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P60860

- HISX_MYCPA

UniProt

P60860 - HISX_MYCPA

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521NADUniRule annotation
Binding sitei216 – 2161NADUniRule annotation
Binding sitei263 – 2631NADUniRule annotation
Binding sitei286 – 2861SubstrateUniRule annotation
Metal bindingi308 – 3081ZincUniRule annotation
Binding sitei308 – 3081SubstrateUniRule annotation
Metal bindingi311 – 3111ZincUniRule annotation
Binding sitei311 – 3111SubstrateUniRule annotation
Active sitei377 – 3771Proton acceptorUniRule annotation
Active sitei378 – 3781Proton acceptorUniRule annotation
Binding sitei378 – 3781SubstrateUniRule annotation
Metal bindingi411 – 4111ZincUniRule annotation
Binding sitei411 – 4111SubstrateUniRule annotation
Binding sitei465 – 4651SubstrateUniRule annotation
Metal bindingi470 – 4701ZincUniRule annotation
Binding sitei470 – 4701SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1313-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:MAP_1293
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Histidinol dehydrogenasePRO_0000135797Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP1293.

Structurei

3D structure databases

ProteinModelPortaliP60860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiGFLFHAN.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60860-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRPDIDLSS SGTMDTVSPT PASPMAGIDL RGAELTAARL RSALPRGGAD
60 70 80 90 100
VETVLPKVRP IVQAVAERGA DAALEFGASF DGVRPAAVRV PEAALDKALA
110 120 130 140 150
DLDAAVADAL RVMIDRARAV HADQRRTDVT TTLGPGATVT ERWVPVERVG
160 170 180 190 200
LYVPGGNAVY PSSVVMNVVP AQAAGVASLV VASPPQAQFD GLPHPTILAA
210 220 230 240 250
ARLLGVDEVW AVGGAQAVAL LAYGGTDTGA EWPGFSSDRA RSASSPGADA
260 270 280 290 300
ELVPVDMITG PGNIYVTAAK RLCRSRVGID AEAGPTEIAI LADHTADPAH
310 320 330 340 350
VAADLISQAE HDEMAGSVLV TPSEDLAAAT DAELAAQLPT TVHRERVTAA
360 370 380 390 400
LGGRQSAIIL VDDLDAGITV VNAYAAEHLE IQTADAAAVA GRIRAAGAVF
410 420 430 440 450
VGPYSPVSLG DYCAGSNHVL PTAGSARHSS GLSVQTFLRG IHVVDYTEAA
460 470 480
LKDVSGHVIT LAQAEDLPAH GEAIRRRFER
Length:480
Mass (Da):49,373
Last modified:April 13, 2004 - v1
Checksum:iD51BE3BAB2ABB107
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS03610.1.
RefSeqiNP_960227.1. NC_002944.2.
WP_010949149.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS03610; AAS03610; MAP_1293.
GeneIDi2717805.
KEGGimpa:MAP1293.
PATRICi17995063. VBIMycAvi108102_1362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS03610.1 .
RefSeqi NP_960227.1. NC_002944.2.
WP_010949149.1. NC_002944.2.

3D structure databases

ProteinModelPortali P60860.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP1293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS03610 ; AAS03610 ; MAP_1293 .
GeneIDi 2717805.
KEGGi mpa:MAP1293.
PATRICi 17995063. VBIMycAvi108102_1362.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi GFLFHAN.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci MAVI262316:GCQR-1313-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiHISX_MYCPA
AccessioniPrimary (citable) accession number: P60860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3