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P60858

- HISX_CORDI

UniProt

P60858 - HISX_CORDI

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei135 – 1351NADUniRule annotation
    Binding sitei199 – 1991NADUniRule annotation
    Binding sitei229 – 2291NADUniRule annotation
    Binding sitei252 – 2521SubstrateUniRule annotation
    Metal bindingi274 – 2741ZincUniRule annotation
    Binding sitei274 – 2741SubstrateUniRule annotation
    Metal bindingi277 – 2771ZincUniRule annotation
    Binding sitei277 – 2771SubstrateUniRule annotation
    Active sitei343 – 3431Proton acceptorUniRule annotation
    Active sitei344 – 3441Proton acceptorUniRule annotation
    Binding sitei344 – 3441SubstrateUniRule annotation
    Metal bindingi377 – 3771ZincUniRule annotation
    Binding sitei377 – 3771SubstrateUniRule annotation
    Binding sitei431 – 4311SubstrateUniRule annotation
    Metal bindingi436 – 4361ZincUniRule annotation
    Binding sitei436 – 4361SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:DIP1566
    OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
    Taxonomic identifieri257309 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000002198: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Histidinol dehydrogenasePRO_0000135759Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257309.DIP1566.

    Structurei

    3D structure databases

    ProteinModelPortaliP60858.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiHTERITQ.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60858-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKRKIMLNV IDLRGHVPTT SELRRTLPRG GTDINSVLPI VEPVVTDVKN    50
    RGAAAALDYG EKFDHVRPTS IRVPQDVIDQ ALDSLDPNVI EALKESIARV 100
    RAVHSEQLPA QHTTSFGEGA TITEKFIPVS RVGLYAPGGN AVYPSSVIMN 150
    VVPAQEAGVE SLVVASPPQK DHGGWPHPTI LAAAKLLGVT EVWAMGGAQA 200
    VALLAYGDDT QQNSAEVLEP VDMITGPGNI FVTAAKRLVR GVVGIDSEAG 250
    PTEIAIVADA QANPVWIAYD LISQAEHDVL AASVLITDSE ELAQRVNEEV 300
    AARYSVTRNA DRVSEALKGQ QSGIVLVDDL PTAVIVADAY AAEHLEIHTA 350
    ESHKVAEQIR NAGAIFVGGY SPVPLGDYSA GSNHVLPTSG SARYSSGLST 400
    HTFLKPVNVI YYDEVALKEI SDTVITLADA EDLPAHGEAI RTRFENLGN 449
    Length:449
    Mass (Da):47,762
    Last modified:April 13, 2004 - v1
    Checksum:i002BB36B98F433FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248358 Genomic DNA. Translation: CAE50091.1.
    RefSeqiNP_939908.1. NC_002935.2.
    WP_010935159.1. NC_002935.2.

    Genome annotation databases

    EnsemblBacteriaiCAE50091; CAE50091; DIP1566.
    GeneIDi2650755.
    KEGGicdi:DIP1566.
    PATRICi21484340. VBICorDip47633_1546.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248358 Genomic DNA. Translation: CAE50091.1 .
    RefSeqi NP_939908.1. NC_002935.2.
    WP_010935159.1. NC_002935.2.

    3D structure databases

    ProteinModelPortali P60858.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257309.DIP1566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE50091 ; CAE50091 ; DIP1566 .
    GeneIDi 2650755.
    KEGGi cdi:DIP1566.
    PATRICi 21484340. VBICorDip47633_1546.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi HTERITQ.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

    Entry informationi

    Entry nameiHISX_CORDI
    AccessioniPrimary (citable) accession number: P60858
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3