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P60894 (GPR85_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 85
Alternative name(s):
Super conserved receptor expressed in brain 2
Gene names
Name:Gpr85
Synonyms:Sreb2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Exclusively expressed in brain. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Probable G-protein coupled receptor 85
PRO_0000069592

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 5711Cytoplasmic Potential
Transmembrane58 – 7821Helical; Name=2; Potential
Topological domain79 – 9618Extracellular Potential
Transmembrane97 – 11721Helical; Name=3; Potential
Topological domain118 – 13720Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=4; Potential
Topological domain159 – 18830Extracellular Potential
Transmembrane189 – 20921Helical; Name=5; Potential
Topological domain210 – 28677Cytoplasmic Potential
Transmembrane287 – 30721Helical; Name=6; Potential
Topological domain308 – 3136Extracellular Potential
Transmembrane314 – 33421Helical; Name=7; Potential
Topological domain335 – 37036Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 172 By similarity

Sequences

Sequence LengthMass (Da)Tools
P60894 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: 7B67A39F6166AAEB

FASTA37041,995
        10         20         30         40         50         60 
MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT LHRAPYYFLL 

        70         80         90        100        110        120 
DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL GVLSCFHTAF MLFCISVTRY 

       130        140        150        160        170        180 
LAIAHHRFYT KRLTFWTCLA VICMVWTLSV AMAFPPVLDV GTYSFIREED QCTFQHRSFR 

       190        200        210        220        230        240 
ANDSLGFMLL LALILLATQL VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA 

       250        260        270        280        290        300 
ANWLAGFGRG PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP 

       310        320        330        340        350        360 
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF STTLLYCRKS 

       370 
RLPREPYCVI

« Hide

References

« Hide 'large scale' references
[1]"The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31."
Hellebrand S., Schaller H.C., Wittenberger T.
Biochim. Biophys. Acta 1493:269-272(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: CD-1.
Tissue: Fetal brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain and Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF254416 mRNA. Translation: AAF79959.1.
BC026975 mRNA. Translation: AAH26975.1.
BC065154 mRNA. Translation: AAH65154.1.
IPIIPI00114420.
RefSeqNP_659503.1. NM_145066.4.
UniGeneMm.167625.
Mm.487258.

3D structure databases

ProteinModelPortalP60894.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4996893.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP60894.

Proteomic databases

PRIDEP60894.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000060442; ENSMUSP00000053837; ENSMUSG00000048216.
ENSMUST00000115491; ENSMUSP00000111154; ENSMUSG00000048216.
ENSMUST00000115492; ENSMUSP00000111155; ENSMUSG00000048216.
GeneID64450.
KEGGmmu:64450.
UCSCuc009ayr.1. mouse.

Organism-specific databases

CTD54329.
MGIMGI:1927851. Gpr85.

Phylogenomic databases

eggNOGNOG237432.
HOGENOMHOG000231471.
HOVERGENHBG051805.
InParanoidP60894.
KOK04302.
OMASMANYSH.
OrthoDBEOG4HQDJK.

Gene expression databases

ArrayExpressP60894.
BgeeP60894.
CleanExMM_GPR85.
GenevestigatorP60894.
GermOnlineENSMUSG00000048216. Mus musculus.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio320089.
SOURCESearch...

Entry information

Entry nameGPR85_MOUSE
AccessionPrimary (citable) accession number: P60894
Secondary accession number(s): Q9JHI6, Q9NPD1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 29, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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