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P60894

- GPR85_MOUSE

UniProt

P60894 - GPR85_MOUSE

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Protein

Probable G-protein coupled receptor 85

Gene
Gpr85, Sreb2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. receptor signaling protein activity Source: MGI

GO - Biological processi

  1. intracellular signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 85
Alternative name(s):
Super conserved receptor expressed in brain 2
Gene namesi
Name:Gpr85
Synonyms:Sreb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1927851. Gpr85.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini47 – 5711Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei58 – 7821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini79 – 9618Extracellular Reviewed predictionAdd
BLAST
Transmembranei97 – 11721Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini118 – 13720Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei138 – 15821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini159 – 18830Extracellular Reviewed predictionAdd
BLAST
Transmembranei189 – 20921Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini210 – 28677Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei287 – 30721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini308 – 3136Extracellular Reviewed prediction
Transmembranei314 – 33421Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini335 – 37036Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Probable G-protein coupled receptor 85PRO_0000069592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi94 ↔ 172 By similarity
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP60894.

PTM databases

PhosphoSiteiP60894.

Expressioni

Tissue specificityi

Exclusively expressed in brain.1 Publication

Gene expression databases

ArrayExpressiP60894.
BgeeiP60894.
CleanExiMM_GPR85.
GenevestigatoriP60894.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996893.

Structurei

3D structure databases

ProteinModelPortaliP60894.
SMRiP60894. Positions 15-354.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237432.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60894.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG73NG3K.
PhylomeDBiP60894.
TreeFamiTF331163.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60894-1 [UniParc]FASTAAdd to Basket

« Hide

MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT    50
LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL 100
GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV 150
AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL 200
VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG 250
PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP 300
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF 350
STTLLYCRKS RLPREPYCVI 370
Length:370
Mass (Da):41,995
Last modified:April 13, 2004 - v1
Checksum:i7B67A39F6166AAEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF254416 mRNA. Translation: AAF79959.1.
BC026975 mRNA. Translation: AAH26975.1.
BC065154 mRNA. Translation: AAH65154.1.
CCDSiCCDS19916.1.
RefSeqiNP_659503.1. NM_145066.4.
XP_006505221.1. XM_006505158.1.
UniGeneiMm.167625.
Mm.487258.

Genome annotation databases

EnsembliENSMUST00000060442; ENSMUSP00000053837; ENSMUSG00000048216.
ENSMUST00000115491; ENSMUSP00000111154; ENSMUSG00000048216.
ENSMUST00000115492; ENSMUSP00000111155; ENSMUSG00000048216.
GeneIDi64450.
KEGGimmu:64450.
UCSCiuc009ayr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF254416 mRNA. Translation: AAF79959.1 .
BC026975 mRNA. Translation: AAH26975.1 .
BC065154 mRNA. Translation: AAH65154.1 .
CCDSi CCDS19916.1.
RefSeqi NP_659503.1. NM_145066.4.
XP_006505221.1. XM_006505158.1.
UniGenei Mm.167625.
Mm.487258.

3D structure databases

ProteinModelPortali P60894.
SMRi P60894. Positions 15-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996893.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P60894.

Proteomic databases

PRIDEi P60894.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060442 ; ENSMUSP00000053837 ; ENSMUSG00000048216 .
ENSMUST00000115491 ; ENSMUSP00000111154 ; ENSMUSG00000048216 .
ENSMUST00000115492 ; ENSMUSP00000111155 ; ENSMUSG00000048216 .
GeneIDi 64450.
KEGGi mmu:64450.
UCSCi uc009ayr.1. mouse.

Organism-specific databases

CTDi 54329.
MGIi MGI:1927851. Gpr85.

Phylogenomic databases

eggNOGi NOG237432.
HOGENOMi HOG000231471.
HOVERGENi HBG051805.
InParanoidi P60894.
KOi K04302.
OMAi SMANYSH.
OrthoDBi EOG73NG3K.
PhylomeDBi P60894.
TreeFami TF331163.

Miscellaneous databases

NextBioi 320089.
PROi P60894.
SOURCEi Search...

Gene expression databases

ArrayExpressi P60894.
Bgeei P60894.
CleanExi MM_GPR85.
Genevestigatori P60894.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31."
    Hellebrand S., Schaller H.C., Wittenberger T.
    Biochim. Biophys. Acta 1493:269-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: CD-1.
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Eye.

Entry informationi

Entry nameiGPR85_MOUSE
AccessioniPrimary (citable) accession number: P60894
Secondary accession number(s): Q9JHI6, Q9NPD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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