SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P60858

- HISX_CORDI

UniProt

P60858 - HISX_CORDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Histidinol dehydrogenase
Gene
hisD, DIP1566
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351NAD By similarity
Binding sitei199 – 1991NAD By similarity
Binding sitei229 – 2291NAD By similarity
Binding sitei252 – 2521Substrate By similarity
Metal bindingi274 – 2741Zinc By similarity
Binding sitei274 – 2741Substrate By similarity
Metal bindingi277 – 2771Zinc By similarity
Binding sitei277 – 2771Substrate By similarity
Active sitei343 – 3431Proton acceptor By similarity
Active sitei344 – 3441Proton acceptor By similarity
Binding sitei344 – 3441Substrate By similarity
Metal bindingi377 – 3771Zinc By similarity
Binding sitei377 – 3771Substrate By similarity
Binding sitei431 – 4311Substrate By similarity
Metal bindingi436 – 4361Zinc By similarity
Binding sitei436 – 4361Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:DIP1566
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Histidinol dehydrogenaseUniRule annotation
PRO_0000135759Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP1566.

Structurei

3D structure databases

ProteinModelPortaliP60858.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiHTERITQ.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60858-1 [UniParc]FASTAAdd to Basket

« Hide

MRKRKIMLNV IDLRGHVPTT SELRRTLPRG GTDINSVLPI VEPVVTDVKN    50
RGAAAALDYG EKFDHVRPTS IRVPQDVIDQ ALDSLDPNVI EALKESIARV 100
RAVHSEQLPA QHTTSFGEGA TITEKFIPVS RVGLYAPGGN AVYPSSVIMN 150
VVPAQEAGVE SLVVASPPQK DHGGWPHPTI LAAAKLLGVT EVWAMGGAQA 200
VALLAYGDDT QQNSAEVLEP VDMITGPGNI FVTAAKRLVR GVVGIDSEAG 250
PTEIAIVADA QANPVWIAYD LISQAEHDVL AASVLITDSE ELAQRVNEEV 300
AARYSVTRNA DRVSEALKGQ QSGIVLVDDL PTAVIVADAY AAEHLEIHTA 350
ESHKVAEQIR NAGAIFVGGY SPVPLGDYSA GSNHVLPTSG SARYSSGLST 400
HTFLKPVNVI YYDEVALKEI SDTVITLADA EDLPAHGEAI RTRFENLGN 449
Length:449
Mass (Da):47,762
Last modified:April 13, 2004 - v1
Checksum:i002BB36B98F433FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248358 Genomic DNA. Translation: CAE50091.1.
RefSeqiNP_939908.1. NC_002935.2.
WP_010935159.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50091; CAE50091; DIP1566.
GeneIDi2650755.
KEGGicdi:DIP1566.
PATRICi21484340. VBICorDip47633_1546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248358 Genomic DNA. Translation: CAE50091.1 .
RefSeqi NP_939908.1. NC_002935.2.
WP_010935159.1. NC_002935.2.

3D structure databases

ProteinModelPortali P60858.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257309.DIP1566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE50091 ; CAE50091 ; DIP1566 .
GeneIDi 2650755.
KEGGi cdi:DIP1566.
PATRICi 21484340. VBICorDip47633_1546.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi HTERITQ.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiHISX_CORDI
AccessioniPrimary (citable) accession number: P60858
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi