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Protein

Probable G-protein coupled receptor 85

Gene

GPR85

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  1. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 85
Alternative name(s):
Super conserved receptor expressed in brain 2
Gene namesi
Name:GPR85
Synonyms:SREB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:4536. GPR85.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 5711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini118 – 13720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 18830ExtracellularSequence AnalysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini210 – 28677CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini308 – 3136ExtracellularSequence Analysis
Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini335 – 37036CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Probable G-protein coupled receptor 85PRO_0000069591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60893.
PRIDEiP60893.

PTM databases

PhosphoSiteiP60893.

Expressioni

Tissue specificityi

Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord.2 Publications

Gene expression databases

BgeeiP60893.
CleanExiHS_GPR85.
ExpressionAtlasiP60893. baseline and differential.
GenevestigatoriP60893.

Interactioni

Protein-protein interaction databases

MINTiMINT-4724443.

Structurei

3D structure databases

ProteinModelPortaliP60893.
SMRiP60893. Positions 18-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237432.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60893.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG73NG3K.
PhylomeDBiP60893.
TreeFamiTF331163.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT
60 70 80 90 100
LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL
110 120 130 140 150
GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV
160 170 180 190 200
AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL
210 220 230 240 250
VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG
260 270 280 290 300
PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP
310 320 330 340 350
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF
360 370
STTLLYCRKS RLPREPYCVI
Length:370
Mass (Da):41,995
Last modified:April 13, 2004 - v1
Checksum:i7B67A39F6166AAEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250237 mRNA. Translation: AAF79956.1.
AB040800 mRNA. Translation: BAA96646.1.
AB065688 Genomic DNA. Translation: BAC05911.1.
AL161959 mRNA. Translation: CAB82307.1.
AC073346 Genomic DNA. Translation: AAQ93365.1.
CCDSiCCDS5758.1.
PIRiT47131.
RefSeqiNP_001139737.1. NM_001146265.1.
NP_001139738.1. NM_001146266.1.
NP_001139739.1. NM_001146267.1.
NP_061843.3. NM_018970.6.
XP_005250508.1. XM_005250451.1.
UniGeneiHs.152009.

Genome annotation databases

EnsembliENST00000297146; ENSP00000297146; ENSG00000164604.
ENST00000424100; ENSP00000396763; ENSG00000164604.
ENST00000449591; ENSP00000401178; ENSG00000164604.
ENST00000610164; ENSP00000476863; ENSG00000164604.
GeneIDi54329.
KEGGihsa:54329.
UCSCiuc003vgp.1. human.

Polymorphism databases

DMDMi46397442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250237 mRNA. Translation: AAF79956.1.
AB040800 mRNA. Translation: BAA96646.1.
AB065688 Genomic DNA. Translation: BAC05911.1.
AL161959 mRNA. Translation: CAB82307.1.
AC073346 Genomic DNA. Translation: AAQ93365.1.
CCDSiCCDS5758.1.
PIRiT47131.
RefSeqiNP_001139737.1. NM_001146265.1.
NP_001139738.1. NM_001146266.1.
NP_001139739.1. NM_001146267.1.
NP_061843.3. NM_018970.6.
XP_005250508.1. XM_005250451.1.
UniGeneiHs.152009.

3D structure databases

ProteinModelPortaliP60893.
SMRiP60893. Positions 18-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4724443.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP60893.

Polymorphism databases

DMDMi46397442.

Proteomic databases

PaxDbiP60893.
PRIDEiP60893.

Protocols and materials databases

DNASUi54329.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297146; ENSP00000297146; ENSG00000164604.
ENST00000424100; ENSP00000396763; ENSG00000164604.
ENST00000449591; ENSP00000401178; ENSG00000164604.
ENST00000610164; ENSP00000476863; ENSG00000164604.
GeneIDi54329.
KEGGihsa:54329.
UCSCiuc003vgp.1. human.

Organism-specific databases

CTDi54329.
GeneCardsiGC07M112720.
HGNCiHGNC:4536. GPR85.
MIMi605188. gene.
neXtProtiNX_P60893.
PharmGKBiPA28929.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG237432.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60893.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG73NG3K.
PhylomeDBiP60893.
TreeFamiTF331163.

Miscellaneous databases

GenomeRNAii54329.
NextBioi56567.
PROiP60893.
SOURCEiSearch...

Gene expression databases

BgeeiP60893.
CleanExiHS_GPR85.
ExpressionAtlasiP60893. baseline and differential.
GenevestigatoriP60893.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31."
    Hellebrand S., Schaller H.C., Wittenberger T.
    Biochim. Biophys. Acta 1493:269-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
    Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
    Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGPR85_HUMAN
AccessioniPrimary (citable) accession number: P60893
Secondary accession number(s): Q9JHI6, Q9NPD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: February 4, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.