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P60893

- GPR85_HUMAN

UniProt

P60893 - GPR85_HUMAN

Protein

Probable G-protein coupled receptor 85

Gene

GPR85

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB

    GO - Biological processi

    1. signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 85
    Alternative name(s):
    Super conserved receptor expressed in brain 2
    Gene namesi
    Name:GPR85
    Synonyms:SREB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:4536. GPR85.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: LIFEdb

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28929.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Probable G-protein coupled receptor 85PRO_0000069591Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP60893.
    PRIDEiP60893.

    PTM databases

    PhosphoSiteiP60893.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord.2 Publications

    Gene expression databases

    ArrayExpressiP60893.
    BgeeiP60893.
    CleanExiHS_GPR85.
    GenevestigatoriP60893.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4724443.

    Structurei

    3D structure databases

    ProteinModelPortaliP60893.
    SMRiP60893. Positions 15-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 5711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini79 – 9618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 13720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 18830ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 28677CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 3136ExtracellularSequence Analysis
    Topological domaini335 – 37036CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237432.
    HOGENOMiHOG000231471.
    HOVERGENiHBG051805.
    InParanoidiP60893.
    KOiK04302.
    OMAiSMANYSH.
    OrthoDBiEOG73NG3K.
    PhylomeDBiP60893.
    TreeFamiTF331163.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60893-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT    50
    LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL 100
    GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV 150
    AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL 200
    VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG 250
    PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP 300
    YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF 350
    STTLLYCRKS RLPREPYCVI 370
    Length:370
    Mass (Da):41,995
    Last modified:April 13, 2004 - v1
    Checksum:i7B67A39F6166AAEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF250237 mRNA. Translation: AAF79956.1.
    AB040800 mRNA. Translation: BAA96646.1.
    AB065688 Genomic DNA. Translation: BAC05911.1.
    AL161959 mRNA. Translation: CAB82307.1.
    AC073346 Genomic DNA. Translation: AAQ93365.1.
    CCDSiCCDS5758.1.
    PIRiT47131.
    RefSeqiNP_001139737.1. NM_001146265.1.
    NP_001139738.1. NM_001146266.1.
    NP_001139739.1. NM_001146267.1.
    NP_061843.3. NM_018970.6.
    XP_005250508.1. XM_005250451.1.
    UniGeneiHs.152009.

    Genome annotation databases

    EnsembliENST00000297146; ENSP00000297146; ENSG00000164604.
    ENST00000424100; ENSP00000396763; ENSG00000164604.
    ENST00000449591; ENSP00000401178; ENSG00000164604.
    ENST00000610164; ENSP00000476863; ENSG00000164604.
    GeneIDi54329.
    KEGGihsa:54329.
    UCSCiuc003vgp.1. human.

    Polymorphism databases

    DMDMi46397442.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF250237 mRNA. Translation: AAF79956.1 .
    AB040800 mRNA. Translation: BAA96646.1 .
    AB065688 Genomic DNA. Translation: BAC05911.1 .
    AL161959 mRNA. Translation: CAB82307.1 .
    AC073346 Genomic DNA. Translation: AAQ93365.1 .
    CCDSi CCDS5758.1.
    PIRi T47131.
    RefSeqi NP_001139737.1. NM_001146265.1.
    NP_001139738.1. NM_001146266.1.
    NP_001139739.1. NM_001146267.1.
    NP_061843.3. NM_018970.6.
    XP_005250508.1. XM_005250451.1.
    UniGenei Hs.152009.

    3D structure databases

    ProteinModelPortali P60893.
    SMRi P60893. Positions 15-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4724443.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P60893.

    Polymorphism databases

    DMDMi 46397442.

    Proteomic databases

    PaxDbi P60893.
    PRIDEi P60893.

    Protocols and materials databases

    DNASUi 54329.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297146 ; ENSP00000297146 ; ENSG00000164604 .
    ENST00000424100 ; ENSP00000396763 ; ENSG00000164604 .
    ENST00000449591 ; ENSP00000401178 ; ENSG00000164604 .
    ENST00000610164 ; ENSP00000476863 ; ENSG00000164604 .
    GeneIDi 54329.
    KEGGi hsa:54329.
    UCSCi uc003vgp.1. human.

    Organism-specific databases

    CTDi 54329.
    GeneCardsi GC07M112720.
    HGNCi HGNC:4536. GPR85.
    MIMi 605188. gene.
    neXtProti NX_P60893.
    PharmGKBi PA28929.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237432.
    HOGENOMi HOG000231471.
    HOVERGENi HBG051805.
    InParanoidi P60893.
    KOi K04302.
    OMAi SMANYSH.
    OrthoDBi EOG73NG3K.
    PhylomeDBi P60893.
    TreeFami TF331163.

    Miscellaneous databases

    GenomeRNAii 54329.
    NextBioi 56567.
    PROi P60893.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P60893.
    Bgeei P60893.
    CleanExi HS_GPR85.
    Genevestigatori P60893.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31."
      Hellebrand S., Schaller H.C., Wittenberger T.
      Biochim. Biophys. Acta 1493:269-272(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
      Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
      Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.
    3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGPR85_HUMAN
    AccessioniPrimary (citable) accession number: P60893
    Secondary accession number(s): Q9JHI6, Q9NPD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3