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P60862 (HISX_METMP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:MMP0968
OrganismMethanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]
Taxonomic identifier267377 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135898

Sites

Active site3221Proton acceptor By similarity
Active site3231Proton acceptor By similarity
Metal binding2561Zinc By similarity
Metal binding2591Zinc By similarity
Metal binding3561Zinc By similarity
Metal binding4151Zinc By similarity
Binding site1271NAD By similarity
Binding site1881NAD By similarity
Binding site2111NAD By similarity
Binding site2341Substrate By similarity
Binding site2561Substrate By similarity
Binding site2591Substrate By similarity
Binding site3231Substrate By similarity
Binding site3561Substrate By similarity
Binding site4101Substrate By similarity
Binding site4151Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P60862 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: 314636FBE12A573A

FASTA42446,184
        10         20         30         40         50         60 
MIVKKISKLN EKELDIILNR NKTNISGILP TVSEILENVQ KNGDNALKEY TKKFDGVDID 

        70         80         90        100        110        120 
NFKVSTEEID KAYDKIDSKV VESLEKAYEN IREFHEIQFK NLNEWEIDKK GIKAGQIIRP 

       130        140        150        160        170        180 
VEKAGCYVPG GRAFYPSTVL MTVTPAKVAG VKEVIVTSPP NGTEGNPATL VASDIAKADG 

       190        200        210        220        230        240 
IYKIGGAQAI GALAYGTKSI PKVDIIVGPG NIFVTAAKKL VYGEVSIDFP AGPSEVLIMC 

       250        260        270        280        290        300 
DESSNEEYVA MDFLAQAEHD PNASCIITVT SEKKAEKIKE RILMEIKTAK RTEIIEKSIL 

       310        320        330        340        350        360 
NSAIVIGSID ECIELSNSYA PEHLEIMTKN PREVLKSIEN AGSIFLGNYA PVPVGDYASG 

       370        380        390        400        410        420 
TNHVLPTSAC AKMYSGLSVE TFIKKPTVQE LTKEGLLGIS DIVTTLAEAE GLFNHSEAVK 


RRLN 

« Hide

References

[1]"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis."
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. expand/collapse author list , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.
J. Bacteriol. 186:6956-6969(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S2 / LL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950229 Genomic DNA. Translation: CAF30524.1.
RefSeqNP_988088.1. NC_005791.1.

3D structure databases

ProteinModelPortalP60862.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267377.MMP0968.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF30524; CAF30524; MMP0968.
GeneID2762510.
KEGGmmp:MMP0968.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAYAAKLCG.

Enzyme and pathway databases

BioCycMMAR267377:GJ77-998-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_METMP
AccessionPrimary (citable) accession number: P60862
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways