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P60893 (GPR85_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 85
Alternative name(s):
Super conserved receptor expressed in brain 2
Gene names
Name:GPR85
Synonyms:SREB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord. Ref.1 Ref.2

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Probable G-protein coupled receptor 85
PRO_0000069591

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 5711Cytoplasmic Potential
Transmembrane58 – 7821Helical; Name=2; Potential
Topological domain79 – 9618Extracellular Potential
Transmembrane97 – 11721Helical; Name=3; Potential
Topological domain118 – 13720Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=4; Potential
Topological domain159 – 18830Extracellular Potential
Transmembrane189 – 20921Helical; Name=5; Potential
Topological domain210 – 28677Cytoplasmic Potential
Transmembrane287 – 30721Helical; Name=6; Potential
Topological domain308 – 3136Extracellular Potential
Transmembrane314 – 33421Helical; Name=7; Potential
Topological domain335 – 37036Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 172 By similarity

Sequences

Sequence LengthMass (Da)Tools
P60893 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: 7B67A39F6166AAEB

FASTA37041,995
        10         20         30         40         50         60 
MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT LHRAPYYFLL 

        70         80         90        100        110        120 
DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL GVLSCFHTAF MLFCISVTRY 

       130        140        150        160        170        180 
LAIAHHRFYT KRLTFWTCLA VICMVWTLSV AMAFPPVLDV GTYSFIREED QCTFQHRSFR 

       190        200        210        220        230        240 
ANDSLGFMLL LALILLATQL VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA 

       250        260        270        280        290        300 
ANWLAGFGRG PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP 

       310        320        330        340        350        360 
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF STTLLYCRKS 

       370 
RLPREPYCVI 

« Hide

References

« Hide 'large scale' references
[1]"The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31."
Hellebrand S., Schaller H.C., Wittenberger T.
Biochim. Biophys. Acta 1493:269-272(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.
[2]"An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.
[3]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF250237 mRNA. Translation: AAF79956.1.
AB040800 mRNA. Translation: BAA96646.1.
AB065688 Genomic DNA. Translation: BAC05911.1.
AL161959 mRNA. Translation: CAB82307.1.
AC073346 Genomic DNA. Translation: AAQ93365.1.
CCDSCCDS5758.1.
PIRT47131.
RefSeqNP_001139737.1. NM_001146265.1.
NP_001139738.1. NM_001146266.1.
NP_001139739.1. NM_001146267.1.
NP_061843.3. NM_018970.6.
XP_005250508.1. XM_005250451.1.
UniGeneHs.152009.

3D structure databases

ProteinModelPortalP60893.
SMRP60893. Positions 15-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4724443.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP60893.

Polymorphism databases

DMDM46397442.

Proteomic databases

PaxDbP60893.
PRIDEP60893.

Protocols and materials databases

DNASU54329.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297146; ENSP00000297146; ENSG00000164604.
ENST00000424100; ENSP00000396763; ENSG00000164604.
ENST00000449591; ENSP00000401178; ENSG00000164604.
ENST00000501255; ENSP00000445808; ENSG00000164604.
ENST00000610164; ENSP00000476863; ENSG00000164604.
GeneID54329.
KEGGhsa:54329.
UCSCuc003vgp.1. human.

Organism-specific databases

CTD54329.
GeneCardsGC07M112720.
HGNCHGNC:4536. GPR85.
MIM605188. gene.
neXtProtNX_P60893.
PharmGKBPA28929.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237432.
HOGENOMHOG000231471.
HOVERGENHBG051805.
InParanoidP60893.
KOK04302.
OMASMANYSH.
OrthoDBEOG73NG3K.
PhylomeDBP60893.
TreeFamTF331163.

Gene expression databases

ArrayExpressP60893.
BgeeP60893.
CleanExHS_GPR85.
GenevestigatorP60893.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi54329.
NextBio56567.
PROP60893.
SOURCESearch...

Entry information

Entry nameGPR85_HUMAN
AccessionPrimary (citable) accession number: P60893
Secondary accession number(s): Q9JHI6, Q9NPD1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries