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P60894

- GPR85_MOUSE

UniProt

P60894 - GPR85_MOUSE

Protein

Probable G-protein coupled receptor 85

Gene

Gpr85

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. receptor signaling protein activity Source: MGI

    GO - Biological processi

    1. intracellular signal transduction Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 85
    Alternative name(s):
    Super conserved receptor expressed in brain 2
    Gene namesi
    Name:Gpr85
    Synonyms:Sreb2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1927851. Gpr85.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Probable G-protein coupled receptor 85PRO_0000069592Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP60894.

    PTM databases

    PhosphoSiteiP60894.

    Expressioni

    Tissue specificityi

    Exclusively expressed in brain.1 Publication

    Gene expression databases

    ArrayExpressiP60894.
    BgeeiP60894.
    CleanExiMM_GPR85.
    GenevestigatoriP60894.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4996893.

    Structurei

    3D structure databases

    ProteinModelPortaliP60894.
    SMRiP60894. Positions 15-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 5711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini79 – 9618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 13720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 18830ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 28677CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 3136ExtracellularSequence Analysis
    Topological domaini335 – 37036CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237432.
    HOGENOMiHOG000231471.
    HOVERGENiHBG051805.
    InParanoidiP60894.
    KOiK04302.
    OMAiSMANYSH.
    OrthoDBiEOG73NG3K.
    PhylomeDBiP60894.
    TreeFamiTF331163.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60894-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT    50
    LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL 100
    GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV 150
    AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL 200
    VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG 250
    PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP 300
    YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF 350
    STTLLYCRKS RLPREPYCVI 370
    Length:370
    Mass (Da):41,995
    Last modified:April 13, 2004 - v1
    Checksum:i7B67A39F6166AAEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254416 mRNA. Translation: AAF79959.1.
    BC026975 mRNA. Translation: AAH26975.1.
    BC065154 mRNA. Translation: AAH65154.1.
    CCDSiCCDS19916.1.
    RefSeqiNP_659503.1. NM_145066.4.
    XP_006505221.1. XM_006505158.1.
    UniGeneiMm.167625.
    Mm.487258.

    Genome annotation databases

    EnsembliENSMUST00000060442; ENSMUSP00000053837; ENSMUSG00000048216.
    ENSMUST00000115491; ENSMUSP00000111154; ENSMUSG00000048216.
    ENSMUST00000115492; ENSMUSP00000111155; ENSMUSG00000048216.
    GeneIDi64450.
    KEGGimmu:64450.
    UCSCiuc009ayr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254416 mRNA. Translation: AAF79959.1 .
    BC026975 mRNA. Translation: AAH26975.1 .
    BC065154 mRNA. Translation: AAH65154.1 .
    CCDSi CCDS19916.1.
    RefSeqi NP_659503.1. NM_145066.4.
    XP_006505221.1. XM_006505158.1.
    UniGenei Mm.167625.
    Mm.487258.

    3D structure databases

    ProteinModelPortali P60894.
    SMRi P60894. Positions 15-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4996893.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P60894.

    Proteomic databases

    PRIDEi P60894.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060442 ; ENSMUSP00000053837 ; ENSMUSG00000048216 .
    ENSMUST00000115491 ; ENSMUSP00000111154 ; ENSMUSG00000048216 .
    ENSMUST00000115492 ; ENSMUSP00000111155 ; ENSMUSG00000048216 .
    GeneIDi 64450.
    KEGGi mmu:64450.
    UCSCi uc009ayr.1. mouse.

    Organism-specific databases

    CTDi 54329.
    MGIi MGI:1927851. Gpr85.

    Phylogenomic databases

    eggNOGi NOG237432.
    HOGENOMi HOG000231471.
    HOVERGENi HBG051805.
    InParanoidi P60894.
    KOi K04302.
    OMAi SMANYSH.
    OrthoDBi EOG73NG3K.
    PhylomeDBi P60894.
    TreeFami TF331163.

    Miscellaneous databases

    NextBioi 320089.
    PROi P60894.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P60894.
    Bgeei P60894.
    CleanExi MM_GPR85.
    Genevestigatori P60894.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31."
      Hellebrand S., Schaller H.C., Wittenberger T.
      Biochim. Biophys. Acta 1493:269-272(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: CD-1.
      Tissue: Fetal brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Eye.

    Entry informationi

    Entry nameiGPR85_MOUSE
    AccessioniPrimary (citable) accession number: P60894
    Secondary accession number(s): Q9JHI6, Q9NPD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3