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P60861

- HISX_RHOPA

UniProt

P60861 - HISX_RHOPA

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Protein
Histidinol dehydrogenase
Gene
hisD, RPA4531
Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei214 – 2141NAD By similarity
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei327 – 3271Proton acceptor By similarity
Active sitei328 – 3281Proton acceptor By similarity
Binding sitei328 – 3281Substrate By similarity
Metal bindingi361 – 3611Zinc By similarity
Binding sitei361 – 3611Substrate By similarity
Binding sitei415 – 4151Substrate By similarity
Metal bindingi420 – 4201Zinc By similarity
Binding sitei420 – 4201Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:RPA4531
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenaseUniRule annotation
PRO_0000135835Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA4531.

Structurei

3D structure databases

ProteinModelPortaliP60861.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiQKSLHAV.
OrthoDBiEOG6CVVCR.
PhylomeDBiP60861.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60861-1 [UniParc]FASTAAdd to Basket

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MPLRLDNASP DFASKFKAFL AMKREVAADI EAATRAIVDD VAHRGDAALL    50
EATEKFDRLT LDAAGMRVGE AEVEAAVKAC DSETVDALKL ARDRIEFFHR 100
RQLPKDDRFT DPLGVELGWR WSAIEAVGLY VPGGTAAYPS SVLMNAIPAK 150
VAGVERVVMV VPSPGGTLNP LVLAAAQLAG ATEIYRIGGA QAVAALAYGT 200
ATIAPVAKIV GPGNAYVAAA KRLVFGRVGI DMIAGPSEVV VVADKTANPD 250
WIAADLLAQA EHDANAQSIL ITDSAVLAAD VERALAAQLT TLPRVKIARA 300
SWDEFGAIIK VAKLEDAVPL ANAIAAEHLE IMTADPEAFA DKIRNAGAIF 350
LGGHTPEAIG DYVGGSNHVL PTARSARFSS GLGVLDFMKR TSILKCGPEQ 400
LAVLGPAAMA LGKAEGLDAH ARSVGLRLNQ R 431
Length:431
Mass (Da):45,117
Last modified:April 13, 2004 - v1
Checksum:iE560EA9B918F015B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX572607 Genomic DNA. Translation: CAE29971.1.
RefSeqiNP_949865.1. NC_005296.1.

Genome annotation databases

EnsemblBacteriaiCAE29971; CAE29971; RPA4531.
GeneIDi2689094.
KEGGirpa:RPA4531.
PATRICi23293709. VBIRhoPal84835_4762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX572607 Genomic DNA. Translation: CAE29971.1 .
RefSeqi NP_949865.1. NC_005296.1.

3D structure databases

ProteinModelPortali P60861.
ModBasei Search...

Protein-protein interaction databases

STRINGi 258594.RPA4531.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE29971 ; CAE29971 ; RPA4531 .
GeneIDi 2689094.
KEGGi rpa:RPA4531.
PATRICi 23293709. VBIRhoPal84835_4762.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi QKSLHAV.
OrthoDBi EOG6CVVCR.
PhylomeDBi P60861.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-98 / CGA009.

Entry informationi

Entry nameiHISX_RHOPA
AccessioniPrimary (citable) accession number: P60861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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