Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable G-protein coupled receptor 85

Gene

GPR85

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164604-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 85
Alternative name(s):
Super conserved receptor expressed in brain 2
Gene namesi
Name:GPR85
Synonyms:SREB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:4536. GPR85.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 57CytoplasmicSequence analysisAdd BLAST11
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 96ExtracellularSequence analysisAdd BLAST18
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 137CytoplasmicSequence analysisAdd BLAST20
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 188ExtracellularSequence analysisAdd BLAST30
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 286CytoplasmicSequence analysisAdd BLAST77
Transmembranei287 – 307Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini308 – 313ExtracellularSequence analysis6
Transmembranei314 – 334Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini335 – 370CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54329.
OpenTargetsiENSG00000164604.
PharmGKBiPA28929.

Polymorphism and mutation databases

BioMutaiGPR85.
DMDMi46397442.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695911 – 370Probable G-protein coupled receptor 85Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60893.
PeptideAtlasiP60893.
PRIDEiP60893.

PTM databases

iPTMnetiP60893.
PhosphoSitePlusiP60893.

Expressioni

Tissue specificityi

Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord.2 Publications

Gene expression databases

BgeeiENSG00000164604.
CleanExiHS_GPR85.
ExpressionAtlasiP60893. baseline and differential.
GenevisibleiP60893. HS.

Interactioni

Subunit structurei

Interacts with DLG4 AND DLG3.1 Publication

Protein-protein interaction databases

BioGridi119932. 1 interactor.
MINTiMINT-4724443.
STRINGi9606.ENSP00000297146.

Structurei

3D structure databases

ProteinModelPortaliP60893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60893.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG091G0AOZ.
PhylomeDBiP60893.
TreeFamiTF331163.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT
60 70 80 90 100
LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL
110 120 130 140 150
GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV
160 170 180 190 200
AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL
210 220 230 240 250
VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG
260 270 280 290 300
PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP
310 320 330 340 350
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF
360 370
STTLLYCRKS RLPREPYCVI
Length:370
Mass (Da):41,995
Last modified:April 13, 2004 - v1
Checksum:i7B67A39F6166AAEB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074204152M → T Found in a patient with autism spectrum disorder; unknown pathological significance; induces response to endoplasmic reticulum stress; negative regulation of dendrite morphogenesis. 1 Publication1
Natural variantiVAR_074205221V → L Found in a patient with autism spectrum disorder; unknown pathological significance; induces response to endoplasmic reticulum stress; negative regulation of dendrite morphogenesis. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250237 mRNA. Translation: AAF79956.1.
AB040800 mRNA. Translation: BAA96646.1.
AB065688 Genomic DNA. Translation: BAC05911.1.
AL161959 mRNA. Translation: CAB82307.1.
AC073346 Genomic DNA. Translation: AAQ93365.1.
CCDSiCCDS5758.1.
PIRiT47131.
RefSeqiNP_001139737.1. NM_001146265.1.
NP_001139738.1. NM_001146266.1.
NP_001139739.1. NM_001146267.1.
NP_061843.3. NM_018970.6.
XP_005250508.1. XM_005250451.2.
XP_016867841.1. XM_017012352.1.
UniGeneiHs.152009.

Genome annotation databases

EnsembliENST00000297146; ENSP00000297146; ENSG00000164604.
ENST00000424100; ENSP00000396763; ENSG00000164604.
ENST00000449591; ENSP00000401178; ENSG00000164604.
ENST00000610164; ENSP00000476863; ENSG00000164604.
GeneIDi54329.
KEGGihsa:54329.
UCSCiuc003vgp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250237 mRNA. Translation: AAF79956.1.
AB040800 mRNA. Translation: BAA96646.1.
AB065688 Genomic DNA. Translation: BAC05911.1.
AL161959 mRNA. Translation: CAB82307.1.
AC073346 Genomic DNA. Translation: AAQ93365.1.
CCDSiCCDS5758.1.
PIRiT47131.
RefSeqiNP_001139737.1. NM_001146265.1.
NP_001139738.1. NM_001146266.1.
NP_001139739.1. NM_001146267.1.
NP_061843.3. NM_018970.6.
XP_005250508.1. XM_005250451.2.
XP_016867841.1. XM_017012352.1.
UniGeneiHs.152009.

3D structure databases

ProteinModelPortaliP60893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119932. 1 interactor.
MINTiMINT-4724443.
STRINGi9606.ENSP00000297146.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP60893.
PhosphoSitePlusiP60893.

Polymorphism and mutation databases

BioMutaiGPR85.
DMDMi46397442.

Proteomic databases

PaxDbiP60893.
PeptideAtlasiP60893.
PRIDEiP60893.

Protocols and materials databases

DNASUi54329.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297146; ENSP00000297146; ENSG00000164604.
ENST00000424100; ENSP00000396763; ENSG00000164604.
ENST00000449591; ENSP00000401178; ENSG00000164604.
ENST00000610164; ENSP00000476863; ENSG00000164604.
GeneIDi54329.
KEGGihsa:54329.
UCSCiuc003vgp.2. human.

Organism-specific databases

CTDi54329.
DisGeNETi54329.
GeneCardsiGPR85.
HGNCiHGNC:4536. GPR85.
MIMi605188. gene.
neXtProtiNX_P60893.
OpenTargetsiENSG00000164604.
PharmGKBiPA28929.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiP60893.
KOiK04302.
OMAiSMANYSH.
OrthoDBiEOG091G0AOZ.
PhylomeDBiP60893.
TreeFamiTF331163.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164604-MONOMER.

Miscellaneous databases

GenomeRNAii54329.
PROiP60893.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164604.
CleanExiHS_GPR85.
ExpressionAtlasiP60893. baseline and differential.
GenevisibleiP60893. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR85_HUMAN
AccessioniPrimary (citable) accession number: P60893
Secondary accession number(s): Q9JHI6, Q9NPD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.