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P60862

- HISX_METMP

UniProt

P60862 - HISX_METMP

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Protein

Histidinol dehydrogenase

Gene
hisD, MMP0968
Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei188 – 1881NAD By similarity
Binding sitei211 – 2111NAD By similarity
Binding sitei234 – 2341Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Active sitei322 – 3221Proton acceptor By similarity
Active sitei323 – 3231Proton acceptor By similarity
Binding sitei323 – 3231Substrate By similarity
Metal bindingi356 – 3561Zinc By similarity
Binding sitei356 – 3561Substrate By similarity
Binding sitei410 – 4101Substrate By similarity
Metal bindingi415 – 4151Zinc By similarity
Binding sitei415 – 4151Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-998-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:MMP0968
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000590: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Histidinol dehydrogenaseUniRule annotationPRO_0000135898Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP0968.

Structurei

3D structure databases

ProteinModelPortaliP60862.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60862-1 [UniParc]FASTAAdd to Basket

« Hide

MIVKKISKLN EKELDIILNR NKTNISGILP TVSEILENVQ KNGDNALKEY    50
TKKFDGVDID NFKVSTEEID KAYDKIDSKV VESLEKAYEN IREFHEIQFK 100
NLNEWEIDKK GIKAGQIIRP VEKAGCYVPG GRAFYPSTVL MTVTPAKVAG 150
VKEVIVTSPP NGTEGNPATL VASDIAKADG IYKIGGAQAI GALAYGTKSI 200
PKVDIIVGPG NIFVTAAKKL VYGEVSIDFP AGPSEVLIMC DESSNEEYVA 250
MDFLAQAEHD PNASCIITVT SEKKAEKIKE RILMEIKTAK RTEIIEKSIL 300
NSAIVIGSID ECIELSNSYA PEHLEIMTKN PREVLKSIEN AGSIFLGNYA 350
PVPVGDYASG TNHVLPTSAC AKMYSGLSVE TFIKKPTVQE LTKEGLLGIS 400
DIVTTLAEAE GLFNHSEAVK RRLN 424
Length:424
Mass (Da):46,184
Last modified:April 13, 2004 - v1
Checksum:i314636FBE12A573A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF30524.1.
RefSeqiNP_988088.1. NC_005791.1.
WP_011170912.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF30524; CAF30524; MMP0968.
GeneIDi2762510.
KEGGimmp:MMP0968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF30524.1 .
RefSeqi NP_988088.1. NC_005791.1.
WP_011170912.1. NC_005791.1.

3D structure databases

ProteinModelPortali P60862.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267377.MMP0968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF30524 ; CAF30524 ; MMP0968 .
GeneIDi 2762510.
KEGGi mmp:MMP0968.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci MMAR267377:GJ77-998-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S2 / LL.

Entry informationi

Entry nameiHISX_METMP
AccessioniPrimary (citable) accession number: P60862
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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