Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S20

Gene

RPS20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S20
Alternative name(s):
Small ribosomal subunit protein uS101 Publication
Gene namesi
Name:RPS20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000008988.9
HGNCiHGNC:10405 RPS20
MIMi603682 gene
neXtProtiNX_P60866

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4K → R: Enhanced readthrough on the poly(A)-stall sequences; when associated with R-8. 2 Publications1
Mutagenesisi8K → R: Enhanced readthrough on the poly(A)-stall sequences; when associated with R-4. 2 Publications1

Organism-specific databases

DisGeNETi6224
MalaCardsiRPS20
OpenTargetsiENSG00000008988
Orphaneti144 Hereditary nonpolyposis colon cancer
PharmGKBiPA34807

Polymorphism and mutation databases

BioMutaiRPS20
DMDMi46397703

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001466832 – 11940S ribosomal protein S20Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei8N6-succinyllysine; alternateBy similarity1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate2 Publications
Modified residuei9PhosphothreonineCombined sources1
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei75N6-acetyllysineBy similarity1
Modified residuei93PhosphoserineCombined sources1

Post-translational modificationi

Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP60866
MaxQBiP60866
PaxDbiP60866
PeptideAtlasiP60866
PRIDEiP60866
TopDownProteomicsiP60866-1 [P60866-1]
P60866-2 [P60866-2]

PTM databases

iPTMnetiP60866
PhosphoSitePlusiP60866
SwissPalmiP60866

Expressioni

Gene expression databases

BgeeiENSG00000008988
CleanExiHS_RPS20
ExpressionAtlasiP60866 baseline and differential
GenevisibleiP60866 HS

Organism-specific databases

HPAiHPA003570

Interactioni

Subunit structurei

Component of the 40S small ribosomal subunit.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112138, 167 interactors
CORUMiP60866
DIPiDIP-31245N
IntActiP60866, 41 interactors
MINTiP60866
STRINGi9606.ENSP00000429374

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SU1-119[»]
4V6Xelectron microscopy5.00AU1-119[»]
5A2Qelectron microscopy3.90U1-119[»]
5AJ0electron microscopy3.50BU1-119[»]
5FLXelectron microscopy3.90U1-119[»]
5LKSelectron microscopy3.60SU1-119[»]
5OA3electron microscopy4.30U1-119[»]
5T2Celectron microscopy3.60AB1-119[»]
5VYCX-ray6.00U1/U2/U3/U4/U5/U61-119[»]
6EK0electron microscopy2.90SU1-119[»]
6FECelectron microscopy6.30h16-119[»]
ProteinModelPortaliP60866
SMRiP60866
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0900 Eukaryota
COG0051 LUCA
GeneTreeiENSGT00390000003248
HOGENOMiHOG000270245
HOVERGENiHBG004448
InParanoidiP60866
KOiK02969
OMAiWDRYELK
OrthoDBiEOG091G0VNB
PhylomeDBiP60866
TreeFamiTF300222

Family and domain databases

Gene3Di3.30.70.600, 1 hit
HAMAPiMF_00508 Ribosomal_S10, 1 hit
InterProiView protein in InterPro
IPR001848 Ribosomal_S10
IPR018268 Ribosomal_S10_CS
IPR027486 Ribosomal_S10_dom
IPR036838 Ribosomal_S10_dom_sf
IPR005729 Ribosomal_S10_euk/arc
PANTHERiPTHR11700 PTHR11700, 1 hit
PfamiView protein in Pfam
PF00338 Ribosomal_S10, 1 hit
PRINTSiPR00971 RIBOSOMALS10
SMARTiView protein in SMART
SM01403 Ribosomal_S10, 1 hit
SUPFAMiSSF54999 SSF54999, 1 hit
TIGRFAMsiTIGR01046 uS10_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00361 RIBOSOMAL_S10, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV
60 70 80 90 100
KGPVRMPTKT LRITTRKTPC GEGSKTWDRF QMRIHKRLID LHSPSEIVKQ
110
ITSISIEPGV EVEVTIADA
Length:119
Mass (Da):13,373
Last modified:April 13, 2004 - v1
Checksum:i8802DF7894ADDF94
GO
Isoform 2 (identifier: P60866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-119: VEVTIADA → LIESTDAEPMDTEGQQYTLRSVFESPGTCPF

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):16,006
Checksum:i9EB2D51538E812A9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042724112 – 119VEVTIADA → LIESTDAEPMDTEGQQYTLR SVFESPGTCPF in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06498 mRNA Translation: AAA60286.1
AB061842 Genomic DNA Translation: BAB79480.1
AK301342 mRNA Translation: BAG62890.1
AK311808 mRNA Translation: BAG34751.1
AC107376 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86771.1
CH471068 Genomic DNA Translation: EAW86772.1
BC007507 mRNA Translation: AAH07507.1
BC087850 mRNA Translation: AAH87850.1
AB007156 Genomic DNA Translation: BAA25820.1
CCDSiCCDS55231.1 [P60866-2]
CCDS6163.1 [P60866-1]
PIRiS33710
RefSeqiNP_001014.1, NM_001023.3 [P60866-1]
NP_001139699.1, NM_001146227.1 [P60866-2]
UniGeneiHs.8102

Genome annotation databases

EnsembliENST00000009589; ENSP00000009589; ENSG00000008988 [P60866-1]
ENST00000519807; ENSP00000429374; ENSG00000008988 [P60866-2]
ENST00000521262; ENSP00000427788; ENSG00000008988 [P60866-1]
ENST00000618656; ENSP00000478703; ENSG00000008988 [P60866-2]
GeneIDi6224
KEGGihsa:6224
UCSCiuc003xsm.3 human [P60866-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRS20_HUMAN
AccessioniPrimary (citable) accession number: P60866
Secondary accession number(s): B2R4F4
, B4DW28, P17075, Q5M8S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health