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Protein

Probable G-protein coupled receptor 85

Gene

Gpr85

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 85
Alternative name(s):
Super conserved receptor expressed in brain 2
Gene namesi
Name:Gpr85
Synonyms:Sreb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1927851. Gpr85.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 5711CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9618ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 13720CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 18830ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini210 – 28677CytoplasmicSequence analysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini308 – 3136ExtracellularSequence analysis
Transmembranei314 – 33421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini335 – 37036CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Probable G-protein coupled receptor 85PRO_0000069592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60894.
PRIDEiP60894.

PTM databases

PhosphoSiteiP60894.

Expressioni

Tissue specificityi

Exclusively expressed in brain.1 Publication

Gene expression databases

BgeeiP60894.
CleanExiMM_GPR85.
ExpressionAtlasiP60894. baseline and differential.
GenevisibleiP60894. MM.

Interactioni

Subunit structurei

Interacts with DLG4 AND DLG3.By similarity

Protein-protein interaction databases

BioGridi211078. 1 interaction.
MINTiMINT-4996893.
STRINGi10090.ENSMUSP00000053837.

Structurei

3D structure databases

ProteinModelPortaliP60894.
SMRiP60894. Positions 15-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60894.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG73NG3K.
PhylomeDBiP60894.
TreeFamiTF331163.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT
60 70 80 90 100
LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL
110 120 130 140 150
GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV
160 170 180 190 200
AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL
210 220 230 240 250
VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG
260 270 280 290 300
PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP
310 320 330 340 350
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF
360 370
STTLLYCRKS RLPREPYCVI
Length:370
Mass (Da):41,995
Last modified:April 13, 2004 - v1
Checksum:i7B67A39F6166AAEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254416 mRNA. Translation: AAF79959.1.
BC026975 mRNA. Translation: AAH26975.1.
BC065154 mRNA. Translation: AAH65154.1.
CCDSiCCDS19916.1.
RefSeqiNP_659503.1. NM_145066.4.
XP_006505221.1. XM_006505158.2.
XP_011239379.1. XM_011241077.1.
XP_011239380.1. XM_011241078.1.
XP_011239381.1. XM_011241079.1.
UniGeneiMm.167625.
Mm.487258.

Genome annotation databases

EnsembliENSMUST00000060442; ENSMUSP00000053837; ENSMUSG00000048216.
ENSMUST00000115491; ENSMUSP00000111154; ENSMUSG00000048216.
ENSMUST00000115492; ENSMUSP00000111155; ENSMUSG00000048216.
GeneIDi64450.
KEGGimmu:64450.
UCSCiuc009ayr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254416 mRNA. Translation: AAF79959.1.
BC026975 mRNA. Translation: AAH26975.1.
BC065154 mRNA. Translation: AAH65154.1.
CCDSiCCDS19916.1.
RefSeqiNP_659503.1. NM_145066.4.
XP_006505221.1. XM_006505158.2.
XP_011239379.1. XM_011241077.1.
XP_011239380.1. XM_011241078.1.
XP_011239381.1. XM_011241079.1.
UniGeneiMm.167625.
Mm.487258.

3D structure databases

ProteinModelPortaliP60894.
SMRiP60894. Positions 15-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211078. 1 interaction.
MINTiMINT-4996893.
STRINGi10090.ENSMUSP00000053837.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP60894.

Proteomic databases

PaxDbiP60894.
PRIDEiP60894.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060442; ENSMUSP00000053837; ENSMUSG00000048216.
ENSMUST00000115491; ENSMUSP00000111154; ENSMUSG00000048216.
ENSMUST00000115492; ENSMUSP00000111155; ENSMUSG00000048216.
GeneIDi64450.
KEGGimmu:64450.
UCSCiuc009ayr.1. mouse.

Organism-specific databases

CTDi54329.
MGIiMGI:1927851. Gpr85.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60894.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG73NG3K.
PhylomeDBiP60894.
TreeFamiTF331163.

Miscellaneous databases

PROiP60894.
SOURCEiSearch...

Gene expression databases

BgeeiP60894.
CleanExiMM_GPR85.
ExpressionAtlasiP60894. baseline and differential.
GenevisibleiP60894. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31."
    Hellebrand S., Schaller H.C., Wittenberger T.
    Biochim. Biophys. Acta 1493:269-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: CD-1.
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Eye.

Entry informationi

Entry nameiGPR85_MOUSE
AccessioniPrimary (citable) accession number: P60894
Secondary accession number(s): Q9JHI6, Q9NPD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.