Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P60860

- HISX_MYCPA

UniProt

P60860 - HISX_MYCPA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (13 Apr 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei152 – 1521NADUniRule annotation
    Binding sitei216 – 2161NADUniRule annotation
    Binding sitei263 – 2631NADUniRule annotation
    Binding sitei286 – 2861SubstrateUniRule annotation
    Metal bindingi308 – 3081ZincUniRule annotation
    Binding sitei308 – 3081SubstrateUniRule annotation
    Metal bindingi311 – 3111ZincUniRule annotation
    Binding sitei311 – 3111SubstrateUniRule annotation
    Active sitei377 – 3771Proton acceptorUniRule annotation
    Active sitei378 – 3781Proton acceptorUniRule annotation
    Binding sitei378 – 3781SubstrateUniRule annotation
    Metal bindingi411 – 4111ZincUniRule annotation
    Binding sitei411 – 4111SubstrateUniRule annotation
    Binding sitei465 – 4651SubstrateUniRule annotation
    Metal bindingi470 – 4701ZincUniRule annotation
    Binding sitei470 – 4701SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciMAVI262316:GCQR-1313-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:MAP_1293
    OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
    Taxonomic identifieri262316 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000000580: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Histidinol dehydrogenasePRO_0000135797Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262316.MAP1293.

    Structurei

    3D structure databases

    ProteinModelPortaliP60860.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    KOiK00013.
    OMAiGFLFHAN.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60860-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYRPDIDLSS SGTMDTVSPT PASPMAGIDL RGAELTAARL RSALPRGGAD    50
    VETVLPKVRP IVQAVAERGA DAALEFGASF DGVRPAAVRV PEAALDKALA 100
    DLDAAVADAL RVMIDRARAV HADQRRTDVT TTLGPGATVT ERWVPVERVG 150
    LYVPGGNAVY PSSVVMNVVP AQAAGVASLV VASPPQAQFD GLPHPTILAA 200
    ARLLGVDEVW AVGGAQAVAL LAYGGTDTGA EWPGFSSDRA RSASSPGADA 250
    ELVPVDMITG PGNIYVTAAK RLCRSRVGID AEAGPTEIAI LADHTADPAH 300
    VAADLISQAE HDEMAGSVLV TPSEDLAAAT DAELAAQLPT TVHRERVTAA 350
    LGGRQSAIIL VDDLDAGITV VNAYAAEHLE IQTADAAAVA GRIRAAGAVF 400
    VGPYSPVSLG DYCAGSNHVL PTAGSARHSS GLSVQTFLRG IHVVDYTEAA 450
    LKDVSGHVIT LAQAEDLPAH GEAIRRRFER 480
    Length:480
    Mass (Da):49,373
    Last modified:April 13, 2004 - v1
    Checksum:iD51BE3BAB2ABB107
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS03610.1.
    RefSeqiNP_960227.1. NC_002944.2.
    WP_010949149.1. NC_002944.2.

    Genome annotation databases

    EnsemblBacteriaiAAS03610; AAS03610; MAP_1293.
    GeneIDi2717805.
    KEGGimpa:MAP1293.
    PATRICi17995063. VBIMycAvi108102_1362.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS03610.1 .
    RefSeqi NP_960227.1. NC_002944.2.
    WP_010949149.1. NC_002944.2.

    3D structure databases

    ProteinModelPortali P60860.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262316.MAP1293.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS03610 ; AAS03610 ; MAP_1293 .
    GeneIDi 2717805.
    KEGGi mpa:MAP1293.
    PATRICi 17995063. VBIMycAvi108102_1362.

    Phylogenomic databases

    eggNOGi COG0141.
    KOi K00013.
    OMAi GFLFHAN.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci MAVI262316:GCQR-1313-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
      Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
      Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-968 / K-10.

    Entry informationi

    Entry nameiHISX_MYCPA
    AccessioniPrimary (citable) accession number: P60860
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3