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P60860

- HISX_MYCPA

UniProt

P60860 - HISX_MYCPA

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Protein
Histidinol dehydrogenase
Gene
hisD, MAP_1293
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521NAD By similarity
Binding sitei216 – 2161NAD By similarity
Binding sitei263 – 2631NAD By similarity
Binding sitei286 – 2861Substrate By similarity
Metal bindingi308 – 3081Zinc By similarity
Binding sitei308 – 3081Substrate By similarity
Metal bindingi311 – 3111Zinc By similarity
Binding sitei311 – 3111Substrate By similarity
Active sitei377 – 3771Proton acceptor By similarity
Active sitei378 – 3781Proton acceptor By similarity
Binding sitei378 – 3781Substrate By similarity
Metal bindingi411 – 4111Zinc By similarity
Binding sitei411 – 4111Substrate By similarity
Binding sitei465 – 4651Substrate By similarity
Metal bindingi470 – 4701Zinc By similarity
Binding sitei470 – 4701Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1313-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:MAP_1293
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Histidinol dehydrogenaseUniRule annotation
PRO_0000135797Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP1293.

Structurei

3D structure databases

ProteinModelPortaliP60860.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiGFLFHAN.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60860-1 [UniParc]FASTAAdd to Basket

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MYRPDIDLSS SGTMDTVSPT PASPMAGIDL RGAELTAARL RSALPRGGAD    50
VETVLPKVRP IVQAVAERGA DAALEFGASF DGVRPAAVRV PEAALDKALA 100
DLDAAVADAL RVMIDRARAV HADQRRTDVT TTLGPGATVT ERWVPVERVG 150
LYVPGGNAVY PSSVVMNVVP AQAAGVASLV VASPPQAQFD GLPHPTILAA 200
ARLLGVDEVW AVGGAQAVAL LAYGGTDTGA EWPGFSSDRA RSASSPGADA 250
ELVPVDMITG PGNIYVTAAK RLCRSRVGID AEAGPTEIAI LADHTADPAH 300
VAADLISQAE HDEMAGSVLV TPSEDLAAAT DAELAAQLPT TVHRERVTAA 350
LGGRQSAIIL VDDLDAGITV VNAYAAEHLE IQTADAAAVA GRIRAAGAVF 400
VGPYSPVSLG DYCAGSNHVL PTAGSARHSS GLSVQTFLRG IHVVDYTEAA 450
LKDVSGHVIT LAQAEDLPAH GEAIRRRFER 480
Length:480
Mass (Da):49,373
Last modified:April 13, 2004 - v1
Checksum:iD51BE3BAB2ABB107
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS03610.1.
RefSeqiNP_960227.1. NC_002944.2.
WP_010949149.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS03610; AAS03610; MAP_1293.
GeneIDi2717805.
KEGGimpa:MAP1293.
PATRICi17995063. VBIMycAvi108102_1362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS03610.1 .
RefSeqi NP_960227.1. NC_002944.2.
WP_010949149.1. NC_002944.2.

3D structure databases

ProteinModelPortali P60860.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP1293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS03610 ; AAS03610 ; MAP_1293 .
GeneIDi 2717805.
KEGGi mpa:MAP1293.
PATRICi 17995063. VBIMycAvi108102_1362.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi GFLFHAN.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci MAVI262316:GCQR-1313-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiHISX_MYCPA
AccessioniPrimary (citable) accession number: P60860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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