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Protein

40S ribosomal protein S20

Gene

RPS20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S20
Alternative name(s):
Small ribosomal subunit protein uS101 Publication
Gene namesi
Name:RPS20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000008988.9.
HGNCiHGNC:10405. RPS20.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4K → R: Enhanced readthrough on the poly(A)-stall sequences; when associated with R-8. 2 Publications1
Mutagenesisi8K → R: Enhanced readthrough on the poly(A)-stall sequences; when associated with R-4. 2 Publications1

Organism-specific databases

DisGeNETi6224.
MalaCardsiRPS20.
OpenTargetsiENSG00000008988.
Orphaneti144. Hereditary nonpolyposis colon cancer.
PharmGKBiPA34807.

Polymorphism and mutation databases

BioMutaiRPS20.
DMDMi46397703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001466832 – 11940S ribosomal protein S20Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei8N6-succinyllysine; alternateBy similarity1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate2 Publications
Modified residuei9PhosphothreonineCombined sources1
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei75N6-acetyllysineBy similarity1
Modified residuei93PhosphoserineCombined sources1

Post-translational modificationi

Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP60866.
MaxQBiP60866.
PaxDbiP60866.
PeptideAtlasiP60866.
PRIDEiP60866.
TopDownProteomicsiP60866-1. [P60866-1]
P60866-2. [P60866-2]

PTM databases

iPTMnetiP60866.
PhosphoSitePlusiP60866.
SwissPalmiP60866.

Expressioni

Gene expression databases

BgeeiENSG00000008988.
CleanExiHS_RPS20.
ExpressionAtlasiP60866. baseline and differential.
GenevisibleiP60866. HS.

Organism-specific databases

HPAiHPA003570.

Interactioni

Subunit structurei

Component of the 40S small ribosomal subunit.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112138. 163 interactors.
CORUMiP60866.
DIPiDIP-31245N.
IntActiP60866. 39 interactors.
MINTiMINT-5000180.
STRINGi9606.ENSP00000429374.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SU1-119[»]
4V6Xelectron microscopy5.00AU1-119[»]
5A2Qelectron microscopy3.90U1-119[»]
5AJ0electron microscopy3.50BU1-119[»]
5FLXelectron microscopy3.90U1-119[»]
5LKSelectron microscopy3.60SU1-119[»]
5T2Celectron microscopy3.60AB1-119[»]
ProteinModelPortaliP60866.
SMRiP60866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0900. Eukaryota.
COG0051. LUCA.
GeneTreeiENSGT00390000003248.
HOGENOMiHOG000270245.
HOVERGENiHBG004448.
InParanoidiP60866.
KOiK02969.
OMAiWDRYELK.
OrthoDBiEOG091G0VNB.
PhylomeDBiP60866.
TreeFamiTF300222.

Family and domain databases

Gene3Di3.30.70.600. 1 hit.
HAMAPiMF_00508. Ribosomal_S10. 1 hit.
InterProiView protein in InterPro
IPR001848. Ribosomal_S10.
IPR018268. Ribosomal_S10_CS.
IPR027486. Ribosomal_S10_dom.
IPR005729. Ribosomal_S10_euk/arc.
PANTHERiPTHR11700. PTHR11700. 1 hit.
PfamiView protein in Pfam
PF00338. Ribosomal_S10. 1 hit.
PRINTSiPR00971. RIBOSOMALS10.
SMARTiView protein in SMART
SM01403. Ribosomal_S10. 1 hit.
SUPFAMiSSF54999. SSF54999. 1 hit.
TIGRFAMsiTIGR01046. uS10_euk_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00361. RIBOSOMAL_S10. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV
60 70 80 90 100
KGPVRMPTKT LRITTRKTPC GEGSKTWDRF QMRIHKRLID LHSPSEIVKQ
110
ITSISIEPGV EVEVTIADA
Length:119
Mass (Da):13,373
Last modified:April 13, 2004 - v1
Checksum:i8802DF7894ADDF94
GO
Isoform 2 (identifier: P60866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-119: VEVTIADA → LIESTDAEPMDTEGQQYTLRSVFESPGTCPF

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):16,006
Checksum:i9EB2D51538E812A9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042724112 – 119VEVTIADA → LIESTDAEPMDTEGQQYTLR SVFESPGTCPF in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06498 mRNA. Translation: AAA60286.1.
AB061842 Genomic DNA. Translation: BAB79480.1.
AK301342 mRNA. Translation: BAG62890.1.
AK311808 mRNA. Translation: BAG34751.1.
AC107376 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86771.1.
CH471068 Genomic DNA. Translation: EAW86772.1.
BC007507 mRNA. Translation: AAH07507.1.
BC087850 mRNA. Translation: AAH87850.1.
AB007156 Genomic DNA. Translation: BAA25820.1.
CCDSiCCDS55231.1. [P60866-2]
CCDS6163.1. [P60866-1]
PIRiS33710.
RefSeqiNP_001014.1. NM_001023.3. [P60866-1]
NP_001139699.1. NM_001146227.1. [P60866-2]
UniGeneiHs.8102.

Genome annotation databases

EnsembliENST00000009589; ENSP00000009589; ENSG00000008988. [P60866-1]
ENST00000519807; ENSP00000429374; ENSG00000008988. [P60866-2]
ENST00000521262; ENSP00000427788; ENSG00000008988. [P60866-1]
ENST00000618656; ENSP00000478703; ENSG00000008988. [P60866-2]
GeneIDi6224.
KEGGihsa:6224.
UCSCiuc003xsm.3. human. [P60866-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRS20_HUMAN
AccessioniPrimary (citable) accession number: P60866
Secondary accession number(s): B2R4F4
, B4DW28, P17075, Q5M8S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 27, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families