Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromobox protein homolog 7

Gene

Cbx7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 7
Gene namesi
Name:Cbx7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi735027. Cbx7.

Subcellular locationi

  • Nucleus By similarity

  • Note: Detected in faculative heterochromatin and on the inactivated X-chromosome in females.By similarity

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • heterochromatin Source: Ensembl
  • nuclear chromatin Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: RGD
  • PcG protein complex Source: UniProtKB
  • PRC1 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Chromobox protein homolog 7PRO_0000080214Add
BLAST

Proteomic databases

PaxDbiP60889.

Expressioni

Gene expression databases

GenevisibleiP60889. RN.

Interactioni

Subunit structurei

Component of a PRC1-like complex (By similarity). Interacts with RING1. Interacts with RNF2/RING1B. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6 (By similarity).By similarity

Protein-protein interaction databases

IntActiP60889. 2 interactions.
MINTiMINT-6594215.
STRINGi10116.ENSRNOP00000022631.

Structurei

3D structure databases

ProteinModelPortaliP60889.
SMRiP60889. Positions 8-62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 6959ChromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2748. Eukaryota.
ENOG41122KC. LUCA.
GeneTreeiENSGT00530000063056.
HOGENOMiHOG000233642.
HOVERGENiHBG019320.
InParanoidiP60889.
KOiK11454.
OMAiFFREWEL.
OrthoDBiEOG77T15B.
PhylomeDBiP60889.
TreeFamiTF106456.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD
60 70 80 90 100
PRLVMAYEEK EEKDRASGYR KRGPKPKRLL LQESAAPDVL QATGDWEPVE
110 120 130 140 150
QPPEEEAEAD LTNGPPPWTP MLPSSEVTVT DITANSVTVT FREAQAAEGF

FRDRSGKL
Length:158
Mass (Da):17,966
Last modified:April 13, 2004 - v1
Checksum:iD2D11F0406DEDC5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062392 mRNA. Translation: AAH62392.1.
RefSeqiNP_954548.1. NM_199117.2.
XP_006242087.1. XM_006242025.2.
UniGeneiRn.12512.

Genome annotation databases

EnsembliENSRNOT00000022631; ENSRNOP00000022631; ENSRNOG00000016875.
ENSRNOT00000077731; ENSRNOP00000074584; ENSRNOG00000016875.
GeneIDi362962.
KEGGirno:362962.
UCSCiRGD:735027. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062392 mRNA. Translation: AAH62392.1.
RefSeqiNP_954548.1. NM_199117.2.
XP_006242087.1. XM_006242025.2.
UniGeneiRn.12512.

3D structure databases

ProteinModelPortaliP60889.
SMRiP60889. Positions 8-62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP60889. 2 interactions.
MINTiMINT-6594215.
STRINGi10116.ENSRNOP00000022631.

Proteomic databases

PaxDbiP60889.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022631; ENSRNOP00000022631; ENSRNOG00000016875.
ENSRNOT00000077731; ENSRNOP00000074584; ENSRNOG00000016875.
GeneIDi362962.
KEGGirno:362962.
UCSCiRGD:735027. rat.

Organism-specific databases

CTDi23492.
RGDi735027. Cbx7.

Phylogenomic databases

eggNOGiKOG2748. Eukaryota.
ENOG41122KC. LUCA.
GeneTreeiENSGT00530000063056.
HOGENOMiHOG000233642.
HOVERGENiHBG019320.
InParanoidiP60889.
KOiK11454.
OMAiFFREWEL.
OrthoDBiEOG77T15B.
PhylomeDBiP60889.
TreeFamiTF106456.

Miscellaneous databases

NextBioi681939.
PROiP60889.

Gene expression databases

GenevisibleiP60889. RN.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiCBX7_RAT
AccessioniPrimary (citable) accession number: P60889
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 11, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.