteinModelPortaliP60894.
SMRiP60894. Positions 15-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237432.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60894.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG73NG3K.
PhylomeDBiP60894.
TreeFamiTF331163.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60894-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT
60 70 80 90 100
LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL
110 120 130 140 150
GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV
160 170 180 190 200
AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL
210 220 230 240 250
VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG
260 270 280 290 300
PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP
310 320 330 340 350
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF
360 370
STTLLYCRKS RLPREPYCVI
Length:370
Mass (Da):41,995
Last modified:April 13, 2004 - v1
Checksum:i7B67A39F6166AAEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254416 mRNA. Translation: AAF79959.1.
BC026975 mRNA. Translation: AAH26975.1.
BC065154 mRNA. Translation: AAH65154.1.
CCDSiCCDS19916.1.
RefSeqiNP_659503.1. NM_145066.4.
XP_006505221.1. XM_006505158.1.
UniGeneiMm.167625.
Mm.487258.

Genome annotation databases

EnsembliENSMUST00000060442; ENSMUSP00000053837; ENSMUSG00000048216.
ENSMUST00000115491; ENSMUSP00000111154; ENSMUSG00000048216.
ENSMUST00000115492; ENSMUSP00000111155; ENSMUSG00000048216.
GeneIDi64450.
KEGGimmu:64450.
UCSCiuc009ayr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254416 mRNA. Translation: AAF79959.1 .
BC026975 mRNA. Translation: AAH26975.1 .
BC065154 mRNA. Translation: AAH65154.1 .
CCDSi CCDS19916.1.
RefSeqi NP_659503.1. NM_145066.4.
XP_006505221.1. XM_006505158.1.
UniGenei Mm.167625.
Mm.487258.

3D structure databases

ProteinModelPortali P60894.
SMRi P60894. Positions 15-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996893.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P60894.

Proteomic databases

PRIDEi P60894.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060442 ; ENSMUSP00000053837 ; ENSMUSG00000048216 .
ENSMUST00000115491 ; ENSMUSP00000111154 ; ENSMUSG00000048216 .
ENSMUST00000115492 ; ENSMUSP00000111155 ; ENSMUSG00000048216 .
GeneIDi 64450.
KEGGi mmu:64450.
UCSCi uc009ayr.1. mouse.

Organism-specific databases

CTDi 54329.
MGIi MGI:1927851. Gpr85.

Phylogenomic databases

eggNOGi NOG237432.
HOGENOMi HOG000231471.
HOVERGENi HBG051805.
InParanoidi P60894.
KOi K04302.
OMAi SMANYSH.
OrthoDBi EOG73NG3K.
PhylomeDBi P60894.
TreeFami TF331163.

Miscellaneous databases

NextBioi 320089.
PROi P60894.
SOURCEi Search...

Gene expression databases

Bgeei P60894.
CleanExi MM_GPR85.
ExpressionAtlasi P60894. baseline and differential.
Genevestigatori P60894.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31."
    Hellebrand S., Schaller H.C., Wittenberger T.
    Biochim. Biophys. Acta 1493:269-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: CD-1.
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Eye.

Entry informationi

Entry nameiGPR85_MOUSE
AccessioniPrimary (citable) accession number: P60894
Secondary accession number(s): Q9JHI6, Q9NPD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3