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P60862

- HISX_METMP

UniProt

P60862 - HISX_METMP

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei127 – 1271NADUniRule annotation
    Binding sitei188 – 1881NADUniRule annotation
    Binding sitei211 – 2111NADUniRule annotation
    Binding sitei234 – 2341SubstrateUniRule annotation
    Metal bindingi256 – 2561ZincUniRule annotation
    Binding sitei256 – 2561SubstrateUniRule annotation
    Metal bindingi259 – 2591ZincUniRule annotation
    Binding sitei259 – 2591SubstrateUniRule annotation
    Active sitei322 – 3221Proton acceptorUniRule annotation
    Active sitei323 – 3231Proton acceptorUniRule annotation
    Binding sitei323 – 3231SubstrateUniRule annotation
    Metal bindingi356 – 3561ZincUniRule annotation
    Binding sitei356 – 3561SubstrateUniRule annotation
    Binding sitei410 – 4101SubstrateUniRule annotation
    Metal bindingi415 – 4151ZincUniRule annotation
    Binding sitei415 – 4151SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciMMAR267377:GJ77-998-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:MMP0968
    OrganismiMethanococcus maripaludis (strain S2 / LL)
    Taxonomic identifieri267377 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000590: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Histidinol dehydrogenasePRO_0000135898Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi267377.MMP0968.

    Structurei

    3D structure databases

    ProteinModelPortaliP60862.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60862-1 [UniParc]FASTAAdd to Basket

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    MIVKKISKLN EKELDIILNR NKTNISGILP TVSEILENVQ KNGDNALKEY    50
    TKKFDGVDID NFKVSTEEID KAYDKIDSKV VESLEKAYEN IREFHEIQFK 100
    NLNEWEIDKK GIKAGQIIRP VEKAGCYVPG GRAFYPSTVL MTVTPAKVAG 150
    VKEVIVTSPP NGTEGNPATL VASDIAKADG IYKIGGAQAI GALAYGTKSI 200
    PKVDIIVGPG NIFVTAAKKL VYGEVSIDFP AGPSEVLIMC DESSNEEYVA 250
    MDFLAQAEHD PNASCIITVT SEKKAEKIKE RILMEIKTAK RTEIIEKSIL 300
    NSAIVIGSID ECIELSNSYA PEHLEIMTKN PREVLKSIEN AGSIFLGNYA 350
    PVPVGDYASG TNHVLPTSAC AKMYSGLSVE TFIKKPTVQE LTKEGLLGIS 400
    DIVTTLAEAE GLFNHSEAVK RRLN 424
    Length:424
    Mass (Da):46,184
    Last modified:April 13, 2004 - v1
    Checksum:i314636FBE12A573A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950229 Genomic DNA. Translation: CAF30524.1.
    RefSeqiNP_988088.1. NC_005791.1.
    WP_011170912.1. NC_005791.1.

    Genome annotation databases

    EnsemblBacteriaiCAF30524; CAF30524; MMP0968.
    GeneIDi2762510.
    KEGGimmp:MMP0968.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950229 Genomic DNA. Translation: CAF30524.1 .
    RefSeqi NP_988088.1. NC_005791.1.
    WP_011170912.1. NC_005791.1.

    3D structure databases

    ProteinModelPortali P60862.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267377.MMP0968.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF30524 ; CAF30524 ; MMP0968 .
    GeneIDi 2762510.
    KEGGi mmp:MMP0968.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci MMAR267377:GJ77-998-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S2 / LL.

    Entry informationi

    Entry nameiHISX_METMP
    AccessioniPrimary (citable) accession number: P60862
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3