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Protein

Chromobox protein homolog 7

Gene

Cbx7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded and double-stranded RNA. Plays a role in the timely repression of differentiation-specific genes in pluripotent embryonic stem cells to maintain the undifferentiated state. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 7
Gene namesi
Name:Cbx7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi735027. Cbx7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802141 – 158Chromobox protein homolog 7Add BLAST158

Proteomic databases

PaxDbiP60889.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016875.
GenevisibleiP60889. RN.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Distinct PRC1-like core complexes are composed of a RING1 subunit (RING1B or RING1A), one of the six PCGF proteins (PCGF1-6), one PHC protein (PHC1-3) and one of the CBX proteins (CBX2, CBX4, CBX6, CBX7 or CBX8). The composition of the PRC1 complex may differ between the PRC1 complex in pluripotent embryonic stem cells containing RNF2, CBX7 and PCGF2, and the PRC1 complex in differentiating cells containing RNF2, CBX2, CBX4 and BMI1. Interacts with RING1. Interacts with RNF2/RING1B. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6. Interacts (via chromodomain) with histone H3K9Me3 and H3K27me3. Interacts with H3K9Me2 and H4K20Me1. Interacts (via chromodomain) with single-stranded and double-stranded RNA; RNA binding seems to be required for the localization to chromatin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP60889. 2 interactors.
MINTiMINT-6594215.
STRINGi10116.ENSRNOP00000022631.

Structurei

3D structure databases

ProteinModelPortaliP60889.
SMRiP60889.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 69ChromoPROSITE-ProRule annotationAdd BLAST59

Phylogenomic databases

eggNOGiKOG2748. Eukaryota.
ENOG41122KC. LUCA.
GeneTreeiENSGT00530000063056.
HOGENOMiHOG000233642.
HOVERGENiHBG019320.
InParanoidiP60889.
KOiK11454.
OMAiFFREWEL.
OrthoDBiEOG091G0SXA.
PhylomeDBiP60889.
TreeFamiTF106456.

Family and domain databases

CDDicd00024. CHROMO. 1 hit.
InterProiView protein in InterPro
IPR033773. CBX7_C.
IPR016197. Chromo-like_dom_sf.
IPR000953. Chromo/chromo_shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR023779. Chromodomain_CS.
PfamiView protein in Pfam
PF17218. CBX7_C. 1 hit.
PF00385. Chromo. 1 hit.
PRINTSiPR00504. CHROMODOMAIN.
SMARTiView protein in SMART
SM00298. CHROMO. 1 hit.
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiView protein in PROSITE
PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P60889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD
60 70 80 90 100
PRLVMAYEEK EEKDRASGYR KRGPKPKRLL LQESAAPDVL QATGDWEPVE
110 120 130 140 150
QPPEEEAEAD LTNGPPPWTP MLPSSEVTVT DITANSVTVT FREAQAAEGF

FRDRSGKL
Length:158
Mass (Da):17,966
Last modified:April 13, 2004 - v1
Checksum:iD2D11F0406DEDC5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062392 mRNA. Translation: AAH62392.1.
RefSeqiNP_954548.1. NM_199117.2.
XP_006242087.1. XM_006242025.3.
UniGeneiRn.12512.

Genome annotation databases

EnsembliENSRNOT00000022631; ENSRNOP00000022631; ENSRNOG00000016875.
ENSRNOT00000077731; ENSRNOP00000074584; ENSRNOG00000016875.
GeneIDi362962.
KEGGirno:362962.
UCSCiRGD:735027. rat.

Similar proteinsi

Entry informationi

Entry nameiCBX7_RAT
AccessioniPrimary (citable) accession number: P60889
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: January 31, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome